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61. 发明申请

WO2017059245A3 DEADMAN AND PASSCODE MICROBIAL KILL SWITCHES 审中-公开
标题翻译： DEADMAN和PASSCODE MICROBIAL KILL SWITCHES
公开(公告)号：WO2017059245A3
公开(公告)日：2017-08-03
申请号：PCT/US2016054767
申请日：2016-09-30
申请人： UNIV BOSTON
发明人： CHAN TSZ YAN CLEMENT , COLLINS JAMES J , LEE JEONG WOOK , CAMERON DOUGLAS EWEN
IPC分类号： A61K48/00 , C12N15/11 , C12N15/62 , C12N15/63 , C12N15/85
CPC分类号： C12N15/70 , C12N15/635
摘要： Provided herein are systems, methods and compositions for rendering cells or the expression of an effector protein sensitive to a predetermined condition. In one aspect, cells can be rendered dependent upon the presence of an environmental agent, e.g., an exogenous agent, without which the cell will default to expression of a death protein and be killed. In another aspect, cells can be rendered sensitive to the presence of a set of predetermined conditions such that cells will only grow when two or more necessary exogenous agents are supplied, and without either of which, the cells are killed. In this aspect, hybrid transcription factors provide a vast array of possible predetermined conditions.
摘要翻译：本文提供用于使细胞或效应蛋白表达对预定条件敏感的系统，方法和组合物。在一个方面，细胞可以取决于环境因子例如外源因子的存在，否则细胞将默认表达死亡蛋白并被杀死。在另一方面，细胞可以对一组预定条件的存在敏感，从而使细胞仅在提供两种或更多种必需的外源性试剂时才生长，并且不杀死任何一种细胞。在这方面，杂合转录因子提供了大量可能的预定条件。

62. 发明申请

WO2016187392A3 METHODS AND COMPOSITIONS RELATING TO ANTI-TMIGD1/IGPR-2 审中-公开
标题翻译：与抗TMIGD1 / IGPR-2相关的方法和组合物
公开(公告)号：WO2016187392A3
公开(公告)日：2016-12-22
申请号：PCT/US2016033209
申请日：2016-05-19
申请人： UNIV BOSTON
发明人： RAHIMI NADER
IPC分类号： A61K38/00 , A61K39/395 , C12Q1/68
CPC分类号： A61K39/395 , A61K48/00 , C07K16/2803
摘要： The technology described herein is directed to the diagnosis, prognosis, and treatment of conditions of the kidney, e.g., kidney cancer and/or kidney disease, and also relates to methods, compositions and kits comprising an agonist of the TMIGD1 (transmembrane and immunoglobulin containing 1) polypeptide.
摘要翻译：本文描述的技术涉及肾的病症，例如肾癌和/或肾脏疾病的诊断，预后和治疗，并且还涉及包含TMIGD1激动剂（跨膜和含有免疫球蛋白的免疫球蛋白）的方法，组合物和试剂盒 1）多肽。

63. 发明申请

WO2016141339A9 ADAPTIVE OPTICS FOR IMAGING THROUGH HIGHLY SCATTERING MEDIA IN OIL RESERVOIR APPLICATIONS 审中-公开
标题翻译：通过油藏储存应用中高分辨率介质成像的自适应光学
公开(公告)号：WO2016141339A9
公开(公告)日：2016-10-13
申请号：PCT/US2016021004
申请日：2016-03-04
申请人： ARAMCO SERVICES CO , SAUDI ARABIAN OIL CO , UNIV BOSTON
发明人： BIFANO THOMAS , EICHMANN SHANNON LEE , GOLDBERG BENNELT B , KANJ MAZEN , PAUDEL HARI P , SHAIN WILLIAM
IPC分类号： G02B27/00 , G01N21/64 , G02B21/00
CPC分类号： G02B21/0028 , G01N21/6458 , G01N2201/0675 , G02B21/002 , G02B21/0032 , G02B21/0048 , G02B21/0076 , G02B21/008 , G02B21/02 , G02B21/367 , G02B27/0068
摘要： Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system. The invention images stationary and dynamic nanoparticles, surfactants, fluid-fluid interfaces and tracers which can be used to study properties such as diffusion, mobility, adhesion, stickiness and wettability within the 3D structure of cores and thin sections.
摘要翻译：本发明的实施例提供了一种使用自适应光学和优化算法的成像系统和方法，用于通过油藏应用中的高散射介质和基于实验室的石油研究进行成像。双光子/多光子荧光显微镜与自适应光学结合使用，用于在散射储层介质中增强成像和检测能力。先进的荧光技术被用于允许超级穿透成像补偿在感兴趣的领域内外的像差，从而延伸孔几何可以在岩石基质内成像超过目前的共聚焦显微镜能力的深度。在该应用中，散射和折射率失配是主要像差的可变形镜或空间光调制器的放置在与成像系统中的物镜的光瞳平面共轭的光学平面中。本发明将稳定和动态的纳米颗粒，表面活性剂，流体 - 流体界面和示踪剂图像化，可用于研究核心和薄部分的3D结构内的扩散，迁移率，粘附性，粘性和润湿性等性质。

64. 发明申请

WO2015031765A3 INTERMEDIATE METABOLISM PRODUCTS TO POTENTIATE AMINOGLYCOSIDE ANTIBIOTICS IN BACTERIAL INFECTIONS 审中-公开
标题翻译：中间代谢产物在细菌感染中增强氨基糖甙类抗生素
公开(公告)号：WO2015031765A3
公开(公告)日：2015-11-05
申请号：PCT/US2014053425
申请日：2014-08-29
申请人： UNIV BOSTON , GEN HOSPITAL CORP
发明人： COLLINS JAMES J , MEYLAN SYLVAIN , MOSKOWITZ SAMUEL
IPC分类号： A61K31/7036 , A61K31/00 , A61P31/00
CPC分类号： A61K31/198 , A01N37/06 , A01N43/16 , A61K31/19 , A61K31/191 , A61K31/194 , A61K31/7004 , A61K31/7036 , A61K45/06 , A61K2300/00
摘要： Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and treatment with one or more proton motive force (PMF) stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known.
摘要翻译：本文提供了使用氨基糖苷类抗生素的特定组合和用一种或多种质子动力（PMF）刺激化合物治疗来改善慢性感染治疗并减少，延缓或抑制生物膜形成的组合物和方法。这些新方法很容易适用于临床环境，因为所使用的抗生素和代谢物的毒性和功效已经在体内研究，并且已知抗生素和代谢物的剂量。

65. 发明申请

WO2013177060A3 METHODS AND SYSTEMS FOR MONITORING, DIAGNOSING, AND TREATING CHRONIC OBSTRUCTIVE POLMONARY DISEASE 审中-公开
标题翻译：用于监测，诊断和治疗慢性阻塞性疾病的方法和系统
公开(公告)号：WO2013177060A3
公开(公告)日：2015-08-20
申请号：PCT/US2013041857
申请日：2013-05-20
申请人： UNIV BOSTON , LAM STEPHEN
发明人： LAM STEPHEN , STEILING KATRINA , SPIRA AVRUM , LENBURG MARC
IPC分类号： C12Q1/68 , A61P11/00
CPC分类号： C12Q1/6883 , A61K31/137 , A61K31/198 , A61K31/357 , A61K31/46 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/56 , A61K31/575 , A61K31/58 , A61K38/06 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of classifying the (COPD) status of a subject are provided. Systems for expression-based classification of COPD disease status are provided. Methods of treating COPD are also provided, among other things.
摘要翻译：提供了一组用于测量慢性阻塞性肺疾病（COPD）活性的生物标志物的呼吸道上皮中表达的98个基因。提供了对主题（COPD）状态进行分类的方法。提供了基于表达的COPD疾病分类系统。还提供了治疗COPD的方法。

66. 发明申请

WO2015047497A3 AN OPTICAL ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING (O-OFDM) SYSTEM WITH PULSE-WIDTH MODULATION (PWM) DIMMING 审中-公开
标题翻译：具有脉宽调制（PWM）调光的光学正交频分多路复用（O-OFDM）系统
公开(公告)号：WO2015047497A3
公开(公告)日：2015-05-21
申请号：PCT/US2014043820
申请日：2014-06-24
申请人： UNIV BOSTON
发明人： ELGALA HANY , LITTLE THOMAS
IPC分类号： H04J11/00 , H04B10/116 , H04J14/00
CPC分类号： H04B10/116 , H04L25/4902 , H04L27/2627 , H04L27/2697
摘要： An optical orthogonal frequency division multiplexing (O-OFDM) system with pulse-width modulation (PWM) dimming includes a driver responsive to one or more predetermined dimming set points configured to generate PWM signals having a predetermined duty cycle and configured to supply current to one or more light emitting diodes (LEDs). An O-OFDM generator responsive to the one or more predetermined dimming set points and digital data is configured to generate digital inverted O-OFDM signals during on-states of the PWM signals and non-inverted O-OFDM signals during off-states of the PWM signals according to the predetermined duty cycle and convert the digital inverted O-OFDM signals and the digital non-inverted O-OFDM signals to analog output O-OFDM signals. A combiner circuit responsive to the current from the driver and the analog output O-OFDM signals is configured such that the analog output O-OFDM signals modulate the current to the one or more LEDs to provide a high capacity visible light communication link.
摘要翻译：具有脉宽调制（PWM）调光的光学正交频分多路复用（O-OFDM）系统包括响应于一个或多个预定调光设定点的驱动器，所述预定调光设定点被配置为产生具有预定占空比的PWM信号并且被配置为向一个或更多的发光二极管（LED）。响应于所述一个或多个预定调光设置点和数字数据的O-OFDM发生器被配置为在所述PWM信号和非反相O-OFDM信号的导通状态期间在所述PWM信号和所述非反相O-OFDM信号的导通状态期间生成数字反相O-OFDM信号 PWM信号，并将数字反相O-OFDM信号和数字非反相O-OFDM信号转换成模拟输出O-OFDM信号。响应来自驱动器的电流和模拟输出O-OFDM信号的组合器电路被配置为使得模拟输出O-OFDM信号调制到一个或多个LED的电流以提供高容量可见光通信链路。

67. 发明申请

WO2014190208A2 METHODS AND APPARATUS FOR EARLY SENSORY INTEGRATION AND ROBUST ACQUISITION OF REAL WORLD KNOWLEDGE 审中-公开
标题翻译：用于早期感知整合的方法和设备，并且实际获取世界知识
公开(公告)号：WO2014190208A2
公开(公告)日：2014-11-27
申请号：PCT/US2014039239
申请日：2014-05-22
申请人： NEURALA INC , UNIV BOSTON
发明人： GORSHECHNIKOV ANATOLY , VERSACE MASSIMILIANO , BARNES TIM
IPC分类号： G06F19/00
CPC分类号： B25J9/1694 , B25J9/1664 , B25J9/1697 , G06F17/30241 , G06F17/30321 , G06K9/4619 , G06K9/4671 , G06N3/008 , G06N3/02 , G06N5/02 , Y10S901/01 , Y10S901/09 , Y10S901/46 , Y10S901/47
摘要： The systems and methods disclosed herein include a path integration system that calculates optic flow, infers angular velocity from the flow field, and incorporates this velocity estimate into heading calculations. The resulting system fuses heading estimates from accelerometers, 5 gyroscopes, engine torques, and optic flow to determine self-localization. The system also includes a motivational system that implements a reward drive, both positive and negative, into the system. In some implementations, the drives can include: a) a curiosity drive that encourages exploration of new areas, b) a resource drive that attracts the agent towards the recharging base when the battery is low, and c) a mineral reward drive that attracts the agent 10 towards previously explored scientific targets.
摘要翻译：本文公开的系统和方法包括计算光流的路径积分系统，推测来自流场的角速度，并将该速度估计结合到航向计算中。所得到的系统将加速度计，5个陀螺仪，发动机转矩和光流量估算出来，以确定自身定位。该系统还包括一个激励系统，该系统实现系统中积极和消极的奖励驱动。在一些实施方案中，驱动器可以包括：a）鼓励探索新区域的好奇心驱动器，b）当电池电量低时吸引代理朝向充电基地的资源驱动器，以及c）吸引代理10针对以前探索的科学目标。

68. 发明申请

WO2014062254A3 DETECTION OF ELECTROMAGNETIC RADIATION USING NONLINEAR MATERIALS 审中-公开
标题翻译：使用非线性材料检测电磁辐射
公开(公告)号：WO2014062254A3
公开(公告)日：2014-07-31
申请号：PCT/US2013049020
申请日：2013-07-02
申请人： MASSACHUSETTS INST TECHNOLOGY , UNIV BOSTON
发明人： LIU MENGKUN , HWANG HAROLD Y , AVERITT RICHARD D , NELSON KEITH A , SERNBACH AARON , FAN KEBIN
IPC分类号： H01L31/00
CPC分类号： G01J5/28 , G01J5/20 , G01J2005/0077 , G01J2005/202 , G01J2005/283 , G01J2005/286 , H01L27/14636 , H01L27/1464 , H01L27/14669 , H01L31/09
摘要： An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension that is less than the wavelength of target electromagnetic radiation within the target frequency range, and each of the resonator structures includes at least two conductive structures separated by a spacing. Charge carriers are induced in the substrate near the spacing when the resonator structures are exposed to the target electromagnetic radiation. A measure of the change in conductivity of the substrate due to the induced charge carriers provides an indication of the presence of the target electromagnetic radiation.
摘要翻译：提供一种用于检测目标频率范围内的电磁辐射的装置。该装置包括衬底和设置在衬底上的一个或多个谐振器结构。衬底可以是电介质或半导体材料。一个或多个谐振器结构中的每一个具有小于目标频率范围内的目标电磁辐射的波长的至少一个维度，并且每个谐振器结构都包括由间隔隔开的至少两个导电结构。当谐振器结构暴露于目标电磁辐射时，电荷载流子在衬底附近被感应。由于感应的电荷载体导致的衬底的电导率变化的测量提供了目标电磁辐射的存在的指示。

69. 发明申请

WO2014025785A2 PRION PROTEIN LIGANDS AS THERAPEUTIC AGENTS FOR NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：作为神经干细胞移植治疗药物的PRION蛋白配体
公开(公告)号：WO2014025785A2
公开(公告)日：2014-02-13
申请号：PCT/US2013053796
申请日：2013-08-06
申请人： UNIV BOSTON , UNI DI PERUGIA
发明人： BIASINI EMILIANO , HARRIS DAVID A , BEELER AARON , FLUHARTY BRIAN R , BARRECA MARIA LETIZIA , IRACI NUNZIO , INGHAM OSCAR
IPC分类号： A61K31/175
CPC分类号： A61K31/145 , A61K31/18 , A61K31/365 , A61K31/41 , A61K31/7008 , A61K45/06 , C07C337/08 , C07C2601/14 , C07D307/33 , C07D309/14 , A61K2300/00
摘要： The invention provides compositions and methods for treatment of neurodegenerative diseases or disorders, particularily neurodegenerative diseases and disoders associated with protein aggregration.
摘要翻译：本发明提供用于治疗神经变性疾病或病症，特别是与蛋白质聚集相关的神经变性疾病和解码器的组合物和方法。

70. 发明申请

WO2013177060A2 METHODS AND SYSTEMS FOR MONITORING, DIAGNOSING, AND TREATING CHRONIC OBSTRUCTIVE POLMONARY DISEASE 审中-公开
标题翻译：用于监测，诊断和治疗慢性阻塞性疾病的方法和系统
公开(公告)号：WO2013177060A2
公开(公告)日：2013-11-28
申请号：PCT/US2013041857
申请日：2013-05-20
申请人： UNIV BOSTON , LAM STEPHEN
发明人： LAM STEPHEN , STEILING KATRINA , SPIRA AVRUM , LENBURG MARC
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/137 , A61K31/198 , A61K31/357 , A61K31/46 , A61K31/522 , A61K31/53 , A61K31/5377 , A61K31/56 , A61K31/575 , A61K31/58 , A61K38/06 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of classifying the (COPD) status of a subject are provided. Systems for expression-based classification of COPD disease status are provided. Methods of treating COPD are also provided, among other things.
摘要翻译：提供了一组用于测量慢性阻塞性肺疾病（COPD）活性的生物标志物的呼吸道上皮中表达的98个基因。提供了对主题（COPD）状态进行分类的方法。提供了基于表达的COPD疾病分类系统。还提供了治疗COPD的方法。

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