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61. 发明申请

US20070100445A1 Intraocular lenses and business methods 审中-公开
标题翻译：人工晶状体和商业方法
公开(公告)号：US20070100445A1
公开(公告)日：2007-05-03
申请号：US11507946
申请日：2006-08-21
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61F2/16
CPC分类号： A61F2/1635
摘要： An intraocular accommodating lens comprising a resilient polymer monolith with a peripheral component that has a Young's modulus and an equilibrium memory shape that imparts to the capsular sac's periphery the natural shape of the capsule in an accommodated state. The intraocular lens includes a central deformable optic that provides accommodated and disaccommodated shapes. The peripheral component is deformable to a disequilibrium, stressed shape in responsive to equatorial tensioning-and is capable of applying restorative forces to move the lens toward the accommodated shape from a disequilibrium disaccommodated shape. In one embodiment, the central optic portion includes a displaceable media than can be displaced by very low forces of zonular excursion, wherein the displaceable media can comprise a very low modulus polymer or an index-matched fluid.
摘要翻译：一种眼内容镜片，其包括具有杨氏模量和平衡记忆形状的周边部件的弹性聚合物整体，所述平衡记忆形状在囊状物的周围赋予胶囊的自然形状。眼内透镜包括提供容纳和不适应形状的中心可变形光学元件。外围部件可以根据赤道张力而变形为不平衡的应力形状，并且能够施加恢复力以将镜片从不平衡不适应的形状移动到容纳的形状。在一个实施例中，中心光学部分包括可移动的介质，可以通过非常低的区域偏移力移动，其中可移动介质可以包括非常低模量的聚合物或折射率匹配的流体。

62. 发明申请

US20060224154A1 Medical instrument and method of use 有权
公开(公告)号：US20060224154A1
公开(公告)日：2006-10-05
申请号：US11329381
申请日：2006-01-10
申请人： John Shadduck , Michael Hoey
发明人： John Shadduck , Michael Hoey
IPC分类号： A61B18/18 , A61F7/00 , A61F7/12
CPC分类号： A61B18/042 , A61B18/04 , A61B2018/00619 , A61B2018/0063 , A61B2018/046 , A61B2018/048
摘要： An instrument for thermally-mediated therapies in targeted tissue volumes or for volumetric removal of tissue. In one embodiment, the instrument has an interior chamber that includes a diffuser structure for diffusing a biocompatible conductive fluid that is introduced under high pressure. The interior chamber further includes surfaces of opposing polarity electrodes for vaporizing the small cross-section diffused fluid flows created within a diffuser structure. In one embodiment, the diffuser structure includes a negative temperature coefficient of resistance material between the opposing polarity surfaces. The NTCR structure can self-adjust the lengths of current paths between the opposing polarities to insure complete vaporization of the volume of flow of conductive fluid. The non-ionized vapor phase media is ejected from a working surface of the instrument and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat of vaporization to ablate tissue. In another embodiment, the instrument provides voltage means for converting the non-ionized vapor phase media into an ionized media or plasma for applying energy to body structure.

63. 发明申请

US20060149224A1 Surgical instruments and techniques for treating gastro-esophageal reflux disease 审中-公开
公开(公告)号：US20060149224A1
公开(公告)日：2006-07-06
申请号：US11365943
申请日：2006-03-01
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B18/14
CPC分类号： A61N1/326 , A61B18/1485 , A61B18/1492 , A61B90/39 , A61B2018/00047 , A61B2018/00285 , A61B2018/00482 , A61B2018/00494 , A61B2018/00553 , A61B2018/00678 , A61B2018/00726 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1861 , A61B2090/3782 , A61B2218/002
摘要： Instruments for thermally-mediated treatment of a patient's lower esophageal sphincter (LES) to induce an injury healing response to thereby populate the extracellular compartment of walls of the LES with collagen matrices to altere the biomechanics of the LES to provide an increased intra-esophageal pressure for preventing acid reflux. A preferred embodiment is a bougie-type device for trans-esophageal introduction that carries conductive electrodes for delivering Rf energy to walls of the LES (i) to induce the injury healing response or (ii) to “model” collagenous tissues of the LES by shrinking collagen fibers therein.

64. 发明申请

US20050090812A1 Surgical device and method of use 审中-公开
标题翻译：手术装置及使用方法
公开(公告)号：US20050090812A1
公开(公告)日：2005-04-28
申请号：US10692961
申请日：2003-10-24
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B18/00 , A61B18/14 , A61B18/18
CPC分类号： A61B18/042 , A61B18/1402
摘要： A medical device having a working surface of a photonic lattice for controlled diffraction of electromagnetic energy within, and energy emissions from, the working surface to control energy delivery to tissue. The working surface can apply energy to tissue at high or low intensities for thermal therapies, ablations or volumetric removal of tissue volumes. In one embodiment, the energy emitting surface comprises a lattice of a refractory material with interior spatial regions of a selected geometry to provide a band gap. The energy modes confined within the lattice can create a high intensity conditioned plasma for delivering energy to tissue positioned proximate to the lattice. In an exemplary embodiment, the photonic lattice defines a lattice constant of less than about 5 microns for altering a non-preferred energy mode to a preferred mode to control infrared emissions from the working surface. Additional Rf energy can be coupled to the conditioned plasma for enhanced application of energy to tissue.
摘要翻译：一种具有光子晶格的工作表面的医疗装置，用于控制电磁能量的衍射，并从工作表面释放能量，以控制向组织的能量输送。工作表面可以以高或低强度的组织施加能量，用于热治疗，消融或体积去除组织体积。在一个实施例中，能量发射表面包括具有选定几何形状的内部空间区域的耐火材料的格子以提供带隙。限制在晶格内的能量模式可以产生高强度条件等离子体，用于将能量传递到靠近晶格定位的组织。在示例性实施例中，光子晶格限定了小于约5微米的晶格常数，用于将非优选能量模式改变为优选模式以控制来自工作表面的红外发射。附加的Rf能量可以与调节的等离子体耦合，以增强能量到组织的应用。

65. 发明申请

US20070118109A1 Medical instruments and techniques for treatment of gastro-esophageal reflux disease 失效
公开(公告)号：US20070118109A1
公开(公告)日：2007-05-24
申请号：US11656062
申请日：2007-01-22
申请人： James Baker , John Shadduck
发明人： James Baker , John Shadduck
IPC分类号： A61B18/14 , A61F7/00 , A61F7/12
CPC分类号： A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/00505 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00714 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898 , A61B2018/126
摘要： Apparatus and methods for treating tissue at or near a sphincter provide for transluminal introduction of an energy delivery device. The device includes a tissue compression member to compress target tissue at or near the sphincter. A radiofrequency energy source is coupleable to the delivery device to deliver radiofrequency energy to the target tissue. Energy is delivered to heat the tissue to a desired temperature. The desired temperature is selected to induce an injury-healing response or to inducing shrinkage of collagen fibers in the target tissue to thereby reduce laxity in the target tissue.

66. 发明申请

US20060200172A1 Instruments and techniques for controlled removal of epidermal layers 有权
公开(公告)号：US20060200172A1
公开(公告)日：2006-09-07
申请号：US11417396
申请日：2006-05-03
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B17/50
CPC分类号： A61B17/545 , A61B17/50 , A61B17/54 , A61B2017/00761 , A61B2017/320004 , A61B2217/005 , A61B2217/007 , A61M1/0064 , A61M35/00
摘要： An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response. The method of the invention creates more normal dermal architectures in skin with limited depths of skin removal by the series of superficial treatments that may be comparable to the extent of neocollagenesis caused by a deep skin removal treatment (e.g., CO2 laser skin removal).

67. 发明申请

US20060135955A1 Medical instrument and method of use 有权
标题翻译：医疗仪器及使用方法
公开(公告)号：US20060135955A1
公开(公告)日：2006-06-22
申请号：US11244329
申请日：2005-10-05
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B18/04 , A61B18/14
CPC分类号： A61B17/3203 , A61B18/04 , A61B18/042 , A61B18/1492 , A61B2017/00504 , A61B2018/00404 , A61B2018/0041 , A61B2018/00541 , A61B2018/00559 , A61B2018/048 , A61B2018/1213 , A61B2218/002
摘要： This invention relates to surgical instruments for applying energy to tissue. In one embodiment, an elongated introducer has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid under pressure. An energy source causes a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the introducer. The flow of vapor is controlled by a computer controller to cause a selected pressure, a selected volume of vapor, and an optional aspiration of vapor condensate. Contemporaneous with tissue contact, the vapor undergoes a vapor-to-liquid phase transition which delivers large amount of energy to the targeted tissue. In one embodiment, the system is configured for volumetric removal of tissue by means of high velocity ejection of a vapor media from a first vapor port proximate to soft tissue wherein the vapor-to-liquid phase change of the media applies energy to the tissue. The system provides a second port coupled to a suction source that cooperates with the first vapor port to suction tissue debris from the targeted site.
摘要翻译：本发明涉及用于向组织施加能量的外科器械。在一个实施例中，细长导引器具有手柄部分，其包括在压力下供应生物相容性液体的内部腔室。能量源导致内部室内的液体 - 蒸汽相变，并且从导引器的工作端喷出蒸气介质流。蒸气流由计算机控制器控制，以引起所选择的压力，所选择的体积的蒸汽，以及可选的蒸汽冷凝物抽吸。在与组织接触的同时，蒸气经历蒸气到液体的相变，其向目标组织递送大量的能量。在一个实施例中，该系统被配置为通过从靠近软组织的第一蒸汽端口高速喷射蒸气介质来体积移除组织，其中介质的气 - 液相变向该组织施加能量。该系统提供了一个耦合到吸入源的第二端口，其与第一蒸气端口配合以从目标部位抽吸组织碎屑。

68. 发明申请

US20050267570A1 Endovascular occlusion devices and methods of use 审中-公开
标题翻译：血管内闭塞装置及使用方法
公开(公告)号：US20050267570A1
公开(公告)日：2005-12-01
申请号：US11140421
申请日：2005-05-27
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/06 , A61F2/82 , A61F2/90
CPC分类号： A61F2/90 , A61B17/12022 , A61B17/12113 , A61B17/12118 , A61B17/12172 , A61B2017/00867 , A61F2/07 , A61F2/856 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/075 , A61F2002/077 , A61F2002/30092 , A61F2002/823 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2210/0014 , A61F2210/0076
摘要： An implantable stent-like device for treating and occluding arteriovascular malformations (AVMs), fistulas, varicose veins or the like. More particularly, this invention relates to an implant body that includes an open-cell shape-transformable polymer structure that provides stress-free means for occluding an AVM without applying additional pressures an any distended walls of the AVM. In one embodiment, the shape-transformable polymer is a shape memory polymer implant body that self-deploys from a temporary shape to a memory shape. In another embodiment, the shape memory polymer structure is capable of a temporary compacted shape for carrying about the struts of an expandable stent for self-deployment to occlude an aneurysm.
摘要翻译：用于治疗和阻塞动脉血管畸形（AVM），瘘，静脉曲张等的可植入支架样装置。更具体地说，本发明涉及一种植入体，其包括开放细胞形状可变形的聚合物结构，其提供用于阻塞AVM的无压力装置，而不对AVM的任何扩张壁施加附加压力。在一个实施方案中，形状可变形聚合物是形状记忆聚合物植入体，其自身从临时形状展现到记忆形状。在另一个实施方案中，形状记忆聚合物结构能够临时压实形状，用于承载用于自展开以阻塞动脉瘤的可扩张支架的支柱。

69. 发明申请

US20050149183A1 Intraocular lens system and method for power adjustment 有权
标题翻译：人工晶状体系统及功率调节方法
公开(公告)号：US20050149183A1
公开(公告)日：2005-07-07
申请号：US11069136
申请日：2005-02-28
申请人： John Shadduck
发明人： John Shadduck
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2002/169 , A61F2250/0001
摘要： An intraocular lens (IOL) that provides for optical power adjustment following its implantation, for example, for use in treating cataract patients. The lens body has first and second surface portions that bound at least one interior chamber or space that extends from the central optic portion to the lens periphery. The interior chamber or space has a microporous body that is intermediate inner and outer portions of the space. In one embodiment, the microporous body is capable of cooperating with an external Rf or light source to expose a charge to a charge-carrying fluid within the interior chamber. By this system, fluid flows are induced to alter the optical parameters of the lens.
摘要翻译：眼内透镜（IOL），其在植入之后提供光学功率调整，例如用于治疗白内障患者。透镜体具有第一和第二表面部分，其结合从中心光学部分延伸到透镜周边的至少一个内部室或空间。内部室或空间具有位于该空间的中部内部和外部的微孔体。在一个实施例中，微孔体能够与外部Rf或光源配合，以将电荷暴露于内部室内的带电荷的流体。通过该系统，引起流体流动以改变透镜的光学参数。

70. 发明申请

US20120271300A9 MEDICAL INSTRUMENT AND METHOD OF USE 有权
标题翻译：医用仪器及其使用方法
公开(公告)号：US20120271300A9
公开(公告)日：2012-10-25
申请号：US11329381
申请日：2006-01-10
申请人： John Shadduck , Michael Hoey
发明人： John Shadduck , Michael Hoey
IPC分类号： A61B18/18 , A61F7/12 , A61F7/00
CPC分类号： A61B18/042 , A61B18/04 , A61B2018/00619 , A61B2018/0063 , A61B2018/046 , A61B2018/048
摘要： An instrument for thermally-mediated therapies in targeted tissue volumes or for volumetric removal of tissue. In one embodiment, the instrument has an interior chamber that includes a diffuser structure for diffusing a biocompatible conductive fluid that is introduced under high pressure. The interior chamber further includes surfaces of opposing polarity electrodes for vaporizing the small cross-section diffused fluid flows created within a diffuser structure. In one embodiment, the diffuser structure includes a negative temperature coefficient of resistance material between the opposing polarity surfaces. The NTCR structure can self-adjust the lengths of current paths between the opposing polarities to insure complete vaporization of the volume of flow of conductive fluid. The non-ionized vapor phase media is ejected from a working surface of the instrument and a controlled vapor-to-liquid phase change in an interface with tissue applies thermal energy substantially equal to the heat of vaporization to ablate tissue. In another embodiment, the instrument provides voltage means for converting the non-ionized vapor phase media into an ionized media or plasma for applying energy to body structure.
摘要翻译：用于靶向组织体积或体积去除组织的热介导疗法的仪器。在一个实施例中，仪器具有内部腔室，其包括用于扩散在高压下引入的生物相容性导电流体的扩散器结构。内部腔室还包括相对极性电极的表面，用于蒸发在扩散器结构内产生的小横截面扩散的流体流。在一个实施例中，扩散器结构包括在相对的极性表面之间的电阻材料的负温度系数。 NTCR结构可以自我调节相对极性之间的电流通路的长度，以确保导电流体流量的完全蒸发。非离子化的气相介质从仪器的工作表面喷出，并且与组织的界面中受控的蒸气 - 液相变化施加基本上等于蒸发热消融组织的热能。在另一个实施例中，仪器提供电压装置，用于将非电离气相介质转换成离子化介质或等离子体，以将能量施加到体结构。

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