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61. 发明授权

US07252833B2 Calcium phosphate cements comprising an osteoclastogenic agent 有权
标题翻译：包含破骨细胞生成剂的磷酸钙胶结剂
公开(公告)号：US07252833B2
公开(公告)日：2007-08-07
申请号：US10717171
申请日：2003-11-18
申请人： Brent R. Constantz , David Delaney
发明人： Brent R. Constantz , David Delaney
IPC分类号： A61K33/42 , A61K31/00 , A61K31/695 , A61F2/00 , A01N59/26 , A01N61/00 , A01N55/00
CPC分类号： A61L24/02
摘要： Methods and compositions are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products that include an osteoclastogenic agent. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid and an osteoclastogenic agent, e.g., RANKL or a mimetic thereof, and the combined reactants are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.
摘要翻译：提供了用于生产可流动组合物的方法和组合物，例如。糊剂，其设置为包含破骨细胞生成剂的磷酸钙产品。在本发明方法中，将包含钙源和磷酸盐源的干燥反应物与凝固液和破骨细胞生成剂如RANKL或其模拟物组合，并将合并的反应物混合以产生可流动组合物。还提供了组合物本身以及用于制备它们的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。

62. 发明授权

US07252672B2 Use of vibration with orthopedic cements 有权
标题翻译：使用振动与矫形水泥
公开(公告)号：US07252672B2
公开(公告)日：2007-08-07
申请号：US10797907
申请日：2004-03-09
申请人： Duran Yetkinler , David Delaney , Brent R. Constantz
发明人： Duran Yetkinler , David Delaney , Brent R. Constantz
IPC分类号： A61B17/58 , A61F2/00
CPC分类号： A61B17/8822 , A61F2002/4602 , A61F2002/4683 , A61K33/42
摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.
摘要翻译：提供使用骨缺损填充的方法，例如矫形水泥，例如磷酸钙水泥等。主题方法的一个特征是，与水泥的使用结合使用振动，例如在准备水泥时，在制备目标地点时，将水泥输送到目标地点和/或在运送之后的水泥到目标地点。还提供了用于实践主题方法的设备，系统和工具包。主题方法，设备和系统可用于各种不同的应用。

63. 发明授权

US06730063B2 Catheter devices and methods for their use in the treatment of calcified vascular occlusions 有权
标题翻译：导管装置及其用于治疗钙化血管闭塞的方法
公开(公告)号：US06730063B2
公开(公告)日：2004-05-04
申请号：US09911529
申请日：2001-07-23
申请人： Dave Delaney , Peter Johansson , Brent R. Constantz
发明人： Dave Delaney , Peter Johansson , Brent R. Constantz
IPC分类号： A61M300
CPC分类号： A61B5/14539 , A61B17/22 , A61B2017/22084 , A61M29/02 , A61M2025/0004 , A61M2025/0034 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： Catheter devices and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter devices include at least a first, second and third lumen, where: (a) the first lumen is used for delivery of an acidic dissolution solution to the vascular site; (b) the second lumen is used for delivery of a buffer solution to the vascular site; and (c) the third lumen is used for removal of fluid from the vascular site. In many preferred embodiments, the first, second and third lumens are coaxial. In practicing the subject methods, the vascular site is flushed simultaneously with an acidic dissolution fluid and a buffer solution, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the acidic dissolution fluid and the remainder of the vascular site is not contacted with fluid having a pH that is lower than about 4. Flushing is carried out in this manner for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter devices and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.
摘要翻译：提供了用于增强通过血管闭塞占据的血管部位的流体流动的导管装置和方法。主题导管装置包括至少第一，第二和第三腔，其中：（a）第一腔用于将酸性溶解溶液递送至血管部位; （b）第二管腔用于将缓冲溶液递送至血管部位; 和（c）第三腔用于从血管部位去除流体。在许多优选实施例中，第一，第二和第三管腔是同轴的。在实施本发明的方法中，血管部位与酸性溶解液和缓冲溶液同时冲洗，其中以如下方式进行冲洗，使得只有血管闭塞的表面与酸性溶解液接触，其余部分血管部位不与pH低于约4的液体接触。以这种方式进行冲洗足以使液体流过血管部位以增强的时间，例如增加或建立主题导管装置和方法可用于治疗各种不同血管疾病，其特征在于存在钙化血管闭塞，包括外周和冠状动脉血管疾病。

64. 发明授权

US06712798B2 Multilumen catheters and methods for their use 有权
公开(公告)号：US06712798B2
公开(公告)日：2004-03-30
申请号：US10101544
申请日：2002-03-18
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61M2500
CPC分类号： A61M25/0032 , A61M25/10 , A61M2025/1052
摘要： Multilumen catheters are provided. The subject multilumen catheters include a proximal end and a distal end separated by a non-coaxial multilumen tube. The subject catheters are further characterized in that they include a multiport manifold at their proximal ends, where at least two of the ports of the multiport manifold may comprise luer valves. Also provided are systems for use in flushing a vascular site with fluid, usually at least two different fluids, where the subject systems are made up of two multilumen catheters according to the subject invention, where one of the catheters is inserted inside of the other. In addition, kits comprising various components of the subject systems, e.g., at least two different multilumen catheters, are provided. The subject multilumen catheters, systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions.

65. 发明授权

US06394096B1 Method and apparatus for treatment of cardiovascular tissue mineralization 失效
标题翻译：治疗心血管组织矿化的方法和装置
公开(公告)号：US06394096B1
公开(公告)日：2002-05-28
申请号：US09118193
申请日：1998-07-15
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61B1900
CPC分类号： A61B17/22 , A61B2017/22084 , A61B2017/22098
摘要： A method and several assemblies for the reducing of mineralization of cardiovascular tissue in vivo is provided. The method involves contacting cardiovascular tissue, such as a valve or a vessel, with an acidic treatment solution. One apparatus is a balloon catheter assembly for the infusion of an acidic treatment solution into a define area of a cardiovascular tissue. A second apparatus is a flexible cup which forms a defined area with the wall of a vessel for the introduction of an acidic treatment solution for the reduction of mineralization of a vessel. A third apparatus is an assembly for the introduction of an acidic treatment solution on one side of a valve, and the removal of the acidic treatment solution from the opposite side of the valve. Each apparatus can take the form of an elongated catheter for use in minimally invasive procedures or as hand held devices for use in an open surgical field.
摘要翻译：提供了一种用于体内减少心血管组织矿化的方法和几个装置。该方法包括将心血管组织如阀或血管与酸性处理溶液接触。一种装置是用于将酸性处理溶液输注到心血管组织的限定区域中的气囊导管组件。第二装置是柔性杯，其与容器的壁形成限定的区域，用于引入用于还原矿化矿化的酸性处理溶液。第三装置是用于在阀的一侧引入酸性处理溶液并从阀的相对侧除去酸性处理溶液的组件。每个装置可以采用细长导管的形式用于微创手术或用作在开放手术领域中使用的手持装置。

66. 发明授权

US6149655A Methods and devices for the preparation, storage and administration of calcium phosphate cements 失效
标题翻译：磷酸钙水泥的制备，储存和施用的方法和装置
公开(公告)号：US6149655A
公开(公告)日：2000-11-21
申请号：US989845
申请日：1997-12-12
申请人： Brent R. Constantz , Ben Clawson
发明人： Brent R. Constantz , Ben Clawson
IPC分类号： A61B17/88 , A61F2/46 , A61J1/00 , A61J1/20 , B01F11/00 , B01F13/00 , B01F15/02 , B05C17/005 , B05C17/01 , B65D81/32 , A61B17/58
CPC分类号： A61J1/2093 , A61B17/8822 , A61B17/8833 , B01F11/0065 , B01F13/002 , B01F15/0205 , B01F15/0206 , B01F15/0224 , B05C17/00553 , B05C17/01 , B65D81/3266 , B65D81/3272 , A61B17/8827 , A61B2017/8838 , A61B2090/037 , A61J1/2027
摘要： A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.
摘要翻译：提供了一种用于磷酸钙水泥的储存，制备和施用的系统。本发明提供了一种用于储存具有液体组分和干燥组分的双组分磷酸钙水泥的储存装置。还提供了一种用于在存在于存储装置中时将水泥的两个部件组合在一起的制备装置。本发明还提供了一种将制备的水泥施用于生理部位的方法。本发明的设备和方法可用于各种应用，其中需要引入能够将固体磷酸钙矿物质固化至生理部位的可流动材料，包括牙科和矫形应用。

67. 发明授权

US6083229A Methods and devices for the preparation, storage and administration of calcium phosphate cements 有权
公开(公告)号：US6083229A
公开(公告)日：2000-07-04
申请号：US183920
申请日：1998-10-30
申请人： Brent R. Constantz , Ben Clawson
发明人： Brent R. Constantz , Ben Clawson
IPC分类号： A61B17/88 , A61F2/46 , A61J1/00 , A61J1/20 , B01F11/00 , B01F13/00 , B01F15/02 , B05C17/005 , B05C17/01 , B65D81/32 , A61B17/58
CPC分类号： A61J1/2093 , A61B17/8822 , A61B17/8833 , B01F11/0065 , B01F13/002 , B01F15/0205 , B01F15/0206 , B01F15/0224 , B05C17/00553 , B05C17/01 , B65D81/3266 , B65D81/3272 , A61B17/8827 , A61B2017/8838 , A61B2090/037 , A61J1/2027
摘要： A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.

68. 发明授权

US5962028A Carbonated hydroxyapatite compositions and uses 失效
公开(公告)号：US5962028A
公开(公告)日：1999-10-05
申请号：US963481
申请日：1992-10-16
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , A61K9/00 , A61K33/06 , A61K33/42
CPC分类号： A61L24/02 , A61K6/0067 , A61K6/0085 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293
摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.

69. 发明授权

US5900254A Carbonated hydroxyapatite compositions and uses 失效
标题翻译：碳酸羟基磷灰石组合物及用途
公开(公告)号：US5900254A
公开(公告)日：1999-05-04
申请号：US670514
申请日：1996-06-27
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , A61K33/06 , A61K33/42 , C01F11/02
CPC分类号： A61L24/02 , A61K6/0067 , A61K6/0085 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293
摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.
摘要翻译：描述了碳酸化羟基磷灰石组合物及其制备方法。组合物是生物可吸收的并且被制备成可流动的质量，其可以通过注射器施用以原位置换以用作支撑结构，填充物，假体等。任选地，组合物可以包括蛋白质或用作用于药理学兴趣的组合物的贮库。

70. 发明授权

US5683667A Reactive tricalcium phosphate compositions 失效
标题翻译：活性磷酸三钙组合物
公开(公告)号：US5683667A
公开(公告)日：1997-11-04
申请号：US570237
申请日：1995-12-11
申请人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
发明人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
IPC分类号： A61L24/00 , A61F2/00 , A61L24/02 , A61L27/12 , C01B25/32 , C04B12/02 , C04B28/34
CPC分类号： C01B25/32 , A61L24/02 , A61L27/12 , C01B25/321 , C04B12/02 , C04B12/025 , C04B28/34 , C04B28/344 , C04B28/346 , A61F2310/00293 , C04B2111/00836
摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
摘要翻译：提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

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