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61. 发明申请

WO2004108716A1 3-ARYLSULFANYL AND 3-HETEROARYLSULFANYL SUBSTITUTED BENZO[B]THIOPHENES AS THERAPEUTIC AGENTS 审中-公开
标题翻译： 3-ARYLSULFANYL和3-HETEROARYLSULFANYL替代苯甲[B]噻吩类作为治疗剂
公开(公告)号：WO2004108716A1
公开(公告)日：2004-12-16
申请号：PCT/IB2004/001866
申请日：2004-05-24
申请人： WARNER-LAMBERT COMPANY LLC , GOGLIOTTI, Rocco, Dean , LEE, Helen, Tsenwhei , SEXTON, Karen, Elaine , VISNICK, Melean
发明人： GOGLIOTTI, Rocco, Dean , LEE, Helen, Tsenwhei , SEXTON, Karen, Elaine , VISNICK, Melean
IPC分类号： C07D409/12
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides benzo[b]thiophenes of Formula I wherein R 1 , R 2 , R 3 , and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
摘要翻译：本发明提供式I的苯并[b]噻吩，其中R 1，R 2，R 3和L具有在说明书中定义的任何值及其药学上可接受的盐，其是有用的作为治疗疾病和病症的药剂，包括炎性疾病，心血管疾病和癌症。还提供了包含一种或多种式I化合物的药物组合物。

62. 发明申请

WO2003060520A3 SAMPLE PREPARATION FOR THE DETECTION OF INFECTIOUS AGENTS 审中-公开
公开(公告)号：WO2003060520A3
公开(公告)日：2003-07-24
申请号：PCT/GB2002/005923
申请日：2002-12-24
申请人： LEE, Helen , HUANG, Ling , NADALA, Elpidio, Cesar, Jr. , BUTTRESS, Nigel, Derek
发明人： LEE, Helen , HUANG, Ling , NADALA, Elpidio, Cesar, Jr. , BUTTRESS, Nigel, Derek
IPC分类号： G01N33/571
摘要： Methods for improving the quality of sub-optimal patient samples for dectection of infectious agents are described. In particular, endocervical fluid samples or vaginal fluid samples are treated with DNase to improve the reliability of detection of infectious agents. Kits for carrying out the methods are also described.

63. 发明申请

WO2003018553A1 ORAL ANTIDIABETIC AGENTS 审中-公开
标题翻译：口服抗生素
公开(公告)号：WO2003018553A1
公开(公告)日：2003-03-06
申请号：PCT/IB2002/002843
申请日：2002-07-15
申请人： WARNER-LAMBERT COMPANY LLC , BIGGE, Christopher, Franklin , BRIDGES, Alexander, James , CASIMIRO-GARCIA, Agustin , FAKHOURY, Stephen, Alan , LEE, Helen, Tsenwhei , REED, Jessica, Elizabeth , SCHAUM, Robert, Philipp , SCHLOSSER, Kevin, Matthew , SEXTON, Karen, Elaine , ZHOU, Hairong
发明人： BIGGE, Christopher, Franklin , BRIDGES, Alexander, James , CASIMIRO-GARCIA, Agustin , FAKHOURY, Stephen, Alan , LEE, Helen, Tsenwhei , REED, Jessica, Elizabeth , SCHAUM, Robert, Philipp , SCHLOSSER, Kevin, Matthew , SEXTON, Karen, Elaine , ZHOU, Hairong
IPC分类号： C07D207/32
CPC分类号： C07D207/325 , C07D207/327 , C07D207/34 , C07D209/08 , C07D263/32 , C07D263/58 , C07D277/26 , C07D309/38 , C07D401/10 , C07D401/12 , C07D403/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention provides compounds of Formula (I): f I wherein A, X, Q, Y, B, D, Z, and E have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antidiabetic agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, process for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
摘要翻译：本发明提供式（I）的化合物：其中A，X，Q，Y，B，D，Z和E具有说明书中定义的任何值及其药学上可接受的盐，其可用作抗糖尿病药。还公开了包含一种或多种式I化合物，制备式I化合物的方法和可用于制备式I化合物的中间体的药物组合物。

64. 发明申请

WO0232931A3 HAPLOTYPES OF THE FOS GENE 审中-公开
标题翻译： FOS基因的快乐
公开(公告)号：WO0232931A3
公开(公告)日：2002-09-06
申请号：PCT/US0146142
申请日：2001-10-19
申请人： GENAISSANCE PHARMACEUTICALS , ANASTASIO ALISON E , KLIEM STEFANIE E , KOSHY BEENA , LEE HELEN H
发明人： ANASTASIO ALISON E , KLIEM STEFANIE E , KOSHY BEENA , LEE HELEN H
IPC分类号： C07K14/82 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/82 , A01K2217/05 , C12Q1/6886 , C12Q2600/156
摘要： Novel genetic variants of the V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog (FOS) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the FOS gene. Compositions and methods for haplotyping and/or genotyping the FOS gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
摘要翻译：描述了V-Fos FBJ小鼠骨肉瘤病毒基因同源物（FOS）基因的新型遗传变体。 FOS基因披露了一般美国人群中存在的各种基因型，单元型和单倍型对。还公开了个体中FOS基因的单倍型和/或基因分型的组合物和方法。还描述了由本文公开的单倍型定义的多核苷酸。

65. 发明申请

WO02053579A2 HAPLOTYPES OF THE FMO2 GENE 审中-公开
标题翻译： FMO2基因的快乐
公开(公告)号：WO02053579A2
公开(公告)日：2002-07-11
申请号：PCT/US0149059
申请日：2001-12-18
申请人： GENAISSANCE PHARMACEUTICALS , BENTIVEGNA STEVEN C , DUDA AMY , KAZEMI AMIR , LEE HELEN H , MESSER CHAD , PARKS KATIE E
发明人： BENTIVEGNA STEVEN C , DUDA AMY , KAZEMI AMIR , LEE HELEN H , MESSER CHAD , PARKS KATIE E
IPC分类号： C12N9/02 , C12N15/53 , C12Q1/68 , C07K
CPC分类号： C12N9/0071 , C12Q1/6876 , C12Q2600/156 , C12Y114/13008
摘要： Novel genetic variants of the Flavin Containing Monooxygenase 2 (FMO2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the FMO2 gene. Compositions and methods for haplotyping and/or genotyping the FMO2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
摘要翻译：描述了含有黄素加氧酶2（FMO2）基因的新型遗传变异体。对于FMO2基因，公开了存在于美国一般群体中的各种基因型，单元型和单倍型对。还公开了个体中FMO2基因的单倍型和/或基因分型的组合物和方法。还描述了由本文公开的单倍型定义的多核苷酸。

66. 发明申请

WO2002004667A3 IMPROVED DETECTION SIGNAL AND CAPTURE IN DIPSTICK ASSAYS 审中-公开
公开(公告)号：WO2002004667A3
公开(公告)日：2002-01-17
申请号：PCT/GB2001/003021
申请日：2001-07-06
申请人： LEE, Helen , DINEVA, Magda, Anastassova
发明人： LEE, Helen , DINEVA, Magda, Anastassova
IPC分类号： C12Q1/68
摘要： Improved dipstick assays for testing for the presence of a target nucleic acid in a sample solution are described. A dipstick is provided which comprises a contact end for contacting the sample solution and a capture zone remote from the contact end for capturing target nucleic acid. Sample solution is contacted with the contact end to cause sample solution to move by capillary action to the capture zone. Target nucleic acid in the sample solution is captured at the capture zone and is detected by a plurality of different labelled detection probes each capable of hybridising to a different region of the target nucleic acid. The detection signal is thereby enhanced. In other methods a plurality of different capture probes are added to the sample solution which can then be bound by a capture moiety at the capture zone to indirectly capture target nucleic acid. Capture of target nucleic acid is thereby improved. Kits and dipsticks for carrying out such methods are also described.

67. 发明申请

WO0204667A2 IMPROVED DETECTION SIGNAL AND CAPTURE IN DIPSTICK ASSAYS 审中-公开
标题翻译： DIPSTICK测试中改进的检测信号和捕获
公开(公告)号：WO0204667A2
公开(公告)日：2002-01-17
申请号：PCT/GB0103021
申请日：2001-07-06
申请人： LEE HELEN
发明人： LEE HELEN , DINEVA MAGDA ANASTASSOVA
IPC分类号： G01N33/53 , B01L3/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/543 , G01N33/569 , G01N33/571
CPC分类号： C12Q1/6818 , B01L3/5023 , C12Q1/6816 , C12Q2565/625
摘要： Improved dipstick assays for testing for the presence of a target nucleic acid in a sample solution are described. A dipstick is provided which comprises a contact end for contacting the sample solution and a capture zone remote from the contact end for capturing target nucleic acid. Sample solution is contacted with the contact end to cause sample solution to move by capillary action to the capture zone. Target nucleic acid in the sample solution is captured at the capture zone and is detected by a plurality of different labelled detection probes each capable of hybridising to a different region of the target nucleic acid. The detection signal is thereby enhanced. In other methods a plurality of different capture probes are added to the sample solution which can then be bound by a capture moiety at the capture zone to indirectly capture target nucleic acid. Capture of target nucleic acid is thereby improved. Kits and dipsticks for carrying out such methods are also described.
摘要翻译：描述了用于测试样品溶液中靶核酸存在的改进的测试片测定法。提供量油尺，其包括用于接触样品溶液的接触端和远离接触端的用于捕获靶核酸的捕获区。样品溶液与接触端接触，使样品溶液通过毛细管作用移动到捕获区。样品溶液中的靶核酸在捕获区被捕获并且被多个不同的标记的检测探针检测，每个标记的检测探针都能够与靶核酸的不同区域杂交。检测信号由此被增强。在其他方法中，将多个不同的捕获探针添加到样品溶液中，然后可以在捕获区域通过捕获部分结合以间接捕获目标核酸。靶核酸的捕获因此得到改善。还描述了执行这些方法的试剂盒和量规。

68. 发明申请

WO2008090340A3 NUCLEIC ACID AMPLIFICATION AND TESTING 审中-公开
标题翻译：核酸扩增和测试
公开(公告)号：WO2008090340A3
公开(公告)日：2009-01-08
申请号：PCT/GB2008000235
申请日：2008-01-23
申请人： DIAGNOSTICS FOR THE REAL WORLD , LEE HELEN HWAI-AN , DINEVA MAGDA ANASTASSOVA , FLETCHER-BROWN FIONA FRANCES S
发明人： LEE HELEN HWAI-AN , DINEVA MAGDA ANASTASSOVA , FLETCHER-BROWN FIONA FRANCES S
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6865
摘要： Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities or instruments. Compositions, lyophilised formulations, and kits for carrying out the methods are also described.
摘要翻译：描述了通过自持扩增方法扩增靶核酸的方法。这些方法特别设计在不使用专门的实验室设备或仪器的情况下进行。还描述了组合物，冻干制剂和用于实施方法的试剂盒。

69. 发明申请

WO2004108709A1 TETRAZOL BENZOFURANCARBOXAMIDES WITH P13K AKTIVITY AS THERAPEUTIC AGENTS 审中-公开
标题翻译：具有P13K稀释剂作为治疗剂的四氮唑苯并呋喃半胱氨酸
公开(公告)号：WO2004108709A1
公开(公告)日：2004-12-16
申请号：PCT/IB2004/001788
申请日：2004-05-24
申请人： WARNER-LAMBERT COMPANY LLC , GOGLIOTTI, Rocco, Dean , LEE, Helen, Tsenwhei , SEXTON, Karen, Elaine , VISNICK, Melean
发明人： GOGLIOTTI, Rocco, Dean , LEE, Helen, Tsenwhei , SEXTON, Karen, Elaine , VISNICK, Melean
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D405/14
摘要： The present invention provides benzofurans of Formula (I): wherein R 1 , R 2 , R 3 , and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).
摘要翻译：本发明提供式（I）的苯并呋喃：其中R 1，R 2，R 3和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗疾病和病症的药物，包括炎性疾病，心血管疾病和癌症。还提供了包含一种或多种式（I）化合物的药物组合物。

70. 发明申请

WO2004010873A1 LIQUID SAMPLER AND METHOD 审中-公开
标题翻译：液体取样器和方法
公开(公告)号：WO2004010873A1
公开(公告)日：2004-02-05
申请号：PCT/GB2003/003206
申请日：2003-07-25
申请人： LEE, Helen, Hwai-an , SMETHAM, Grant, Timothy, Lewis , STANKUS, Phillip, John , HAZLEWOOD, Shaun, Christopher , NADALA, Elipidio, Cesar, Braga , WISNIEWSKI, Craig, Alan
发明人： SMETHAM, Grant, Timothy, Lewis , STANKUS, Phillip, John , HAZLEWOOD, Shaun, Christopher , NADALA, Elipidio, Cesar, Braga , WISNIEWSKI, Craig, Alan
IPC分类号： A61B10/00
CPC分类号： A61B10/007
摘要： In a sampler for sampling a first portion of a liquid flow, the liquid flow enters at a sampler inlet (12). The sample passes through a valve (30) into a sample chamber (8) and then the valve closes, diverting the remainder of the liquid flow to a sampler overflow (6). The valve comprises a valve inlet (24) coupled to the sampler inlet, a valve outlet (38, 36) opening into the sample chamber and positioned, in use, substantially below the valve inlet, a shut-off chamber (32) separating the valve outlet from the valve inlet, and a valve overflow (34) leading from the shut-off chamber to the sampler overflow (6). When the liquid level in the sample chamber rises to a predetermined level it disrupts the flow of liquid through the valve outlet and diverts later flow through the valve inlet into the shut-off chamber and through the valve overflow.
摘要翻译：在用于对液体流的第一部分进行采样的采样器中，液体流进入采样器入口（12）。样品通过阀（30）进入样品室（8），然后阀关闭，将剩余的液体流转向采样器溢流（6）。所述阀包括联接到所述采样器入口的阀入口（24），阀入口（38,36），所述阀出口（38,36）通向所述样品室并且在使用中基本上位于所述阀入口的下方;隔离室（32）来自阀入口的阀出口和从关闭室引导到采样器溢流（6）的阀溢流（34）。当样品室中的液面上升到预定的水平时，它会破坏通过阀出口的液体流动，并且稍后将流过阀入口进入截流室并通过阀溢流。

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