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61. 发明公开

EP3161131A1 TISSUE ENGINEERED CONSTRUCTS 有权
标题翻译：组织工程结构
公开(公告)号：EP3161131A1
公开(公告)日：2017-05-03
申请号：EP15736012.4
申请日：2015-06-23
申请人： The University Of Leeds , Xiros Limited
发明人： FINLAY, Scott , SEEDHOM, Bahaa Botros
IPC分类号： C12N5/077 , A61L27/38
摘要： A method of forming an implantable tissue engineered construct, a bioreactor for forming a tissue engineered construct, and a tissue engineered construct itself are disclosed The method includes seeding a scaffold with cells to form a tissue construct; locating the tissue construct in a space defined by a tissue construct support element; locating the tissue construct support element within a bioreactor; and operating a load applicator of the bioreactor to apply a cyclical compressive mechanical load to the tissue construct, to stimulate the deposition of tissue matrix in the tissue construct, in which the tissue construct, the tissue construct support element and the load applicator are arranged so that the load applicator can at least initially contact both the tissue construct and the tissue construct support element, so that at least part of a total load generated by the load applicator is borne by the tissue construct support element.
摘要翻译：公开了形成可植入组织工程构建体，用于形成组织工程构建体的生物反应器和组织工程构建体本身的方法。所述方法包括将细胞接种到支架以形成组织构建体; 将组织构建体定位在由组织构建体支撑元件限定的空间中; 将组织构建体支撑元件定位在生物反应器内; 以及操作生物反应器的负载施加器以向组织构建体施加循环压缩机械负载以刺激组织构建体在组织构建体中的沉积，其中组织构建体，组织构建体支撑元件和负载施加器布置成如此载荷施加器可以至少首先接触组织构建体和组织构建体支撑元件两者，使得由载荷施加器产生的总负载的至少一部分由组织构建体支撑元件承受。

62. 发明公开

EP2956156A1 SCAFFOLD PROTEINS DERIVED FROM PLANT CYSTATINS 有权转让
标题翻译：植物细胞来源的花叶蛋白
公开(公告)号：EP2956156A1
公开(公告)日：2015-12-23
申请号：EP14705565.1
申请日：2014-02-14
申请人： The University Of Leeds
发明人： MCPHERSON, Michael , TOMLINSON, Darren
IPC分类号： A61K38/16 , C07K14/415 , G01N33/53
摘要： The present invention relates to scaffold proteins derived from plant cystatins and to nucleic acids encoding them. The scaffolds are highly stable and have the ability to display peptides. The scaffolds are particularly well suited for constructing libraries, e.g., in phage display or related systems. The invention also relates to various uses of the scaffolds, including in therapy, diagnosis, environmental and security monitoring, synthetic biology and research, and to cells and cell cultures expressing the scaffold proteins.
摘要翻译：本发明涉及从植物胱抑素衍生的支架蛋白和编码它们的核酸。支架非常稳定并且具有展示肽的能力。支架特别适用于构建文库，例如在噬菌体展示或相关系统中。本发明还涉及支架的各种用途，包括治疗，诊断，环境和安全监测，合成生物学和研究，以及表达支架蛋白的细胞和细胞培养物。

63. 发明公开

EP2934770A2 ULTRASOUND GENERATION 有权转让
标题翻译： ULTRASCHALLERZEUGUNG
公开(公告)号：EP2934770A2
公开(公告)日：2015-10-28
申请号：EP13808190.6
申请日：2013-12-13
申请人： The University Of Leeds
发明人： FREEAR, Steven , COWELL, David Matthew Joseph , SMITH, Peter Raymond
IPC分类号： B06B1/02
CPC分类号： G10K11/18 , B06B1/0215 , B06B2201/76
摘要： An ultrasound generator having a signal generator; and to generate a pulsed drive signal from a modulating signal, the pulsed drive signal having at least a zero output level, a positive output level and a negative output level. The position and width of pulses are defined by at least first and second switching angles per half cycle of the modulating signal. In part of the range of the modulating signal one switching angle increases while the other switching angle decreases simultaneously such that the fundamental frequency of the pulsed drive signal increases or decreases with the modulating signal and such that a selected harmonic component of the generated pulsed drive signal is maintained below a first threshold. A transducer is arranged to generate ultrasound in response to the pulsed drive signal.

64. 发明公开

EP2598462A1 CERAMIC 有权转让
标题翻译： KERAMIK
公开(公告)号：EP2598462A1
公开(公告)日：2013-06-05
申请号：EP11738788.6
申请日：2011-07-19
申请人： The University Of Leeds
发明人： BELL, Andrew, John , COMYN, Timothy
IPC分类号： C04B35/26 , C04B35/462 , C04B35/475 , H01L41/187 , H01L41/24
CPC分类号： H01L41/1878 , C04B35/26 , C04B35/462 , C04B35/475 , C04B2235/3201 , C04B2235/3232 , C04B2235/3272 , C04B2235/3275 , C04B2235/3296 , C04B2235/3298 , C04B2235/656 , C04B2235/6562 , C04B2235/6565 , C04B2235/6567 , C04B2235/76 , C04B2235/765 , C04B2235/766 , C04B2235/768 , C04B2235/77 , C04B2235/81 , H01L41/187 , H01L41/43
摘要： The present invention relates to a ceramic comprising (or consisting essentially of) a solid solution containing Bi, K, Ti and Fe (and optionally Pb) which exhibits piezoelectric behaviour.
摘要翻译：本发明涉及一种包含（或基本上由其组成）的含有Bi，K，Ti和Fe（和任选的Pb）的固体的陶瓷，其表现出压电性能。

65. 发明公开

EP2094325A2 PREPARATION OF TISSUE FOR MENISCAL IMPLANTATION 有权
标题翻译：组织的半月板植入剂
公开(公告)号：EP2094325A2
公开(公告)日：2009-09-02
申请号：EP07824573.5
申请日：2007-11-13
申请人： THE UNIVERSITY OF LEEDS
发明人： INGHAM, Eileen , FISHER, John , STAPLETON, Thomas , INGRAM, Joanne
IPC分类号： A61L27/36 , A61F2/38
CPC分类号： A61L27/3612 , A61F2/3872 , A61L27/3683 , A61L2430/40
摘要： The present invention relates to a method of preparing a tissue matrix and its subsequent use in the replacement and/or repair of a damaged or defective meniscus. The invention also provides meniscal tissue that is substantially decellularised.

66. 发明公开

EP1780264A2 Nucleic acid nematicides 审中-公开
标题翻译：核酸杀线虫剂
公开(公告)号：EP1780264A2
公开(公告)日：2007-05-02
申请号：EP06026923.0
申请日：2002-12-17
申请人： THE UNIVERSITY OF LEEDS
发明人： Atkinson, Howard , McPherson, Michael , Urwin, Peter
IPC分类号： C12N5/04 , C12N15/11
CPC分类号： C12N15/8285 , A61K38/00 , C12N15/113 , C12N2310/14 , C12N2310/53 , Y02A40/164
摘要： The invention is the identification of double stranded RNA nematicides to nematode genes and a screening assay for the identification of agents, typically dsRNA's, with nematicidal activity.
摘要翻译：本发明是鉴定线虫基因的双链RNA杀线虫剂和用于鉴定具有杀线虫活性的试剂（通常是dsRNA）的筛选试验。

67. 发明公开

EP1663871A1 PROCESS FOR THE RECOVERY OF TITANIUM DIOXIDE FROM TITANIUM-CONTAINING COMPOSITIONS 有权
标题翻译：一种获得钛白粉含组合物
公开(公告)号：EP1663871A1
公开(公告)日：2006-06-07
申请号：EP04768471.7
申请日：2004-09-14
申请人： THE UNIVERSITY OF LEEDS
发明人： JHA, Animesh , TATHAVADKAR, Vilas, Dattatray
IPC分类号： C01G23/047 , C22B34/12
CPC分类号： C22B34/1259 , C01G23/04 , C01G23/047 , C22B34/1209 , C22B34/1236
摘要： The present invention seeks to improve beneficiation of a titanium oxide-containing composition (such as a low-grade or highly radioactive TiO2 ore) by combining a roasting and selective leaching steps.

68. 发明授权

EP1237896B1 PREPARATION OF METALLOCENES CARRYING A CYCLOPENTADIENE COMPRISING A BASIC DONOR GROUP 有权
标题翻译：制造金属茂ON环戊二烯施主HAVING碱性
公开(公告)号：EP1237896B1
公开(公告)日：2004-12-01
申请号：EP00991658.6
申请日：2000-12-13
申请人： THE UNIVERSITY OF LEEDS
发明人： MCGOWAN, Patrick, Columba , MCGOWAN, Margaret, Dymphna
IPC分类号： C07F17/00
CPC分类号： C07F17/00 , Y10S526/943
摘要： The invention provides a method for the preparation of a metallocene halide salt having at least one cyclopentadiene group substituted by a basic group, the method comprising reacting together a metal halide with a cyclopentadiene substituted by a basic group. In a preferred embodiment, the substituted cyclopentadiene is substituted with an amino group and the metal halide titanium tetrachloride. The invention provides a single step process for the preparation of metallocene derivatives which are useful in the formulation of medicaments and as polymerisation catalyst precursors.

69. 发明公开

EP1421188A1 METHODS TO INCREASE THE PRODUCTIVITY OF HETEROLOGOUS GENE EXPRESSION 审中-公开
标题翻译：法提高异源蛋白的表达
公开(公告)号：EP1421188A1
公开(公告)日：2004-05-26
申请号：EP02755300.7
申请日：2002-09-02
申请人： THE UNIVERSITY OF LEEDS
发明人： DENECKE, J.,Leeds Inst. Plant Biotech.&Agricuture
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The present invention provides a method of increasing heterologous protein expression/production in a cell by controlling proteolysis in the post ER compartment of the cell. Proteolysis can be controlled by limiting/preventing export of proteins from the ER to the post ER compartment of the cell and/or by re-directing proteins from the vacuolar sorting route back to the ER or on towards the cell surface.

70. 发明公开

EP1392372A1 DECELLULARISATION OF MATRICES 有权
标题翻译：脱细胞组织基质
公开(公告)号：EP1392372A1
公开(公告)日：2004-03-03
申请号：EP02735577.5
申请日：2002-05-20
申请人： THE UNIVERSITY OF LEEDS
发明人： FISHER, John , BOOTH, Catherine , INGHAM, Eileen
IPC分类号： A61L27/36 , A01N1/02
CPC分类号： A61L27/3687 , A61L27/3633
摘要： A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in combination with protease inhibitors.

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