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61. 发明申请

WO2020089772A1 INSULATING GLAZING WITH LUMINESCENT SOLAR CONCENTRATOR FOR PRODUCTION OF ELECTRICAL ENERGY 审中-公开
公开(公告)号：WO2020089772A1
公开(公告)日：2020-05-07
申请号：PCT/IB2019/059229
申请日：2019-10-28
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA , GLASS TO POWER S.P.A.
发明人： MEINARDI, Francesco , BROVELLI, Sergio , BRUNI, Francesco , GANDINI, Marina
IPC分类号： E06B3/663 , H01L31/048
摘要： Insulating glazing (1) comprising at least two panels (4, 5, 6) made of transparent or semi-transparent material. At least one (5) of these panels is a luminescent solar concentrator.

62. 发明申请

WO2020089398A1 COMBINATORIAL DRUG TREATMENT FOR CANCER 审中-公开
公开(公告)号：WO2020089398A1
公开(公告)日：2020-05-07
申请号：PCT/EP2019/079843
申请日：2019-10-31
申请人： UNIVERSITA' DEGLI STUDI DI MILANO BICOCCA , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： ALBERGHINA, Lilia , MORESCO, Rosa Maria , VALTORTA, Silvia , GAGLIO, Daniela
IPC分类号： A61K31/5375 , A61K31/501 , A61K45/06 , A61P35/00
摘要： The present invention concerns the field of cancer, and in particular to oncogene-driven metabolic alterations which can simultaneously influence multiple metabolic pathways, thus generating unique cancer phenotypes. The present invention relates to a pharmaceutical kit for the treatment of cancer, particularly to the combination of therapeutic treatment of glycolysis/PI3K and of glutamine metabolism targets, using anti-cancer therapeutic agents showing enhanced anti-cancer effects.

63. 发明申请

WO2019123227A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
公开(公告)号：WO2019123227A1
公开(公告)日：2019-06-27
申请号：PCT/IB2018/060222
申请日：2018-12-18
申请人： POLITECNICO DI MILANO , UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA , CONSIGLIO NAZIONALE DELLE RICERCHE
发明人： RAIMONDI, Manuela Teresa , CERULLO, Giulio , CONCI, Claudio , ZANDRINI, Tommaso , OSELLAME, Roberto , CHIRICO, Giuseppe
IPC分类号： A61B5/00 , A61B5/06 , C12M3/00 , C12M1/00
CPC分类号： A61B5/0071 , A61B5/064 , A61B5/686
摘要： An implantable medical device obtained by means of two- photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multiphoton fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.

64. 发明申请

WO2016128816A1 METHOD AND APPARATUS FOR THE MORPHOMETRIC ANALYSIS OF CELLS OF A CORNEAL ENDOTHELIUM 审中-公开
标题翻译：角膜内皮细胞形态分析的方法与装置
公开(公告)号：WO2016128816A1
公开(公告)日：2016-08-18
申请号：PCT/IB2016/000074
申请日：2016-02-02
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
发明人： BORGHESI, Alessandro , TAVAZZI, Silvia , FERRARO, Lorenzo , COZZA, Federica
IPC分类号： G06T7/60
CPC分类号： G06T7/0012 , G06T7/62 , G06T7/90 , G06T2207/10056 , G06T2207/20152 , G06T2207/30041 , G06T2207/30242
摘要： The present invention relates to a method and apparatus for the morphometric analysis of endothelial cells, which is based on the use of an image taken from a camera connected to a biomicroscope which is digitally reprocessed and subsequently analyzed.
摘要翻译：本发明涉及一种用于内皮细胞形态测定分析的方法和装置，其基于使用从连接到数字再处理和随后分析的生物显微镜的照相机获取的图像。

65. 发明申请

WO2016103216A1 REGIONAL SCOAGULATION SYSTEM FOR AN EXTRACORPOREAL CIRCULATION CIRCUIT 审中-公开
标题翻译：用于外部循环电路的区域分离系统
公开(公告)号：WO2016103216A1
公开(公告)日：2016-06-30
申请号：PCT/IB2015/059947
申请日：2015-12-23
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
发明人： PESENTI, Antonio Maria , ZANELLA, Alberto , SALERNO, Domenico , MANTEGAZZA, Francesco , SCARAVILLI, Vittorio , CASTAGNA, Luigi
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61M1/3479 , A61M1/3413 , A61M1/3472 , A61M1/3486 , A61M1/3672 , A61M1/3675 , B01D15/362
摘要： The present invention concerns an extracorporeal circuit (1, 100) for regional scoagulation of blood comprising a line for taking the blood (2) from the patient, a first filtering unit (6), and a line for returning the blood (5) to the patient defining a main circuit (12), the extracorporeal circuit (1, 100) comprising a secondary circuit (32) for recirculation of the plasma water comprising: - a calcium removal assembly (4) adapted to provide a solution with low calcium content (30, 40a) in said main circuit (12); the extracorporeal circuit (1, 100) further comprising: - first means (13, 14) for the infusion of said solution with low calcium content (30) into said main circuit (12) upstream of said first filtering unit (6) and of said calcium removal assembly (4) with respect to the blood flow direction in the main circuit (12) and - second means (19) for the infusion of an electrolytic re- establishment solution (29) located downstream of said first means (13, 14) with respect to the direction of the blood flow in said main circuit (12).
摘要翻译：本发明涉及一种用于血液区域凝血的体外循环（100），其包括用于从患者取血的线（2），第一过滤单元（6）和用于将血液（5）返回到所述患者定义主回路（12），所述体外回路（1,100）包括用于等离子体水的再循环的次级回路（32），所述次级回路包括： - 钙去除组件（4），其适于提供低钙含量的溶液（30,30a）在所述主电路（12）中; 所述体外回路（1,100）还包括： - 用于将所述具有低钙含量（30）的所述溶液浸入所述第一过滤单元（6）上游的所述主回路（12）的第一装置（13,14）和所述钙去除组件（4）相对于主回路（12）中的血液流动方向;以及 - 用于输注位于所述第一装置（13）下游的电解重建溶液（29）的第二装置（19） 14）相对于所述主回路（12）中的血流方向。

66. 发明申请

WO2016016870A1 EXTRACORPOREAL CIRCUIT FOR CO2 REMOVAL FROM BLOOD 审中-公开
标题翻译：从血液中去除二氧化碳的超声波电路
公开(公告)号：WO2016016870A1
公开(公告)日：2016-02-04
申请号：PCT/IB2015/055837
申请日：2015-07-31
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA
发明人： PESENTI, Antonio Maria , ZANELLA, Alberto , SALERNO, Domenico , PATRONITI, Nicolò Antonino , MANTEGAZZA, Francesco
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/3482 , A61M1/1698 , A61M1/32 , A61M1/3479 , A61M2202/0225 , B01D61/145 , B01D61/42 , B01D61/58
摘要： The present invention relates to an extracorporeal circuit (1) for CO2 removal from blood comprising a line for taking blood (2) from the patient, a decarboxylation assembly (4) and a line for returning the blood (5) to the patient; said decarboxylation assembly (4) comprising a first filtering unit (6), an oxygenator (9), an electrodialyzer (10) adapted to generate an acid solution (30a) and a basic solution (30b) and means (15) for the infusion of said acid solution upstream of said oxygenator (9), characterized in that said electrodialyzer (10) comprises a first electrodialysis chamber (21) and a second electrodialysis chamber (22), said first and second electrodialysis chambers (21, 22) being separated by an ionic membrane (23), and in that said first chamber (21) and said second chamber (22) are respectively separated from the positive electrode (24), or anode, and from the negative electrode (25), or cathode, by means of a bipolar membrane (26, 27).
摘要翻译：本发明涉及一种用于从血液中除去CO 2的体外循环（1），包括从患者取血（2）的管线，脱羧组件（4）和将血液（5）返回给患者的管线; 所述脱羧组件（4）包括第一过滤单元（6），氧合器（9），适于产生酸溶液（30a）和碱性溶液（30b）的电渗析器（10）和用于输注的装置（15）在所述氧合器（9）上游的所述酸溶液的特征在于，所述电渗析器（10）包括第一电渗析室（21）和第二电渗析室（22），所述第一和第二电渗析室（21,22）被分离通过离子膜（23），并且所述第一室（21）和所述第二室（22）分别与正极（24）或阳极以及从负极（25）或阴极分离，通过双极膜（26,27）。

67. 发明申请

WO2015001024A1 2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： 2-ACYLAMINOTHIAZOLES治疗癌症
公开(公告)号：WO2015001024A1
公开(公告)日：2015-01-08
申请号：PCT/EP2014/064197
申请日：2014-07-03
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA , UNIVERSITÉ DE GENÈVE , UNIVERSITÉ CLAUDE BERNARD LYON 1
发明人： GAMBACORTI-PASSERINI, Carlo , MOLOGNI, Luca , SCAPOZZA, Leonardo , BISSON, William , GOEKJIAN, Peter , BENOIT, Joseph
IPC分类号： C07D417/12 , A61K31/427 , A61K31/496 , C07D277/46 , A61P31/00
CPC分类号： C07D277/46 , C07D417/12 , C07D417/14 , C07F7/0812 , C07F7/1856
摘要： The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.
摘要翻译：本发明涉及如本文所述的式（I）的致癌蛋白激酶ALK的抑制剂及其药物组合物。式（I）的化合物可用于制备药物，特别是用于治疗癌症。

68. 发明申请

WO2013017548A1 1,4-DIARYL-2-AZETIDINONES WITH ANTI-TUMORAL ACTIVITY 审中-公开
标题翻译：具有抗肿瘤活性的1,4-DIARYL-2-AZETIDINONES
公开(公告)号：WO2013017548A1
公开(公告)日：2013-02-07
申请号：PCT/EP2012/064825
申请日：2012-07-27
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA , PAGLIARIN, Roberto , ORSINI, Fulvia , MONTANO, Giuseppe , TRIPODI, Farida , COCCETTI, Paola , FUSI, Paola Alessandra
发明人： PAGLIARIN, Roberto , ORSINI, Fulvia , MONTANO, Giuseppe , TRIPODI, Farida , COCCETTI, Paola , FUSI, Paola Alessandra
IPC分类号： C07D205/08 , C07D205/085 , A61K31/397 , A61P35/00
CPC分类号： C07D205/08 , C07D205/085
摘要： Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R 1 is selected from H and OCH 3 , and the other is the group:(III) wherein R 2 is selected from H, OH, NO 2 , NH 2 ; R 3 is selected from OH and NH 2 ;15 the salts, enantiomers and diastereoisomers thereof; with the exclusion of the following compounds: 3,4-cis-3-hydroxy-4-(3-nitro-4-methoxyphenyl)-1-(3,4,5- trimethoxyphenyl)azetidin-2-one; 3,4-cis-4-(3-amino-4-methoxyphenyl)-3-hydroxy-1-(3,4,5-20 trimethoxyphenyl)-azetidin-2-one; for use as antitumor agents.
摘要翻译：公开了式（I）的化合物：其中A和B中的一个是基团：其中R 1选自H和OCH 3，另一个是基团：其中R 2选自H，OH， NO2，NH2; R3选自OH和NH2; 15是其盐，对映异构体和非对映异构体; 除了以下化合物：3,4-顺式-3-羟基-4-（3-硝基-4-甲氧基苯基）-1-（3,4,5-三甲氧基苯基）氮杂环丁-2-酮; 3,4-顺式-4-（3-氨基-4-甲氧基苯基）-3-羟基-1-（3,4,5-20三甲氧基苯基） - 吖丁啶-2-酮; 用作抗肿瘤剂。

69. 发明申请

WO2012041480A3 LIGHTING SYSTEM 审中-公开
公开(公告)号：WO2012041480A3
公开(公告)日：2012-04-05
申请号：PCT/EP2011/004818
申请日：2011-09-26
申请人： UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA , MIGLIO, Leonida , TASSONE, Francesco , FATTORINI, Franco , NEMNI, Raffaello
发明人： MIGLIO, Leonida , TASSONE, Francesco , FATTORINI, Franco , NEMNI, Raffaello
IPC分类号： B32B27/00
摘要： The present invention relates to a device to convert the blue light from solid- state sources into white light comprising a transparent polymer matrix with laminar structure, diffusing particles and phosphors.

70. 发明申请

WO2008145366A1 IDENTIFICATION AND QUANTIFICATION OF ONCOGENIC HPV NUCLEIC ACIDS BY MEANS OF REAL-TIME PCR ASSAYS 审中-公开
标题翻译：通过实时荧光定量PCR方法鉴定和定量荧光HPV核酸
公开(公告)号：WO2008145366A1
公开(公告)日：2008-12-04
申请号：PCT/EP2008/004277
申请日：2008-05-29
申请人： UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA , COCUZZA, Clementina, Elvezia, Anna , BROCCOLO, Francesco
发明人： COCUZZA, Clementina, Elvezia, Anna , BROCCOLO, Francesco
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： Method for the identification and quantification of oncogenic HPV nucleic acids comprising: a) first line screening by means of 5 independent SYBR Green I Real-time PCR assays to determine the total viral load and to identify the presence of one or more of 13 high risk HPV genotypes in the sample; b) second line assays to be applied to samples positives for: - 5 independent TaqMan Real-time PCR assays to determine the presence and the viral load of the most common oncogenic HPV types: HPV types: 16, 18, 31, 45, 33 group (including 33, 52, 58, 67 genotypes). - 6 independent SYBR Green I RT Real-time PCR assays to determine the presence in the sample of the oncogenic transcripts E6/E7 of HPV types 16, 18, 31, 33, 45, 58.
摘要翻译：用于识别和定量致癌HPV核酸的方法，包括：a）通过5次独立的SYBR Green I实时PCR测定进行一线筛选以确定总病毒载量并鉴定13种高风险中的一种或多种的存在样本中的HPV基因型; b）应用于样品阳性的二线测定： - 5个独立的TaqMan实时PCR测定法，以确定最常见的致癌HPV类型的存在和病毒载量：HPV类型：16,18,31,45,33 组（包括33,52,58,67个基因型）。 - 6个独立的SYBR Green I RT实时PCR测定法，以确定在16,18,31,33,45,58等HPV类型的致癌转录物E6 / E7的样品中的存在。

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