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61. 发明申请

WO2010039615A3 Papio cynocephalus toll-like receptor 3 审中-公开
标题翻译： BABOUIN PAPIO CYNOCEPHALUS型TOLL-3接收器
公开(公告)号：WO2010039615A3
公开(公告)日：2010-06-10
申请号：PCT/US2009058430
申请日：2009-09-25
申请人： CENTOCOR ORTHO BIOTECH INC , JORDAN JARRAT , SCHREITER JESSICA , SWENCKI-UNDERWOOD BETHANY
发明人： JORDAN JARRAT , SCHREITER JESSICA , SWENCKI-UNDERWOOD BETHANY
IPC分类号： C07H21/04 , C12N5/00
CPC分类号： G01N33/5088 , C07K14/705 , C07K16/2896 , G01N33/566 , G01N2333/46 , G01N2500/10
摘要： Isolated polynucleotides encoding Papio cynocephalus Toll- Like Receptor 3 (Baboon TLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.
摘要翻译：本发明涉及编码所述Toll样受体3狒狒狒狒cynocephalus（狒狒TLR3）分离的多核苷酸，由这些多核苷酸，重组细胞，和使用方法的表达衍生的多肽。

62. 发明申请

WO2010051213A1 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE 审中-公开
标题翻译：人胚胎干细胞对胰腺内皮细胞系的分化
公开(公告)号：WO2010051213A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/061635
申请日：2009-10-22
申请人： CENTOCOR ORTHO BIOTECH INC. , REZANIA, Alireza
发明人： REZANIA, Alireza
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , C12N2501/115 , C12N2501/117 , C12N2501/155 , C12N2501/16 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2501/998 , C12N2506/02
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage using a TEF_beta receptor agonist such as activin A, activin B, activin C, GDF_8, GDF_11 or GDF_15.
摘要翻译：本发明提供促进多能干细胞分化的方法。特别地，本发明提供了使用TEFβeta受体激动剂如激活素A，激活素B，激活素C，GDF_8，GDF_11或GDF_15来增加与胰腺内分泌谱系相关的标志物的表达的方法。

63. 发明申请

WO2010044952A2 BIOMARKERS FOR ANTI-TNF TREATMENT IN ULCERATIVE COLITIS AND RELATED DISORDERS 审中-公开
标题翻译：生物标记物在抗精神病药物治疗和相关疾病中的作用
公开(公告)号：WO2010044952A2
公开(公告)日：2010-04-22
申请号：PCT/US2009054287
申请日：2009-08-19
申请人： CENTOCOR ORTHO BIOTECH INC , LI KATHERINE , BARIBAUD FREDERIC
发明人： LI KATHERINE , BARIBAUD FREDERIC
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Methods and kits are provided for the assessment of the suitability of and/or effectiveness of a target therapy for a TNF mediated-related disorder, such as ulcerative colitis, in a subject, which methods and kits evaluate the presence, absence, and/or magnitude of expression of two or more genes up or down regulated in association with anti-TNF responders in inflammatory gastrointestinal disorders, such as ulcerative colitis, with at least two genes including BCL6 (Genbank Ace. No. AW264036; SEQ K) NO:118) and tx82aO4.x1 (Genbank Acc. No. AI689210; SEQ ID NO:123), optionally further comprising at least one to three of C5AR1 ((Genbank Acc. No.NM001736; SEQ ID NO:119), FOLR1 ((Genbank Acc. No. U81501; SEQ ID NO:142) and OSM (Genbank Acc. No. A1079327; SEQ ID NO:173), optionally further comprising at least one of the listed genes presented in Figure 7 with a therapeutic response to at least one anti-TNFa agents (e.g., infliximab, golimumab, Enbrel , Humira , or other anti-TNF biologic or small molecule drug), in subjects with ulcerative colitis or other gastrointestinal disorder, such as but not limited to Crohn's disease, inflammatory bowel disorder and the like, including mild, moderate, severe, pediatric or adult forms, as well as other forms such as but not limited to steroid, methotrexate or NSAID resistant forms.
摘要翻译：提供了方法和试剂盒，用于评估受试者中TNF介导相关病症（例如溃疡性结肠炎）的靶向治疗的适用性和/或有效性，该方法和试剂盒评估存在，不存在和/或与炎症性胃肠道疾病如溃疡性结肠炎中的至少两种基因（Genbank Ace.No.AW264036; SEQK）NO：118相关联的上调或下调两个或更多个基因的表达量的大小）和tx82aO4.x1（Genbank Acc。编号AI689210; SEQ ID NO：123），任选地还包含至少一个至三个C5AR1（（Genbank Acc.No001736; SEQ ID NO：119）），FOLR1（（Genbank （SEQ ID NO：142）和OSM（Genbank Acc.No.A1079327; SEQ ID NO：173），任选地还包含至少一个列于图7中的列出的基因，至少具有至少一种抗TNFa剂（例如，英夫利昔单抗，戈利木单抗，恩贝雷尔，Humira或其它抗TNF生物学或小分子药物），在具有溃疡性结肠炎或其他胃肠道疾病的受试者中，例如但不限于克罗恩病，炎症性肠病等，包括轻度，中度，重度，儿科或成人形式，以及其他形式，例如但不限于类固醇，甲氨蝶呤或NSAID抗性形式。

64. 发明申请

WO2009105570A3 METHODS, SURFACE MODIFIED PLATES AND COMPOSITIONS FOR CELL ATTACHMENT, CULTIVATION AND DETACHMENT 审中-公开
标题翻译：方法，表面改性片和细胞连接，培养和分离的组合物
公开(公告)号：WO2009105570A3
公开(公告)日：2010-04-15
申请号：PCT/US2009034558
申请日：2009-02-19
申请人： CENTOCOR ORTHO BIOTECH INC , FRYER BENJAMIN , NELSON SHELLEY , NIELSEN VILLY , BREVIG THOMAS , MARWOOD TINA KRISTENSEN
发明人： FRYER BENJAMIN , NELSON SHELLEY , NIELSEN VILLY , BREVIG THOMAS , MARWOOD TINA KRISTENSEN
IPC分类号： C12N5/07 , C12N5/0735
CPC分类号： C12N5/0606 , C12N2501/70 , C12N2509/00 , C12N2533/00
摘要： The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity.
摘要翻译：本发明涉及哺乳动物细胞培养领域，并提供用于细胞附着，培养和固定基质表面的方法和组合物，所述固体基质表面含有至少约0.5％的N，O和N的总和大于或等于等于17.2％，接触角至少约13.9度，缺少饲养细胞层，缺少粘附层。在本发明的一个实施方案中，用能够抑制Rho激酶活性的化合物处理细胞。在另一个实施方案中，用能够抑制Rho活性的化合物处理细胞。

65. 发明申请

WO2010002846A1 DIFFERENTIATION OF PLURIPOTENT STEM CELLS 审中-公开
标题翻译：多发性干细胞的分化
公开(公告)号：WO2010002846A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049183
申请日：2009-06-30
申请人： CENTOCOR ORTHO BIOTECH INC. , LIU, Jia, Jian , DAVIS, Janet , PARMENTER, Christine , BONNET, Pasale
发明人： LIU, Jia, Jian , DAVIS, Janet , PARMENTER, Christine , BONNET, Pasale
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N5/0678 , C12N2501/11 , C12N2501/119 , C12N2501/135 , C12N2501/16 , C12N2501/165 , C12N2501/19 , C12N2501/999 , C12N2506/02
摘要： The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
摘要翻译：本发明涉及分化多能干细胞的方法。特别地，本发明涉及将多能干细胞分化成表达定形内胚层谱系特征性标志物的细胞的方法和组合物，其包括在含有足够数量的GDF-8的培养基中培养多能干细胞以引起多能分化干细胞进入表达定形内胚层谱系特征标志物的细胞。

66. 发明申请

WO2009132068A3 TREATMENT OF PLURIPOTENT CELLS 审中-公开
标题翻译：治疗多功能细胞
公开(公告)号：WO2009132068A3
公开(公告)日：2009-12-17
申请号：PCT/US2009041356
申请日：2009-04-22
申请人： CENTOCOR ORTHO BIOTECH INC , DAVIS JANET E , LIU JIAJIAN
发明人： DAVIS JANET E , LIU JIAJIAN
IPC分类号： C12N5/0735
CPC分类号： C12N5/0676 , A61K31/00 , C12N5/0606 , C12N2501/105 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/415 , C12N2501/48 , C12N2501/70 , C12N2506/00 , C12N2506/02
摘要： The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.
摘要翻译：本发明涉及治疗多能细胞的方法，其中多能细胞可以在培养中有效地扩增并通过用GSK-3B酶活性抑制剂处理多能细胞来分化。

67. 发明申请

WO2009132063A2 PLURIPOTENT CELLS 审中-公开
标题翻译： PLUIPOTENT细胞
公开(公告)号：WO2009132063A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/041348
申请日：2009-04-22
申请人： CENTOCOR ORTHO BIOTECH INC. , REZANIA, Alireza
发明人： REZANIA, Alireza
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2500/02 , C12N2501/105 , C12N2501/16 , C12N2501/415 , C12N2501/70 , C12N2533/90
摘要： The present invention is directed to pluripotent cells that can be readily expanded in culture on tissue culture substrate that is not pre-treated with protein or an extracellular matrix, and do not require a feeder cell line. The present invention also provides methods to derive the pluripotent cell line from human embryonic stem cells.
摘要翻译：本发明涉及能够在不用蛋白质或细胞外基质预处理并且不需要饲养细胞系的组织培养基质上容易地在培养物中扩增的多能细胞。本发明还提供了从人胚胎干细胞衍生多能细胞系的方法。

68. 发明申请

WO2009105570A2 METHODS, SURFACE MODIFIED PLATES AND COMPOSITIONS FOR CELL ATTACHMENT, CULTIVATION AND DETACHMENT 审中-公开
标题翻译：方法，表面改性片和细胞连接，培养和分离的组合物
公开(公告)号：WO2009105570A2
公开(公告)日：2009-08-27
申请号：PCT/US2009/034558
申请日：2009-02-19
申请人： CENTOCOR ORTHO BIOTECH INC. , FRYER, Benjamin , NELSON, Shelley , NIELSEN, Villy , BREVIG, Thomas , MARWOOD, Tina, Kristensen
发明人： FRYER, Benjamin , NELSON, Shelley , NIELSEN, Villy , BREVIG, Thomas , MARWOOD, Tina, Kristensen
IPC分类号： C12N5/06
CPC分类号： C12N5/0606 , C12N2501/70 , C12N2509/00 , C12N2533/00
摘要： The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and a contact angle of at least about 13.9 degrees, lacking a feeder cell layer and lacking an adlayer. In one embodiment of the present invention, the cells are treated with a compound capable of inhibiting Rho kinase activity. In another embodiment, the cells are treated with a compound capable of inhibiting Rho activity.
摘要翻译：本发明涉及哺乳动物细胞培养领域，并提供用于细胞附着，培养和固定基质表面的方法和组合物，所述固体基质表面含有至少约0.5％的N，O和N的总和大于或等于等于17.2％，接触角至少约13.9度，缺少饲养细胞层，缺少粘附层。在本发明的一个实施方案中，用能够抑制Rho激酶活性的化合物处理细胞。在另一个实施方案中，用能够抑制Rho活性的化合物处理细胞。

69. 发明申请

WO2011143299A3 DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：人类胚胎干细胞的分化
公开(公告)号：WO2011143299A3
公开(公告)日：2012-03-01
申请号：PCT/US2011036043
申请日：2011-05-11
申请人： CENTOCOR ORTHO BIOTECH INC , XU JEAN
发明人： XU JEAN
IPC分类号： C12N5/071 , C07K14/47 , C07K14/50 , C12N5/02 , C12N5/0735 , C12Q1/68
CPC分类号： C12N5/0678 , A61K35/12 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/727 , C12N2501/998 , C12N2506/02
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
摘要翻译：本发明提供促进多能干细胞分化成胰岛素生成细胞的方法。特别地，本发明提供了一种产生表达胰腺内胚层谱系特征性标志物的细胞群的方法，其中大于50％的群体中的细胞共表达PDX1和NKX6.1。

70. 发明申请

WO2011130533A1 ENGINEERED PLANT CYSTEINE PROTEASES AND THEIR USES 审中-公开
标题翻译：工程植物CYSTEINE PROTEASES及其用途
公开(公告)号：WO2011130533A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032526
申请日：2011-04-14
申请人： CENTOCOR ORTHO BIOTECH INC. , CHI, Ellen , HUNTER, Michael , SWANSON, Ronald
发明人： CHI, Ellen , HUNTER, Michael , SWANSON, Ronald
IPC分类号： C07K14/08 , C12N9/50 , C12N15/37
CPC分类号： C12N9/506 , C07K14/005 , C12N2770/34022
摘要： The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
摘要翻译：本发明涉及马铃薯病毒NIa蛋白酶变体或其片段，编码它们的多核苷酸，以及制备和使用上述物质的方法。

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