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61. 发明授权

US5067492A Disposable airway adapter 失效
标题翻译：一次性气道适配器
公开(公告)号：US5067492A
公开(公告)日：1991-11-26
申请号：US564179
申请日：1990-08-07
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/08 , A61B5/083 , A61B5/097
CPC分类号： A61B5/0836 , A61B5/097
摘要： A disposable endotracheal airway adapter for use in proximity of a patient's mouth in the measurement of the concentraton of respiratory gases. The disposable airway adapter of the invention provides a conduit for patient respiratory gases and allows the passage of infrared radiation through the gases for measuring the constituent concentration of the respiratory gases while keeping the patient gases from coming in contact with the analyzer mechanism. The body of the airway adapter is designed to connect in series with the airway tubing which connects a patient to a mechanical respirator or anesthesia breathing circuit. The body of the airway adapter is very light in weight and is formed of inexpensive material such as polyethylene or polypropylene so that it may be manufactured inexpensively and discarded after each use. An inexpensive optical window in the adapter is also formed of material such as polyethylene or polypropylene so that the gas analyzer can pass light into the sample for analysis. Preferably, the optical windows of the invention are made of the same material as the adapter body. Since the adapter of the invention may be disposed of after use on a single patient, sterilization expenses and cross-contamination may be minimized. Also, calibrating integrity is maintained through a calibration process which accounts for the non-linearity of the absorption spectra of the window material in the region of interest.
摘要翻译：用于测量呼吸气体浓度的患者口腔附近的一次性气管插管气道适配器。本发明的一次性气道适配器提供用于患者呼吸气体的导管，并允许红外辐射通过气体，用于测量呼吸气体的组成浓度，同时保持患者气体不与分析器机构接触。气道适配器的主体设计成与将患者连接到机械呼吸器或麻醉呼吸回路的气道管串联连接。气道适配器的主体重量非常轻，并且由诸如聚乙烯或聚丙烯的廉价材料形成，使得可以在每次使用后廉价地制造和丢弃。适配器中的廉价的光学窗口也由诸如聚乙烯或聚丙烯的材料形成，使得气体分析仪可以将光通过样品进行分析。优选地，本发明的光学窗口由与适配器主体相同的材料制成。由于本发明的适配器可以在使用后在单个患者身上处理，因此可以使灭菌费用和交叉污染最小化。此外，校准完整性通过考虑到感兴趣区域中窗口材料的吸收光谱的非线性的校准过程来维持。

62. 发明授权

US4600412A Water separator 失效
标题翻译：水分离器
公开(公告)号：US4600412A
公开(公告)日：1986-07-15
申请号：US659097
申请日：1984-10-09
申请人： Max D. Liston , James R. Braig , Wayne Blackburn , Paul Hsei
发明人： Max D. Liston , James R. Braig , Wayne Blackburn , Paul Hsei
IPC分类号： G01N30/14 , B01D45/00
CPC分类号： G01N30/14
摘要： A water separator adapted for use in a gas monitor includes a gas inlet port, a gas outlet port, a two-stage gas/water separator section, and a fluid reservoir. The two-stage gas/water separator section includes a first portion defining a first chamber which communicates with the gas inlet and gas outlet ports via a connecting conduit, a second portion defining a second chamber which communicates with the first chamber and the fluid reservoir, and an intermediate portion interposed between the first and second portions and defining a constricted passage between the first and second chambers. The second chamber has a frusto-conical shape in longitudinal cross section.
摘要翻译：适用于气体监测器的水分离器包括气体入口，气体出口，两级气/水分离器部分和流体储存器。两级气/水分离器部分包括限定通过连接导管与气体入口和气体出口连通的第一腔室的第一部分，限定与第一腔室和流体容器连通的第二腔室的第二部分，以及介于所述第一和第二部分之间并且限定所述第一和第二腔室之间的收缩通道的中间部分。第二腔室具有纵截面的截头圆锥形状。

63. 发明授权

US4586026A Infrared gas analyzer using count quadrature sampling 失效
标题翻译：红外气体分析仪采用计数正交采样
公开(公告)号：US4586026A
公开(公告)日：1986-04-29
申请号：US549411
申请日：1983-11-07
申请人： James R. Braig , Max D. Liston
发明人： James R. Braig , Max D. Liston
IPC分类号： G01N21/25 , G01N21/35
CPC分类号： H03M1/48 , G01N21/256 , G01N21/3504
摘要： The percentage gas concentration within a sample as measured in a conventional optical bench is derived from the composite signal of the reference beam and sample beam transmitted through a sample cell in the optical bench. The primary source, which generates the reference beam and the secondary source which generates the sample beam are driven ninety degrees out of phase. The composite signal derived from the detector in the optical bench is digitized and then integrated according to the quadrature of the primary component of the composite signal derived from the reference beam, and is also integrated according to the quadrature of the secondary component of the composite signal derived from the sample beam. What is obtained is the integral of the absolute value of the secondary component and the integral of the absolute value of the primary component of the composite signal over one cycle of the reference beam and sample beam. The ratio of these component signals is computed to obtain a signal which is related to the percentage concentration of reference gas contained within the sample.
摘要翻译：在常规光学平台中测量的样品中的气体浓度百分比是从参考光束和通过光学平台中的样品池传输的样品光束的复合信号导出的。产生参考光束的主光源和产生采样光束的次光源相位驱动九十度。从光台上的检测器导出的复合信号被数字化，然后根据从参考光束导出的复合信号的主分量的正交积分，并且还根据复合信号的次分量的正交积分源自样品束。获得的是二次分量的绝对值的积分和复合信号的主要分量的绝对值的积分在参考光束和样本光束的一个周期上。计算这些分量信号的比率以获得与样品中包含的参考气体的浓度百分比相关的信号。

64. 发明授权

US09561001B2 Fluid handling cassette system for body fluid analyzer 有权
标题翻译：流体处理盒系统用于体液分析仪
公开(公告)号：US09561001B2
公开(公告)日：2017-02-07
申请号：US12986112
申请日：2011-01-06
申请人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
发明人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
IPC分类号： G01N33/50 , A61B5/157
CPC分类号： A61B5/157 , G01N33/50
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
摘要翻译：用于体液分析的流体处理系统。该系统包括被配置为与主仪器接口的第一流体处理模块。第一流体处理模块具有第一流体处理网络，并且第一流体处理网络包括适于在输注通道内移动流体的输注通道和输液流体压力构件。流体处理系统还具有与第一模块分离的第二流体处理模块，第一模块被配置为与主仪器相接触。第二流体处理模块具有第二流体处理网络和可经由第二流体处理网络访问的至少一个样品分析单元。第一和第二模块被配置为在第一和第二流体处理网络和样品池之间互连并提供流体连通。

65. 发明授权

US09091676B2 Systems and methods for measuring multiple analytes in a sample 有权
标题翻译：用于测量样品中多种分析物的系统和方法
公开(公告)号：US09091676B2
公开(公告)日：2015-07-28
申请号：US13156295
申请日：2011-06-08
申请人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
IPC分类号： G01N33/49 , A61B5/155 , A61B5/145 , A61B5/1455 , A61B5/1495 , A61B5/15 , A61B5/153 , A61B5/00 , G01N21/31 , G01N21/35
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
摘要翻译：提供了用于分析流体样品的多个组分的系统和方法。在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分的样品分离后。

66. 发明授权

US08786838B2 Analyte monitoring systems and methods 有权
标题翻译：分析物监测系统和方法
公开(公告)号：US08786838B2
公开(公告)日：2014-07-22
申请号：US13423029
申请日：2012-03-16
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.
摘要翻译：能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。全血系统还具有光束的光路中的检测器。全血系统还具有容纳源和检测器的壳体。全血系统还具有位于束的光路中的样品元件。样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

67. 发明授权

US08449524B2 Fluid component analysis systems and methods for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US08449524B2
公开(公告)日：2013-05-28
申请号：US13174610
申请日：2011-06-30
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/168
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

68. 发明授权

US08251907B2 System and method for determining a treatment dose for a patient 有权
标题翻译：用于确定患者治疗剂量的系统和方法
公开(公告)号：US08251907B2
公开(公告)日：2012-08-28
申请号：US12702196
申请日：2010-02-08
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
IPC分类号： A61B5/00 , A61B5/05 , C12M1/34 , C12M3/00 , C12M1/36 , C12M1/00
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00 , G06F19/3468 , G16H10/40 , G16H20/17
摘要： In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
摘要翻译：在某些实施例中，维持患者健康的方法使用分析物检测系统。分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

69. 发明授权

US07872734B2 In vitro determination of analyte levels within body fluids 有权
公开(公告)号：US07872734B2
公开(公告)日：2011-01-18
申请号：US12815372
申请日：2010-06-14
申请人： James R. Braig , Peter Rule , Phillip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Phillip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： G01N33/48
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

70. 发明授权

US07860543B2 Analyte detection system with reduced sample volume 有权
标题翻译：分析物检测系统，样品量减少
公开(公告)号：US07860543B2
公开(公告)日：2010-12-28
申请号：US11504139
申请日：2006-08-15
申请人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
发明人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要翻译：在某些实施方案中，方法对患者的体液进行取样。该方法包括提供具有一个或多个流体通道的流体处理系统。该方法还包括通过流体处理系统通过一个或多个流体通道将输注液输入患者体内。该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。所得样品的体积不超过5毫升。该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

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