专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US06923964B1 Active immunization of AScr for prion disorders 有权
标题翻译： AScr主动免疫朊病毒疾病
公开(公告)号：US06923964B1
公开(公告)日：2005-08-02
申请号：US09585817
申请日：2000-06-01
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： A61K38/00 , A61K38/17 , A61K38/19 , A61K39/00 , C07K14/47 , C07K16/18 , G01N33/68
CPC分类号： G01N33/6896 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K16/18 , C07K2317/34 , C07K2319/00 , A61K2300/00
摘要： Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive amounts of amyloid fibril components, particularly fibril-forming peptides or proteins. Also disclosed are therapeutic compositions and methods which use immune reagents that react with such fibril components.
摘要翻译：公开了用于预防或治疗许多淀粉样蛋白病的药物组合物和方法，包括阿尔茨海默病，朊病毒病，家族性淀粉样蛋白神经病等。药物组合物包括免疫反应量的淀粉样蛋白原纤维组分，特别是原纤维形成肽或蛋白质。还公开了使用与这种原纤维组分反应的免疫试剂的治疗组合物和方法。

62. 发明授权

US09067981B1 Hybrid amyloid-beta antibodies 有权
标题翻译：杂交淀粉样β抗体
公开(公告)号：US09067981B1
公开(公告)日：2015-06-30
申请号：US12608869
申请日：2009-10-29
申请人： Guriqbal Basi , Dale B. Schenk , Hadar Hana Feinberg , William I. Weis
发明人： Guriqbal Basi , Dale B. Schenk , Hadar Hana Feinberg , William I. Weis
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/60
摘要： The present invention provides crystals including amino acids 1-7 of SEQ ID NO:1 and a Fab fragment of 12A11, 12B4, 10D5 or 3D6, as well as of amino acids 1-40 of SEQ ID NO:1 and a Fab fragment of 12A11 or 3D6, as well as methods for preparing the crystals. The present invention also provides a computer implemented method for analyzing binding of a candidate antibody fragment to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, a method for identifying an antibody fragment that can mimic the Fab fragment of 12A11, a method for identifying an antibody fragment that can mimic the Fab fragment of 3D6, a method for identifying a candidate antibody fragment that binds to a peptide including an epitope of amino acids 1-7 of SEQ ID NO:1, and a method for designing a humanized antibody that binds to a peptide comprising an epitope of amino acids 1-7 of SEQ ID NO:1.
摘要翻译：本发明提供了包含SEQ ID NO：1的氨基酸1-7和12A11,12B4,10D5或3D6的Fab片段以及SEQ ID NO：1的氨基酸1-40的晶体和包含SEQ ID NO： 12A11或3D6，以及制备晶体的方法。本发明还提供了一种用于分析候选抗体片段与包含SEQ ID NO：1的氨基酸1-7的表位的肽的结合的计算机实施方法，用于鉴定可以模拟SEQ ID NO：1的Fab片段的抗体片段的方法 12A11，鉴定可以模拟3D6的Fab片段的抗体片段的方法，鉴定与包含SEQ ID NO：1的氨基酸1-7的表位的肽结合的候选抗体片段的方法，以及方法用于设计与包含SEQ ID NO：1的氨基酸1-7的表位的肽结合的人源化抗体。

63. 发明授权

US08741298B2 APOE immunotherapy 有权
标题翻译： APOE免疫治疗
公开(公告)号：US08741298B2
公开(公告)日：2014-06-03
申请号：US13368260
申请日：2012-02-07
申请人： Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
发明人： Dale B. Schenk , Tarlochan S. Nijjar , Philip W. Payne , Robin Barbour
IPC分类号： A61K39/395 , C07K16/18 , C07K4/12 , C12N5/06 , C12N15/74 , C12N15/81
CPC分类号： C07K16/18 , A61K39/00 , C07K14/775 , C07K2317/24 , G01N33/6896 , G01N2333/775 , G01N2800/2821
摘要： The present invention provides antibodies that preferentially bind to an ApoE(1-272) fragment relative to ApoE(1-299). These antibodies serve to reduce the toxicity of this fragment and find use in treatment and prophylaxis of a variety of neurological diseases.
摘要翻译：本发明提供了相对于ApoE（1-299）优先结合ApoE（1-272）片段的抗体。这些抗体用于降低该片段的毒性，可用于治疗和预防各种神经疾病。

64. 发明申请

US20110306756A1 Prevention and Treatment of Amyloidogenic Disease 审中-公开
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20110306756A1
公开(公告)日：2011-12-15
申请号：US12977013
申请日：2010-12-22
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： C07K16/18
CPC分类号： C07K14/4711 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0005 , A61K39/0007 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K16/18 , C07K2317/34 , C07K2317/70 , C07K2317/77 , C07K2319/00 , G01N2800/2821 , Y02A50/412 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is Aβ peptide, active fragments thereof or an antibody thereto.
摘要翻译：本发明提供了治疗淀粉样变性疾病的组合物和方法。这样的方法需要施用一种诱导针对患者淀粉样沉积物的有益免疫应答的药剂。该方法对阿尔茨海默病的预防和治疗特别有用。在这种方法中，合适的试剂是A＆bgr; 肽，其活性片段或其抗体。

65. 发明授权

US08034348B2 Prevention and treatment of amyloidogenic disease 有权
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US08034348B2
公开(公告)日：2011-10-11
申请号：US11842113
申请日：2007-08-20
申请人： Dale B. Schenk , Nicki Vasquez , Theodore Yednock
发明人： Dale B. Schenk , Nicki Vasquez , Theodore Yednock
IPC分类号： A61K39/385 , A61K39/39 , A61K38/08 , A61K39/05
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , Y02A50/472 , A61K2300/00
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the amyloid deposit. The methods are useful for prophylactic and therapeutic treatment of Alzheimer's disease. Preferred agents including N-terminal fragments of Aβ and antibodies binding to the same.
摘要翻译：本发明提供用于治疗与淀粉样蛋白沉积相关的疾病的改进剂和方法。在病人的大脑中。这样的方法需要对淀粉样蛋白沉积物诱导有益的免疫原性应答的施用试剂。该方法可用于预防和治疗阿尔茨海默氏病。优选的试剂包括A末端的N末端片段; 和结合相同的抗体。

66. 发明授权

US07893214B2 Humanized antibodies that recognize beta amyloid peptide 有权
标题翻译：识别β淀粉样蛋白肽的人源化抗体
公开(公告)号：US07893214B2
公开(公告)日：2011-02-22
申请号：US11842023
申请日：2007-08-20
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K39/3955 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/77 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.
摘要翻译：本发明提供用于治疗与淀粉样蛋白沉积相关的疾病的改进剂和方法。在病人的大脑中。优选的试剂包括人源化抗体。

67. 发明申请

US20080281082A1 HUMANIZED ANTIBODIES THAT RECOGNIZE BETA AMYLOID PEPTIDE 审中-公开
公开(公告)号：US20080281082A1
公开(公告)日：2008-11-13
申请号：US11842056
申请日：2007-08-20
申请人： Guriq Basi , Jose William Saldanha , Dale B. Schenk
发明人： Guriq Basi , Jose William Saldanha , Dale B. Schenk
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K39/3955 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/77 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.

68. 发明申请

US20080248029A1 PREVENTION AND TREATMENT OF AMYLOIDOGENIC DISEASES 有权
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US20080248029A1
公开(公告)日：2008-10-09
申请号：US11842052
申请日：2007-08-20
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K39/0007 , A61K2039/505 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , C07K16/18 , C07K2317/77 , G01N2800/2814 , G01N2800/2821
摘要： Disclosed are pharmaceutical compositions and methods for preventing or treating a number of amyloid diseases, including Alzheimer's disease, prion diseases, familial amyloid neuropathies and the like. The pharmaceutical compositions include immunologically reactive amounts of amyloid fibril components, particularly fibril-forming peptides or proteins. Also disclosed are therapeutic compositions and methods which use immune reagents that react with such fibril components.
摘要翻译：公开了用于预防或治疗许多淀粉样蛋白病的药物组合物和方法，包括阿尔茨海默病，朊病毒病，家族性淀粉样蛋白神经病等。药物组合物包括免疫反应量的淀粉样蛋白原纤维组分，特别是原纤维形成肽或蛋白质。还公开了使用与这种原纤维组分反应的免疫试剂的治疗组合物和方法。

69. 发明授权

US06808712B2 Prevention and treatment of amyloidogenic disease 有权
标题翻译：预防和治疗淀粉样变性疾病
公开(公告)号：US06808712B2
公开(公告)日：2004-10-26
申请号：US10815353
申请日：2004-03-31
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： A61K39385
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/2009 , A61K9/2031 , A61K9/2054 , A61K9/4866 , A61K9/7023 , A61K31/00 , A61K31/739 , A61K38/1709 , A61K38/193 , A61K39/00 , A61K39/0007 , A61K47/646 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , C07K14/4711 , C07K2317/24 , C07K2317/567 , C07K2319/00 , Y02A50/472 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response an amyloid deposit in the patient. The methods are particularly useful for prophylatic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is A&bgr; peptide or an antibody thereto.
摘要翻译：本发明提供了治疗淀粉样变性疾病的组合物和方法。这种方法需要在患者体内施用诱导有益免疫应答的药物淀粉样蛋白沉积物。该方法对预防和治疗阿尔茨海默病特别有用。在这种方法中，合适的试剂是Aβ肽或其抗体。

70. 发明授权

US06787140B1 Prevention and treatment of amyloidogenic disease 有权
公开(公告)号：US06787140B1
公开(公告)日：2004-09-07
申请号：US09724489
申请日：2000-11-28
申请人： Dale B. Schenk
发明人： Dale B. Schenk
IPC分类号： A61K3800
CPC分类号： C07K16/18 , A61K38/1709 , A61K38/193 , A61K39/0007 , A61K2039/505 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/6037 , A61K2039/605 , G01N2800/2821 , Y10T436/105831 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylactic and therapeutic treatment of Alzheimer's disease. In such methods, a suitable agent is A&bgr; peptide or an antibody thereto.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式