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61. 发明申请

WO1985005453A1 NEW COMPOSITIONS OF LIPOSOMES HAVING A SPECIFIC ACTION WITH REGARD TO THE PROLIFERATION OF GIVEN CELLS 审中-公开
标题翻译：具有关于增殖细胞的特定行为的脂质体的新组合物
公开(公告)号：WO1985005453A1
公开(公告)日：1985-12-05
申请号：PCT/FR1985000125
申请日：1985-05-21
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MACHY, Patrick , LESERMAN, Lee, Daniel
发明人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N44/53
CPC分类号： A61K9/1271 , G01N33/5432 , G01N33/549 , G01N33/56966 , G01N33/56977
摘要： The compositions of liposomes comprise at least one compound which is active with regard to the cell proliferation, and is encapsulated in a liposome to which is bound a ligand capable of specifically targetting the cells to be saved.

62. 发明申请

WO2009071850A2 NANOPARTICULES D'ACTIFS THERAPEUTIQUES DE FAIBLE SOLUBILITE AQUEUSE 审中-公开
标题翻译：低水溶性治疗活性成分的纳米颗粒
公开(公告)号：WO2009071850A2
公开(公告)日：2009-06-11
申请号：PCT/FR2008/052147
申请日：2008-11-27
申请人： UNIVERSITE PARIS SUD VI , STELLA, Barbara , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COUVREUR, Patrick , LAKKIREDDY, Harivardhan, Reddy , DOSIO, Franco , CATTEL, Luigi
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COUVREUR, Patrick , LAKKIREDDY, Harivardhan, Reddy , DOSIO, Franco , CATTEL, Luigi
IPC分类号： A61K9/14 , A61K9/10 , A61K31/16 , A61K31/337 , A61K38/28 , A61P35/00 , A61P3/10
CPC分类号： A61K47/48023 , A61K47/54 , A61K47/6929 , Y10T428/2982
摘要： La présente invention concerne un dérivé hydrodispersible d'un actif thérapeutique de faible solubilité aqueuse formé d'au moins une molécule dudit actif couplée de manière covalente à au moins une molécule d'un dérivé hydrocarboné à structure squalénique ou analogue. Elle vise en outre des nanoparticules correspondantes.
摘要翻译：
本发明涉及缺陷。低溶解度的治疗性资产的水分散性含水形式; 以共价方式偶联至少一个所述活性剂分子; 至少一个缺陷分子烃＆eacute; ＆Agrave; squ structure状结构等。它也针对相应的纳米粒子。

63. 发明申请

WO1998029396A1 HETEROCYCLIC AROMATIC ANION SALTS, AND THEIR USES AS IONIC CONDUCTING MATERIALS 审中-公开
标题翻译：杂环芳香阴离子盐及其作为离子导电材料的用途
公开(公告)号：WO1998029396A1
公开(公告)日：1998-07-09
申请号：PCT/CA1997001011
申请日：1997-12-30
申请人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MICHOT, Christophe , ARMAND, Michel , GAUTHIER, Michel , CHOQUETTE, Yves
发明人： HYDRO-QUEBEC , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07D239/60
CPC分类号： B01J31/0224 , B01J31/0215 , B01J31/0222 , B01J31/0225 , B01J31/0227 , B01J31/0235 , B01J31/0239 , B01J31/0247 , B01J31/0251 , B01J31/0252 , B01J31/0267 , B01J31/0271 , B01J31/0281 , B01J31/0288 , B01J31/0289 , B01J31/04 , B01J31/06 , B01J31/068 , B01J31/124 , B01J31/1815 , B01J31/2208 , B01J2231/122 , B01J2231/14 , B01J2231/326 , B01J2231/341 , B01J2231/348 , B01J2231/4205 , B01J2231/543 , B01J2531/35 , B01J2531/824 , C07B37/02 , C07B37/12 , C07C45/46 , C07C45/69 , C07C67/00 , C07C255/10 , C07C255/17 , C07C255/27 , C07C255/46 , C07C255/65 , C07C257/14 , C07C311/03 , C07C311/04 , C07C311/09 , C07C311/48 , C07C317/04 , C07C317/08 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/34 , C07C317/44 , C07C2601/10 , C07C2602/42 , C07D207/452 , C07D213/76 , C07D219/10 , C07D231/18 , C07D233/90 , C07D239/60 , C07D241/42 , C07D249/04 , C07D249/10 , C07D249/12 , C07D251/70 , C07D277/64 , C07D277/82 , C07D285/125 , C07D285/135 , C07D285/15 , C07D285/16 , C07D303/34 , C07D307/54 , C07D307/64 , C07D311/52 , C07D311/58 , C07D311/82 , C07D319/06 , C07D333/16 , C07D333/24 , C07D405/06 , C07D409/12 , C07D417/10 , C07D417/14 , C07F17/02 , C08F4/04 , C08G65/3344 , C09B69/00 , C09B69/02 , C09B69/10 , G02F1/1525 , G02F2001/151 , H01B1/122 , H01B1/128 , H01G9/022 , H01G9/038 , H01G11/02 , H01G11/62 , H01M4/00 , H01M4/02 , H01M4/131 , H01M4/133 , H01M4/134 , H01M4/382 , H01M4/405 , H01M4/48 , H01M4/485 , H01M4/505 , H01M4/525 , H01M4/5815 , H01M4/5825 , H01M4/60 , H01M4/625 , H01M4/661 , H01M6/00 , H01M6/04 , H01M6/164 , H01M6/166 , H01M6/168 , H01M6/181 , H01M6/183 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0567 , H01M10/0568 , Y02E60/13 , Y10S430/127 , Y10T29/49108 , Y10T428/2918 , C07C49/84 , C07C49/553
摘要： The invention relates to ionic compounds in which the anionic load has been displaced, and the uses of these compounds. A compound disclosed by the invention comprises an anionic portion combined with at least one cationic portion M in sufficient numbers to ensure overall electronic neutrality. The anionic portion is comprised of one of the groups (A) and (B) wherein Y1, Y2, Y3, Y4, and Y5 represent a carbonyl group, a sulphonyl group, a thiocarbonyl group, a thionyl group, a -C(=NCN)- group or a -C(=C(CN)2)- group; Z represents an electroattractive radical; each of the substituents, RA, RB, RC, and RD represents independently of one another a monovalent or divalent organic radical or is part of a polymer chain, with at least one or the substituents RC and RD being a perfluorinated radical. The compounds can be used especially for ionic conducting materials, electronic conducting materials, colorants, and the catalysis of various chemical reactions.
摘要翻译：本发明涉及阴离子负载已被置换的离子化合物，以及这些化合物的用途。本发明公开的化合物包含与足够数量的至少一个阳离子部分M + m结合的阴离子部分以确保整体电子中性。阴离子部分由（A）和（B）中的一个组成，其中Y 1，Y 2，Y 3，Y 4和Y 5表示羰基，磺酰基，硫代羰基，亚硫酰基，-C（= NCN） - 基团或-C（= C（CN）2） - 基团; Z表示电吸引基团; 每个取代基RA，RB，RC和RD彼此独立地表示一价或二价有机基团或者是聚合物链的一部分，其中至少一个或取代基RC和RD是全氟化基团。该化合物可以特别用于离子导电材料，电子导电材料，着色剂和各种化学反应的催化。

64. 发明申请

WO1998015982A1 NORMALLY CONDUCTING DUAL THYRISTOR 审中-公开
标题翻译：正常导通双重THRISTOR
公开(公告)号：WO1998015982A1
公开(公告)日：1998-04-16
申请号：PCT/FR1997001756
申请日：1997-10-03
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SANCHEZ, Jean-Louis , JALADE, Jean , LAUR, Jean-Pierre , FOCH, Henri
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： H01L29/745
CPC分类号： H01L29/749 , H01L29/7416 , H01L29/7455
摘要： The invention concerns a component constituting a dual thyristor, normally conducting and capable of being blocked by a voltage pulse on the control electrode, comprising a thyristor (Th), a first depletion MOS transistor (MD1) whose grid is coupled with the source connected between the anode gate (GA) and the cathode (K) of the thyristor, and second enrichment MOS transistor (ME2) whose grid is connected to a control terminal (G).
摘要翻译：本发明涉及一种构成双晶闸管的部件，其通常是导通的并且能够被控制电极上的电压脉冲阻挡，包括晶闸管（Th），第一耗尽型MOS晶体管（MD1），其栅极与源极相连，晶闸管的阳极栅极（GA）和阴极（K），栅极与控制端子（G）连接的第二浓缩MOS晶体管（ME2）。

65. 发明申请

WO1998002534A2 TRANSGENIC ANIMAL WHOSE EXPRESSION OF THE OPIATE RECEPTORS IS MODIFIED 审中-公开
标题翻译：转基因动物表达的亲和素被修饰
公开(公告)号：WO1998002534A2
公开(公告)日：1998-01-22
申请号：PCT/FR1997001282
申请日：1997-07-11
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , KIEFFER, Brigitte, Lina , MATTHES, Hans, W., D. , SIMONIN, Frédéric, Hervé , DIERICH, Andrée , LEMEUR, Marianne
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A01K2267/0356 , C07K14/705
摘要： The invention concerns the use of a non-human transgenic mammal whose expression of a gene coding for an opiate receptor is modified, particularly in the nerve tissues with respect to a normal expression, in particular in the nerve tissues, for producing a medicine for the treatment of pathological conditions involving opiate receptors, in particular severe acute or chronic pains, drug addiction or the prevention or the treatment of transplant rejections.
摘要翻译：本发明涉及非编码转基因哺乳动物的用途，其中编码阿片剂受体的基因的表达在特定神经组织中尤其在神经组织中特别是在神经组织中被修饰，用于生产用于治疗涉及鸦片类受体的病理状况，特别是严重的急性或慢性疼痛，药物成瘾或预防或治疗移植排斥反应。

66. 发明申请

WO1998001579A1 SYSTEM FOR DETECTING PROTEIN-PROTEIN INTERACTIONS 审中-公开
标题翻译：用于检测蛋白质 - 蛋白质相互作用的系统
公开(公告)号：WO1998001579A1
公开(公告)日：1998-01-15
申请号：PCT/FR1997001133
申请日：1997-06-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , GRANGER, Michèle , SCHNARR, Manfred
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12Q01/68
CPC分类号： C12N15/1055 , C07K2319/73 , C07K2319/80 , C12N15/62 , C12Q1/6897 , G01N33/68
摘要： The invention concerns the use of a DNA sequence comprising: a nucleotide sequence coding for an indicator protein (indicator gene); a promoter; a mutated operator; the said nucleotide sequence being under the control of the said promoter comprising the said mutated operator containing two sequences and deriving from an operator containing two inverted repeat sequences (palindrome), this mutated operator being such that one of its sequences is mutated (mutation 1), while the other is for instance wild. The transcription of the indicator gene is repressed by controlling proteins in the form of heterodimers via their DNA binding sites, each monomer of these heterodimers being such that it recognises specifically one the sequence comprising mutation 1, the other the wild sequence, in particular for detecting interactions between two proteins, these interactions being revealed when there is repression of the transcription of the said indicator gene, this repression resulting from the formation of heterodimers.
摘要翻译：本发明涉及DNA序列的用途，其包含：编码指示蛋白（指示基因）的核苷酸序列; 启动子变异算子所述核苷酸序列在所述启动子的控制下，所述启动子包含所述突变的操纵子，其含有两个序列，并衍生自含有两个反向重复序列（回文）的操纵子，该突变的操纵子使得其序列之一被突变（突变1）而另一个则是野生动物。指示基因的转录通过控制异源二聚体形式的蛋白质通过它们的DNA结合位点而被抑制，这些异源二聚体的每个单体使得它能够特异性识别一个包含突变1的序列，另一个是野生序列，特别是用于检测两种蛋白质之间的相互作用，当抑制所述指示基因的转录时，这些相互作用被揭示，这是由形成异二聚体引起的抑制。

67. 发明申请

WO1997031935A1 COMPOUNDS RELATED TO THE AMIDINIUM FAMILY, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND USES THEREOF 审中-公开
标题翻译：与氨基酸家族有关的化合物，含有它们的药物组合物及其用途
公开(公告)号：WO1997031935A1
公开(公告)日：1997-09-04
申请号：PCT/FR1997000364
申请日：1997-02-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEHN, Jean-Marie , LEHN, Pierre , VIGNERON, Jean-Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07J41/00
CPC分类号： C07J41/0055 , A61K9/1272
摘要： Novel amidinium derivatives of formula (I), wherein R1 is a cholesterol derivative or an alkylamino-NR'R" grouping, and each of R2 and R3 is independently a hydrogen atom or a grouping of formula (II), wherein each of R4 and R5 is independently a hydrogen atom or a grouping of formula (III), are disclosed. The corresponding pharmaceutical compositions, which are particularly useful in gene therapy for transferring therapeutic genes into cells, are also disclosed.
摘要翻译：式（I）的新型脒鎓衍生物，其中R1是胆固醇衍生物或烷基氨基-NR'R“基团，R2和R3各自独立地是氢原子或式（II）的基团，其中R4和 R5也独立地是氢原子或式（III）的基团，也公开了特别可用于将治疗基因转移到细胞中的基因治疗中的药物组合物。

68. 发明申请

WO1997028901A1 METHOD AND DEVICE FOR SEPARATING PARTICLES FROM AN ELECTRICALLY CONDUCTIVE LIQUID FLOW USING ELECTROMAGNETIC FORCES 审中-公开
标题翻译：使用电磁力从电导液流中分离颗粒的方法和装置
公开(公告)号：WO1997028901A1
公开(公告)日：1997-08-14
申请号：PCT/FR1997000235
申请日：1997-02-06
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , PILLIN, Béatrice , GILLON, Pascale , BEAUGON, Eric
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： B03C01/23
CPC分类号： C22B21/066 , B03C1/035 , B03C1/23 , C22B9/023 , Y02P10/234
摘要： A method for separating inclusions from an electrically conductive liquid flow using electromagnetic forces, wherein the inclusions and the liquid have differing electrical conductivities, is disclosed. Said flow is exposed to a spatially heterogeneous magnetic flux produced by a continuous static magnetic field.
摘要翻译：公开了一种使用电磁力从导电液体流中分离夹杂物的方法，其中夹杂物和液体具有不同的电导率。所述流动暴露于由连续静磁场产生的空间异质磁通。

69. 发明申请

WO1997024309A1 METHOD FOR PREPARATION OF PERFLUOROALCANECARBOXYLIC AND PERFLUOROALCANESULFONIC ACIDS 审中-公开
标题翻译：全氟代羧酸和全氟代氨基酸的制备方法
公开(公告)号：WO1997024309A1
公开(公告)日：1997-07-10
申请号：PCT/FR1996002079
申请日：1996-12-24
申请人： ELECTRICITE DE FRANCE SERVICE NATIONAL , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MARZOUK, Hatem , PETIT, Laurent , TORDEUX, Marc , BERECIBAR, Amaya , WAKSELMAN, Claude
发明人： ELECTRICITE DE FRANCE SERVICE NATIONAL , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07C53/21
CPC分类号： C07C303/16 , C07C51/34 , C07C53/21 , C07C309/06
摘要： The invention consists of a new method for preparing perfluoroalcanecarboxylic and perfluoroalcanesulfonic acids in which ozone is made to react, in a protic environment, upon a perfluoroalkyl chain comprising at least one oxydizable chemical group.
摘要翻译：本发明包括一种制备全氟羧酸和全氟马烷磺酸的新方法，其中使臭氧在质子环境下与包含至少一个可氧化化学基团的全氟烷基链反应。

70. 发明申请

WO1997012982A1 DNA SEQUENCES CODING FOR A CINNAMOYL CoA REDUCTASE, AND APPLICATIONS THEREOF IN THE CONTROL OF LIGNIN CONTENTS IN PLANTS 审中-公开
标题翻译： CINNAMOYL CoA还原酶的DNA序列编码及其在植物控制中的应用
公开(公告)号：WO1997012982A1
公开(公告)日：1997-04-10
申请号：PCT/FR1996001544
申请日：1996-10-03
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , BOUDET, Alain-Michel , PICHON, Magalie , GRIMA-PETTENATI, Jacqueline , BECKERT, Michel , GAMAS, Pascal , BRIAT, Jean-François
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
IPC分类号： C12N15/53
CPC分类号： C12N9/0008 , C12N15/8255
摘要： The present invention relates to any DNA sequence comprising as a coding region all or part of the nucleotidic sequence coding for a mRNA coding coding for a cinnamoyl CoA reductase (CCR) in lucern and/or corn, or all or part of the nucleotide sequence complementary of the latter and coding for an antisense mRNA susceptible of hybridizing with said mRNA. The invention also relates to the use of said sequences for implementing processes for the regulation of lignin biosynthesis in plants.
摘要翻译：本发明涉及包含编码区的全部或部分编码在编码赖氨酸和/或玉米中的肉桂酰辅酶A还原酶（CCR）的mRNA编码的核苷酸序列的全部或部分，或全部或部分互补的核苷酸序列并编码易于与所述mRNA杂交的反义mRNA。本发明还涉及所述序列用于实施植物中木质素生物合成调节方法的用途。

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