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61. 发明授权

KR101118587B1 감응성 고분자 캡슐 및 그 제조방법 失效
标题翻译： 감응성고분자캡슐및그제조방법
公开(公告)号：KR101118587B1
公开(公告)日：2012-06-12
申请号：KR1020090075739
申请日：2009-08-17
申请人： 포항공과대학교 산학협력단
发明人： 김기문 , 이지영 , 김동우 , 김은주 , 정현태
IPC分类号： C08G61/12 , C08L65/00 , C08J3/12 , A61K47/34
CPC分类号： C08J3/12 , A61K9/5138 , C08J2300/00 , C08J2365/00 , C08L65/00 , Y10T428/2982
摘要： 하기 화학식 1로 표시되는 화합물을 중합하여 얻어지거나, 하기 화학식 1의화합물과 하기 화학식 2의 화합물을 중합하여 얻어지는 고분자 캡슐이 제시된다:

(Y
1 )
j -Z-(Y
2 )
k
상기 화학식 1 및 2 에서,
CY, A, B, p, m, Z, Y
1 , Y
2 , j 및 k는 발명의 상세한 설명을 참조한다.
쿠커비투릴(cucurbituril)
摘要翻译：通过聚合由式1表示的化合物或聚合式1的化合物和式2的化合物而制备的聚合物胶囊，其中详细描述中提供了式1和2的化合物的详细结构。

62. 发明公开

KR1020110076469A 자기 조립형 약물 및 세포 전달체의 제조 방법 및 이에 의해 제조된 자기 조립형 약물 및 세포 전달체 有权
标题翻译：自组装药物和细胞递送系统的制备方法，以及自身组装药物和细胞递送系统
公开(公告)号：KR1020110076469A
公开(公告)日：2011-07-06
申请号：KR1020090133187
申请日：2009-12-29
申请人： 포항공과대학교 산학협력단
发明人： 한세광 , 김기문 , 정현태 , 양정아 , 박경민
IPC分类号： A61K9/22 , A61K47/30 , A61K39/395 , A61P35/00
CPC分类号： A61K9/20 , A61K39/395 , A61K47/38 , B82Y5/00
摘要： PURPOSE: A method for preparing a self-assembled drug and a cell delivery system is provided to easily synthesize a polymer composite and to prepare a drug and cell delivery system. CONSTITUTION: A method for preparing a self-assembled drug and a cell delivery system comprises a step of mixing: a compound of chemical formula I([B]m-[H]n); a drug, fluorescent substance, radioactive isotope, target oriented material, or imaging material which interacts with the compound of chemical formula I; and a functional group which interacts with the compound of chemical formula I in a solvent. The solvent is water, saline solution, buffer solution, or ethanol. The self-assembled delivery system is a hydrogel.
摘要翻译：目的：提供一种制备自组装药物和细胞递送系统的方法，以容易地合成聚合物复合物并制备药物和细胞递送系统。构成：制备自组装药物和细胞递送系统的方法包括混合化学式I（[B] m- [H] n）的化合物; 与化学式I化合物相互作用的药物，荧光物质，放射性同位素，靶向材料或成像材料; 以及在溶剂中与化学式I的化合物相互作用的官能团。溶剂为水，盐水溶液，缓冲溶液或乙醇。自组装输送系统是水凝胶。

63. 发明公开

KR1020100114425A 고분자 캡슐을 포함하는 광역학 치료용 조성물 失效
标题翻译：包含聚合物胶囊的药物组合物
公开(公告)号：KR1020100114425A
公开(公告)日：2010-10-25
申请号：KR1020090032959
申请日：2009-04-15
申请人： 포항공과대학교 산학협력단
发明人： 백강균 , 윤경원 , 김영국 , 김기문 , 라구난단호타 , 박경민 , 정현태
IPC分类号： A61K47/34 , A61K9/48 , A61P35/00
CPC分类号： A61K9/4816 , A61K9/5146 , A61K31/337 , A61K31/506 , A61K31/704 , A61K41/0071 , A61K47/34 , A61K47/58 , A61N5/062 , Y10T428/2982
摘要： PURPOSE: A composition containing polymer capsule for photodynamic therapy is provided to ensure photosensitized treatment effect and reduce side effect. CONSTITUTION: A composition for photodynamic therapy contains polymer capsule having diameter of 10-2000nm which is formed by polymerizing a compound of chemical formulas 1 and 2. The compound of chemical formula 1 has ethenyl(-CH=CH_2) or ethinyl group(-C≡CH). The compound of chemical formula 2 is 1,8-octanedithiol, 3,6-dioxa-1,8-octandithiol, pentaerythritol tetrakis(3-mercaptopionate), trimethylolpropane tri(3-mercapsopropionate) or mixture thereof. The composition is used for treating liver cancer, lung cancer, uterine cancer, skin cancer, brain cancer, or gastric cancer.
摘要翻译：目的：提供含有光动力治疗聚合物胶囊的组合物，以确保光敏治疗效果，减少副作用。构成：用于光动力学治疗的组合物含有直径为10-2000nm的聚合物胶囊，其通过聚合化学式1和化合物2的化合物形成。化学式1的化合物具有乙烯基（-CH = CH 2）或乙炔基（-C ≡CH）。化学式2的化合物是1,8-辛二硫醇，3,6-二氧杂-1,8-辛二硫醇，季戊四醇四（3-巯基戊酸酯），三羟甲基丙烷三（3-巯基丙酸酯）或其混合物。该组合物用于治疗肝癌，肺癌，子宫癌，皮肤癌，脑癌或胃癌。

64. 发明公开

KR1020090109809A 쿠커비투릴 유도체와 게스트 화합물의 비공유 결합을이용한 세포 구성 성분의 분리 및 정제 방법, 및 이를이용한 키트 有权
标题翻译：使用CUCURBITURIL衍生物和顾客化合物之间的非共价键和使用其的装置分离和纯化细胞组分的方法
公开(公告)号：KR1020090109809A
公开(公告)日：2009-10-21
申请号：KR1020080035223
申请日：2008-04-16
申请人： 포항공과대학교 산학협력단
发明人： 이돈욱 , 류성호 , 하상훈 , 정현태 , 마이낙베너지 , 셀바팔람나라야난 , 김기문 , 박경민
IPC分类号： C12N15/10
CPC分类号： C07K1/22
摘要： PURPOSE: A method for isolating or purifying cellular components through non-covalent bond of cucurbituril derivative and guest compound is provided to isolate various compounds. CONSTITUTION: A method for isolating or purifying cellular components through non-covalent bond of cucurbituril derivative and guest compound comprises: a step of contacting reactive compound with cells; a step of performing lysis the cells; a step of adding solid phase which is connected with a host compound in the solution in which cells are lyzed; a step of isolating and purifying the guest compound and host compound; and a step of isolating cell component.
摘要翻译：目的：提供通过葫芦素衍生物和客体化合物的非共价键分离或纯化细胞成分的方法以分离各种化合物。构成：通过葫芦巴衍生物和客体化合物的非共价键分离或纯化细胞成分的方法包括：使反应性化合物与细胞接触的步骤; 细胞裂解步骤; 在将细胞溶解的溶液中添加与主体化合物连接的固相的工序; 分离和纯化客体化合物和主体化合物的步骤; 以及隔离细胞成分的步骤。

65. 发明公开

KR1020110102267A 감응성 고분자 캡슐 및 그 제조방법 失效
标题翻译：反应性聚合物胶囊及其制备方法
公开(公告)号：KR1020110102267A
公开(公告)日：2011-09-16
申请号：KR1020110077381
申请日：2011-08-03
申请人： 포항공과대학교 산학협력단
发明人： 김기문 , 이지영 , 김동우 , 김은주 , 정현태
IPC分类号： C08G61/12 , C08L65/00 , C08J3/12 , A61K47/34
摘要： 하기 화학식 1로 표시되는 화합물을 중합하여 얻어지거나, 하기 화학식 1의화합물과 하기 화학식 2의 화합물을 중합하여 얻어지는 고분자 캡슐이 제시된다:

(Y
1 )
j -Z-(Y
2 )
k
상기 화학식 1 및 2 에서,
CY, A, B, p, m, Z, Y
1 , Y
2 , j 및 k는 발명의 상세한 설명을 참조한다.

66. 发明公开

KR1020140090287A 신규한 히알루론산 기반 하이드로겔 및 이의 용도 有权
标题翻译：基于羟丙酸的新型氢化物及其用途
公开(公告)号：KR1020140090287A
公开(公告)日：2014-07-17
申请号：KR1020120145758
申请日：2012-12-13
申请人： 포항공과대학교 산학협력단 , 주식회사 제넥신
发明人： 성영철 , 한세광 , 김기문 , 김수진 , 염준석 , 정현태 , 서유석 , 진현탁
IPC分类号： A61K9/06 , A61K31/728
CPC分类号： A61K31/728 , A61K9/06 , A61K31/203 , A61K31/573
摘要： The present invention relates to hyaluronic acid-based hydrogel including a cell differentiating agent or a cell activity inducing material and produced using cucurbituril and polyamine, a cell treatment-assisting composition including the hydrogel, a cell treating composition including the hydrogel including a cell differentiating agent or a cell activity inducing material and mesenchymal stem cells, and a cell treatment-assisting composition including the hyaluronic acid-based hydrogel produced using cucurbituril and polyamine. Another purpose of the present invention relates to a cell treatment composition including the hydrogel and mesenchymal stem cells. The hyaluronic acid-based hydrogel provided in the present invention plays a role as a supplementary material for supporting stem cells which expresses a treatment material used as a cell treatment agent so as to promote the secretion of the treatment material and increase cell survival rates, so that the treatment effects of the cell treatment agent can be maximized. Accordingly, the hyaluronic acid-based hydrogel can be widely used to develop a cell treatment agent which exhibits improved effects.
摘要翻译：本发明涉及包含细胞分化剂或细胞活性诱导材料并使用葫芦巴和多胺制备的透明质酸系水凝胶，包含该水凝胶的细胞治疗辅助组合物，包含水凝胶的细胞处理组合物，其包含细胞分化剂或细胞活性诱导材料和间充质干细胞，以及包含使用葫芦巴和多胺制备的透明质酸类水凝胶的细胞治疗辅助组合物。本发明的另一个目的涉及包含水凝胶和间充质干细胞的细胞处理组合物。本发明中提供的透明质酸水凝胶作为支持干细胞的辅助材料起作用，其表达用作细胞处理剂的处理材料，以促进处理材料的分泌并增加细胞存活率，因此可以使细胞处理剂的处理效果最大化。因此，透明质酸系水凝胶可广泛用于开发显示改善效果的细胞处理剂。

67. 发明公开

KR1020110018111A 감응성 고분자 캡슐 및 그 제조방법 失效
标题翻译：反应性聚合物胶囊及其制备方法
公开(公告)号：KR1020110018111A
公开(公告)日：2011-02-23
申请号：KR1020090075739
申请日：2009-08-17
申请人： 포항공과대학교 산학협력단
发明人： 김기문 , 이지영 , 김동우 , 김은주 , 정현태
IPC分类号： C08G61/12 , C08L65/00 , C08J3/12 , A61K47/34
CPC分类号： C08J3/12 , A61K9/5138 , C08J2300/00 , C08J2365/00 , C08L65/00 , Y10T428/2982
摘要： PURPOSE: Responsive polymer capsules are provided to enable degradation within cells not but within blood and to effectively deliver drug within cytoplasm by employing pharmacologically active agents and/or targeted materials within capsules. CONSTITUTION: Polymer capsules are obtained by polymerizing a compound of chemical formula 1, or the compound of chemical formula 1 and a compound of chemical formula 2. The polymer capsules further include targeted compounds encapsulated in inner void of a cucurbituril ring and/or pharmacologically active agents sealed within the polymer capsules. The pharmacologically active agent is selected from the group consisting of hydrocortisone, prednisolone, spironolactone, testosterone, megestrol acetate, danazol, progesterone, indomethacin, amphotericin B and combinations thereof.
摘要翻译：目的：提供响应性聚合物胶囊，以在细胞内但不在血液内降解，并通过在胶囊内采用药理活性剂和/或靶向物质，有效地将药物递送至细胞质内。构成：聚合物胶囊通过聚合化学式1的化合物或化学式1的化合物和化学式2的化合物而获得。聚合物胶囊还包括封装在葫芦巴环的内部空隙中和/或药理活性的靶向化合物密封在聚合物胶囊内的试剂。药理活性剂选自氢化可的松，泼尼松龙，螺内酯，睾酮，醋酸甲地孕酮，达那唑，孕酮，吲哚美辛，两性霉素B及其组合。

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