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61. 发明申请

WO1994019316A1 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：WO1994019316A1
公开(公告)日：1994-09-01
申请号：PCT/SE1994000153
申请日：1994-02-24
申请人： AKTIEBOLAGET ASTRA , THE UNIVERSITY OF MARYLAND , CORNELL RESEARCH FOUNDATION INC. , BJÖRK, Susanna, Karin, Maria , CARPENTIER, Barry, K. , GOTTHAMMAR, Kristina, Brigitta , LINDERBERG, Mat, Torbjörn , LUTHMAN, Per, Johan , PERSSON, Kerstin, Margareta, Irma , SCHWARCZ, Robert
发明人： AKTIEBOLAGET ASTRA , THE UNIVERSITY OF MARYLAND , CORNELL RESEARCH FOUNDATION INC.
IPC分类号： C07C229/64
CPC分类号： C07D333/20 , C07C45/27 , C07C47/277 , C07C205/37 , C07C205/59 , C07C205/60 , C07C229/64
摘要： The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R and R are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different and selected from alkoxy, aryloxy, alkyl, alkylthio, arylthio, fluoroalkyl, halogen, cyano, OSO2CH3, OSO2CF3, OCF3 and SCF3 with the proviso that the compound of formula (I) wherein R and R = H, X = Br and Y = Me is excluded; or a pharmaceutically acceptable salt thereof, methods and intermediates for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.
摘要翻译：本发明涉及通式（I）的3-羟基邻氨基苯甲酸的新型衍生物，其中R 1和R 2相同或不同并且选自H，烷基，芳基和芳基烷基; X和Y相同或不同，并且选自烷氧基，芳氧基，烷基，烷硫基，芳硫基，氟烷基，卤素，氰基，OSO 2 CH 3，OSO 2 CF 3，OCF 3和SCF 3，条件是其中R 1，和R 2 = H，X = Br和Y = Me; 或其药学上可接受的盐，其制备方法和中间体，新型药物组合物及其用于抑制负责内源性神经毒素喹啉酸QUIN的3-羟基邻氨基苯甲酸酶加氧酶3-HAO的用途。

62. 发明申请

WO1993005012A1 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：WO1993005012A1
公开(公告)日：1993-03-18
申请号：PCT/SE1992000581
申请日：1992-08-24
申请人： AB ASTRA , THE UNIVERSITY OF MARYLAND AT BALTIMORE
发明人： AB ASTRA , THE UNIVERSITY OF MARYLAND AT BALTIMORE , BJÖRK, Susanna, Karin, Maria , CARPENTER, Barry , GOTTHAMMAR, Kristina, Birgitta , HAGBERG, Curt-Eric , HÖGBERG, Thomas , LINDERBERG, Mats, Torbjörn , SCHWARCZ, Robert , STENING, Göran, Bertil
IPC分类号： C07C229/64
CPC分类号： C07C229/64 , C07C323/62 , C07C323/63
摘要： The present invention relates to novel derivatives of 3-hydroxyanthranilic acid of general formula (I), methods for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate oxygenase, 3-HAO, responsible for the production of the endogenous neurotoxin quinolinic acid, QUIN.

63. 发明申请

WO2022256102A2 NUCLEAR REACTOR CORE WITH ROTATING FUEL MODULES AND RELATED SYSTEMS 审中-公开
公开(公告)号：WO2022256102A2
公开(公告)日：2022-12-08
申请号：PCT/US2022/027044
申请日：2022-04-29
申请人： OHIO STATE INNOVATION FOUNDATION , VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. , JACKSONVILLE UNIVERSITY , THE UNIVERSITY OF MARYLAND
发明人： SMIDTS, Carol , HAGHIGHAT, Alireza , ALDEMIR, Tunc , AYDOGAN, Fatih , KHAFIZOV, Marat , HORACK, John , CAO, Lei Raymond , ZHAO, Ji-Cheng
IPC分类号： G21C19/20 , G21C3/02 , G21C3/04 , G21C3/322 , G21C7/08 , G21C3/40 , G21C7/30 , G21D5/04
摘要： Nuclear reactor cores and related systems are described herein. An example nuclear reactor core includes a plurality of fuel modules, where each of the plurality of fuel modules includes nuclear fuel; at least one fuel-module actuator mechanically coupled to at least one of the plurality of fuel modules, where the at least one fuel-module actuator is configured to rotate the at least one of the plurality of fuel modules; and at least one neutron source configured to emit neutrons and trigger a fission chain reaction in the at least one of the plurality of fuel modules.

64. 发明申请

WO2008143914A1 NOVEL METHODS FOR RECOVERY OF LEAF PROTEINS 审中-公开
标题翻译：用于恢复叶蛋白的新方法
公开(公告)号：WO2008143914A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006205
申请日：2008-05-15
申请人： THE UNIVERSITY OF MARYLAND, COLLEGE PARK , LO, Martin , FU, Hong
发明人： LO, Martin , FU, Hong
IPC分类号： C07K1/14 , C07K14/415
CPC分类号： C12N9/88 , A61K36/81 , B01D9/0059 , B01D11/0288 , C07K1/145 , C07K1/30 , C07K1/36 , C12Y401/01039
摘要： A novel method for processing soluble plant leaf proteins is described. While leaf proteins are considered potentially the most abundant source of protein in nature, the lack of efficient processing techniques for leaf proteins has limited their commercial use. The method described in this patent provides a means of extracting and purifying leaf proteins from plants which is suitable for leaf protein production on an industrial scale.
摘要翻译：描述了一种处理可溶性植物叶蛋白的新方法。尽管叶蛋白质被认为是潜在的蛋白质最丰富的来源，但叶缺乏有效的叶蛋白加工技术限制了其商业用途。该专利中描述的方法提供了从植物中提取和纯化叶蛋白的方法，其适用于工业规模的叶蛋白生产。

65. 发明申请

WO2007087263A2 HUMAN ZIP1, ZINC AND CITRATE FOR PROSTATE CANCER SCREENING 审中-公开
标题翻译：人类ZIP1，ZINC和CITRATE为前列腺癌筛查
公开(公告)号：WO2007087263A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/001681
申请日：2007-01-23
申请人： THE UNIVERSITY OF MARYLAND, BALTIMORE , FRANKLIN, Renty, B. , COSTELLO, Leslie, C.
发明人： FRANKLIN, Renty, B. , COSTELLO, Leslie, C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , Y10T436/201666
摘要： The present invention provides methods of detecting prostate cancer employing biomarkers, including hZIPl, zinc and citrate. Also provided are antibodies to detect hZIPl protein or peptides and an expression vector comprising a genetic sequence effective to increase uptake of zinc into a prostate cell upon expression thereof. Furthermore, methods of treating prostate cancer and of increasing uptake of zinc into a prostate cell are provided.
摘要翻译：本发明提供使用生物标志物检测前列腺癌的方法，包括hZIP1，锌和柠檬酸盐。还提供了检测hZIP1蛋白或肽的抗体和包含有效增加锌在表达后摄入前列腺细胞的基因序列的表达载体。此外，提供了治疗前列腺癌和增加锌摄入前列腺细胞的方法。

66. 发明申请

WO2006121307A1 AUTHENTICATION METHOD FOR WIRELESS DISTRIBUTED SYSTEM 审中-公开
标题翻译：无线分布式系统认证方法
公开(公告)号：WO2006121307A1
公开(公告)日：2006-11-16
申请号：PCT/KR2006/001787
申请日：2006-05-12
申请人： SAMSUNG ELECTRONICS CO., LTD. , THE UNIVERSITY OF MARYLAND COLLEGE PARK
发明人： LEE, In-Sun , YUN, Sang-Boh , ARBAUGH, William, Albert , CLANCY, T., Charles , SHIN, Min-Ho
IPC分类号： H04L9/32
CPC分类号： H04W12/06 , H04L9/32 , H04L9/3271 , H04L63/06 , H04L63/08 , H04L63/0884 , H04L2209/80 , H04W4/06 , H04W8/26 , H04W12/04 , H04W88/08
摘要： The present invention relates to an authentication method for wireless distribution system including at least one base station providing access service to mobile stations in a coverage of the base station. In the authentication method, an unregistered base station receives an authentication request from a mobile station, multicast an identity request for identifying the mobile station over the wireless distribution system, receives identity responses from at least one base station in response to the identity request, and performs authentication of the mobile station on the basis of the identity responses. The distributed authentication method of the present invention is performed without AAA server, when a new base station is installed or isolated base stations are joined, such that it is possible to extend the network in an easy manner without degradation of the security degree and additional labor burden of the operator.
摘要翻译：本发明涉及一种无线分配系统的认证方法，包括至少一个基站向基站的覆盖范围内的移动台提供接入服务。在认证方法中，未注册基站从移动台接收认证请求，通过无线分发系统多播用于识别移动台的身份请求，响应于身份请求从至少一个基站接收身份响应，以及基于身份响应来执行移动台的认证。本发明的分布式认证方法在没有AAA服务器的情况下进行，当安装新的基站或者隔离的基站被连接时，可以容易地扩展网络而不降低安全程度和额外的劳动操作人员的负担。

67. 发明申请

WO1997011713A1 LANTIBIOTIC MUTANTS AND CHIMERAS OF ENHANCED STABILITY AND ACTIVITY 审中-公开
标题翻译：生态脆弱性和增强稳定性和活性的CHIMERAS
公开(公告)号：WO1997011713A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015160
申请日：1996-09-30
申请人： THE UNIVERSITY OF MARYLAND COLLEGE PARK
发明人： THE UNIVERSITY OF MARYLAND COLLEGE PARK , HANSEN, J., Norman
IPC分类号： A61K35/74
CPC分类号： A21D2/267 , A23L3/3571 , A61K38/00 , C07K14/315 , C07K14/32 , C07K2319/00
摘要： Lantibiotics, such as nisin and subtilin, are peptides that are substantially modified post-translationally, such as by dehydration of serines and threonines and by formation of thioether crosslinkages. Lantibiotics are synthesized with a leader region that directs proper processing; this leader is specific both for the synthesizing organism and for the mature sequence. Chimeric lantibiotics were synthesized that contained the subtilin leader region and either a subtilin-nisin fusion or a nisin-subtilin fusion for the mature region. The nisin-subtilin chimera was efficiently processed into a functional lantibiotic, but the subtilin-nisin fusion produced a heterogeneous mixture of products, none of which had the expected properties of a correctly process polypeptide. This mixture contained a minor component with a specific activity exceeding that of nisin itself.
摘要翻译：羊抗生素如乳链菌肽和子链霉素是在翻译后基本上修饰的肽，例如通过丝氨酸和苏氨酸的脱水以及硫醚交联的形成。羊抗生素与引导适当处理的引导区合成; 这个领导者对于合成生物体和成熟序列都是特异的。合成嵌合羊毛硫抗生素，其含有子带蛋白前导区和成熟区的子生物肽 - 乳链菌肽融合或乳链菌肽 - 子素融合。乳链菌肽 - 子胶质嵌合体被有效地加工成功能性的羊毛硫抗生素，但是子链 - 乳链菌肽融合产生了产物的不均匀混合物，其中没有一个具有正确过程多肽的预期性质。该混合物含有特定活性超过乳链菌肽本身的次要成分。

68. 发明申请

WO1995006398A1 METHOD AND APPARATUS IMPARTING VIBRATIONS TO BONE 审中-公开
标题翻译：方法和装置将骨折植入骨骼
公开(公告)号：WO1995006398A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009409
申请日：1994-08-25
申请人： AUDIODONTICS, INC. , THE UNIVERSITY OF MARYLAND AT BALTIMORE
发明人： AUDIODONTICS, INC. , THE UNIVERSITY OF MARYLAND AT BALTIMORE , MERSKY, Barry, L. , THOMPSON, Van, P.
IPC分类号： H04R25/00
CPC分类号： H04R25/606
摘要： Vibrations for application to hard living tissue, such as bones, teeth, etc., are derived from a magnetorestrictive element (20) disposed in a varying electromagnetic field to create dimensional variations in the magnetorestrictive element (20). In an audiodontic vibrator for the hearing impaired, a magnetorestrictive rod (20) is disposed in the hollow core of an electromagnetic coil (17) through which current flows in response to acoustic signals. The resulting electromagnetic field in the core passes through the magnetorestrictive rod (20), causing small dimensional variations in the rod (20) corresponding to amplitude variations in the field. An actuator (31) in contact with the rod extends from the housing and transmits the dimensional changes as low amplitude vibrations to the hard tissue via a bracket (41) mounted on a tooth (40) by an adhesive resin-based cement. The bracket (41) has a receiving channel (43) contoured to slidably and removably receive the distal end (37) of the actuator (31) in close fitting frictional relation.
摘要翻译：用于施加到硬的生物体组织（例如骨骼，牙齿等）上的振动源自设置在变化的电磁场中的磁致伸缩元件（20），以产生磁致伸缩元件（20）中的尺寸变化。在用于听力受损的听觉振动器中，磁致伸缩杆（20）设置在电磁线圈（17）的空心芯中，电流响应于声信号而流过。芯中产生的电磁场通过磁致伸缩杆（20），导致对应于场中振幅变化的杆（20）的小的尺寸变化。与杆接触的致动器（31）从壳体延伸，并且通过基于粘合树脂的水泥通过安装在齿（40）上的支架（41）将尺寸变化作为低振幅振动传递到硬组织。支架（41）具有接合通道（43），其形状可滑动地和可拆卸地以紧密的摩擦关系接收致动器（31）的远端（37）。

69. 发明申请

WO1993013564A1 SUPERCONDUCTING FIELD EFFECT DEVICES AND METHODS OF THEIR FABRICATION 审中-公开
标题翻译：超导场效应器件及其制造方法
公开(公告)号：WO1993013564A1
公开(公告)日：1993-07-08
申请号：PCT/US1992010719
申请日：1992-12-16
申请人： THE UNIVERSITY OF MARYLAND AT COLLEGE PARK
发明人： THE UNIVERSITY OF MARYLAND AT COLLEGE PARK , XI, Xiaoxing , DOUGHTY, Chris , VENKATESAN, Thirumalai
IPC分类号： H01L39/22
CPC分类号： H01L39/146 , Y10S505/702
摘要： A superconducting field effect device includes a substrate (1) with an epitaxial superconducting film (3) upon it and an insulating layer (24) above a thinner region of the film which protects the film from the atmosphere and isolates it from a gate electrode (25) which is on the insulating layer above a channel region of the thin film, and the epitaxial film has thicker regions (2) suitable for contact to source and drain electrodes (4). Gate electrodes may be isolated from and oppose both sides of the superconducting thin regions so that enhanced modulation of a current in the thin region is provided. The invention provides high speed and high efficiency switches and modulators.

70. 发明申请

WO1992013265A1 METHOD AND APPARATUS FOR MULTI-DIMENSIONAL PHASE FLUORESCENCE LIFETIME IMAGING 审中-公开
标题翻译：多维相变荧光成像的方法与装置
公开(公告)号：WO1992013265A1
公开(公告)日：1992-08-06
申请号：PCT/US1992000242
申请日：1992-01-23
申请人： THE UNIVERSITY OF MARYLAND , NOWACZYK, Kazimierz , SZMACINSKI, Henryk , JOHNSON, Michael, L. , LAKOWICZ, Joseph, R. , BERNDT, Klaus, W.
发明人： THE UNIVERSITY OF MARYLAND , NOWACZYK, Kazimierz , SZMACINSKI, Henryk , JOHNSON, Michael, L.
IPC分类号： G01N21/64
CPC分类号： G01K11/20 , G01N15/1427 , G01N21/6408 , G01N21/6456 , G01N2015/144 , G01N2015/1454 , G01N2021/6439
摘要： A method and apparatus for detection and/or measurement of physical characteristics of a sample based on multi-dimensional phase-modulation fluorescence lifetime imaging using at least one fluorescent probe having known and/or variable fluorescent lifetimes.
摘要翻译：一种用于使用具有已知和/或可变荧光寿命的至少一个荧光探针，基于多维相位调制荧光寿命成像来检测和/或测量样品的物理特性的方法和装置。

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