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61. 发明专利

AU2003260068A1 VAPOR PHASE METHOD FOR PRODUCING SILANE COATINGS 未知
公开(公告)号：AU2003260068A1
公开(公告)日：2004-05-04
申请号：AU2003260068
申请日：2003-08-21
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： HANZEL DAVID K
IPC分类号： B05D7/24 , C09D143/00 , G01N27/447

62. 发明专利

AU2003276975A1 HIGH DENSITY FLUIDIC CHIP DESIGN AND METHOD OF SAMPLE INJECTION 未知
公开(公告)号：AU2003276975A1
公开(公告)日：2004-04-19
申请号：AU2003276975
申请日：2003-09-25
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： BLAGA IULIU-IOAN , NI JING , NIELSEN WILLIAM D
IPC分类号： G01N27/447
摘要： The present invention discloses a high-density parallel channel design for a microfabricated capillary array electrophoresis chip, with vertical T or double T design for sample injection. An alternative embodiment of the invention includes a closed buffer reservoirs with integrated electrodes and buffer feeding ports. Also disclosed are novel sample loading and injection methods, including the use of using either a capillary array connected to an electrode, or an array of metal pens as the loader/electrode.

63. 发明专利

CA2482338A1 MULTIPLEXED CAPILLARY ELECTROPHORESIS SYSTEMS 未知
公开(公告)号：CA2482338A1
公开(公告)日：2003-10-23
申请号：CA2482338
申请日：2003-04-14
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： BURGI DEAN , DOLNIK VLADISLAV , ARMSTRONG THOMAS M , OLSON NELS A , JOVANOVICH STEVAN BOGDAN , HUTTERER KATARIINA MARIA
IPC分类号： G01N21/64 , G01N27/447 , G01N27/453 , G01N30/46 , G02B21/00
摘要： Multi-capillary systems for high-throughput electrophoretic separation and detection of biomolecules are disclosed. One embodiment of the invention use s galactomannans as a size-sieving matrix for multi-channel electrophoretic separations of biomolecules. Multi-color detection for the simultaneous analysis of controls and standards in the same channels as the samples, and endogenous fluorescence detection are also disclosed (Figure 6B). Another embodiment of the invention is a two dimensional system for separation of complex samples, using multiplexed capillary electrophoresis system as the second dimension, with a fraction collection step connecting the two separation steps. The systems allow for separations to be accomplished with a highly parallel manner, or in a two-dimensional format.

64. 发明专利

AU2002366631A1 HUMAN PROSTATE CANCER CANDIDATE PROTEIN 1 未知
公开(公告)号：AU2002366631A1
公开(公告)日：2003-06-23
申请号：AU2002366631
申请日：2002-11-22
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： GUO JINJIAO
IPC分类号： C07K14/47 , C12N15/12 , G01N33/53 , A61K38/17 , A61K39/00 , C12N15/09 , C12N15/63 , C12N5/10 , C07K16/18 , C12Q1/68 , G01N33/48
摘要： The invention provides isolated nucleic acids that encode prostate cancer candidate protein 1 (PCCP1), and fragments thereof, vectors for propagating and expressing PCCP1 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel PCCP1 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human PCCP1 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human PCCP1 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the PCCP1 nucleic acids, proteins, and antibodies of the present invention.

65. 发明专利

DE69728572D1 未知
公开(公告)号：DE69728572D1
公开(公告)日：2004-05-13
申请号：DE69728572
申请日：1997-09-12
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： KAIN C
IPC分类号： G01N21/64 , G01N21/27 , G02B21/02 , G02B21/36 , G01N21/00 , G01N21/55 , G02B21/00
摘要： The present invention features two flat-field, telecentric, infinite conjugate, achromatic objectives each of which has an external pupil lying in a common plane located equidistant from the two objectives, defining a mechanically accessible central pupil of an imaging system centered in the common plane. Each of the objectives are afocal in the common plane, with one of the lenses forming a focal plane proximate to a sample. The lenses are adapted to provide varying levels of magnification while keeping constant the number of resolvable points in the field of view. An array detector is positioned proximate to a focal plane formed of the remaining objective lens. The double objective lens assembly is described as being included in transillumination and epi-illumination systems.

66. 发明专利

AU2003276975A8 High density fluidic chip design and method of sample injection 未知
公开(公告)号：AU2003276975A8
公开(公告)日：2004-04-19
申请号：AU2003276975
申请日：2003-09-25
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： NI JING , NIELSEN WILLIAM D , BLAGA IULIU-IOAN
IPC分类号： G01N27/447 , G01N27/453
摘要： The present invention discloses a high-density parallel channel design for a microfabricated capillary array electrophoresis chip, with vertical T or double T design for sample injection. An alternative embodiment of the invention includes a closed buffer reservoirs with integrated electrodes and buffer feeding ports. Also disclosed are novel sample loading and injection methods, including the use of using either a capillary array connected to an electrode, or an array of metal pens as the loader/electrode.

67. 发明专利

AU2003276973A8 Detection methods 未知
公开(公告)号：AU2003276973A8
公开(公告)日：2004-04-19
申请号：AU2003276973
申请日：2003-09-25
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： LOUKOLA ANU-MARIA , HANZEL DAVID KAGEN , WITTE JOHN S , PENN SHARRON GAYNOR , RANK DAVID RUSSELL , CASEY GRAHAM
IPC分类号： C07H21/04 , A61B20060101 , A61B1/00 , C07K16/00 , C12M1/34 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/00 , C12Q1/68 , G01N33/53 , G01N33/574
摘要： The present invention relates to the prognosis, diagnosis and treatment of cancer, particularly prostate cancer. Polynucleotides having single nucleotide polymorphisms (SNPs) and haplotypes are provided which are of utility in the prognosis, diagnosis, prophylaxis and treatment of prostate and breast cancer.

68. 发明专利

AU2003217369A1 METHOD AND APPARATUS FOR PERFORMING SUBMICROLITER REACTIONS WITH NUCLEIC ACIDS OR PROTEINS 未知
公开(公告)号：AU2003217369A1
公开(公告)日：2003-09-02
申请号：AU2003217369
申请日：2003-02-07
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： JOVANOVICH STEVAN BOGDAN , SALAS-SOLANO OSCAR , LI JENG-THUN
IPC分类号： G01N21/78 , B01L3/00 , B01L3/02 , B01L7/00 , C12N15/09 , C12P1/00 , C12Q1/00 , C12Q1/68 , C40B40/06 , C40B60/14

69. 发明专利

DE69815121D1 未知
公开(公告)号：DE69815121D1
公开(公告)日：2003-07-03
申请号：DE69815121
申请日：1998-01-29
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： KAIN C , MARASON G , JOHNSTON F
IPC分类号： G01N21/01 , G01N21/64 , G02B21/06
摘要： A sample substrate (51, Fig. 4A) for use in a fluorescence imaging system (Fig. I) includes a rigid base with a specularly reflective surface, typically metal, on which is deposited a transparent coating layer (53). The coating layer has a thickness selected so that a particular fluorescence excitation wavelength, corresponding to a specified fluorescent constituent to besought in sample material, has an optical path from the top of the coating layer to the reflecting surface in the base of substantially an odd multiple of one-quarter wavelength, so that the standing wave of the fluorescence excitation wavelength of light incident of the substrate has an antinode (61) located at or near where sample material would be disposed on top of the coating layer. This maximizes fluorescence excitation of the sample on the reflective substrate. The transparent coating layer may be a dielectric material (e.g. silica) or may be a multilayer structure with a top layer of biologically active material for binding a specified sample constituent.

70. 发明专利

CA2464839A1 ARTIFICIAL GENES FOR USE AS CONTROLS IN GENE EXPRESSION ANALYSIS SYSTEMS 未知
公开(公告)号：CA2464839A1
公开(公告)日：2003-06-05
申请号：CA2464839
申请日：2002-10-23
申请人： AMERSHAM BIOSCIENCES SV CORP
发明人： YANG WEN , HARKINS TIMOTHY , BUI SON , HOUTS THOMAS , SAMARTZIDOU HRISSI
IPC分类号： C12N15/09 , C12Q1/68
摘要： Method of producing universal controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from intergenic or intronic regions of a genome. Twenty-three specif ic control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.

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