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61. 发明申请

WO2012125676A1 IMPLANTABLE MEDICAL DEVICES INCORPORATING X-RAY MIRRORS 审中-公开
标题翻译：包含X射线镜的可植入医疗器械
公开(公告)号：WO2012125676A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028996
申请日：2012-03-14
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , FLANAGAN, Aiden
发明人： WEBER, Jan , FLANAGAN, Aiden
IPC分类号： A61L27/04 , A61L27/10 , A61L29/18 , A61L31/02 , A61L31/18
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61L27/04 , A61L27/10 , A61L29/18 , A61L31/022 , A61L31/026 , B82Y10/00 , G21K1/062
摘要： An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.
摘要翻译：可植入医疗装置包括设置有x射线反射镜的射线可透射部件，该X射线反射镜反射入射的X射线辐射以使装置可视化。 x射线镜包括具有通过具有第一折射率的原子层沉积沉积的第一金属或陶瓷层的交替层的多层纳米材料，以及通过原子层沉积沉积的具有不同于第二折射率的第二金属或陶瓷层从第一折射率。纳米层压材料总共包括至少四层。

62. 发明申请

WO2012078465A1 DRUG ELUTING BALLOONS WITH ABILITY FOR DOUBLE TREATMENT 审中-公开
标题翻译：具有双重治疗能力的药物气球
公开(公告)号：WO2012078465A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063068
申请日：2011-12-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , WETZELS, Jos
发明人： WEBER, Jan , WETZELS, Jos
IPC分类号： A61M25/10
CPC分类号： A61M25/104 , A61L29/08 , A61L29/146 , A61L29/16 , A61L2300/61 , A61M25/10 , A61M2025/0057 , A61M2025/1031 , A61M2025/105 , A61M2025/1086 , A61M2025/1088
摘要： In embodiments, medical devices, such as balloon catheters, can deliver a biologically active material to body tissue of a patient. The medical device includes a sponge delivery layer which can deliver multiple doses of one or more therapeutic agents to the body tissue. The medical device can further include a drug reservoir, which can supply the delivery layer with one or more therapeutic agents.
摘要翻译：在实施例中，诸如气囊导管的医疗装置可将生物活性物质递送至患者的身体组织。医疗装置包括海绵输送层，其可以将多个剂量的一种或多种治疗剂递送至身体组织。医疗装置还可以包括药物储存器，其可以向输送层提供一种或多种治疗剂。

63. 发明申请

WO2011022623A2 MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：包含治疗剂的医疗设备
公开(公告)号：WO2011022623A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/046125
申请日：2010-08-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HINGSTON, John , ROBICHAUD, Michael , WEBER, Jan , MCNAMARA, Adrian , FLANAGAN, Aiden , HORGAN, Fergal
发明人： HINGSTON, John , ROBICHAUD, Michael , WEBER, Jan , MCNAMARA, Adrian , FLANAGAN, Aiden , HORGAN, Fergal
IPC分类号： A61L31/08
CPC分类号： A61L31/088 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2400/12
摘要： According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after implantation in a subject. In various embodiments, a therapeutic agent delivery profile of this type is provided by employing a temporary barrier layer which initially permits little to no release of the therapeutic agent, but which layer permits much greater release levels after a predetermined period of time. Other aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其可以在植入受试者后将一种或多种治疗剂的释放延迟预定时间。在各种实施方案中，通过使用临时阻挡层来提供这种类型的治疗剂递送特征，所述临时阻挡层最初几乎不允许释放治疗剂，但是该层在预定的时间段之后允许更大的释放水平。本发明的其它方面涉及形成这种装置的方法和使用这种装置的方法。

64. 发明申请

WO2010101901A2 SELF-BUFFERING MEDICAL IMPLANTS 审中-公开
标题翻译：自助医疗植入物
公开(公告)号：WO2010101901A2
公开(公告)日：2010-09-10
申请号：PCT/US2010/025896
申请日：2010-03-02
申请人： BOSTON SCIENTIFIC SCIMED, INC. , ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
发明人： ATANASOSKA, Liliana , SHIPPY, James, Lee, III , HOLMAN, Tom , ARNEY, Michael, S. , SCHOENLE, Victor , GENOVESE, Frank , FENG, James Q. , FLANAGAN, Aiden , WEBER, Jan
IPC分类号： A61L27/04
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

65. 发明申请

WO2010096516A3 BIOERODIBLE ENDOPROSTHESIS 审中-公开
公开(公告)号：WO2010096516A3
公开(公告)日：2010-08-26
申请号：PCT/US2010/024520
申请日：2010-02-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
发明人： SCHEUERMANN, Torsten , WEBER, Jan , ALBRECHT, Peter
IPC分类号： A61L29/02 , A61L29/14 , A61L31/02 , A61L31/14 , C22C38/04 , C22C38/02
摘要： A bioerodible stent, having a composition comprising Fe, Mn, Si and C has desirable mechanical, erosion, and physiological characteristics.

66. 发明申请

WO2010014510A1 COILS FOR VASCULAR IMPLANTS OR OTHER USES 审中-公开
标题翻译：用于血管植入物或其他用途的线圈
公开(公告)号：WO2010014510A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/051690
申请日：2009-07-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan
发明人： WEBER, Jan
IPC分类号： A61F2/00
CPC分类号： A61F2/88 , A61F2/0077 , A61F2220/0016 , A61F2250/0067
摘要： Medical devices comprising implants for use in blood vessels or other body lumens. The implant comprises an elongate member that, in its native configuration, follows a generally helical path. The elongate member is formed of one or more strands that are wound into a coil of minor windings, wherein the coil of minor windings is itself wound into the generally helical path. The one or more strands are formed of materials that provide the elongate member with the desired flexibility. In some cases, the elongate member may be capable of delivering a therapeutic agent. This can be accomplished by, for example, using capsules, swellable materials, corrodable elements, magnetically-sensitive particles, coatings, and/or core wires. Also provided are a method of treating a superficial femoral artery and a method of making an implant.
摘要翻译：包括用于血管或其他体腔的植入物的医疗装置。植入物包括细长构件，其在其天然构造中遵循大致螺旋形路径。细长构件由一个或多个缠绕在小绕组线圈中的线构成，其中小绕组的线圈本身缠绕在大致螺旋状的路径中。一根或多根股线由提供细长部件所需的柔性的材料形成。在一些情况下，细长构件可以能够递送治疗剂。这可以通过例如使用胶囊，可膨胀材料，可腐蚀元件，磁敏颗粒，涂层和/或芯线来实现。还提供了治疗浅表股动脉的方法和制造植入物的方法。

67. 发明申请

WO2009140257A2 COATING FOR MEDICAL IMPLANTS 审中-公开
标题翻译：医用植绒涂层
公开(公告)号：WO2009140257A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043591
申请日：2009-05-12
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan
发明人： WEBER, Jan
IPC分类号： A61L31/02 , A61L31/08 , A61L31/14
CPC分类号： A61L31/16 , A61L27/04 , A61L27/28 , A61L27/58 , A61L31/022 , A61L31/08 , A61L31/148 , A61L2300/102 , A61L2300/22 , A61L2300/624 , A61L2400/12 , A61L2420/04
摘要： A medical implant can include a body including a bioerodible metal and a coating overlying a surface of the bioerodible metal. The coating can include a matrix that includes a fatty acid salt and nano-particles within the matrix.
摘要翻译：医疗植入物可以包括包括生物腐蚀性金属的物体和覆盖在生物腐蚀性金属的表面上的涂层。涂层可以包括在基质内包含脂肪酸盐和纳米颗粒的基质。

68. 发明申请

WO2009132176A2 MEDICAL DEVICES HAVING INORGANIC PARTICLE LAYERS 审中-公开
标题翻译：具有无机颗粒层的医疗器械
公开(公告)号：WO2009132176A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041520
申请日：2009-04-23
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
发明人： KUEHLING, Michael , SEIDEL, Dominique , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61L31/08 , A61L31/16
CPC分类号： A61L31/16 , A61L31/08 , A61L2300/61 , A61L2300/62 , A61L2420/02
摘要： An expandable medical device having a particle layer disposed over a reservoir containing a therapeutic agent. The particle layer has a first porosity when the medical device is in the unexpanded configuration and a second porosity when the medical device is in the expanded configuration. The particle layer comprises a plurality of micron-sized or nano-sized particles. In certain embodiments, the particles are not connected to each other, and as such, the different porosities are provided by changes in the spacing between the particles as the medical device is expanded/unexpanded. Also disclosed are medical devices having a particle layer, wherein the particle layer comprises a plurality of encapsulated particles, and methods of coating medical devices with particles.
摘要翻译：一种可膨胀医疗装置，其具有设置在含有治疗剂的贮器上方的颗粒层。当医疗装置处于未膨胀构型时，颗粒层具有第一孔隙度，并且当医疗装置处于膨胀构型时具有第二孔隙率。颗粒层包含多个微米级或纳米尺寸的颗粒。在某些实施方案中，颗粒彼此不连接，因此，当医疗装置膨胀/未膨胀时，由颗粒之间的间隔的变化提供不同的孔隙度。还公开了具有颗粒层的医疗装置，其中所述颗粒层包含多个包封的颗粒，以及用颗粒涂覆医疗装置的方法。

69. 发明申请

WO2009014793A2 MEDICAL BALLOONS AND THE METHODS OF MAKING THE SAME 审中-公开
标题翻译：医用气囊及其制造方法
公开(公告)号：WO2009014793A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/063816
申请日：2008-05-16
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , ATANSOSKA, Liliana
发明人： WEBER, Jan , ATANSOSKA, Liliana
IPC分类号： A61L29/12
CPC分类号： A61L29/126 , A61M25/104
摘要： Medical balloons are provided that have enhanced properties, such as thinner walls, enhanced tensile strength, and/or electrical conductivity. Methods are also disclosed.
摘要翻译：提供了具有增强性能的医用气囊，例如更薄的壁，增强的拉伸强度和/或导电性。还公开了方法。

70. 发明申请

WO2008140482A2 MEDICAL DEVICES HAVING COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY 审中-公开
标题翻译：具有用于受控治疗药物递送的涂层的医疗装置
公开(公告)号：WO2008140482A2
公开(公告)日：2008-11-20
申请号：PCT/US2007/023601
申请日：2007-11-09
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim , O'BRIEN, Barry, J. , CLARKE, John , MCMORROW, David
发明人： WEBER, Jan , FLANAGAN, Aiden , O'CONNOR, Tim , O'BRIEN, Barry, J. , CLARKE, John , MCMORROW, David
IPC分类号： A61F2/82 , A61L31/08
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括设置在包括基底的结构的至少一部分上的纳米颗粒衍生的无机层，以及任选地，设置在至少一部分上的治疗剂含有层的基底。在一些实施方案中，无机层是纳米多孔无机层。本发明的其它方面包括用于形成这种医疗装置的方法。

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