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61. 发明专利

AR082353A1 LIGANDO OX40 Y DE LINFOPOYETINA DEL ESTROMA TIMICO (TSLP) EN EL CANCER 未知
公开(公告)号：AR082353A1
公开(公告)日：2012-11-28
申请号：ARP110102697
申请日：2011-07-26
申请人： BAYLOR RES INST
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA
IPC分类号： A61K38/16 , A61K39/395 , A61P29/00 , A61P35/00 , C07K16/24
摘要： Reivindicación 1: Una composición terapéutica para el tratamiento de un tumor de origen epitelial en un sujeto humano, caracterizada porque comprende: uno o más agentes activos que se unen y neutralizan la actividad de una linfopoyetina del estroma tímico (TSLP), en donde dichos uno o más agentes activos se seleccionan del grupo que consiste de un anticuerpo anti-TSLP, un fragmento de un anticuerpo anti-TSLP, un conjugado de anticuerpo anti-TSLP-vehículo, una proteína de fusión de unión a TSLP, un antagonista de TSLP, un inhibidor de TSLP, un antagonista del receptor de TSLP o un agente bloqueante de TSLP opcionalmente solubilizado, disperso o suspendido en un medio adecuado en una cantidad suficiente para inhibir el desarrollo del tumor.Reivindicación 9: Uso de una composición farmacéutica caracterizada porque es para la fabricación de un medicamento para tratar o aliviar síntomas de un cáncer de origen epitelial en un sujeto humano, donde el tratamiento comprende los pasos de: identificar al sujeto que necesita tratamiento contra el cáncer; y administrar una cantidad terapéuticamente eficaz de una composición farmacéutica suficiente para tratar o aliviar los síntomas del cáncer en el sujeto, que comprende uno o más anticuerpos monoclonales o policlonales seleccionados del grupo que consiste de un anticuerpo anti-OX40L, un anticuerpo anti-linfopoyetina del estroma tímico (TSLP) o ambos.

63. 发明专利

AU2010235902A1 Method of treating malignancies through induction of blood immune responses 未知
公开(公告)号：AU2010235902A1
公开(公告)日：2010-11-11
申请号：AU2010235902
申请日：2010-10-19
申请人： BAYLOR RES INST , UNIV ROCKEFELLER
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , FAY JOSEPH , STEINMAN RALPH , DHODAPKAR MADHAV , WITTKOWSKI KNUT M
IPC分类号： C12Q1/02 , A61K35/14 , A61K39/00 , A61K48/00 , A61P35/00 , C12N5/06 , C12N5/0784 , C12P21/08 , G01N33/50
摘要： The invention pertains to a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides and with control antigens, and its use for the treatment and prevention of malignancies.

64. 发明专利

PT1224264E MODIFICAÇÃO DE CÉLULAS IMUNOGÉNICAS 未知
公开(公告)号：PT1224264E
公开(公告)日：2010-03-15
申请号：PT00970961
申请日：2000-10-16
申请人： BAYLOR RES INST
发明人： BANCHEREAU JACQUES F , BERARD FREDERIC , BLANCO PATRICK , NEIDHART-BERARD EVE-MARIE , NOURI-SHIRAZI MAHYAR , PALUCKA ANNA KAROLINA
IPC分类号： A61K35/12 , A61K39/00 , A61P35/00 , C12N5/0784

65. 发明专利

AU2007286915A2 Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections 未知
公开(公告)号：AU2007286915A2
公开(公告)日：2009-07-09
申请号：AU2007286915
申请日：2007-08-10
申请人： UNIV TEXAS , BAYLOR RES INST
发明人： CHAUSSABEL DAMIEN , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.

66. 发明专利

CA2704288A1 DIAGNOSIS OF METASTATIC MELANOMA AND MONITORING INDICATORS OF IMMUNOSUPPRESSION THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 未知
公开(公告)号：CA2704288A1
公开(公告)日：2008-08-21
申请号：CA2704288
申请日：2007-11-03
申请人： BAYLOR RES INST
发明人： PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN
IPC分类号： C12Q1/68 , C40B30/02 , C40B30/04 , C40B40/08 , G06F19/00
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.

67. 发明专利

AU2007286915A1 Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections 未知
公开(公告)号：AU2007286915A1
公开(公告)日：2008-02-28
申请号：AU2007286915
申请日：2007-08-10
申请人： BAYLOR RES INST , UNIV TEXAS
发明人： CHAUSSABEL DAMIEN , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.

68. 发明专利

AU2007269245A1 Dendritic cells generated using GM-CSF and interferon alpha and loaded with heat-treated and killed cancer cells 未知
公开(公告)号：AU2007269245A1
公开(公告)日：2008-01-10
申请号：AU2007269245
申请日：2007-06-29
申请人： BAYLOR RES INST
发明人： BURKEHOLDER SUSAN , TAQUET NICOLAS , PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F
IPC分类号： A61K39/00 , A61K39/395
摘要： The present invention includes compositions and methods for making a pharmaceutically effective amount of one or more dendritic cells matured by exposure to IFN± loaded with cancer antigens from cells that are heat shocked and subsequently killed, wherein the one or more IFN± dendritic cells are under conditions to present the one or more cancer antigens are presented within the context of autolo

70. 发明专利

AU2006213800A1 Anti-interferon alpha monoclonal antibodies and methods for use 未知
公开(公告)号：AU2006213800A1
公开(公告)日：2006-08-17
申请号：AU2006213800
申请日：2006-02-09
申请人： BAYLOR RES INST
发明人： BANCHEREAU JACQUES , PALUCKA ANNA KAROLINA , PRILLIMAN KILEY , PASCUAL VIRGINIA
IPC分类号： C07K16/24 , A61K39/395
摘要： The present invention includes compositions and methods that include antibodies that selectively neutralize a bioactivity of at least two interferon alpha (IFNα) protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, I, J1, K, 4a, 4b and WA, but does not neutralize at least one bioactivity of IFNα protein subtype D. Examples of bioactivity for measurement include activation of the MxA promoter or antiviral activity and variants, derivatives and fragments thereof. The invention also includes host cells, hybridomas and plasmacytomas that produce antibodies. Because of their unique selectivity and affinity, the antibodies of the present invention are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.

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