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61. 发明授权

US08600494B2 Method and device for treating abnormal tissue growth with electrical therapy 有权
标题翻译：用电疗法治疗异常组织生长的方法和装置
公开(公告)号：US08600494B2
公开(公告)日：2013-12-03
申请号：US13226319
申请日：2011-09-06
申请人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
发明人： Edward A. Schroeppel , Mark W. Kroll , Kai Kroll
IPC分类号： A61N1/30
CPC分类号： A61N1/326 , A61K47/6957 , A61N1/205 , A61N1/30
摘要： This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various chemotherapeutic agent and radiation therapies are described which may be advantageously used in conjunction with electrical therapy to ameliorate cancer.
摘要翻译：本发明一般涉及通过向受影响的组织施加电压来恶性肿瘤和肿瘤的电处理。描述了其中的装置和各种适应性用于电疗法。另外，描述了可以有利地与电疗法一起使用以改善癌症的各种化学治疗剂和放射疗法。

62. 发明授权

US07720549B2 Partially implantable system for the electrical treatment of abnormal tissue growth 有权
标题翻译：部分可植入系统用于电处理异常组织生长
公开(公告)号：US07720549B2
公开(公告)日：2010-05-18
申请号：US10819641
申请日：2004-04-06
申请人： Edward A Schroeppel , Mark Kroll , Kai Kroll
发明人： Edward A Schroeppel , Mark Kroll , Kai Kroll
IPC分类号： A61N1/18
CPC分类号： A61N1/326
摘要： This present embodiment relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. Additionally, various ambulatory devices are described which advantageously increase versatility of the electrical therapy system. The ambulatory devices may include an internal and external power source and/or a first and second power source. The ambulatory devices may also include communication means for communicating between various portions of the device.
摘要翻译：本实施例一般涉及通过向受影响的组织施加电压来恶性肿瘤和赘生物的电处理。描述了其中的装置和各种适应性用于电疗法。另外，描述了有利地增加电疗系统的多功能性的各种移动装置。移动装置可以包括内部和外部电源和/或第一和第二电源。移动装置还可以包括用于在装置的各个部分之间进行通信的通信装置。

63. 发明申请

US20100049188A1 Non-Thermal Ablation System for Treating Tissue 有权
标题翻译：用于治疗组织的非热消融系统
公开(公告)号：US20100049188A1
公开(公告)日：2010-02-25
申请号：US12544134
申请日：2009-08-19
申请人： Tom A. Nelson , Kai Kroll , Benjamin R. Fruland , Michael C. Holtz , Stephen K. Sundquist
发明人： Tom A. Nelson , Kai Kroll , Benjamin R. Fruland , Michael C. Holtz , Stephen K. Sundquist
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/055 , A61B8/08 , A61B18/1206 , A61B18/16 , A61B18/1815 , A61B34/25 , A61B2018/00083 , A61B2018/00148 , A61B2018/0022 , A61B2018/00285 , A61B2018/00547 , A61B2018/00577 , A61B2018/00702 , A61B2018/00755 , A61B2018/00767 , A61B2018/00791 , A61B2018/00875 , A61B2018/00982 , A61B2018/00988 , A61B2018/1266 , A61B2018/143 , A61B2018/1467 , A61B2018/1475 , A61B2018/1861 , A61B2090/378 , A61B2218/002 , A61N1/36071
摘要： Systems and methods for non-thermal ablation of tissue are provided. A non-implantable minimally invasive system for treatment of tissue in a body via direct current ablation is provided including a catheter, a plurality of electrodes for deployment through the catheter, a power source for applying power to the electrodes, and a fixation element for maintaining the catheter in a treatment position during treatment of the tissue. A minimally invasive method for treating tissue in a body via direct current ablation is provided including inserting a catheter into the body such that a portion of the catheter remains outside of the body, deploying a fixation element to fix the catheter in a treatment position, deploying a plurality of electrodes through the catheter, applying power to the plurality of electrodes, using the electrodes to apply a current to the tissue, and removing the catheter from the body.
摘要翻译：提供了组织非热消融的系统和方法。提供一种用于通过直流消融来治疗身体中的组织的非植入式微创系统，包括导管，用于通过导管展开的多个电极，用于向电极施加电力的电源以及用于维持的固定元件导管在处理组织时处于治疗位置。提供了一种用于通过直流消融来治疗身体中的组织的微创方法，包括将导管插入体内，使得导管的一部分保持在身体外部，展开固定元件以将导管固定在治疗位置，部署通过导管的多个电极，向多个电极施加电力，使用电极向组织施加电流，以及从身体移除导管。

64. 发明申请

US20050222646A1 Method and device for treating cancer with modified output electrical therapy 审中-公开
标题翻译：用改良输出电疗法治疗癌症的方法和装置
公开(公告)号：US20050222646A1
公开(公告)日：2005-10-06
申请号：US10881375
申请日：2004-06-29
申请人： Kai Kroll , Edward Schroeppel , Mark Kroll
发明人： Kai Kroll , Edward Schroeppel , Mark Kroll
IPC分类号： A61N1/00 , A61N1/18 , A61N1/32
CPC分类号： A61N1/326
摘要： This invention relates generally to the electrical treatment of malignant tumors and neoplasms by applying a voltage to affected tissue. Devices and various adaptations therein are described for use in electrical therapy. In one embodiment, electrical therapy output is modified to deliver a duty cycle less than 100 percent.
摘要翻译：本发明一般涉及通过向受影响的组织施加电压来恶性肿瘤和肿瘤的电处理。描述了其中的装置和各种适应性用于电疗法。在一个实施例中，电疗治疗输出被修改以提供小于100％的占空比。

65. 发明授权

US06853859B1 Electrical cardiac output forcer 失效
标题翻译：电心输出量
公开(公告)号：US06853859B1
公开(公告)日：2005-02-08
申请号：US09693551
申请日：2000-10-20
申请人： Kai Kroll , Mark W. Kroll
发明人： Kai Kroll , Mark W. Kroll
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/3625 , A61N1/395
摘要： An electrical method and apparatus for stimulating cardiac cells causing contraction to force hemodynamic output during fibrillation, hemodynamically compromising tachycardia, or asystole. Forcing fields are applied to the heart to give cardiac output on an emergency basis until the arrhythmia ceases or other intervention takes place. The device is used as a stand alone external or internal device, or as a backup to an ICD, atrial defibrillator, or an anti-tachycardia pacemaker. The method and apparatus maintain some cardiac output and not necessarily defibrillation.
摘要翻译：用于刺激引起收缩的心脏细胞以促进原纤维化期间的血流动力学输出，血流动力学上抵消心动过速或心搏停止的电气方法和装置。强迫场应用于心脏以在紧急情况下产生心输出量，直到心律失常停止或其他干预发生。该设备用作独立的外部或内部设备，或作为ICD，心房除颤器或抗心动过速起搏器的备用。该方法和装置维持一些心输出量，而不一定除颤。

66. 发明授权

US06540662B2 Method and apparatus for reduced feedback in implantable hearing assistance systems 有权
标题翻译：在可植入式助听器系统中减少反馈的方法和装置
公开(公告)号：US06540662B2
公开(公告)日：2003-04-01
申请号：US09899594
申请日：2001-07-05
申请人： Kai Kroll , Donald J. Bushek , Scott C. Meyerson , Paul J. Urbanski
发明人： Kai Kroll , Donald J. Bushek , Scott C. Meyerson , Paul J. Urbanski
IPC分类号： H04R2500
CPC分类号： H04R25/456 , A61F2002/183 , H04R25/606
摘要： A method and apparatus assists a hearing impaired person by introducing and maintaining a mechanical feedback barrier between a microphone and a transducer of an implantable hearing assistance system. In this method, mechanical sound vibrations impinging on the person's body habitus are received with an electromechanical device (e.g. microphone) disposed at a body habitus sound reception site. The body habitus sound reception site can be located within the external auditory canal, or external of the external auditory canal either subdermally or external of the scalp. The mechanical sound vibrations are converted with the electromechanical device to an amplified electrical signal. Next, the amplified electrical signal is delivered to the inner ear with a transducer operatively coupled between the electromechanical device and the middle ear or the inner ear. Finally, a mechanical feedback barrier is introduced and maintained between the sound reception site and the transducer to in mimize acoustic feedback therebetween. Preferably, this feedback barrier is established by removing, separating, or fixing, or combinations thereof, a portion of the hearing impaired person's ossicular chain (e.g malleus, incus, or stapes).
摘要翻译：一种方法和装置通过在麦克风和可植入式助听器系统的换能器之间引入和维持机械反馈屏障来辅助听障人员。在该方法中，利用设置在身体习惯声音接收部位的机电装置（例如，麦克风）接收撞击身体习惯的机械声音振动。身体习惯声音接收部位可以位于外耳道内，也可以位于外耳道的外耳道外部。机械声振动被机电装置转换成放大的电信号。接下来，放大的电信号通过可操作地耦合在机电装置和中耳或内耳之间的换能器传送到内耳。最后，在声音接收位置和换能器之间引入并保持机械反馈屏障，以模仿它们之间的声反馈。优选地，该反馈屏障是通过去除，分离或固定或组合听觉受损者的小耳链（例如，马蹄骨，砧骨或镫骨）的一部分而建立的。

67. 发明授权

US06488616B1 Hearing aid transducer support 失效
标题翻译：助听器支持
公开(公告)号：US06488616B1
公开(公告)日：2002-12-03
申请号：US09551480
申请日：2000-04-18
申请人： Donald J. Bushek , Kai Kroll
发明人： Donald J. Bushek , Kai Kroll
IPC分类号： H04R2500
CPC分类号： H04R25/606 , A61F2/18 , A61F2002/183
摘要： A support for input and output transducers of a hearing aid is implanted in the middle ear. The support, which is attached to the mastoid bone, can be a single component or comprise two adjustable components. In one embodiment, an arm extends from the proximal end of the support towards an access hole created behind the outer ear, where the arm is attached for further stability. In another embodiment, the arm extends outside the access hole, where it is mounted subcutaneously to the mastoid bone with a mechanical fastener. The support provides positional adjustability, stability, and is invisible externally.
摘要翻译：支持助听器的输入和输出换能器植入中耳。附着于乳突骨的支撑体可以是单个部件或包括两个可调部件。在一个实施例中，臂从支撑件的近端延伸到在外耳后面形成的进入孔，其中臂被附接以进一步的稳定性。在另一个实施例中，臂延伸到进入孔的外部，在那里用机械紧固件皮下地安装到乳突骨。支持提供位置可调性，稳定性，并且在外部是不可见的。

68. 发明授权

US06342035B1 Hearing assistance device sensing otovibratory or otoacoustic emissions evoked by middle ear vibrations 失效
标题翻译：听力辅助装置可感测由中耳震动引起的耳鸣或耳声发射
公开(公告)号：US06342035B1
公开(公告)日：2002-01-29
申请号：US09499076
申请日：2000-02-04
申请人： Kai Kroll , Scott C. Meyerson
发明人： Kai Kroll , Scott C. Meyerson
IPC分类号： H04R2500
CPC分类号： H04R25/606 , A61N1/36036
摘要： A total middle ear implantable (T-MEI) or partial middle ear implantable (PMEI) hearing assistance system provides a transient middle ear mechanical vibration stimulus, and senses emissions from the cochlea. The sensed cochlear emissions include mechanical vibrations (“otovibratory emissions”) and sound pressure waves (“otoacoustic emissions”). Based on the sensed emissions, diagnostic information is provided to the physician at an external programmer, allowing easier positioning and coupling of an electrical-to-mechanical output transducer. Diagnosis of auditory system or hearing assistance system malfunctions is effectively implemented using the data communicated from the implantable hearing assistance device. Signal processing parameters are adjusted based on the sensed cochlear emissions for improved hearing assistance. Otovibratory emission sensing is likely more sensitive than otoacoustic emissions, providing improved audiometric screening data.
摘要翻译：全中耳植入式（T-MEI）或部分中耳可植入式（PMEI）助听系统提供暂时的中耳机械振动刺激，并感测耳蜗的排放。感测到的耳蜗发射包括机械振动（“振动发射”）和声压波（“耳声发射”）。基于所感测的发射，诊断信息在外部编程器上提供给医生，允许更容易地定位和耦合电 - 机械输出传感器。使用从可植入式助听器传送的数据有效地实现听觉系统或助听器系统故障的诊断。信号处理参数根据感测到的耳蜗发射进行调整，以改善助听器。振动发射感测可能比耳声发射更敏感，提供改进的听力测试数据。

69. 发明授权

US06315710B1 Hearing system with middle ear transducer mount 失效
标题翻译：听力系统带中耳传感器座
公开(公告)号：US06315710B1
公开(公告)日：2001-11-13
申请号：US08897851
申请日：1997-07-21
申请人： Donald J. Bushek , Kai Kroll , Scott C. Meyerson
发明人： Donald J. Bushek , Kai Kroll , Scott C. Meyerson
IPC分类号： H04R2500
CPC分类号： H04R25/606 , H04R2225/67
摘要： An improved partial middle ear implantable (P-MEI) or total middle ear implantable (T-MEI) hearing assistance system includes a device and method of providing between a vibrating auditory element and a transducer that senses or provides such mechanical vibrations adjustably positionable contact at a controllable, adjustable, or calibrated force. A screw adjusts a spacing between first and second members of the transducer mount to position the transducer and obtain the desired coupling force between the transducer and the auditory element. A spring provides an adjustable coupling force. A spacer limits further compression of the spring, providing additional force. A calibrated coupling force is obtained by compressing the spring by a known amount, such as by observing visual demarcations, or by reducing the spacing between the first and second members until the spacing is almost limited by the length of the spacer. Optimal ranges of forces for sensing malleus vibrations are disclosed.
摘要翻译：改进的部分中耳可植入（P-MEI）或全中耳植入式（T-MEI）助听系统包括在振动听觉元件和传感器之间提供的装置和方法，所述装置和方法可以感测或提供这样的机械振动，以可调节的位置接触一个可控的，可调节的或校准的力。螺钉调节换能器支架的第一和第二构件之间的间隔，以定位换能器并获得换能器和听觉元件之间所需的耦合力。弹簧提供可调节的联接力。间隔件限制弹簧的进一步压缩，提供额外的力。通过例如通过观察视野划分或通过减小第一和第二构件之间的间距来压缩弹簧获得校准的耦合力，直到间隔几乎被间隔物的长度限制为止。公开了用于感测锤形振动的最佳力量范围。

70. 发明授权

US06314319B1 Method and apparatus for temporarily electrically forcing cardiac output in a tachyarrhythmia patient 有权
标题翻译：用于暂时地迫使急性心律失常患者心输出量的方法和装置
公开(公告)号：US06314319B1
公开(公告)日：2001-11-06
申请号：US09251553
申请日：1999-02-17
申请人： Kai Kroll , Mark W. Kroll
发明人： Kai Kroll , Mark W. Kroll
IPC分类号： A61N139
CPC分类号： A61N1/3622 , A61N1/3625 , A61N1/3918 , A61N1/395 , A61N1/3962
摘要： An electrical method and apparatus for stimulating cardiac cells causing contraction to force hemodynamic output during fibrillation, hemodynamically compromising tachycardia, or asystole. Forcing fields are applied to the heart to give cardiac output on an emergency basis until the arrhythmia ceases or other intervention takes place. The device is used as a stand alone external or internal device, or as a backup to an ICD, atrial defibrillator, or an anti-tachycardia pacemaker. The method and apparatus maintain some cardiac output and not necessarily defibrillation.
摘要翻译：用于刺激引起收缩的心脏细胞以促进原纤维化期间的血流动力学输出，血流动力学上抵消心动过速或心搏停止的电气方法和装置。强迫场应用于心脏以在紧急情况下产生心输出量，直到心律失常停止或其他干预发生。该设备用作独立的外部或内部设备，或作为ICD，心房除颤器或抗心动过速起搏器的备用。该方法和装置维持一些心输出量，而不一定除颤。

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