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61. 发明授权

US4783549A Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them 失效
标题翻译：苯并降冰片烯衍生物，其制备方法和含有它们的药物和化妆品组合物
公开(公告)号：US4783549A
公开(公告)日：1988-11-08
申请号：US772525
申请日：1985-09-04
申请人： Gerard Lang , Jean Maignan , Serge Restle , Braham Shroot
发明人： Gerard Lang , Jean Maignan , Serge Restle , Braham Shroot
IPC分类号： A61K31/10 , A61K8/00 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/21 , A61K31/215 , A61K31/22 , A61K31/235 , A61K31/255 , A61K31/70 , A61K31/7024 , A61P17/00 , A61P27/02 , A61P27/14 , A61P29/00 , A61P37/08 , A61P43/00 , A61Q5/00 , A61Q7/00 , A61Q19/00 , C07C1/00 , C07C13/605 , C07C17/00 , C07C25/22 , C07C27/00 , C07C29/143 , C07C33/34 , C07C33/50 , C07C43/14 , C07C43/20 , C07C45/00 , C07C47/238 , C07C47/546 , C07C49/225 , C07C49/237 , C07C49/252 , C07C49/255 , C07C49/76 , C07C49/792 , C07C49/813 , C07C49/84 , C07C57/50 , C07C57/62 , C07C59/54 , C07C59/72 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C67/00 , C07C69/017 , C07C69/618 , C07C69/76 , C07C233/05 , C07C233/11 , C07C233/65 , C07C313/00 , C07C315/04 , C07C317/14 , C07C317/22 , C07C321/28 , C07C323/09 , C07C323/18 , C07H13/04 , C11D9/50 , C07C69/16
CPC分类号： C07C49/792 , C07C47/546 , C07C49/813 , C07C49/84
摘要： A compound of formula (I) ##STR1## its isomers and its salts in which --R.sub.1, R.sub.3 and R.sub.4 are each indepenently hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, halogen, C.sub.1 -C.sub.8 -acyloxy or hydroxyl;--R' is hydrogen or C.sub.1 -C.sub.6 -alkyl;--R" is either a polyene chain or a benzene ring are useful in cosmetics and in the treatment of various dermatological and other complaints.
摘要翻译：式（I）化合物其中R 1，R 3和R 4各自独立地为氢，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，卤素，C 1 -C 8 - 酰氧基或羟基; -R'是氢或C 1 -C 6 - 烷基; -R“是多烯链或苯环可用于化妆品和治疗各种皮肤病和其他投诉。

62. 发明授权

US4654434A 3-benzylidene-camphors, process for their preparation and their use in protection against UV rays 失效
标题翻译： 3-亚苄基 - 樟脑，其制备方法及其在防紫外线中的应用
公开(公告)号：US4654434A
公开(公告)日：1987-03-31
申请号：US825932
申请日：1986-02-04
申请人： Gerard Lang , Madeleine Leduc , Alain Malaval
发明人： Gerard Lang , Madeleine Leduc , Alain Malaval
IPC分类号： A61K8/35 , A61K8/46 , A61Q17/04 , C07C45/68 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C59/86 , C07C309/25 , C07C69/76 , C07C143/52
CPC分类号： A61K8/466 , A61K8/35 , A61Q17/04 , C07C255/00 , C07C309/00 , C07C45/68 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C59/86
摘要： The invention relates to new 3-benzylidene-camphor derivatives of the formula: ##STR1## in which R.sub.1 denotes H or SO.sub.3.sup..crclbar. M.sup..sym., with M=H, an alkali metal or N.sup..sym. (R.sub.3).sub.4, with R.sub.3 =H or C.sub.1 -C.sub.4 alkyl or hydroxyalkyl; R.sub.2 denotes C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy and n=0-4; and Z denotes ##STR2## in which R.sub.4 has the same meaning as R.sub.1 and can be identical or different, or alternatively ##STR3## in which R.sub.5 denotes H, optionally substituted aryl, C.sub.1 -C.sub.4 alkyl, --CN, --C00R7 or ##STR4## and R.sub.6 denotes --COOR.sub.8 or ##STR5## in which R.sub.7 and R.sub.8, which are identical or different, denote alkyl, alkenyl, cycloalkyl or aralkyl and R.sub.9 and R.sub.10, which are identical or different, denote H, alkyl, alkenyl or cycloalkyl; if R.sub.5 =H, alkyl or aryl, R.sub.6 can represent --COO.sup..crclbar. M.sup..sym. ; the methylidene-camphor radical, on the one hand, and the radical Z, on the other hand, are in the meta or para position. These derivatives act as sun filters.
摘要翻译：本发明涉及下式的新的3-亚苄基 - 樟脑衍生物：其中R 1表示H或SO 3（ - ）M（+），其中M = H，碱金属或N（+）（ R3）4，其中R3 = H或C1-C4烷基或羟烷基; R2表示C1-C4烷基或C1-C4烷氧基，n = 0-4; 并且Z表示其中R 4具有与R 1相同的含义并且可以相同或不同，或者其中R 5表示H，任选取代的芳基，C 1 -C 4烷基，-CN，-COOR 7或

63. 发明授权

US4654354A Retinoic acid derivatives, process for their preparation and pharmaceutical and cosmetic compositions containing them 失效
标题翻译：视黄酸衍生物，其制备方法和含有它们的药物和化妆品组合物
公开(公告)号：US4654354A
公开(公告)日：1987-03-31
申请号：US780019
申请日：1985-09-23
申请人： Braham Shroot , Gerard Lang , Jean Maignan , Michel Colin
发明人： Braham Shroot , Gerard Lang , Jean Maignan , Michel Colin
IPC分类号： C11D9/50 , A61K8/00 , A61K8/49 , A61K8/67 , A61K31/425 , A61K31/428 , A61P17/00 , A61P27/02 , A61P29/00 , A61P37/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q17/04 , A61Q19/00 , C07D275/02 , C07D275/04 , C07D513/04 , C07D409/00
CPC分类号： A61Q19/007 , A61K8/49 , A61K8/671 , A61Q7/00 , A61Q19/005 , A61Q19/008 , Y10S514/852 , Y10S514/859 , Y10S514/864
摘要： The invention provides compounds of formula ##STR1## in which formula R.sub.1 and R.sub.2 are identical or different and denote:(1) taken separately: a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, an unsubstituted phenyl radical or a phenyl radical substituted with a halogen atom, with a C.sub.1 -C.sub.4 alkoxy radical or with a C.sub.1 -C.sub.4 alkoxy radical;(2) taken together either(a) a polymethylene linkage; or(b) a benzene ring; or(c) a cyclic linkage containing a nitrogen atom to constitute an isothiazolopyridinone derivative; m being able to have the values 0 or 1; the group A in the formula (IV) denoting the group ##STR2## where R.sub.8 corresponds to a hydrogen atom, a methyl radical, a hydroxymethyl radical or a --CH.sub.2 O--CO--Ret group. The invention also provides a process for preparing the abovementioned compounds and also drug compositions and cosmetic compositions containing them.
摘要翻译：本发明提供式（IV）的化合物，其中式R 1和R 2相同或不同，表示：（1）分别取代：氢原子，直链或支链C 1 -C 4烷基，未取代的苯基或未取代的苯基被卤素原子取代的苯基与C1-C4烷氧基或C1-C4烷氧基取代; （2）（a）聚亚甲基连接; 或（b）苯环; 或（c）含有氮原子构成异噻唑并吡喃酮衍生物的环状键; m能够具有值0或1; 式（IV）中的基团A表示其中R8对应于氢原子，甲基，羟甲基或-CH 2 O-CO-Ret基团的基团。本发明还提供了制备上述化合物的方法以及含有它们的药物组合物和化妆品组合物。

64. 发明授权

US4608250A Quaternized polymers; process for preparing the same; and cosmetic compositions containing the same 失效
标题翻译：季铵化聚合物; 制备方法; 和含有它们的化妆品组合物
公开(公告)号：US4608250A
公开(公告)日：1986-08-26
申请号：US490852
申请日：1983-05-02
申请人： Bernard Jacquet , Gerard Lang
发明人： Bernard Jacquet , Gerard Lang
IPC分类号： C08L79/00 , A61K8/00 , A61K8/84 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/10 , C08G73/00 , C08G73/02 , A61K7/06 , A45D7/00 , A61K7/09
CPC分类号： C08G73/0226 , A61K8/84 , A61Q5/00 , A61Q5/10 , A61K2800/5426 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12
摘要： A quaternized polymer having recurring units of the formula ##STR1## wherein X.sup..crclbar. represents an anion derived from an organic or mineral acid;R'.sub.2 is an aliphatic radical having a maximum of 20 carbon atoms;R'.sub.1 is an aliphatic, alicyclic or arylaliphatic radical containing a minimum of 2 carbon atoms and a maximum of 20 carbon atoms, or R'.sub.1 and R'.sub.2 together with the nitrogen atom to which they are attached form a ring capable of containing a second heteroatom other than said nitrogen;A represents a divalent group of the formula ##STR2## wherein x, y and t are whole numbers ranging from 0 to 11 and being such that the sum (x+y+t) is greater than or equal to 0 and less than 18, and E and K represent hydrogen or an aliphatic radical having less than 18 carbon atoms;B represents a divalent group of the formula ##STR3## --CH.sub.2 --CHOH--CH.sub.2 --, --(CH.sub.2).sub.n --O--(CH.sub.2).sub.n -- or ##STR4## wherein D and G represent hydrogen or an aliphatic radical having less than 18 carbon atoms and v, z, and u are whole numbers ranging from 0 to 11, two of them being able to be simultaneously equal to 0 such that the sum (v+z+u) is greater than or equal to 1 and lower than 18, and such that the sum (v+z+u) is greater than 1 when the sum (x+y+t) is equal to 0, and n is a whole number equal to 2 or 3.The polymers are usefully employed in cosmetic compositions for application to the hair or skin.
摘要翻译：具有式“IMAGE”的重复单元的季铵化聚合物，其中X（ - ）表示衍生自有机或无机酸的阴离子; R'2是具有最多20个碳原子的脂族基团; R'1是含有最少2个碳原子和最多20个碳原子的脂族，脂环族或芳基脂族基团，或者R 1和R 2与它们所连接的氮原子一起形成能够含有除所述氮之外的第二杂原子; A表示式（1）的二价基团，其中x，y和t为0〜11的整数，并且使（x + y + t）之和大于等于0且小于18，并且E和K表示氢或具有少于18个碳原子的脂族基团; B表示下式的二价基团：-CH 2 -CHOH-CH 2 - ， - （CH 2）n O-（CH 2）n - 或者其中D和G表示氢或具有少于18个碳原子的脂族基团并且v，z和u是从0到11的整数，它们中的两个能够同时等于0，使得（v + z + u）大于等于1且小于18，并且当和（x + y + t）之和等于0时，和（v + z + u）大于1，n是等于2或3的整数。聚合物可用于化妆品适用于头发或皮肤的组合物。

65. 发明授权

US4483983A Substituted derivatives of thiamorpholinone 失效
标题翻译：噻吗啉酮的取代衍生物
公开(公告)号：US4483983A
公开(公告)日：1984-11-20
申请号：US484605
申请日：1983-04-13
申请人： Gerard Lang , Jean Maignan , Jean-Luc Leveque , Laurent Rasseneur
发明人： Gerard Lang , Jean Maignan , Jean-Luc Leveque , Laurent Rasseneur
IPC分类号： A61K8/00 , A61K8/49 , A61K31/54 , A61P17/16 , A61Q17/04 , C07D279/12 , A61K7/40
CPC分类号： C07D279/12
摘要： A substituted derivative of thiamorpholinone, for use in the cosmetic and pharmaceutical field, has the formula ##STR1## wherein n is 0 or 1; R.sub.1 and R.sub.2 each independently represent hydrogen or lower alkyl and R.sub.3 represents hydrogen, mono or polyhydroxyalkyl containing 2-16 carbon atoms, carbamylalkyl, carboxyalkyl or alkoxycarbonylalkyl. When R.sub.3 represents hydrogen, R.sub.4 represents --CO.sub.2 R.sub.5 wherein R.sub.5 is alkyl having 3-18 carbon atoms, optionally interrupted by one or more heteroatoms, or mono or polyhydroxyalkyl having 2-18 carbon atoms. When R.sub.3 represents mono or polyhydroxyalkyl, carbamylalkyl, carboxyalkyl or alkoxycarbonylalkyl, R.sub.4 represents hydrogen or lower alkyl.
摘要翻译：用于化妆品和药物领域的噻吗啉酮的取代衍生物具有下式：其中n为0或1; R 1和R 2各自独立地表示氢或低级烷基，R 3表示氢，含有2〜16个碳原子的单或多羟基烷基，氨基甲酰基烷基，羧基烷基或烷氧基羰基烷基。当R 3表示氢时，R 4表示-CO 2 R 5，其中R 5是具有3-18个碳原子的烷基，任选地被一个或多个杂原子间隔或具有2-18个碳原子的单羟基或多羟基烷基。当R 3表示单或多羟基烷基，氨基甲酰基烷基，羧基烷基或烷氧基羰基烷基时，R 4表示氢或低级烷基。

66. 发明授权

US4411884A Cosmetic agents based on polycationic polymers, and their use in cosmetic compositions 失效
标题翻译：基于聚阳离子聚合物的化妆品及其在化妆品组合物中的用途
公开(公告)号：US4411884A
公开(公告)日：1983-10-25
申请号：US217411
申请日：1980-12-17
申请人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
发明人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
IPC分类号： A61K8/00 , A61K8/34 , A61K8/36 , A61K8/72 , A61K8/84 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61Q7/00 , A61K7/06 , A61K7/09 , A61K7/11
CPC分类号： A61K8/84 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61K2800/5426
摘要： A hair shaping cosmetic composition contains in an aqueous, alcoholic or hydoalcoholic carrier a quaternized polymer.
摘要翻译：毛发成型化妆品组合物在水性，醇类或醇类载体中含有季铵化聚合物。

67. 发明授权

US4405615A Composition for treatment of psoriasis containing 10-substituted 1,8-dihydroxy-9-anthrones 失效
标题翻译：用于治疗含有10-取代的1,8-二羟基-9-蒽酮的牛皮癣的组合物
公开(公告)号：US4405615A
公开(公告)日：1983-09-20
申请号：US330472
申请日：1981-12-14
申请人： Braham Shroot , Jean Maignan , Gerard Lang
发明人： Braham Shroot , Jean Maignan , Gerard Lang
IPC分类号： A61K31/19 , A61K31/215 , A61K31/325 , A61K31/34 , A61P17/00 , C07C59/90 , A61K31/625
CPC分类号： C07C59/90 , A61K31/19 , A61K31/215 , A61K31/34
摘要： A method for the treatment of psoriasis uses a composition which contains in an appopriate vehicle for topical application at least one active ingredient corresponding to the formula: ##STR1## wherein R is a radical of the group represented by ##STR2## wherein R.sub.1 and R'.sub.1 are identical or different and represent H, methyl or ethyl.
摘要翻译：用于治疗牛皮癣的方法使用在适当的载体中含有至少一种对应于下式的活性成分的组合物：其中R是由下式表示的基团的基团：其中R1 和R '1相同或不同，代表H，甲基或乙基。

68. 发明授权

US4390689A Polycationic polymers and their preparation 失效
标题翻译：聚阳离子聚合物及其制备方法
公开(公告)号：US4390689A
公开(公告)日：1983-06-28
申请号：US217403
申请日：1980-12-17
申请人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
发明人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
IPC分类号： B01D21/01 , A61K8/72 , B01F17/18 , B01F17/52 , C08G73/00 , C08G73/02 , D06M15/37 , D06M15/61 , D06M101/12 , D21H17/46 , D21H17/56 , C08G69/26
CPC分类号： A61Q5/12 , A61K8/84 , C08G73/02 , C08G73/0226 , C08G73/024 , C08G73/0253
摘要： Polycationic polymers have been prepared and have been found to be useful in cosmetic compositions for the treatment of the hair and skin, or in the treatment of natural and synthetic textile fibers. These polymer comprise units of the formula ##STR1## .
摘要翻译：已经制备了聚阳离子聚合物，已被发现可用于治疗头发和皮肤的化妆品组合物中，或在天然和合成纺织纤维的处理中。这些聚合物包含式“IMAGE”的单元。

69. 发明授权

US4390522A Cosmetic agents based on cationic polymers, cosmetic compositions containing the same and the use of said cosmetic agents 失效
标题翻译：基于阳离子聚合物的化妆品，含有它们的化妆品组合物和所述化妆品的使用
公开(公告)号：US4390522A
公开(公告)日：1983-06-28
申请号：US217401
申请日：1980-12-17
申请人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
发明人： Bernard Jacquet , Gerard Lang , Alain Malaval , Serge Forestier , Do Le Trung
IPC分类号： A61K8/72 , A61K8/00 , A61K8/34 , A61K8/36 , A61K8/84 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/08 , A61Q5/10 , A61K7/00 , A61K7/04 , A61K7/06 , A61K7/09
CPC分类号： A61Q5/08 , A61K8/84 , A61Q5/02 , A61Q5/10 , A61K2800/5426 , Y10S424/01 , Y10S424/02
摘要： A cosmetic composition for application to the hair, skin or nails comprises in a cosmetic vehicle selected from water, a lower alkanol or a dilute lower alkanol solution, 0.01 to 15 percent by weight of a cationic polymer having units of the formula ##STR1## said polymer having a molecular weight between 1,000 and 50,000. R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent alkyl or hydroxyalkyl wherein the alkyl of each has 1-20 carbon atoms. A is alkylene, hydroxyalkylene, --(CH.sub.2).sub.n --Z--(CH.sub.2).sub.n -- wherein Z is oxygen and n is a whole number ranging from 2-10, or --EO).sub.m.sbsb.1 (DO.sub.m D.sub.1 wherein E is alkylene or hydroxyalkylene containing 1-5 carbon atoms, m.sub.1 is 0 or 1, m is 1-600 with the proviso that m is greater than 1 when m.sub.1 =0. D.sub.1 represents E when m.sub.1 =1 and D.sub.1 represents D when m.sub.1 =0. B represents --EO).sub.m.sbsb.1 (DO).sub.m D.sub.1 wherein E, D, D.sub.1, m and m.sub.1 are defined above X.sup..crclbar. represents a halide anion.
摘要翻译：用于头发，皮肤或指甲的化妆品组合物包含选自水，低级链烷醇或稀低级链烷醇溶液的化妆品载体，0.01至15重量％的具有下式单元的阳离子聚合物：聚合物的分子量在1000至50,000之间。 R 1，R 2，R 3和R 4各自独立地表示烷基或羟烷基，其中各自的烷基具有1-20个碳原子。 A是亚烷基，羟基亚烷基， - （CH2）nZ-（CH2）n-，其中Z是氧，n是整数，范围是2-10或-EO）m1（DOm D1，其中E是含1- 5个碳原子，m1为0或1，m为1-600，条件是当m1 = 0时，m大于1，当m1 = 1时，D1表示E，当m1 = 0时，D1表示D，B表示-EO） m1（DO）m D1其中E，D，D1，m和m1如上定义，X（ - ）表示卤素阴离子。

70. 发明授权

US4228151A Cosmetic composition for imparting to human skin a coloration resembling a natural tan 失效
标题翻译：用于赋予人类皮肤类似天然棕褐色的着色的化妆品组合物
公开(公告)号：US4228151A
公开(公告)日：1980-10-14
申请号：US793317
申请日：1977-05-03
申请人： Gerard Lang , Serge Forestier
发明人： Gerard Lang , Serge Forestier
IPC分类号： A61K8/49 , A61K31/495 , A61Q17/04 , A61K7/42 , A61K7/021 , A61K7/44
CPC分类号： A61Q17/04 , A61K8/494
摘要： A cosmetic composition for imparting to human skin after exposure to sunlight a coloration resembling a natural tan comprises a cosmetic vehicle suitable for topical application to the skin and an effective amount of at least one compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, an aliphatic radical having 1-18 carbon atoms, carbalkoxy having 2-5 carbon atoms, acyl having 2-5 carbon atoms, aryl, aryl substituted by alkyl having 1-4 carbon atoms or hydroxy, a heterocycle containing 4-6 members, substituted or not by alkyl having 1-4 carbon atoms, halogen or hydroxy, or R.sub.1 and R.sub.2 together form a saturated ring containing 4-12 chains, optionally substituted by alkyl having 1-4 carbon atoms, halogen or hydroxy, or bridged and containing a heteroatom selected from N, O or S; and R.sub.3 represents hydrogen, a lower aliphatic group containing 1-6 carbon atoms, lower alkoxy containing 1-4 carbon atoms or halogen, with the proviso that R.sub.1, R.sub.2 and R.sub.3 are not hydrogen simultaneously; and an acid addition salt thereof.
摘要翻译：一种化妆品组合物，用于在暴晒于阳光后赋予人体皮肤的着色是类似于天然棕褐色的化妆品，其包含适合局部施用于皮肤的化妆品载体和有效量的至少一种下式的化合物，其中R1和R2各自独立地表示氢，具有1-18个碳原子的脂族基团，具有2-5个碳原子的烷氧基羰基，具有2-5个碳原子的酰基，芳基，被1-4个碳原子的烷基取代的芳基或羟基，含有4-6个成员，取代或未被具有1-4个碳原子的烷基，卤素或羟基，或R 1和R 2一起形成含有4-12个链的饱和环，任选地被具有1-4个碳原子的烷基，卤素或羟基或桥接的并含有选自N，O或S的杂原子; 并且R 3表示氢，含有1-6个碳原子的低级脂族基团，含有1-4个碳原子的低级烷氧基或卤素，条件是R1，R2和R3不同时为氢; 及其酸加成盐。

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