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61. 发明授权

US08540760B2 Tubular devices having reversible components for deployment of endoluminal occluders and related methods and systems 有权
标题翻译：具有用于部署腔内封堵器的可逆组件的管状装置及相关方法和系统
公开(公告)号：US08540760B2
公开(公告)日：2013-09-24
申请号：US12164520
申请日：2008-06-30
申请人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul, Jr. , Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/84
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12136 , A61B17/12181 , A61B17/1219 , A61B17/3468 , A61B2017/1205
摘要： Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.
摘要翻译：描述了用于在患者的脉管系统内部署一个或多个闭塞假体的装置，方法和系统。示例性装置可以包括包含闭塞假体的展开管或护套，其中护套的一部分可由使用者逆转，以便将该假体从皮肤内腔部署到患者体内。

62. 发明授权

US08470020B2 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US08470020B2
公开(公告)日：2013-06-25
申请号：US13447619
申请日：2012-04-16
申请人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
发明人： Darin G. Schaeffer , Jacob A. Flagle , Michael L. Garrison , Brian C. Case , Andrew K. Hoffa
IPC分类号： A61F2/82
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include first and second longitudinal connecting members joining a first hoop member to a second hoop member such that the first and second longitudinal connecting members extend across an entire space separating the first and second hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括将第一箍构件连接到第二箍构件的第一和第二纵向连接构件，使得第一和第二纵向连接构件跨越分隔第一和第二箍构件的整个空间延伸。

63. 发明授权

US08303647B2 Medical valve leaflet structures with peripheral region receptive to tissue ingrowth 有权
标题翻译：具有周边区域接受组织向内生长的医疗瓣膜小叶结构
公开(公告)号：US08303647B2
公开(公告)日：2012-11-06
申请号：US11367979
申请日：2006-03-03
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2415 , A61F2/2475 , A61F2250/0051
摘要： Composite leaflets and prosthetic valves incorporating the same are disclosed. An illustrative composite leaflet includes a flexible inner region, which is formed with a synthetic polymeric material, and a flexible peripheral region, which is formed with a remodelable material effective to promote tissue ingrowth. The peripheral region extends from at least a portion of the flexible inner region and is configured to contact a wall of a tubular body passage and thereby promote tissue ingrowth into the peripheral region from the wall of the tubular body passage.
摘要翻译：公开了包括其的复合传单和人工瓣膜。示例性的复合传单包括形成有合成聚合物材料的柔性内部区域和柔性周边区域，其形成有效促进组织向内生长的可重塑材料。周边区域从柔性内部区域的至少一部分延伸并且构造成接触管状本体通道的壁，从而促进组织从管状体通道的壁向内延伸进入周边区域。

64. 发明申请

US20120253450A1 Prosthesis Adapted for Placement Under External Imaging 审中-公开
标题翻译：假体适应于外部成像下的放置
公开(公告)号：US20120253450A1
公开(公告)日：2012-10-04
申请号：US13444238
申请日：2012-04-11
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F2/82
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.
摘要翻译：一种具有可成像结构的可扩张假体，其包括通过外部（例如，射线照相或超声）成像系统在视觉上可区分的一个或多个元件，所述结构围绕与假体的结构特征相对应的第一轴定位，所述结构特征被配置为执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。

65. 发明申请

US20120175313A1 SYSTEM AND METHOD FOR ADJUSTMENT OF BLOOD SEPARATION PROCEDURE PARAMETERS 有权
标题翻译：用于调节血液分离程序参数的系统和方法
公开(公告)号：US20120175313A1
公开(公告)日：2012-07-12
申请号：US13345305
申请日：2012-01-06
申请人： John W. Barry, JR. , Brian C. Case , Lan T. Nguyen
发明人： John W. Barry, JR. , Brian C. Case , Lan T. Nguyen
IPC分类号： B01D17/12 , B01D43/00 , B01D17/00
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3672 , A61M2202/0427
摘要： Systems and methods are provided for automatically adjusting the operational parameters of a blood separation procedure. A blood separation device has an inlet for passing fluid thereinto and an outlet for removing fluid therefrom. A pump system is provided for moving fluid into and out of the device. In use, blood is conveyed into the device, where platelets are separated from at least a portion of the blood. A controller determines the amount of platelets in the device. Based at least in part on the amount of platelets in the device, corrective action is taken to avoid platelet aggregation in the device. The corrective action may be conveying an elevated amount of anticoagulant into the blood and/or the device and may be initiated when the determined amount of platelets approaches, meets, or exceeds a threshold predicted likelihood of platelet aggregation.
摘要翻译：提供了用于自动调整血液分离程序的操作参数的系统和方法。血液分离装置具有用于使流体流入的入口和用于从其中除去流体的出口。提供用于将流体移入和移出设备的泵系统。在使用中，将血液输送到装置中，其中血小板与至少一部分血液分离。控制器确定设备中血小板的量。至少部分地基于装置中的血小板的量，采取纠正措施以避免装置中的血小板聚集。纠正措施可能是将升高量的抗凝血剂输送到血液和/或装置中，并且可以在所确定的血小板接近，满足或超过血小板聚集的阈值预测可能性时开始。

66. 发明授权

US08066732B2 Inverting occlusion devices, methods, and systems 有权
标题翻译：反相闭塞装置，方法和系统
公开(公告)号：US08066732B2
公开(公告)日：2011-11-29
申请号：US11322145
申请日：2005-12-29
申请人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul , Brian C. Case , Jacob A. Flagle
IPC分类号： A61M29/00
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括在插管内反转的闭塞装置的经皮递送，其展开和填充，以封闭或消除血管容器的一部分。

67. 发明申请

US20110224484A1 METHODS FOR MODIFYING VASCULAR VESSEL WALLS 有权
标题翻译：修改血管壁水的方法
公开(公告)号：US20110224484A1
公开(公告)日：2011-09-15
申请号：US13048492
申请日：2011-03-15
申请人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
发明人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

68. 发明申请

US20110171181A1 METHODS FOR MODIFYING VASCULAR VESSEL WALLS 有权
公开(公告)号：US20110171181A1
公开(公告)日：2011-07-14
申请号：US13048458
申请日：2011-03-15
申请人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
发明人： Brian C. Case , Michael C. Hiles , Jacob A. Flagle , F. Joseph Obermiller , Umesh H. Patel
IPC分类号： A61K35/34 , A61K35/12 , A61P9/00
CPC分类号： A61B17/12 , A61F2/07 , A61F2/2475 , A61F2002/075 , A61F2002/077
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

69. 发明申请

US20110112621A1 PERCUTANEOUSLY DEPLOYED VASCULAR VALVES 有权
标题翻译： PERCUTANEOUSLY部分血管瓣
公开(公告)号：US20110112621A1
公开(公告)日：2011-05-12
申请号：US13008629
申请日：2011-01-18
申请人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
发明人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
IPC分类号： A61F2/02
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/8483 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0034 , A61F2230/0095
摘要： Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.
摘要翻译：描述的是没有附接的支撑结构的经皮血管瓣和用于在血管容器内提供阀的附接的展开系统和方法。

70. 发明授权

US07909862B2 Delivery systems and methods for deploying expandable intraluminal medical devices 有权
标题翻译：用于部署扩张型管腔内医疗器械的输送系统和方法
公开(公告)号：US07909862B2
公开(公告)日：2011-03-22
申请号：US10804386
申请日：2004-03-19
申请人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
发明人： Michael L. Garrison , Brian C. Case , Andrew K. Hoffa , Jacob A. Flagle , Dusan Pavcnik
IPC分类号： A61F2/06 , A61M29/00
CPC分类号： A61F2/95 , A61F2/013 , A61F2/966 , A61F2002/011 , A61F2002/015 , A61F2230/0006 , A61F2230/005
摘要： Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A delivery device is provided, inserted into a body vessel, and navigated through the vessel to place an associated expandable intraluminal medical device at a desired point of treatment. Once the desired location is reached, an elongate member on which the expandable intraluminal medical device is disposed is spaced from a wall surface of the body vessel using an expandable wire basket, balloon, or other suitable structure. The expandable intraluminal medical device is deployed from the delivery system, which can ultimately be withdrawn from the body vessel.
摘要翻译：提供了用于在体内容器内的期望治疗点递送和部署可膨胀管腔内医疗装置的方法和装置。提供输送装置，插入体内容器，并通过血管导航，将相关的可扩张的管腔内医疗装置放置在期望的治疗点。一旦达到所需的位置，可扩张的管腔内医疗装置就位于其上的细长构件就可以使用可膨胀的丝网筐，球囊或其它合适的结构与身体容器的壁表面间隔开。可扩展的管腔内医疗装置从输送系统部署，其最终可以从体内容器中取出。

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