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61. 发明申请

US20170135556A1 INTRADURAL ENDOSCOPE 审中-公开
公开(公告)号：US20170135556A1
公开(公告)日：2017-05-18
申请号：US15362924
申请日：2016-11-29
申请人： Daniel H. Kim
发明人： Daniel H. Kim
IPC分类号： A61B1/005 , A61B1/04 , A61B17/34 , A61B1/018
CPC分类号： A61B1/0051 , A61B1/018 , A61B1/04 , A61B17/3401
摘要： A method for treating a patient includes inserting an endoscope into an intradural space of the patient via an interspace of a vertebral column of the patient; steering the endoscope along the intradural space to a location; and performing a medical procedure at the location using a working lumen of the endoscope.

62. 发明授权

US09504372B2 Intradural endoscope 有权
标题翻译：内窥镜
公开(公告)号：US09504372B2
公开(公告)日：2016-11-29
申请号：US13509571
申请日：2010-11-12
申请人： Daniel H. Kim
发明人： Daniel H. Kim
IPC分类号： A61B1/00 , A61B1/04 , A61M31/00 , A61M37/00 , A61M25/00 , A61B1/005 , A61B1/018 , A61B17/34
摘要： A method for treating a patient includes inserting an endoscope into an intradural space of the patient via an interspace of a vertebral column of the patient; steering the endoscope along the intradural space to a location; and performing a medical procedure at the location using a working lumen of the endoscope.
摘要翻译：用于治疗患者的方法包括经由患者的椎骨柱的间隙将内窥镜插入到患者的硬膜内空间中; 将内窥镜沿着椎间盘内空间转向一处; 以及使用所述内窥镜的工作内腔在所述位置处进行医疗处理。

63. 发明授权

US09205259B2 Neurostimulation system 有权
标题翻译：神经刺激系统
公开(公告)号：US09205259B2
公开(公告)日：2015-12-08
申请号：US13402786
申请日：2012-02-22
申请人： Daniel H. Kim , Mir A. Imran
发明人： Daniel H. Kim , Mir A. Imran
IPC分类号： A61N1/34 , A61N1/05 , A61N1/36
CPC分类号： A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要： Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译：本发明的一些实施方案通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的神经刺激系统和组件。本发明的一些其他实施方案提供了适用于一种或多种神经根神经节的选择性神经刺激的神经刺激系统以及将神经刺激应用于脊髓的技术。本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件，其与药理学组合。

64. 发明授权

US09161783B2 Interspinous spacer 有权
标题翻译：椎间间隔
公开(公告)号：US09161783B2
公开(公告)日：2015-10-20
申请号：US13619195
申请日：2012-09-14
申请人： Moti Altarac , Shawn Tebbe , Joey Camia Reglos , Yang Cheng , Murali P. Kadaba , Daniel H. Kim
发明人： Moti Altarac , Shawn Tebbe , Joey Camia Reglos , Yang Cheng , Murali P. Kadaba , Daniel H. Kim
IPC分类号： A61B17/70 , A61B17/00 , A61F2/00
CPC分类号： A61B17/7065 , A61B17/7062 , A61B2017/00004 , A61B2017/00557 , A61F2/0077
摘要： An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal earning surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the earning surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.
摘要翻译：提供了用于放置在脊柱运动段中的相邻棘突之间的可植入间隔物。间隔件包括限定纵向轴线和通道的主体。第一臂和第二臂连接到身体。每个臂具有一对延伸部和鞍形部，其限定用于将棘突放置在其中的U形构造。每个臂具有近端收获表面并且能够相对于身体旋转。致动器组件设置在通道内部并连接到主体。当进行时，致动器组件的螺纹轴接触臂的收入表面，以将它们从未部署的构型旋转到展开配置。在展开的构型中，分散的相邻棘突位于臂的U形部分中。

65. 发明授权

US09023084B2 Systems and methods for stabilizing the motion or adjusting the position of the spine 有权
标题翻译：用于稳定运动或调整脊柱位置的系统和方法
公开(公告)号：US09023084B2
公开(公告)日：2015-05-05
申请号：US11006521
申请日：2004-12-06
申请人： Daniel H. Kim
发明人： Daniel H. Kim
IPC分类号： A61B17/70 , A61B17/34 , A61B17/00 , A61B17/02
CPC分类号： A61B17/7065 , A61B17/025 , A61B17/3468 , A61B17/7064 , A61B17/7067 , A61B2017/00557 , A61B2017/0256
摘要： Systems and methods for stabilizing or adjusting the position of at least one spinal motion segment, such as a posterior element distraction system. The system includes an implantable member having at least one of a lateral member and a transverse member. The lateral member may be expandable in at least one dimension, for example, in a direction along the axis of the spine. The expandable member may be an inflatable balloon, expandable scaffolding, strut, or combination thereof and may provide stability and anchoring to the implantable member. The transverse member is configured to engage the spinous process and may extend from the lateral member or may extend between two laterally-opposed members. For example, the transverse members may be configured to engage an outer surface of the spinous process, and as such, act as a saddle or cradle.
摘要翻译：用于稳定或调整至少一个脊柱运动段（例如后部元件牵引系统）的位置的系统和方法。该系统包括具有横向构件和横向构件中的至少一个的可植入构件。横向构件可以在例如沿着脊柱的轴线的方向的至少一个尺寸上可扩张。可膨胀构件可以是可膨胀气囊，可膨胀的支架，支柱或其组合，并且可以提供对可植入构件的稳定性和锚定。横向构件构造成接合棘突，并且可以从侧向构件延伸，或者可以在两个横向相对的构件之间延伸。例如，横向构件可以构造成接合棘突的外表面，并且因此，起到鞍座或支架的作用。

66. 发明授权

US08945183B2 Interspinous process spacer instrument system with deployment indicator 有权
公开(公告)号：US08945183B2
公开(公告)日：2015-02-03
申请号：US12400601
申请日：2009-03-09
申请人： Moti Altarac , Shawn Tebbe , Daniel H. Kim
发明人： Moti Altarac , Shawn Tebbe , Daniel H. Kim
IPC分类号： A61F2/44 , A61B17/70 , A61B17/86 , A61B17/88
CPC分类号： A61B17/7065 , A61B17/7062 , A61B17/861 , A61B17/8877 , A61B17/8888
摘要： A percutaneous and minimally invasive instrument system for implanting an interspinous process spacer into a patient is disclosed. The insertion instrument system includes an inserter and a driver. The inserter is configured to releasably clamp to an interspinous process spacer for its delivery, implantation and deployment. The driver is configured for removable insertion into a proximal end of a passageway of the inserter. The driver has a distal spacer engaging portion configured to engage that part of the spacer requiring activation for the deployment of the spacer from at least one undeployed configuration to at least one deployed configuration and vice versa. As the spacer goes from the undeployed to the deployed configuration and vice versa, the system advantageously provides a degree of deployment information to the user via at least one deployment indicator.

67. 发明授权

US08828035B2 Apparatus and method for prostatic tissue removal 有权
标题翻译：用于前列腺组织去除的装置和方法
公开(公告)号：US08828035B2
公开(公告)日：2014-09-09
申请号：US11969587
申请日：2008-01-04
申请人： Daniel H. Kim
发明人： Daniel H. Kim
IPC分类号： A61B17/32 , A61B17/3207 , A61B17/00 , A61B18/14 , A61B18/20 , A61B18/00 , A61B17/22
CPC分类号： A61B17/320725 , A61B17/320758 , A61B18/1485 , A61B18/20 , A61B2017/00274 , A61B2017/00685 , A61B2017/00867 , A61B2017/22077 , A61B2017/320775 , A61B2018/00547
摘要： Methods and apparatus for medical treating prostatic tissues are provided. In one embodiment, the method includes removing prostatic tissues adjacent the urethra and enlarging the lumen of the urethra, whereby the treatment conserves a natural wall of the urethra.
摘要翻译：提供了治疗前列腺组织的方法和装置。在一个实施方案中，该方法包括去除邻近尿道的前列腺组织并扩大尿道的内腔，由此该治疗节省了尿道的天然壁。

68. 发明授权

US08613747B2 Spacer insertion instrument 有权
标题翻译：间隔插入仪器
公开(公告)号：US08613747B2
公开(公告)日：2013-12-24
申请号：US12338793
申请日：2008-12-18
申请人： Moti Altarac , Shawn Tebbe , Daniel H. Kim
发明人： Moti Altarac , Shawn Tebbe , Daniel H. Kim
IPC分类号： A61F2/44
CPC分类号： A61B17/7074 , A61B17/025 , A61B17/7062 , A61B17/7065 , A61B17/7067 , A61B2017/00004 , A61B2017/0256 , A61F2/0077
摘要： A percutaneous and minimally invasive instrument for inserting an interspinous process spacer into a patient is disclosed. The insertion instrument includes a first assembly connected to a handle assembly. The first assembly includes an inner shaft located inside an outer shaft; the inner and outer shafts being configured for relative translational motion with respect to each other to thereby deflect at least one prong formed on one of the inner or outer shafts wherein such deflection causes engagement with a juxtapositioned interspinous spacer. The instrument further includes a driving tool configured for removable insertion into a proximal end of a passageway of the instrument. The driving tool has a distal spacer engaging portion configured to engage that part of the spacer requiring activation for deployment of the spacer from at least one undeployed configuration to at least one deployed configuration and vice versa.
摘要翻译：公开了一种用于将棘突间间隔物插入患者体内的经皮和微创手术器械。插入器具包括连接到手柄组件的第一组件。第一组件包括位于外轴内部的内轴; 内轴和外轴构造成相对于彼此进行相对平移运动，从而偏转形成在内轴或外轴中的一个上的至少一个叉，其中这种偏转导致与并置的棘突间间隔件的接合。仪器还包括被配置为可移除地插入仪器的通道的近端的驱动工具。所述驱动工具具有远侧间隔件接合部分，所述远侧间隔件接合部分构造成接合所述间隔件的所述部分，所述间隔件需要激活以将间隔件从至少一个未部署构型展开至至少一个部署构型，反之亦然。

69. 发明授权

US08513401B2 Double stranded nucleic acid targeting low copy promoter-specific RNA 有权
标题翻译：靶向低拷贝启动子特异性RNA的双链核酸
公开(公告)号：US08513401B2
公开(公告)日：2013-08-20
申请号：US12772652
申请日：2010-05-03
申请人： John J. Rossi , Daniela Castanotto , Gerd Pfeifer , Stella Tommasi , Kevin V. Morris , Daniel H. Kim
发明人： John J. Rossi , Daniela Castanotto , Gerd Pfeifer , Stella Tommasi , Kevin V. Morris , Daniel H. Kim
IPC分类号： C07H21/04 , C07H21/02
CPC分类号： C12N15/111 , C12N15/1135 , C12N15/63 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.
摘要翻译：本发明涉及哺乳动物（包括人）由小干扰RNA（siRNA）分子介导的细胞的转录基因沉默（TGS）。本发明还涉及引导与产生低拷贝启动子特异性RNA的靶基因相关的组蛋白甲基化的双链核酸。已经发现siRNA可以用于引导哺乳动物（包括人）细胞中组蛋白的甲基化。

70. 发明申请

US20130172933A1 INTERSPINOUS SPACER 有权
公开(公告)号：US20130172933A1
公开(公告)日：2013-07-04
申请号：US13617018
申请日：2012-09-14
申请人： Moti Altarac , Shawn Tebbe , Joey Camia Reglos , Yang Cheng , Murali P. Kadaba , Daniel H. Kim
发明人： Moti Altarac , Shawn Tebbe , Joey Camia Reglos , Yang Cheng , Murali P. Kadaba , Daniel H. Kim
IPC分类号： A61B17/70
CPC分类号： A61B17/7062 , A61B17/7065 , A61B2017/00004 , A61B2017/00557 , A61F2/0077
摘要： An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal caming surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the caming surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.
摘要翻译：提供了用于放置在脊柱运动段中的相邻棘突之间的可植入间隔物。间隔件包括限定纵向轴线和通道的主体。第一臂和第二臂连接到身体。每个臂具有一对延伸部和鞍形部，其限定用于将棘突放置在其中的U形构造。每个臂具有近端凸轮表面并且能够相对于身体旋转。致动器组件设置在通道内部并连接到主体。当前进时，致动器组件的螺纹轴接触臂的凸轮表面，以将它们从未部署的构型旋转到展开配置。在展开的构型中，分散的相邻棘突位于臂的U形部分中。

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