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61. 发明申请

WO2006109174A3 HIV VACCINE COMPRISING A GLYCOPROTEIN 120 SIGNAL SEQUENCE WITH NO MORE THAN ONE POSITIVELY CHARGED AMINO ACID 审中-公开
标题翻译：含有GLYCOPROTEIN 120信号序列的HIV疫苗，不超过一个正在充电的氨基酸
公开(公告)号：WO2006109174A3
公开(公告)日：2008-01-03
申请号：PCT/IB2006001006
申请日：2006-02-24
申请人： UNIV WESTERN ONTARIO , KANG CHIL-YONG , LI YAN
发明人： KANG CHIL-YONG , LI YAN
IPC分类号： C12N7/01 , A61K35/76 , A61K39/21 , C07K14/16 , C12N7/04 , C12N15/48
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5252 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2710/14143 , C12N2710/16061 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16322
摘要： The present application is directed to a lentivirus consisting of a modified glyoprotem 120 (gp120) signal sequence or a functional fragment or variant thereof containing no more than one positively charged ammo acid, a vaccine comprising said virus and a method of preventing or treating a lentviral infection comprising administering said vaccine The modified signal sequence is from HIV-1 defined by SEQ ID Nos 3-6, a modification of the natural signal sequence of a HIV-1 sequence defined by SEQ ID No. 1.
摘要翻译：本申请涉及由修饰的糖基化蛋白120（gp120）信号序列或其不含一个带正电荷的氨基酸的功能片段或变体组成的慢病毒，包含所述病毒的疫苗和预防或治疗慢病毒的方法感染包括施用所述疫苗修饰的信号序列来自由SEQ ID No 3-6定义的HIV-1，其是由SEQ ID No.1定义的HIV-1序列的天然信号序列的修饰。

62. 发明申请

WO2007014169A3 ANTI-CD26 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD26抗体及其使用方法
公开(公告)号：WO2007014169A3
公开(公告)日：2007-05-10
申请号：PCT/US2006028702
申请日：2006-07-24
申请人： Y S THERAPEUTICS INC , AOYAGI TEIKICHI , LUO PEIZHI , ZHONG PINGYU , HSIEH MARK , LI YAN , WANG CAILI C , MORIMOTO CHIKAO
发明人： AOYAGI TEIKICHI , LUO PEIZHI , ZHONG PINGYU , HSIEH MARK , LI YAN , WANG CAILI C , MORIMOTO CHIKAO
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61P37/00 , C07K16/40 , C12N15/13
CPC分类号： C07K16/2896 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , G01N33/574 , G01N2333/70596 , G01N2500/00
摘要： The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
摘要翻译：本发明提供了新的抗CD26抗体和其他相关多肽，以及编码该抗体和多肽的新型多核苷酸。本发明还提供了制备抗体和多肽的方法。还提供了包含抗体或多肽的组合物和细胞。还提供了使用抗体和/或多肽的方法，例如抑制细胞增殖和治疗与CD26相关的病症。

63. 发明申请

WO2007042994A2 METHOD AND APPARATUS FOR FILTERING MULTIPLE CHANNELS OF SIGNALS 审中-公开
标题翻译：用于过滤多个信号通道的方法和装置
公开(公告)号：WO2007042994A2
公开(公告)日：2007-04-19
申请号：PCT/IB2006053695
申请日：2006-10-09
申请人： KONINKL PHILIPS ELECTRONICS NV , ZHU XIA , LI YAN , HU LIANGLIANG
发明人： ZHU XIA , LI YAN , HU LIANGLIANG
IPC分类号： H03H17/02 , H04L1/06
CPC分类号： H03H17/0292 , H04B7/04 , H04L25/03834
摘要： To reduce chip size and lower cost by using a method of multiplexing a device to filter a plurality of signals, the present invention provides an apparatus for filtering the plurality of signals, comprising: a group of storage units, for storing the plurality of signals, wherein the group of storage units comprises a plurality of storage units, each of which is used to store corresponding signal segments in each signal and output the stored signal segments in a predefined order; and a processing module, for weighting and combining the output signals from the group of storage units, to obtain a plurality of filtered signals corresponding to the multiple channels of signals. The group of storage units may further comprise a group of combining units, for combining output signal segments from the storage units to be processed with a same weight value. The present invention further provides the corresponding method for filtering a plurality of signals. With the method and apparatus of the present invention, the filter size may be reduced significantly and the cost may be lowered.
摘要翻译：为了通过使用多路复用装置对多个信号进行滤波的方法来降低芯片尺寸和降低成本，本发明提供了一种用于对多个信号进行滤波的装置，包括：用于存储多个信号的一组存储单元，其中所述存储单元组包括多个存储单元，每个存储单元用于在每个信号中存储对应的信号段，并以预定义的顺序输出所存储的信号段; 以及处理模块，用于对来自该组存储单元的输出信号进行加权和组合，以获得与多个信道信号对应的多个滤波信号。该组存储单元还可以包括一组组合单元，用于组合来自要处理的存储单元的输出信号段具有相同的权重值。本发明还提供了用于过滤多个信号的相应方法。利用本发明的方法和装置，可以显着降低过滤器尺寸并降低成本。

64. 发明申请

WO2005054273A2 HUMANIZED ANTIBODIES AGAINST VASCULAR ENDOTHELIAL GROWTH FACTOR 审中-公开
标题翻译：人类抗血管内皮生长因子的抗体
公开(公告)号：WO2005054273A2
公开(公告)日：2005-06-16
申请号：PCT/US2004039501
申请日：2004-11-22
申请人： ABMAXIS INC , ZHONG PINGYU , LUO PEIZHI , WANG KEVIN C , HSIEH MARK , LI YAN
发明人： ZHONG PINGYU , LUO PEIZHI , WANG KEVIN C , HSIEH MARK , LI YAN
IPC分类号： C07K16/00 , C07K16/22 , C40B40/10 , C07K
CPC分类号： C07K16/00 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , C07K16/22 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C40B40/10 , Y02A90/26
摘要： Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth factor (VEGF) with high affinity and specificity. In another aspect of the invention, monoclonal antibodies against VEGF are provided. In particular, humanized or human anti-VEGF monoclonal antibodies are provided with ability to bind to human VEGF with high affinity, inhibit VEGF-induced proliferation of endothelial cells in vitro and inhibit VEGF-induced angiogenesis in vivo. These antibodies and their derivative can be used in a wide variety of applications such as diagnosis, prevention, and treatment of diseases such as cancer, AMD, diabetic retinopathy, and other diseases derived from pathological angiogenesis.
摘要翻译：提供了用于在计算机和体外以高亲和力和特异性设计和选择针对人抗原的抗体的方法。在一些具体实施方案中，提供了用于以高亲和力和特异性设计和选择针对血管内皮生长因子（VEGF）的人源化或完全人抗体的方法。在本发明的另一方面，提供了针对VEGF的单克隆抗体。特别地，人源化或人抗VEGF单克隆抗体具有以高亲和力结合人VEGF的能力，在体外抑制VEGF诱导的内皮细胞增殖并抑制体内VEGF诱导的血管生成。这些抗体及其衍生物可用于广泛的应用，例如诊断，预防和治疗诸如癌症，AMD，糖尿病性视网膜病和其它源于病理血管发生的疾病。

65. 发明申请

WO2005053258A2 METHOD AND APPARATUS OF FREQUENCY ESTIMATION FOR THE DOWNLINK OF TD-SCDMA SYSTEMS 审中-公开
标题翻译： TD-SCDMA系统下行频率估计的方法与装置
公开(公告)号：WO2005053258A2
公开(公告)日：2005-06-09
申请号：PCT/IB2004052587
申请日：2004-11-29
申请人： KONINKL PHILIPS ELECTRONICS NV , LI YAN , XU LUZHOU , DAI YANZHONG
发明人： LI YAN , XU LUZHOU , DAI YANZHONG
IPC分类号： H04B1/707 , H04L27/00
CPC分类号： H04L27/0014 , H04B1/7075 , H04L2027/003 , H04L2027/0067
摘要： A method of frequency estimation for the downlink of wireless communication systems, comprising steps of: determining, according to the received radio signals , the phase shift of the midamble and that of the downlink synchronization code of the radio signals respectively; calculating the phase shift difference between the midamble and the downlink synchronization code of the radio signals, according to the determined phase shift of the midamble and that of the downlink synchronization code; estimating the frequency offset of the radio signals , according to the phase shift difference between the midamble and the downlink synchronization code of the radio signals and the relationship between the expected midamble and the downlink synchronization code, e.g. the time interval between the midamble and the downlink synchronization code in communication protocols.
摘要翻译：一种用于无线通信系统的下行链路的频率估计方法，包括以下步骤：根据所接收的无线电信号分别确定所述中继码的相移和所述无线信号的下行同步码的相移; 根据确定的中置码相移和下行同步码的相移，计算无线信号的中间码和下行同步码之间的相移差; 根据无线电信号的中间码和下行链路同步码之间的相移差以及预期中间码和下行链路同步码之间的关系，例如估计无线电信号的频率偏移。通信协议中的中间码和下行链路同步码之间的时间间隔。

66. 发明申请

WO2004096842A3 SARS VIRUS NUCLEOTIDE AND AMINO ACID SEQUENCES AND USES THEREOF 审中-公开
标题翻译： SARS病毒核酸和氨基酸序列及其用途
公开(公告)号：WO2004096842A3
公开(公告)日：2005-04-07
申请号：PCT/CA2004000626
申请日：2004-04-28
申请人： BC CANCER AGENCY , PLUMMER FRANK , FELDMANN HEINZ , JONES STEVEN , LI YAN , BASTIEN NATHALIE , BRUNHAM ROBERT , BROOKS-WILSON ANGELA , HOLT ROBERT , UPTON CHRISTOPHER , ROPER RACHEL , ASTELL CAROLINE
发明人： PLUMMER FRANK , FELDMANN HEINZ , JONES STEVEN , LI YAN , BASTIEN NATHALIE , BRUNHAM ROBERT , BROOKS-WILSON ANGELA , HOLT ROBERT , UPTON CHRISTOPHER , ROPER RACHEL , ASTELL CAROLINE
IPC分类号： C07K14/165 , C12N7/00 , A61K39/215 , C12N15/11
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译：本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列相关疾病。

67. 发明申请

WO0238588A2 PUTRESCINE-N-METHYLTRANSFERASE PROMOTER 审中-公开
标题翻译： PUTRESCINE-N-甲基衍生物促进剂
公开(公告)号：WO0238588A2
公开(公告)日：2002-05-16
申请号：PCT/US0147371
申请日：2001-11-07
申请人： UNIV NORTH CAROLINA STATE , CONKLING MARK A , LI YAN
发明人： CONKLING MARK A , LI YAN
IPC分类号： A01H5/00 , C07K14/47 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/82 , C07K
CPC分类号： C07K14/4705 , C12N9/1029 , C12N15/8227
摘要： Putrescine-N-Methyltransferase promoters, particularly promoters isolated from tobacco, are disclosed, along with recombinant nucleic acids containing the same, expression vectors containing the same, and transgenic plants produced therewith. Methods of use thereof are also disclosed.
摘要翻译：公开了特定的烟草-N-甲基转移酶启动子，特别是从烟草中分离的启动子，连同含有相同的重组核酸，含有它们的表达载体以及由其产生的转基因植物。还公开了其使用方法。

68. 发明申请

WO0218607A2 TRANSGENIC PLANTS CONTAINING MOLECULAR DECOYS THAT ALTER PROTEIN CONTENT THEREIN 审中-公开
标题翻译：含有蛋白质含量的分子分解的转基因植物
公开(公告)号：WO0218607A2
公开(公告)日：2002-03-07
申请号：PCT/US0126788
申请日：2001-08-28
申请人： UNIV NORTH CAROLINA STATE , CONKLING MARK A , LI YAN
发明人： CONKLING MARK A , LI YAN
IPC分类号： A01H5/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/29 , C12N15/82
CPC分类号： C12N15/8223 , C07K14/415 , C12N9/1077 , C12N15/8216 , C12N15/8222 , C12N15/8227 , C12N15/8243 , C12N15/8251 , C12N15/8257
摘要： The present application describes isolated nucleic acids that contain a Nic gene product responsive element, and the use thereof in methods of producing transgenic tobacco plants having reduced levels of nicotine and/or TSNA therein, as well as other plants or host cells that contain altered levels of a protein of interest therein due to inclusion of a cis -acting decoy element therein.
摘要翻译：本申请描述了含有Nic基因产物响应元件的分离的核酸，以及其在生产具有降低的尼古丁和/或TSNA水平的转基因烟草植物以及含有改变水平的其它植物或宿主细胞的方法中的用途的由于在其中包含顺式起始诱饵元件而引起的目的蛋白质。

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