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61. 发明专利

CA2746516A1 NON-POLAR PHOTOSENSITIZER FORMULATIONS FOR PHOTODYNAMIC THERAPY 未知
公开(公告)号：CA2746516A1
公开(公告)日：2005-03-17
申请号：CA2746516
申请日：2004-06-23
申请人： CERAMOPTEC IND INC
发明人： ALBRECHT VOLKER , FAHR ALFRED , SCHEGLMANN DIETRICH , GRAFE SUSANNA , NEUBERGER WOLFGANG
IPC分类号： A61K9/127 , A61K31/409 , A61K41/00
摘要： A pharmaceutical liposomal formulation for photodynamic therapy comprising a non-polar porphyrin photosensitizer and one or more phospholipids, which are stable in storage without requiring freeze-drying is described. The liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. The phospholipids may be modified by pegylation, i.e. they contain poly ethylene glycol as an integral part of the phospholipids. The formed liposomes contain the non-polar photosensitizer within the membrane and are useful for the combined targeting of a nonpolar photosensitizer and a second polar substance. The invention also relates to the liposome composition formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are also useful for intravenous administration.

62. 发明专利

CA2536977A1 NON-POLAR PHOTOSENSITIZER FORMULATIONS FOR PHOTODYNAMIC THERAPY 未知
公开(公告)号：CA2536977A1
公开(公告)日：2005-03-17
申请号：CA2536977
申请日：2004-06-23
申请人： CERAMOPTEC IND INC
发明人： ALBRECHT VOLKER , FAHR ALFRED , GRAEFE SUSANNA , NEUBERGER WOLFGANG , SCHEGLMANN DIETRICH
IPC分类号： A61K9/127 , A61K41/00
摘要： A pharmaceutical liposomal formulation for photodynamic therapy comprising a non-polar porphyrin photosensitizer and one or more phospholipids, which are stable in storage without requiring freeze-drying is described. The liposoma l formulation provides therapeutically effective amounts of the photosensitize r for intravenous administration. The phospholipids may be modified by pegylation, i.e. they contain poly ethylene glycol as an integral part of th e phospholipids. The formed liposomes contain the non-polar photosensitizer within the membrane and are useful for the combined targeting of a nonpolar photosensitizer and a second polar substance. When a formulation includes th e presence of monosaccharides or polyalcohols, it can be efficiently freeze- dried preserving the size of the liposomal vehicles and the content of a therapeutically effective amount of the photosensitizing agent. The inventio n also relates to the liposome composition formed upon reconstitution with an aqueous vehicle. The freeze-dried formulation upon reconstitution with a suitable aqueous vehicle forms liposomes that are also useful for intravenou s administration.

63. 发明专利

AU2003293340A8 Multipurpose diode laser system for ophthalmic laser treatments 未知
公开(公告)号：AU2003293340A8
公开(公告)日：2004-06-30
申请号：AU2003293340
申请日：2003-12-03
申请人： CERAMOPTEC IND INC
发明人： BERNDT DETLEV , NEUBERGER WOLFGANG , MAUGHAN JULIAN
IPC分类号： A61F9/008 , A61N5/06 , A61N5/067 , A61B18/18
摘要： A laser device and method for treating ophthalmic diseases is enclosed. The laser device and method for treating a variety of ophthalmic diseases comprises a system for irradiating the eye with electromagnetic irradiation with a wavelength in the range of 654-681 nm from at least one high power laser diode. The optical system of the present invention being able to focus the radiation onto a spot sized of about 100 mum. The system preferably comprises a laser source and ancillary equipment to direct and regulate the radiation. The use of this wavelength range makes the present invention effective for a wide variety of ophthalmic indications. It is capable of providing photocoagulation treatments for diseases such as glaucoma, diabetic retinopathy and age-related macular degeneration.

64. 发明专利

CA2461662A1 METHOD AND TOOLS FOR ORAL HYGIENE 未知
公开(公告)号：CA2461662A1
公开(公告)日：2003-04-03
申请号：CA2461662
申请日：2002-09-09
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61C17/00 , A45C3/06 , A45C13/08 , A46B15/00 , A61C1/00 , A61C17/26 , A61C19/06 , A61K6/00 , A61K8/00 , A61K8/35 , A61K8/49 , A61K8/64 , A61K8/96 , A61K8/97 , A61K39/395 , A61N5/06 , A61Q11/00 , C09B3/00 , A61K7/16 , A61K41/00
摘要： A method and material for self-cleaning of the teeth and mouth using a sourc e of light (14) in the visible range in conjunction with a photosensitive oral hygiene composition possessing a broad absorption spectrum in the visible range. The invention selectively eliminates harmful bacteria by use of a photosensitive agent and a light source (14). The present invention involves the use of a light-providing dental device to activate a photosensitive agen t and destroy harmful bacteria in the oral cavity. It prevents or deters oral diseases, inflammations, and infections.

65. 发明专利

CA2387446A1 LASER SYSTEM FOR IMPROVED TRANSBARRIER THERAPEUTIC RADIATIONDELIVERY 未知
公开(公告)号：CA2387446A1
公开(公告)日：2001-05-10
申请号：CA2387446
申请日：2000-11-01
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/20 , A61B18/22 , A61B18/24 , A61M37/00 , A61N1/30
摘要： The present invention describes a system and method to improve radiation delivery to subsurface skin tissue (504) without damaging surface tissue encountered during therapeutic laser treatment. To achieve this result, a bi o- chemical fluid is preoperatively administered to the tissue (504). The bio- compatible fluid is a light-scattering fluid for achieving a more uniform, enhanced heating over a treatment area. A second dispersion fluid can be add ed to the tissue to enhance even more improved light dispersion throughout the treatment site. Laser radiation is then administered by optical fibers (509) to the tissue through micropores created by a micro-needle patch device (502 ). The micro-needle patch device may deliver fluid and radiation simultaneously , or separate patches may be employed having micro-needles with through-passag es for delivering the light or fluid.

66. 发明专利

BRPI0910724A2 Dispositivos e método para tratamento endoluminal de vaso sanguíneo 未知
公开(公告)号：BRPI0910724A2
公开(公告)日：2022-03-29
申请号：BRPI0910724
申请日：2009-03-02
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/18
摘要： para tratamento endoluminal de vaso sanguíneo. um método e dispositivo melhorados são proporcionados para tratamento endoluminal de insuficiência venosa de baixa densidade de energia seguro e eficiente. esse dispositivo emite energia pulsada ou contínua radialmente através de uma extremidade de fibra ótica com uma ponta de forma cônica para emissão radial de 360º. em algumas modalidades, uma superfície reflexiva cônica é distalmente espaçada oposta a e defronte à ponta emissora para melhorar a eficiência de emissão radial refletindo-se para fora qualquer energia transmitida projetada para frente ou restante em direção radiais. outros dispositivos incluem faces emissoras planas seladas dentro de capas transparentes a radiação protetoras. a radiação a laser é transmitida a um comprimento de onda e potência tais que é substancialmente totalmente absorvida dentro da parede do vaso sanguíneo para danificar suficientemente o endotélio intravascular e, por sua vez, alcançar o fechamento do vaso sanguíneo. como a energia é substancialmente totalmente absorvida dentro da parede do vaso sanguíneo, a necessidade de uma anestesia local ao longo da área de tratamento do vaso sanguíneo pode ser substancialmente evitada.

67. 发明专利

AR087320A1 SISTEMA DE TRATAMIENTO CON LASER CLASE 1 未知
公开(公告)号：AR087320A1
公开(公告)日：2014-03-12
申请号：ARP120102705
申请日：2012-07-26
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61B18/02
摘要： Se divulgan sistemas de tratamiento láser de Clase 1 o Clase 3R para aplicaciones médicas, de baja densidad de potencia y seguros para el ojo. Los sistemas que poseen irradiación de energía y rayos controlado pueden cumplir con los requisitos de seguridad láser de acuerdo con IEC 60825-1:2007 o equivalente para clasificación de seguro para la vista; la clasificación como láser de Clase 1 o láser Clase 3R. El sistema láser comprende una fuente láser de diodo, una sonda de fibra óptica, medios para detectar e identificar dicha sonda óptica y medios para asegurar que la energía láser transmitida desde la sonda de fibra está limitada a nivel de energía máximo pre-especificado por aplicación; longitud de onda; características de emisión; características de sonda; valores limitantes de acuerdo con las regulaciones de seguridad aplicadas. El dispositivo puede identificar la sonda de fibra óptica conectada para excluir el uso de sondas de fibra óptica no conformes y/o limitar la salida máxima de energía óptica de acuerdo con las regulaciones de seguridad láser. El sistema opera preferentemente en una longitud de onda de 1400 nm o mayor. La ruptura o goteo de la sonda de fibra es detectable y evitable.

68. 发明专利

BRPI0614453A2 未知
公开(公告)号：BRPI0614453A2
公开(公告)日：2012-12-11
申请号：BRPI0614453
申请日：2006-07-27
申请人： CERAMOPTEC IND INC
发明人： CASTRO DANILO SUAREZ , NEUBERGER WOLFGANG
IPC分类号： A61K35/32 , A61K35/36
摘要： Photosensitizer mixtures and method of treating cellulites by light illumination are presented. Photosensitizer is combined with cellular products, e.g. adipose cells, collagen, previously removed by liposuction. Concentrations used depend on treatment area, cellulite stage and whether cellulites are in depressed or elevated skin areas. The cosmetic treatment reduces/removes localized lipodystrophies, flaccidity, cellulite using localized laser, LED, etc emissions. Applied light energy destroys fat cells by a combination of chemical reactions primarily, and temperature, wherein cell walls break releasing cell fluid. Transmission devices guide radiation to the treatment site. One or more light sources like laser diodes or LEDs may be coupled into one or more optical fibers to increase the covered area and increase the amount of radiation in that area. Optical fibers can be introduced percutaneously or interstitially. Cell fluid in the treatment area is removed by a combination of techniques.

69. 发明专利

CA2461662C METHOD AND TOOLS FOR ORAL HYGIENE 未知
公开(公告)号：CA2461662C
公开(公告)日：2011-11-01
申请号：CA2461662
申请日：2002-09-09
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61C17/00 , A61K8/97 , A45C3/06 , A45C13/08 , A46B15/00 , A61C1/00 , A61C17/26 , A61C19/06 , A61K6/00 , A61K8/00 , A61K8/35 , A61K8/36 , A61K8/49 , A61K8/64 , A61K8/96 , A61K31/122 , A61K31/192 , A61K36/38 , A61K39/395 , A61K41/00 , A61N5/06 , A61P1/02 , A61Q11/00 , C09B3/00
摘要： A method and material for self-cleaning of the teeth and mouth using a source of light (14) in the visible range in conjunction with a photosensitive oral hygiene composition possessing a broad absorption spectrum in the visible range. The invention selectively eliminates harmful bacteria by use of a photosensitive agent and a light source (14). The present invention involves the use of a light-providing dental device to activate a photosensitive agent and destroy harmful bacteria in the oral cavity. It prevents or deters oral diseases, inflammations, and infections.

70. 发明专利

MX2008011980A METODO Y DISPOSITIVO PARA EL TRATAMIENTO DE HIPERPLASIA PROSTATICA BENIGNA. 未知
公开(公告)号：MX2008011980A
公开(公告)日：2008-12-01
申请号：MX2008011980
申请日：2007-03-16
申请人： CERAMOPTEC IND INC
发明人： NEUBERGER WOLFGANG
IPC分类号： A61N5/06
摘要： Se proporciona un método y un dispositivo que logran la extirpación de tejido así como también la coagulación de tejido de manera sustancialmente simultánea durante el tratamiento de hiperplasia prostática benigna (BPH) utilizando al menos dos longitudes de onda de luz. El método y el dispositivo mejoran el flujo urinario y reducen al mínimo la pérdida de sangre posterior al tratamiento, mientras que mantienen un campo de operación casi libre de sangre durante el tratamiento, irradiándolo de manera sustancialmente simultánea con al menos dos longitudes de onda diferentes. El presente dispositivo y método usan fibras ópticas que incluyen en modalidades preferidas fibras ópticas de emisión lateral especial para proporcionar un tratamiento práctico, mínimamente invasivo, de próstatas agrandadas. De acuerdo con la presente invención, la extirpación del tejido es afectada teniendo una longitud de onda que es absorbida grandemente en el tejido prostático, mientras que otra longitud de onda absorbida en menor grado coagula los tejidos hiperplásicos circundantes mientras que mantiene mínimo el daño térmico al tejido normal que rodea a la hiperplasia. En una modalidad preferida, la longitud de onda con alto grado de absorción es de aproximadamente 1460 nm y la menos absorbida por el agua pero con absorción significativa de hemoglobina es de aproximadamente 980 nm. Esta combinación ayuda al paciente reduciendo la pérdida de sangre y edema. Puede ayudar al médico, especialmente cuando se empelan técnicas de formación de imagen, manteniendo un área sustancialmente libre de sangre durante el tratamiento.

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