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61. 发明授权

US08318953B2 Reactive coumarin derivatives and their use in cellular analyses 有权
标题翻译：活性香豆素衍生物及其在细胞分析中的应用
公开(公告)号：US08318953B2
公开(公告)日：2012-11-27
申请号：US12822091
申请日：2010-06-23
申请人： Zhenjun Diwu , Chunmei Wei , Qinglin Meng , Haitao Guo , Jingfang Liao
发明人： Zhenjun Diwu , Chunmei Wei , Qinglin Meng , Haitao Guo , Jingfang Liao
IPC分类号： C07D405/12
CPC分类号： C12Q1/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , G01N33/5005
摘要： Chemically reactive 7-hydroxycoumarin derivatives and their application for analyzing cell function, for example in combination with additional fluorescent labels. The coumarin derivatives exhibit a strong absorption at 405 nm and high fluorescence quantum yields.
摘要翻译：化学反应性7-羟基香豆素衍生物及其用于分析细胞功能的应用，例如与额外的荧光标记组合。香豆素衍生物在405nm处表现出强吸收和高荧光量子产率。

62. 发明申请

US20120258514A1 Kits for analysis of biological samples 审中-公开
标题翻译：用于生物样品分析的试剂盒
公开(公告)号：US20120258514A1
公开(公告)日：2012-10-11
申请号：US13374994
申请日：2012-01-27
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12N9/96 , C12N1/20 , C07H7/06 , C07H21/04 , C07K14/00 , C12N5/071 , C07K2/00
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

63. 发明申请

US20120183954A1 LUMINESCENT DYES WITH A WATER-SOLUBLE INTRAMOLECULAR BRIDGE AND THEIR BIOLOGICAL CONJUGATES 有权
标题翻译：具有水溶性分子桥的发光体及其生物学结合
公开(公告)号：US20120183954A1
公开(公告)日：2012-07-19
申请号：US13181107
申请日：2011-07-12
申请人： Zhenjun Diwu , Qinglin Meng , Jinfang Liao , Haitao Guo , Timothy Dubrovsky , Barnaby Abrams
发明人： Zhenjun Diwu , Qinglin Meng , Jinfang Liao , Haitao Guo , Timothy Dubrovsky , Barnaby Abrams
IPC分类号： G01N21/64 , C07D498/16 , C07F5/00 , C12N9/96 , C07D403/14 , C07K17/02 , C08B37/02 , C07H19/00 , C07K5/00 , C07D487/14
CPC分类号： C09B23/083 , C09B11/08 , C09B11/24 , C09B11/26 , C09B57/00 , C09B57/10 , G01N33/533
摘要： Chemically reactive dyes that are intramolecularly crosslinked with a water-soluble bridge, their bioconjugates and their uses are described. Reactive fluorescent dyes that have a water-soluble bridge are superior to those of conjugates of spectrally non-crosslinked dyes or the dyes that are crosslinked with a hydrophobic bridge. The invention includes reactive fluorescent dyes, their biological conjugates and uses.
摘要翻译：描述了与水溶性桥分子内交联的化学活性染料及其生物共轭物及其用途。具有水溶性桥梁的活性荧光染料优于光谱非交联染料或与疏水桥交联的染料的共轭物。本发明包括反应性荧光染料，它们的生物共轭物和用途。

64. 发明授权

US08183375B2 Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings 有权
标题翻译：含稠环的1,2-二氢-7-羟基喹啉的衍生物
公开(公告)号：US08183375B2
公开(公告)日：2012-05-22
申请号：US12901713
申请日：2010-10-11
申请人： Zhenjun Diwu , Jixiang Liu , Kyle Gee
发明人： Zhenjun Diwu , Jixiang Liu , Kyle Gee
IPC分类号： C07D471/04 , C07D471/06 , G01N1/30 , G01N33/48 , G01N33/50
CPC分类号： G01N33/582 , C07D471/04 , C07D491/04 , C07D491/044 , C07D491/14 , C07D491/147 , C07D491/22 , C07D495/04 , C07D495/14 , C07D495/22 , C07D498/14 , C12Q1/6816 , Y10S436/80 , Y10T436/141111 , Y10T436/143333 , Y10T436/145555 , C12Q2563/107
摘要： The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
摘要翻译：本发明描述了新颖的染料，包括掺入另外的稠合芳环的香豆素，罗丹明和罗丹醇。本发明的染料比不具有稠合芳环的结构相似的染料长的波长吸收。本发明的许多染料是有用的荧光染料。本发明包括化学活性染料，染料共轭物，以及这些染料在染色样品和检测配体或其他分析物中的用途。

65. 发明授权

US08093404B2 Macrocyclic dyes having aryl moieties 有权
标题翻译：具有芳基部分的大环染料
公开(公告)号：US08093404B2
公开(公告)日：2012-01-10
申请号：US12583513
申请日：2009-08-20
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D403/06
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

66. 发明授权

US07985552B2 Dye conjugates of nucleotides and other biological substances 有权
标题翻译：核苷酸和其他生物物质的染料缀合物
公开(公告)号：US07985552B2
公开(公告)日：2011-07-26
申请号：US12807268
申请日：2010-09-01
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , C07D225/00 , C07D209/56
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

67. 发明授权

US07910753B2 Cyanine dyes and their applications as luminescence quenching compounds 有权
标题翻译：花青染料及其作为发光淬灭剂的应用
公开(公告)号：US07910753B2
公开(公告)日：2011-03-22
申请号：US11222049
申请日：2005-09-07
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
IPC分类号： C07D209/46 , C07D209/02
CPC分类号： C07D409/14 , C07D209/60 , C07D403/14 , C07D409/04 , C07D409/06 , C07D417/14 , C07D471/04 , C07H21/04 , C07J43/00 , G01N33/542 , G01N33/582
摘要： The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.
摘要翻译：本发明的淬灭化合物是被一个或多个杂芳族猝灭部分取代的弱发光花青素。本发明的淬灭化合物表现出很少或不可观察到的发光，并有效地淬灭广谱的发光化合物。化学反应猝灭化合物具有用于标记各种物质（包括生物分子）的效用。这些标记的物质对于各种能量转移测定和应用是非常有用的。

68. 发明授权

US07820783B2 Kits for flurotometric analyses 有权
标题翻译：用于荧光分析的试剂盒
公开(公告)号：US07820783B2
公开(公告)日：2010-10-26
申请号：US12287071
申请日：2008-10-06
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D209/56 , C12N5/06 , C12N1/00 , C07K2/00 , C07H21/00 , C07H7/06
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

69. 发明授权

US07816527B2 Quinazoline-containing kits for labeling aldehyde or ketone moieties 有权
标题翻译：用于标记醛或酮部分的含喹唑啉试剂盒
公开(公告)号：US07816527B2
公开(公告)日：2010-10-19
申请号：US11182122
申请日：2005-07-15
申请人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
发明人： Richard P. Haugland , Thomas H. Steinberg , Wayne F. Patton , Zhenjun Diwu
IPC分类号： C07D239/72
CPC分类号： C07D265/22 , C07D239/91 , Y10T436/143333 , Y10T436/200833
摘要： Kits including novel fluorescent derivitization reagents for labeling an aldehyde- and/or ketone-containing target substance in a sample are described. In one embodiment kits are provided the novel fluorescent derivitization reagents of which have the following formula: wherein Q is carbonyl, thiocarbonyl, or sulfonyl, and R5 is -L-Z; L is arylene, or a C1-6 perfluoroalkylene; Z is a carbonyl hydrazide, hydrazide, sulfonyl hydrazide, or a thiocarbonyl hydrazide; R11-R14 are independently H, C1-16 alkyl, C1-6 alkylamino, amino, or halogen; and R21-R24 are independently H, C 1-6 alkyl, C 1-6 alkoxy, C1-6 perfluoroalkyl, C1-6 alkylamino, di(C2-12-alkyl)amino, amino, carboxy, cyano, halogen, hydroxy, nitro, phenyl, sulfo, or -L-Z. The kits and reagents described are particularly useful for labeling glycoproteins or glycopeptides, nucleic acids, and lipopolysaccharides in electrophoresis gels.
摘要翻译：描述了包括用于标记样品中含醛和/或酮的目标物质的新型荧光衍生试剂的试剂盒。在一个实施方案中提供试剂盒，其新型荧光衍生试剂具有下式：其中Q为羰基，硫代羰基或磺酰基，R5为-L-Z; L是亚芳基或C1-6全氟亚烷基; Z是羰基酰肼，酰肼，磺酰肼或硫代羰基酰肼; R11-R14独立地为H，C1-16烷基，C1-6烷基氨基，氨基或卤素; R 21 -R 24独立地为H，C 1-6烷基，C 1-6烷氧基，C 1-6全氟烷基，C 1-6烷基氨基，二（C 2-12 - 烷基）氨基，氨基，羧基，氰基，卤素，羟基，硝基，苯基，磺基或-LZ。所述的试剂盒和试剂特别可用于在电泳凝胶中标记糖蛋白或糖肽，核酸和脂多糖。

70. 发明授权

US07790394B2 Methods of analyzing a biological sample 有权
标题翻译：分析生物样品的方法
公开(公告)号：US07790394B2
公开(公告)日：2010-09-07
申请号：US12287090
申请日：2008-10-06
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , C07D225/00 , C07D245/00 , C07D209/02 , C07D209/04
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

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