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    • 64. 发明申请
    • SECRETORY GRANULES AND GRANULOGENIC FACTORS AS A TARGET FOR CANCER TREATMENT
    • 作为癌症治疗目标的秘密颗粒和造血因子
    • WO2010147274A1
    • 2010-12-23
    • PCT/KR2009/007274
    • 2009-12-07
    • INHA-INDUSTRY PARTNERSHIP INSTITUTEYOO, Seung HyunHUR, Yong Suk
    • YOO, Seung HyunHUR, Yong Suk
    • G01N33/50A61P35/00A61K31/7088
    • G01N33/74G01N33/57407G01N2333/475
    • The present invention relates to a method for screening a cancer therapeutic agent, comprising the steps of: (a) contacting a test substance of interest with a cell containing a granulogenic factor-encoding nucleotide sequence; and (b) analyzing expression of the granulogenic factor or production of secretory granules, wherein the test substance is determined as the cancer therapeutic agent where it inhibits the expression of the granulogenic factor or the production of secretory granules. In the present invention, the expression of the granulogenic factor contributes to induction of secretory granule formation in non-secretory cells, and inhibition of the granulogenic factor expression leads to inhibition of secretory granule formation in secretory cells. In addition, the secretory granules produced by the present granulogenic factor change cell activities via the IP3-dependent cellular Ca2+ regulatory mechanism, and the changes of cellular Ca2+ homeostasis will affect the development and proliferation of cancer cells. Therefore, a pharmaceutical composition containing as an active ingredient a substance which inhibits expression of a granulogenic factor gene, production of secretory granules, or activity of the granulogenic factor may be utilized in cancer prophylaxis or treatment, and also be used as a kit for identifying a cancer.
    • 本发明涉及一种筛选癌症治疗剂的方法,包括以下步骤:(a)使目标物质与含有造粒因子编码核苷酸序列的细胞接触; 和(b)分析造粒因子的表达或分泌颗粒的产生,其中测试物质被确定为其抑制造粒因子的表达或分泌颗粒的产生的癌症治疗剂。 在本发明中,造粒因子的表达有助于非分泌细胞中分泌颗粒形成的诱导,并且造粒因子表达的抑制导致分泌细胞中分泌颗粒形成的抑制。 另外,本发明造粒因子产生的分泌颗粒通过IP3依赖性细胞Ca2 +调节机制改变细胞活性,并且细胞Ca2 +体内平衡的变化将影响癌细胞的发育和增殖。 因此,作为活性成分含有抑制造粒因子基因表达的物质,分泌颗粒的产生或造粒因子的活性的药物组合物,可以用于癌症预防或治疗,也可以用作鉴定用试剂盒 一个癌症。
    • 66. 发明申请
    • SYSTEM AND METHOD FOR RECOGNIZING IMAGES USING T-TEST
    • 使用T检验识别图像的系统和方法
    • WO2008147039A1
    • 2008-12-04
    • PCT/KR2008/001665
    • 2008-03-25
    • INHA-INDUSTRY PARTNERSHIP INSTITUTERHEE, Phill KyuNAM, Mi Young
    • RHEE, Phill KyuNAM, Mi Young
    • G06K9/62
    • G06K9/00288G06K9/6292
    • Disclosed herein is a system and method for recognizing images using t-tests. The system includes an image recognition module, an image normalization module, an image pre-processing module, an image situation classification module, an image situation recognition module, and a recognizer fusion module. The image recognition module loads face images. The image normalization module normalizes the loaded face images. The image pre-processing module removes noise from the normalized face images and generates vector data. The image situation classification module classifies image situations into a user-specified number of types through clustering using a K-average clustering method. The image situation recognition module calculates the average values of the classified image situations based on the image situations and center points using the Euclidean distance formula, and recognizes the image situations. The recognizer fusion module selects recognizers suitable for the individual image situations through classification of the recognizers using t-tests based on the recognized image situations.
    • 本文公开了一种使用t检验识别图像的系统和方法。 该系统包括图像识别模块,图像归一化模块,图像预处理模块,图像状况分类模块,图像状况识别模块和识别器融合模块。 图像识别模块加载脸部图像。 图像归一化模块对加载的脸部图像进行归一化。 图像预处理模块从归一化的脸部图像中去除噪声并产生矢量数据。 图像状态分类模块使用K-average聚类方法通过聚类将图像情境分类为用户指定数量的类型。 图像状态识别模块使用欧几里得距离公式,根据图像情境和中心点计算分类图像情况的平均值,并识别图像情况。 识别器融合模块通过使用基于识别的图像情况的t检验对识别器进行分类来选择适合于各个图像情况的识别器。
    • 69. 发明申请
    • PHOTOBIOREACTOR FOR LARGE-SCALE CULTURE OF MICROALGAL
    • 微波炉大规模文化光电子器件
    • WO2009069967A2
    • 2009-06-04
    • PCT/KR2008/007046
    • 2008-11-28
    • INHA-INDUSTRY PARTNERSHIP INSTITUTEKIM, Z-HunLEE, Choul-Gyun
    • LEE, Choul-Gyun
    • C12M3/00C12M1/18C12M1/00
    • C12M31/10C12M21/02C12M27/20
    • A photobioreactor for a large-scale microalgal culture. The photobioreactor includes a plurality of surface-light- source assemblies using a light emitting diode (LED) element, an organic light emitting diode (OLED) element, or a flexible LED sheet as a light source. The surface-light-source assemblies have the shape of a flat plate or a cylinder, are installed at predetermined intervals in the interior space of a reaction tank having the shape of a cube or a cylinder, and emit light for culturing microalgae in an internally illuminated fashion. Here, the surface-light-source assemblies are installed in such a manner that they are alternately in contact with first and second walls of the reaction tank disposed in parallel to each other in a symmetrical shape, and serve as partitions that portion the interior space of the reaction tank and increase a flow distance of gas.
    • 用于大规模微藻培养的光生物反应器。 光生物反应器包括使用发光二极管(LED)元件,有机发光二极管(OLED)元件或柔性LED片作为光源的多个表面光源组件。 表面光源组件具有平板或圆柱体的形状,以预定间隔安装在具有立方体或圆筒形状的反应罐的内部空间中,并且在内部发射微光以培养微藻 照亮时尚。 这里,表面光源组件以这样的方式安装,使得它们以对称的形状交替地与反应罐的彼此平行地设置的第一和第二壁接触,并且用作将内部空间 并增加气体的流动距离。