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61. 发明申请

US20090226973A1 Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification 审中-公开
公开(公告)号：US20090226973A1
公开(公告)日：2009-09-10
申请号：US12382670
申请日：2009-03-20
申请人： Lawrence J. Wangh , John Rice , J. Aquiles Sanchez , Kenneth Pierce , Jesse Salk , Arthur Reis , Cristina Hartshorn
发明人： Lawrence J. Wangh , John Rice , J. Aquiles Sanchez , Kenneth Pierce , Jesse Salk , Arthur Reis , Cristina Hartshorn
IPC分类号： C12P19/34 , C07H21/00 , C12N9/00
CPC分类号： C12Q1/6848 , C12Q1/686 , C12Q2527/125 , C12Q2525/301 , C12Q2525/186 , C12Q2531/107 , C12Q2527/137
摘要： An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.

62. 发明授权

US07517977B2 Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification 有权
标题翻译：用于提高再现性的试剂和方法，并减少PCR扩增中的错误引物
公开(公告)号：US07517977B2
公开(公告)日：2009-04-14
申请号：US11252506
申请日：2005-10-17
申请人： Lawrence J. Wangh , John Rice , J. Aquiles Sanchez , Kenneth Pierce , Jesse Salk , Arthur Reis , Cristina Hartshorn
发明人： Lawrence J. Wangh , John Rice , J. Aquiles Sanchez , Kenneth Pierce , Jesse Salk , Arthur Reis , Cristina Hartshorn
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6848 , C12Q1/686 , C12Q2527/125 , C12Q2525/301 , C12Q2525/186 , C12Q2531/107 , C12Q2527/137
摘要： An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplifications, including LATE-PCR amplifications when added to initial amplification reaction mixtures. It can be included in oligonucleotide sets and in kits for PCR amplification and assays.
摘要翻译：用于防止聚合酶链反应（PCR）扩增和测定中的错配的添加剂，其包含具有长度超过六个核苷酸的茎双螺旋的发夹寡核苷酸和稳定的茎末端。当添加到初始扩增反应混合物中时，添加剂改进PCR扩增，包括LATE-PCR扩增。它可以包括在寡核苷酸组和用于PCR扩增和测定的试剂盒中。

63. 发明申请

US20070258898A1 MARKERS FOR ADDICTION 有权
标题翻译：添加标记
公开(公告)号：US20070258898A1
公开(公告)日：2007-11-08
申请号：US11681177
申请日：2007-03-01
申请人： Dennis Ballinger , Karel Konvicka , Laura Bierut , John Rice , Frank Saccone , Anthony Hinrichs , Alison Goate , Jen Wang
发明人： Dennis Ballinger , Karel Konvicka , Laura Bierut , John Rice , Frank Saccone , Anthony Hinrichs , Alison Goate , Jen Wang
IPC分类号： C12Q1/68 , A61K49/00 , G01N33/48
CPC分类号： C12Q1/6883 , A61K49/0004 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172 , G01N33/5088 , G01N33/6893 , G01N2500/00
摘要： Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
摘要翻译：提供多态性与成瘾之间的相关性。提供诊断，预后和治疗成瘾的方法。提供了用于诊断，预后和治疗成瘾的系统和试剂盒。还描述了识别成瘾调节剂的方法。

64. 发明申请

US20070192864A1 SOFTWARE ROOT OF TRUST 有权
标题翻译：信托的软件根
公开(公告)号：US20070192864A1
公开(公告)日：2007-08-16
申请号：US11672054
申请日：2007-02-07
申请人： Eric Bryant , Avni Rambhia , Mikhail Atallah , John Rice
发明人： Eric Bryant , Avni Rambhia , Mikhail Atallah , John Rice
IPC分类号： G06F12/14
CPC分类号： G06F21/552 , G06F21/54 , G06F21/57
摘要： A software system that transforms an original application into an STPM enabled application and runs the enabled application. At protect time, an anti-tamper tool accepts the original application, uses anti-tamper techniques to create a guarded application, creates a security wrapper according to a policy file, and wraps the guarded application to create the STPM enabled application. A trusted service provider is inserted at the entry point of the enabled application. A set of core services is made accessible to the enabled application through the trusted service provider. At runtime the trusted service provider creates a TSP thread and passes a security file to an STPM device driver implementing TPM functionality and protected by anti-tamper techniques. The TSP thread actively monitors the enabled application and interacts with the STPM device driver through the set of core services.
摘要翻译：将原始应用程序转换为支持STPM的应用程序并运行启用的应用程序的软件系统。在保护时间，防篡改工具可接受原始应用程序，使用防篡改技术创建受保护的应用程序，根据策略文件创建安全包装器，并将防护应用程序包装以创建启用STPM的应用程序。在启用的应用程序的入口点插入可信服务提供商。启用的应用程序通过可信服务提供商访问一组核心服务。在运行时，可信服务提供商创建一个TSP线程，并将一个安全文件传递给实现TPM功能并受防篡改技术保护的STPM设备驱动程序。 TSP线程主动监视启用的应用程序，并通过一组核心服务与STPM设备驱动程序交互。

65. 发明申请

US20060175846A1 Power linear displacement striker 有权
标题翻译：功率线性位移撞击器
公开(公告)号：US20060175846A1
公开(公告)日：2006-08-10
申请号：US11347800
申请日：2006-02-03
申请人： John Rice , Frank Arabia , Jeffrey Hamminga , Joseph Johnson
发明人： John Rice , Frank Arabia , Jeffrey Hamminga , Joseph Johnson
IPC分类号： E05B15/02
CPC分类号： E05B81/22 , E05B53/008 , Y10T292/699
摘要： A power striker assembly effects final positioning of a vehicle closure member and includes a fixed frame and a striker member carried on a striker plate for selective engagement of a latch carried on the closure member, to displace the closure member from a presented position to a cinched position. Guide means interconnects the frame and striker plate to effect simultaneous translational and rotational displacement of the striker plate between end limits of travel to produce linear displacement of the striker member. An actuator selectively displaces the striker plate between its end limits of travel in response to a control signal. Finally, an interlock fixes the striker plate in the cinched position in the absence of the control signal.
摘要翻译：动力撞击器组件实现车辆关闭构件的最终定位，并且包括固定框架和承载在撞针板上的撞针构件，用于选择性地接合承载在闭合构件上的闩锁，以将闭合构件从呈现位置移动到带状位置。引导装置将框架和撞击板相互连接，以在撞击板的行程终点之间实现撞击板的同时平移和旋转位移，以产生撞击构件的线性位移。致动器响应于控制信号，选择性地将撞击板置于其行程终点之间。最后，在没有控制信号的情况下，互锁将撞击板固定在收紧位置。

66. 发明申请

US20060107070A1 Method and system for secure computational outsourcing and disguise 有权
标题翻译：安全计算外包和伪装的方法和系统
公开(公告)号：US20060107070A1
公开(公告)日：2006-05-18
申请号：US11252049
申请日：2005-10-17
申请人： John Rice , Mikhail Atallah
发明人： John Rice , Mikhail Atallah
IPC分类号： G06F12/14
CPC分类号： G06F21/629 , G06F21/14 , G06F21/606 , G06F21/62 , G06F21/6254
摘要： Method and system for secure computational outsourcing and disguise of data, computer programs, pictures, and databases from unauthorized access, theft, and tampering using disguising and tamperproofing operations. In some embodiments, the disguising operation includes generating a random number for each data element, and modifying each data element with the random numbers. In some embodiments, the computer program, written in a first programming language, is partitioned into first and second programs; the first program determines whether access to the data is authorized, the second program entangles the second program and the data; and the second program is translated into a second programming language. An embodiment of the present invention comprises a method for identifying the subject of a first picture by comparison to a second picture. Embodiments comprise securing a computer program with real programming code by creating dummy program code and mixing the dummy and real program code.
摘要翻译：用于安全计算外包和伪装数据，计算机程序，图片和数据库的方法和系统，从未经授权的访问，盗窃和篡改使用伪装和防篡改操作。在一些实施例中，伪装操作包括为每个数据元素生成随机数，并且用随机数修改每个数据元素。在一些实施例中，以第一编程语言编写的计算机程序被划分为第一和第二程序; 第一程序确定对数据的访问是否被授权，第二程序使第二程序和数据相互交错; 并且第二程序被翻译成第二编程语言。本发明的实施例包括一种通过与第二图像进行比较来识别第一图像的对象的方法。实施例包括通过创建虚拟程序代码并混合虚拟和真实程序代码来确保具有真实编程代码的计算机程序。

67. 发明授权

US06605459B2 Methods for measuring cysteine and determining cysteine synthase activity 失效
标题翻译：测量半胱氨酸和测定半胱氨酸合成酶活性的方法
公开(公告)号：US06605459B2
公开(公告)日：2003-08-12
申请号：US09905290
申请日：2001-07-13
申请人： John Rice , Beth Lanning , John Crawford , Gordon Nye
发明人： John Rice , Beth Lanning , John Crawford , Gordon Nye
IPC分类号： C12N988
CPC分类号： C12N9/88 , C12Q1/48 , G01N2333/91171 , G01N2500/20
摘要： Assays, preferably high throughput assays, for determining cysteine concentration, cysteine synthase activity, and identifying herbicides, fungicides, bactericides, and insecticides. Cysteine concentration is quantitated by contacting cysteine with a coumarin dye capable of conjugating with cysteine but not to O-acetyl serine or sulfide; exciting the conjugate with UV light; and detecting fluorescent light emitted by the conjugate. Cysteine synthase activity is determined by combining O-acetyl-L-serine, sulfide and cysteine synthase to form a reaction mixture under conditions suitable for cysteine production; contacting the reaction mixture with an appropriate coumarin dye; subjecting the reaction mixture to UV light; and detecting fluorescent light emission.
摘要翻译：用于确定半胱氨酸浓度，半胱氨酸合成酶活性和鉴定除草剂，杀真菌剂，杀菌剂和杀虫剂的测定，优选高通量测定。通过使半胱氨酸与能够与半胱氨酸缀合但不与O-乙酰丝氨酸或硫化物偶联的香豆素染料接触来定量半胱氨酸浓度; 用紫外线激发共轭物; 并检测共轭物发出的荧光。通过将O-乙酰基-L-丝氨酸，硫化物和半胱氨酸合成酶组合形成半胱氨酸合成酶活性，在适合于半胱氨酸生产的条件下形成反应混合物; 使反应混合物与合适的香豆素染料接触; 使反应混合物经受紫外光; 并检测荧光发光。

68. 发明授权

US09034605B2 Reagents and methods for PCR 有权
标题翻译：试剂和PCR方法
公开(公告)号：US09034605B2
公开(公告)日：2015-05-19
申请号：US13256038
申请日：2010-03-11
申请人： Lawrence J. Wangh , John Rice , Nicholas Rice , Yanwei Jia
发明人： Lawrence J. Wangh , John Rice , Nicholas Rice , Yanwei Jia
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6853 , C12Q2545/114 , C12Q2531/107 , C12Q2527/107
摘要： Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32° C., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal nucleotide, said modifying groups being polycyclic substituents that do not have bulky portions that are non-planar, said modified oligonucleotide being capable of binding to the 5′ ex-nuclease domains of DNA polymerases and, when included in a PCR or other primer-dependent DNA amplification reaction at a concentration, generally not more than 2000 nM, that is effective for at least one of the functions of suppressing mispriming, increasing polymerase selectivity against 3′ terminal mismatches, increasing polymerase selectivity against AT-rich 3′ ends, reducing scatter among replicates, suppressing polymerase 5′ exonuclease activity, and inhibiting polymerase activity; as well as amplification reaction mixtures containing such modified double-stranded oligonucleotides, and amplification reactions, amplification assays and kits that include such modified double-stranded oligonucleotides.
摘要翻译：修饰的双链寡核苷酸在其每条链上具有长度为6-50个核苷酸的杂交长度，末端区域具有至少32℃的熔解温度Tm，并且包括2-4个修饰基团，每个共价连接到不同的末端区域，优选连接到末端核苷酸，所述修饰基团是不具有非平面的庞大部分的多环取代基，所述修饰的寡核苷酸能够结合DNA的5'前核酸酶结构域聚合酶，并且当包含在浓度通常不大于2000nM的PCR或其它引物依赖性DNA扩增反应中时，对于抑制错配的至少一种功能是有效的，增加针对3'末端错配的聚合酶选择性，提高对富含AT的3'末端的聚合酶选择性，减少重复之间的分散，抑制聚合酶5'核酸外切酶活性，并抑制聚合酶活动; 以及含有这种修饰的双链寡核苷酸的扩增反应混合物，以及包括这种修饰的双链寡核苷酸的扩增反应，扩增分析和试剂盒。

69. 发明申请

US20140004513A1 COMPOSITIONS, METHODS, AND KITS FOR DETECTING AND IDENTIFYING MYCOBACTERIA 审中-公开
标题翻译：用于检测和鉴定MYCOBACTERIA的组合物，方法和试剂盒
公开(公告)号：US20140004513A1
公开(公告)日：2014-01-02
申请号：US13884873
申请日：2011-11-10
申请人： Lawrence J. Wangh , John Rice
发明人： Lawrence J. Wangh , John Rice
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/689 , C12Q2600/106 , C12Q2600/16 , C12Q2527/107 , C12Q2537/101 , C12Q2537/143
摘要： Provided herein are methods for detecting and identifying strains of mycobacteria, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided for the detection and differentiation of mycobacteria based on, for example, pathogenicity, species, and antibiotic resistance or sensitivity. Compositions and methods are provided herein to identify and differentiate mycobacteria in mixtures of different mycobacteria and mycobac teria and non-mycobacteria.
摘要翻译：本文提供了用于检测和鉴定分枝杆菌菌株的方法，以及用于进行这些方法的组合物和试剂盒。特别地，提供核酸扩增和荧光检测方法用于基于例如致病性，物种和抗生素抗性或敏感性的分枝杆菌的检测和分化。本文提供组合物和方法以鉴别和分化不同分枝杆菌和分枝杆菌和非分枝杆菌的混合物中的分枝杆菌。

70. 发明授权

US07849640B2 Track for metal stud walls 有权
标题翻译：轨道为金属螺柱墙
公开(公告)号：US07849640B2
公开(公告)日：2010-12-14
申请号：US11364202
申请日：2006-03-01
申请人： John Rice
发明人： John Rice
IPC分类号： E04B2/58 , G01B5/16
CPC分类号： E04C3/07 , E04B2/7457 , E04B2/767 , E04B2/789 , E04C2003/0421 , E04C2003/0434 , E04C2003/0473
摘要： The present invention provides for track for use in constructing metal stud walls. The track is a generally U-shaped channel having a base and upstanding side walls extending along either side of the base. The base is provided with a plurality of embossed indicator means evenly spaced along the length of the base. The spacing of the embossed indicator means provides a guide for the proper spacing of the studs placed in the base.
摘要翻译：本发明提供了用于构造金属螺柱壁的轨道。该轨道是大致U形的通道，其具有沿基部的两侧延伸的基部和直立的侧壁。底座设置有沿着基部的长度均匀间隔开的多个压花指示器装置。浮雕指示装置的间距为放置在基座中的螺柱的适当间距提供了一个引导件。

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