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61. 发明专利

CA2999682A1 SEMICONDUCTOR LASER DEVICE 未知
公开(公告)号：CA2999682A1
公开(公告)日：2017-04-06
申请号：CA2999682
申请日：2016-09-29
申请人： NIPPON TELEGRAPH & TELEPHONE , UNIV TOHOKU
发明人： ISHII HIROYUKI , FUJIWARA NAOKI , WATANABE KEI , ITOH MIKITAKA , KASAI KEISUKE , NAKAZAWA MASATAKA
IPC分类号： H01S5/022 , G01N21/01 , G02B6/12 , G02B6/42 , H01S5/026 , H01S5/12 , H01S5/125 , H01S5/50
摘要： External resonator-type lasers as configurations for narrowing the spectral line widths of semiconductor lasers to approximately 10 kHz suffer from the problem that a large number of components are required and need to be assembled with high accuracy, and thus, control circuits become complicated. Wavelength variable lasers based on DFB lasers have also been known, but even wavelength variable lasers based on DFB lasers have limits in narrowing of spectrum line widths because it is difficult to uniformly form long resonators due to production variation. The semiconductor laser device according to the present invention has a semiconductor laser that oscillates in a single mode and has a low-loss optical wave circuit using quartz glass arranged on a common substrate. The optical wave circuit is configured such that a part of light outputted from the semiconductor laser propagates a certain length of an optical path, is reflected by a reflector, and returns to the semiconductor laser. Alternatively, the optical wave circuit may be configured such that light outputted from the semiconductor laser is coupled optically, directly to the input waveguide of the optical wave circuit. The present invention can provide a compact laser device which achieves a narrow spectral line width and stable wavelength control.

62. 发明专利

AU2013303492B2 Pluripotent stem cell that induces repair and regeneration after myocardial infarction 未知
公开(公告)号：AU2013303492B2
公开(公告)日：2017-02-16
申请号：AU2013303492
申请日：2013-08-15
申请人： CLIO INC , UNIV GIFU , UNIV TOHOKU
发明人： YOSHIDA MASANORI , MINATOGUCHI SHINYA , DEZAWA MARI
IPC分类号： A61K35/28 , A61P9/10 , C12N5/0775
摘要： The purpose of the present invention is to provide a new medical application using pluripotent stem cells (Muse cells) for regenerative medicine. The present invention provides a cell formulation for treating myocardial infarctions, especially severe, large-scale myocardial infarctions, and accompanying heart failure. Said cell formulation contains SSEA3-positive pluripotent stem cells isolated from either mesenchymal tissue from an organism or cultured mesenchymal cells. This cell formulation is based on the following myocardial-tissue regeneration mechanism: intravenous administration of Muse cells to subjects with the abovementioned disorders results in said Muse cells selectively accumulating in the damaged myocardial tissue and, within said tissue, differentiating into cardiac muscle.

63. 发明专利

DK2418174T3 Fremgangsmåde til fremstilling af alkalimetal-niobat-partikler og alkalimetal-niobat-partikler 未知
公开(公告)号：DK2418174T3
公开(公告)日：2017-01-23
申请号：DK10761671
申请日：2010-04-05
申请人： SAKAI CHEMICAL INDUSTRY CO , UNIV TOHOKU , FUJI CERAM CORP
发明人： MURAMATSU ATSUSHI , KANIE KIYOSHI , TERABE ATSUKI , OKAMOTO YASUHIRO , MIZUTANI HIDETO , SUEDA SATORU , TAKAHASHI HIROFUMI
IPC分类号： C01G33/00 , H01L41/187 , H01L41/22 , H01L41/39

64. 发明专利

AU2012227790C1 Probe for analyzing biological tissue and method for utilizing same 未知
公开(公告)号：AU2012227790C1
公开(公告)日：2016-06-30
申请号：AU2012227790
申请日：2012-03-15
申请人： MEIJI SEIKA PHARMA CO LTD , UNIV TOHOKU
发明人： YAMAGATA YOUHEI , GOTO MASAFUMI , WATANABE KIMIKO
IPC分类号： G01N33/53 , C07K14/435 , C12N5/071 , C12N9/02 , C12N9/52 , C12N15/09
摘要： The invention relates to a method for obtaining a cell or a cell population having a high biological activity from biological tissue by enzymatic isolation in high yield, and also relates to a probe therefor. Specifically, the invention relates to a method for analyzing biological tissue, characterized in that, with respect to two or more proteins binding to a specific biological component, two or more probes each containing a domain binding to the biological component are applied to isolated biological tissue and the amount of each probe which bound to the biological tissue is analyzed.

65. 发明专利

AU2009318554B2 Fusion collagenase to which affinity tag is attached, and method for producing same 未知
公开(公告)号：AU2009318554B2
公开(公告)日：2016-06-09
申请号：AU2009318554
申请日：2009-11-06
申请人： MEIJI SEIKA PHARMA CO LTD , UNIV TOHOKU
发明人： FUKUSHIMA TAKAYOSHI , YOKOYAMA KENGO , MURASHIMA KOICHIRO , GOTO MASAFUMI , YAMAGATA YOUHEI
IPC分类号： C12N15/00 , C07K19/00 , C12N1/21 , C12N5/071 , C12N9/52 , C12N15/09
摘要： A fusion collagenase obtained by attaching an affinity tag to a carboxyl terminal of a collagenase is expressed as a recombinant protein. By purifying the thus-obtained fusion collagenase by affinity chromatography, a collagenase having a collagen-binding site can be selectively collected.

66. 发明专利

CA2717341C METAL FLUORIDE LANTHANIDE SCINTILLATOR 未知
公开(公告)号：CA2717341C
公开(公告)日：2016-05-31
申请号：CA2717341
申请日：2009-03-17
申请人： UNIV TOHOKU , TOKUYAMA CORP
发明人： YOSHIKAWA AKIRA , YANAGIDA TAKAYUKI , FUKUDA KENTARO , ISHIZU SUMITO , KAWAGUCHI NORIAKI , SUYAMA TOSHIHISA
IPC分类号： C09K11/61 , C09K11/00 , C09K11/85 , G01T1/20 , G01T1/202 , G01T3/06
摘要： To provide a scintillator for neutron detection which has high sensitivity to neutron rays, and is reduced in a background noise attributed to .gamma. rays. [Means to Solve the Problems] A scintillator for neutron detection, comprising a metal fluoride crystal containing, as constituent elements, a metal having a valence of 2 or higher, such as calcium, aluminum or yttrium; lithium; and fluorine, the metal fluoride crystal containing 1.1 to 20 atoms per unit volume (atoms/nm3) of 6Li, having an effective atomic number of 10 to 40, containing a lanthanoid such as cerium, praseodymium or europium, and being represented by LiCaAlF6, LiSrAlF6, LiYF4 etc.

67. 发明专利

CA2959957A1 PLURIPOTENT STEM CELL FOR TREATING DIABETIC SKIN ULCER 未知
公开(公告)号：CA2959957A1
公开(公告)日：2016-03-10
申请号：CA2959957
申请日：2015-06-19
申请人： UNIV TOKYO , UNIV TOHOKU
发明人： YOSHIMURA KOTARO , KINOSHITA KAHORI , DEZAWA MARI
IPC分类号： A61K35/12 , A61P3/10 , A61P17/02 , C12N5/07
摘要： The purpose of the present invention is to provide a novel medicinal use in regeneration medicine, said medicinal use comprising using pluripotent stem cells (Muse cells). Provided is a cell preparation for treating skin ulcer, said cell preparation comprising SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue of a living organism or cultured mesenchymal cells. The cell preparation according to the present invention is based on such mechanism of skin tissue regeneration that, when the Muse cells are administered to a skin ulcer site of a subject suffering from the aforesaid disease, the Muse cells differentiate into skin-constituting cells.

68. 发明专利

ES2531402T3 Colagenasa de fusión a la que se une una marca de afinidad, y método para producir la misma 未知
公开(公告)号：ES2531402T3
公开(公告)日：2015-03-13
申请号：ES09827488
申请日：2009-11-06
申请人： MEIJI SEIKA PHARMA CO LTD , UNIV TOHOKU
发明人： FUKUSHIMA TAKAYOSHI , YOKOYAMA KENGO , MURASHIMA KOICHIRO , GOTO MASAFUMI , YAMAGATA YOUHEI
IPC分类号： C12N15/00 , C07K14/78 , C07K19/00 , C12N1/21 , C12N5/071 , C12N9/52 , C12N15/09
摘要： Un método para producir una colagenasa de fusión, en el que: un cultivo obtenido mediante el cultivo de E. coli transformada por uno cualquiera de un ADN que codifica la colagenasa de fusión y un vector de expresión que comprende el ADN se purifica mediante cromatografía por afinidad que corresponde a una marca de afinidad para recoger de ese modo de forma selectiva la colagenasa de fusión que tiene un dominio de unión a colágeno, en donde la colagenasa de fusión tiene las siguientes características (i) a (ii): (i) la marca de afinidad se une directa o indirectamente a un extremo carboxilo de la colagenasa; (ii) la colagenasa se selecciona entre los siguientes (a) a (h): (a) una colagenasa que comprende una secuencia de aminoácidos de las posiciones -110 a 1008 de una cualquiera de las SEC ID Nº: 1 y 2; (b) una colagenasa que comprende una secuencia de aminoácidos de las posiciones -110 a 1008 de una cualquiera de las SEC ID Nº: 1 y 2 en la que se suprimen, sustituyen, insertan o añaden de 1 a 30 aminoácidos; (c) una colagenasa que comprende una secuencia de aminoácidos que tiene una homología de un 80 % o 20 superior con la secuencia de aminoácidos de las posiciones -110 a 1008 de una cualquiera de las SEC ID Nº: 1 y 2; (d) una colagenasa en la que una secuencia de aminoácidos de las posiciones -110 a -1 de una cualquiera de las SEC ID Nº: 1 y 2 se retira de una cualquiera de las colagenasas que se han descrito en (a) a (c); (e) una colagenasa que comprende una secuencia de aminoácidos de las posiciones -40 a 981 de una cualquiera de las SEC ID Nº: 5 y 6; (f) una colagenasa que comprende una secuencia de aminoácidos de las posiciones -40 a 981 de una cualquiera de las SEC ID Nº: 5 y 6 en la que se suprimen, sustituyen, insertan o añaden de 1 a 30 aminoácidos; (g) una colagenasa que comprende una secuencia de aminoácidos que tiene una homología de un 80 % o superior con la secuencia de aminoácidos de las posiciones -40 a 981 de una cualquiera de las SEC ID Nº: 5 y 6; (h) una colagenasa en la que una secuencia de aminoácidos de las posiciones -40 a -1 de una cualquiera de las SEC ID Nº: 5 y 6 se retira de una cualquiera de las colagenasas que se han descrito en (e) a (g).

69. 发明专利

NZ614600A Probe for analyzing biological tissue and method for utilizing same 未知
公开(公告)号：NZ614600A
公开(公告)日：2015-02-27
申请号：NZ61460012
申请日：2012-03-15
申请人： MEIJI SEIKA PHARMA CO LTD , UNIV TOHOKU
发明人： YAMAGATA YOUHEI , GOTO MASAFUMI , WATANABE KIMIKO
IPC分类号： G01N33/53 , C07K14/435 , C12N5/071 , C12N9/02 , C12N9/52 , C12N15/09
摘要： Disclosed is a method for analysing a biological tissue, comprising applying two or more probes respectively containing collagen binding domains of two or more proteases to an isolated biological tissue, and analysing binding amounts of the probes to the biological tissue.

70. 发明专利

BRPI0809378A2 未知
公开(公告)号：BRPI0809378A2
公开(公告)日：2014-09-09
申请号：BRPI0809378
申请日：2008-03-18
申请人： JFE MINERAL CO LTD , UNIV TOHOKU
发明人： SUGINOBE HIDETAKA , SHIOKAWA TAKAHIRO , SATO NOBUAKI , SAITO FUMIO , SUZUKI SHIGERU , KANO JUNYA
IPC分类号： C01B31/30 , C01B32/949 , C01G33/00 , C01G39/00 , C01G41/00 , C01G49/00

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