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61. 发明申请

WO1996017830A1 COMPOUNDS FOR INHIBITION OF GASTRIC ACID SECRETION 审中-公开
标题翻译：用于抑制胃酸分泌的化合物
公开(公告)号：WO1996017830A1
公开(公告)日：1996-06-13
申请号：PCT/SE1995001369
申请日：1995-11-17
申请人： ASTRA AKTIEBOLAG , STARKE, Ingemar
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07D215/44
CPC分类号： C07D215/26 , C07D215/44
摘要： The present invention relates to certain salts of the compound 3-butyryl-4-(2-methylphenylamino)-8-(2-methylsulfinylethoxy)quinoline, which inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.
摘要翻译：本发明涉及抑制外源性或内源性刺激的胃酸分泌的化合物3-丁酰基-4-（2-甲基苯基氨基）-8-（2-甲基亚氨基乙氧基）喹啉的某些盐，因此可用于预防和治疗的胃肠道炎症性疾病。

62. 发明申请

WO1996016082A1 NOVEL POLYPEPTIDES 审中-公开
标题翻译：新的POLYPEPTIDES
公开(公告)号：WO1996016082A1
公开(公告)日：1996-05-30
申请号：PCT/SE1995000761
申请日：1995-06-21
申请人： ASTRA AKTIEBOLAG , BALGANESH, Tanjore, Soundararajan , TOWN, Christine, Mary
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07K14/245
CPC分类号： C12N9/107 , C07K14/245 , C07K14/3156 , C07K2319/00 , C12N9/52 , C12Q1/18 , C12Y204/01018
摘要： The present invention relates to variants of Penicillin Binding Proteins (PBP), which proteins are involved in bacterial peptidoglycan biosynthesis. Disclosed are also DNA molecules coding for the said PBP variants, as well as vectors and cells harbouring such DNA molecules. The invention is also related to processes for assaying and designing therapeutically useful compounds which have high affinity to PBP, which processes utilize the said PBP variants.
摘要翻译：本发明涉及青霉素结合蛋白（PBP）的变体，该蛋白参与细菌肽聚糖生物合成。还公开了编码所述PBP变体的DNA分子以及携带这种DNA分子的载体和细胞。本发明还涉及用于测定和设计对PBP具有高亲和力的治疗有用化合物的方法，该方法利用所述PBP变体。

63. 发明申请

WO1996007400A1 NOVEL PHARMACEUTICAL COMPOSITION CONTAINING THE ACE INHIBITOR RAMIPRIL AND A DIHYDROPYRIDINE COMPOUND 审中-公开
标题翻译：含有ACE抑制剂RAMIPRIL和二氢吡啶化合物的新型药物组合物
公开(公告)号：WO1996007400A1
公开(公告)日：1996-03-14
申请号：PCT/SE1995000972
申请日：1995-08-30
申请人： ASTRA AKTIEBOLAG , BAUER, Brigitte , KARLSSON, Christer , LUNDBERG, Per, Johan , NILSSON, Berit , SANDBERG, Anders , SICKMÜLLER, Alfred
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K09/22
CPC分类号： A61K9/4808 , A61K9/209 , A61K38/556 , A61K31/44 , A61K2300/00
摘要： A pharmaceutical composition which is a combination of the ACE inhibitor ramipril and a calcium antagonist of one of the dihydropyridine type compounds felodipine, nitrendipine, nifedipine and lacidipine. The pharmaceutical composition is for use in the therapy and treatment of hypertension.
摘要翻译：一种药物组合物，其是ACE抑制剂雷米普利和二氢吡啶类化合物非洛地平，尼群地平，硝苯吡啶和拉西地平之一的钙拮抗剂的组合。该药物组合物用于治疗和治疗高血压。

64. 发明申请

WO1996006855A1 NEW PEPTIDE DERIVATIVES WITH 'delta' OPIOID RECEPTOR ANTAGONIST OR MIXED 'mu' AGONIST/'delta' ANTAGONIST EFFECTS 审中-公开
标题翻译：新型肽衍生物与Δ阿片受体拮抗剂拮抗剂或混合型mu AGONIST /δ拮抗剂效应
公开(公告)号：WO1996006855A1
公开(公告)日：1996-03-07
申请号：PCT/SE1995000918
申请日：1995-08-10
申请人： ASTRA AKTIEBOLAG , SCHILLER, Peter
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07K05/065
CPC分类号： C07K5/0817 , A61K38/00 , C07K5/06078
摘要： Compounds of formula (I) as well as methods for their preparation, their pharmaceutical preparations and their use in therapy, especially as analgesics and as immunosuppressive agents.
摘要翻译：式（I）化合物及其制备方法，其药物制剂及其在治疗中的用途，特别是作为止痛剂和免疫抑制剂。

65. 发明申请

WO1996000046A1 MEASUREMENT METHODS AND SYSTEMS 审中-公开
标题翻译：测量方法和系统
公开(公告)号：WO1996000046A1
公开(公告)日：1996-01-04
申请号：PCT/SE1995000590
申请日：1995-05-24
申请人： ASTRA AKTIEBOLAG , DAHLBÄCK, Magnus , FAGERSTRÖM, Per-Olof , MARCHNER, Hans , NERBRINK, Ola
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61D07/04
CPC分类号： A61D7/04 , A61B5/083 , A61M15/0065 , A61M15/008 , A61M15/009 , A61M2016/0039 , A61M2202/064
摘要： In a method for measuring a dose of a drug inhaled by an animal, the momentary concentration of the drug in an aerosol supplied to the animal is determined as well as the momentary inhalation flow rate of the animal. An inhaled partial dose is calculated from each determined inhalation flow rate value and a corresponding concentration value. The calculated inhaled partial doses are added up to obtain the total dose inhaled by the animal. When a predetermined dose is to be administered to the animal, the inhaled partial doses are successively cumulated and compared with the predetermined dose. The aerosol generation is interrupted as soon as the predetermined dose is achieved. Systems for carrying the methods into effect are disclosed.
摘要翻译：在用于测量动物吸入的药物的剂量的方法中，确定供应给动物的气雾剂中药物的瞬间浓度以及动物的瞬时吸入流速。从每个确定的吸入流速值和相应的浓度值计算吸入的部分剂量。加入计算的吸入部分剂量以获得动物吸入的总剂量。当向动物施用预定剂量时，吸入的部分剂量被连续地累积并与预定剂量进行比较。一旦达到预定剂量，气溶胶产生就会中断。公开了实施方法的系统。

66. 发明申请

WO1995033184A1 MEASUREMENT SYSTEM AND METHOD 审中-公开
标题翻译：测量系统和方法
公开(公告)号：WO1995033184A1
公开(公告)日：1995-12-07
申请号：PCT/SE1995000556
申请日：1995-05-17
申请人： ASTRA AKTIEBOLAG , ALDESTAM, Sten , MARNFELDT, Göran , WALDECK, Johan
发明人： ASTRA AKTIEBOLAG
IPC分类号： G01D03/10
CPC分类号： G01R21/133 , A61B5/00 , A61B5/085 , A61B5/1104
摘要： A measurement system comprises at least one sensor unit (s1-sn) which is connected to a processing unit (cp) via a channel unit (ch1-chn). The sensor unit (s1-sn) obtains measurement values and determines a time indication representing the time at which each measurement value was obtained. Each measurement value and the corresponding time indication are transmitted to the corresponding channel unit, which performs those calculations which require only measurement values from its own sensor unit. The processing unit (cp) performs the final calculations requiring measurement data from more than one stream of data. It uses the time indications to synchronise the measurement values which have been obtained at the same time, but which may have been received at different times due to processing of varying duration. A method for processing measurement values is also disclosed.
摘要翻译：测量系统包括经由通道单元（ch1-chn）连接到处理单元（cp）的至少一个传感器单元（s1-sn）。传感器单元（s1-sn）获得测量值，并确定表示获得每个测量值的时间的时间指示。每个测量值和相应的时间指示被发送到对应的通道单元，其执行仅需要其自身传感器单元的测量值的那些计算。处理单元（cp）执行需要来自多于一个数据流的测量数据的最终计算。它使用时间指示来同步已经在同一时间获得的测量值，但是可能由于处理不同的持续时间而在不同的时间接收到的测量值。还公开了一种处理测量值的方法。

67. 发明申请

WO1995027714A1 ACTIVE COMPOUNDS 审中-公开
标题翻译：活性化合物
公开(公告)号：WO1995027714A1
公开(公告)日：1995-10-19
申请号：PCT/SE1995000376
申请日：1995-04-07
申请人： ASTRA AKTIEBOLAG , BRIVING, Carin, Birgitta , NORDBERG, Mats, Peter , STARKE, Carl, Ingemar
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07D491/052
CPC分类号： C07D491/14
摘要： The present invention relates to substituted tricyclic imidazo[1,2-a]pyridines of formula (I) which reversibly inhibit exogenously or endogenously stimulated gastric acid secretion and thus can be used in the prevention and treatment of gastrointestinal inflammatory diseases.
摘要翻译：本发明涉及可逆地抑制外源性或内源性刺激的胃酸分泌的式（I）的取代三环咪唑并[1,2-a]吡啶，因此可用于预防和治疗胃肠道炎症性疾病。

68. 发明申请

WO1995012578A1 SHORT-ACTING DIHYDROPYRIDINES 审中-公开
标题翻译：短效二氢吡啶
公开(公告)号：WO1995012578A1
公开(公告)日：1995-05-11
申请号：PCT/SE1994001031
申请日：1994-11-03
申请人： ASTRA AKTIEBOLAG , ANDERSSON, Kjell, Hjalmar , NORDLANDER, Margareta , WESTERLUND, Rolf, Christer
发明人： ASTRA AKTIEBOLAG
IPC分类号： C07D211/90
CPC分类号： C07D211/90
摘要： Compounds of general formula (I), wherein R1 and R2 are independently selected from the group consisting of hydrogen, chloro, bromo, nitro, cyano, trifluoromethyl, and R3 and R4 are independently selected from straight or branched lower (1-5 carbon atoms) alkyl groups, and including all optical isomers, provided that when R3 is methyl and R4 is tert.-butyl, then R1/R2 are not hydrogen/hydrogen, hydrogen/2'-trifluormethyl, 2'-chloro/3'-chloro, and when R3 is methyl and R1/R2 is hydrogen/3'-nitro, then R4 are not methyl, ethyl, propyl, iso-propyl, tert.-butyl, processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in lowering the blood pressure.
摘要翻译：通式（I）的化合物，其中R 1和R 2独立地选自氢，氯，溴，硝基，氰基，三氟甲基，R 3和R 4独立地选自直链或支链低级（1-5个碳原子））烷基，并且包括所有光学异构体，条件是当R 3是甲基且R 4是叔丁基时，则R 1 / R 2不是氢/氢，氢/ 2'-三氟甲基，2'-氯/ 3'-氯，当R 3为甲基且R 1 / R 2为氢/ 3'-硝基时，则R 4不是甲基，乙基，丙基，异丙基，叔丁基，其制备方法，含有它们的药物制剂以及使用该化合物降低血压。

69. 发明申请

WO1995009609A1 NEW EMULSION FORMULATION 审中-公开
标题翻译：新乳液配方
公开(公告)号：WO1995009609A1
公开(公告)日：1995-04-13
申请号：PCT/SE1994000926
申请日：1994-10-05
申请人： ASTRA AKTIEBOLAG , LUNDQUIST, Stefan
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K09/07
CPC分类号： B82Y5/00 , A61K9/1075 , A61K31/42 , A61K31/425 , Y10S514/938 , Y10S514/974
摘要： The present invention is related to a pharmaceutical formulation which is an oil-in-water emulsion for parenteral and oral use which comprises (i) an emulsion-stabilizing surface active drug in high concentration; (ii) optionally a pharmacologically inert oil; (iii) optionally a surfactant; (iv) water or a buffer; and (v) an agent giving isotonicity to the final formulation; the use of and a process for preparation of the formulation.
摘要翻译：本发明涉及一种药物制剂，其是用于肠胃外和口服使用的水包油乳液，其包含（i）高浓度的乳液稳定表面活性药物; （ii）任选的药理惰性油; （iii）任选的表面活性剂; （iv）水或缓冲液; 和（v）赋予最终制剂等渗性的试剂; 使用和制剂的制备过程。

70. 发明申请

WO1995001783A1 NEW PHARMACEUTICAL FORMULATION 审中-公开
标题翻译：新型药物制剂
公开(公告)号：WO1995001783A1
公开(公告)日：1995-01-19
申请号：PCT/SE1994000681
申请日：1994-07-08
申请人： ASTRA AKTIEBOLAG , BENGTSSON, Inga, Siv , LÖVGREN, Kurt, Ingmar
发明人： ASTRA AKTIEBOLAG
IPC分类号： A61K09/24
CPC分类号： A61K9/2886 , A61K9/5073 , A61K31/44 , A61K31/4439
摘要： A new oral pharmaceutical formulation containing a novel physical form of a magnesium salt of omeprazole, a method for the manufacture of such a formulation, and the use of such a formulation in medicine.
摘要翻译：一种新的口服药物制剂，其含有奥美拉唑镁盐的新物理形式，制备这种制剂的方法以及在医药中使用这种制剂。

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