专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO2006101535A1 INHIBITION OF PROTEASOME FUNCTION TO POTENTIATE THE PROAPOPTOTIC AND ANTITUMOR ACTIVITY OF CYTOKINES 审中-公开
标题翻译：抑制功能抑制细胞因子的副作用和抗肿瘤活性
公开(公告)号：WO2006101535A1
公开(公告)日：2006-09-28
申请号：PCT/US2005/040060
申请日：2005-11-04
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , WIGGINTON, Jon, M. , KHAN, Tahira , SAYERS, Thomas
发明人： WIGGINTON, Jon, M. , KHAN, Tahira , SAYERS, Thomas
IPC分类号： A61K38/19 , A61K31/69 , A61K38/21 , A61P35/00
CPC分类号： A61K38/05 , A61K31/69 , A61K38/191 , A61K38/20 , A61K38/2013 , A61K38/208 , A61K38/21 , A61K2300/00
摘要： Disclosed herein are methods of using proteasome inhibitors to enhance an antitumor activity of a cytokine on a tumor cell that responds to treatment with the cytokine. Also provided herein are pharmaceutical compositions that include at least one cytokine and at least one proteasome inhibitor.
摘要翻译：本文公开了使用蛋白酶体抑制剂来增强对细胞因子治疗作出反应的肿瘤细胞上的细胞因子的抗肿瘤活性的方法。本文还提供了包含至少一种细胞因子和至少一种蛋白酶体抑制剂的药物组合物。

62. 发明申请

WO2005072260A2 FORMALDEHYDE-FREE ADHESIVES AND LIGNOCELLULOSIC COMPOSITES MADE FROM THE ADHESIVES 审中-公开
标题翻译：无胶粘剂和粘合剂制成的木质纤维素复合材料
公开(公告)号：WO2005072260A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/001981
申请日：2005-01-19
申请人： STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY , LI, Kaichang
发明人： LI, Kaichang
IPC分类号： B32B21/14 , C08L97/02 , C09J189/00 , C09J197/00 , C09J197/02
CPC分类号： B32B21/14 , B32B7/12 , C08L97/02 , C08L2666/26 , C09J189/00 , C09J197/005 , Y10T428/31515 , Y10T428/31906
摘要： A first variant of an adhesive composition for making a lignocellulosic composite includes soy protein and/or lignin; at least one substantially formaldehyde-free curing agent that includes at least one amine, amide, imine, imide, or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the soy protein; and at least one compound selected from a boron compound, a group IA oxide or hydroxide, or a group IIA oxide or hydroxide. A second variant of an adhesive composition includes a first component selected from soy protein and/or lignin; and at least one substantially formaldehyde-free curing agent selected from a reaction product of epichlorohydrin with ethylenediamine, a reaction product of epichlorohydrin with bis-hexamethylenetriamine, or a reaction product of epichlorohydrin with hexamethylenediamine.
摘要翻译：用于制备木质纤维素复合物的粘合剂组合物的第一变体包括大豆蛋白和/或木质素; 至少一种基本上不含甲醛的固化剂，其包含可与至少一种大豆蛋白官能团反应的至少一种胺，酰胺，亚胺，酰亚胺或含氮杂环官能团; 和至少一种选自硼化合物，IA族氧化物或氢氧化物或IIA族氧化物或氢氧化物的化合物。粘合剂组合物的第二变体包括选自大豆蛋白和/或木质素的第一组分; 和至少一种选自表氯醇与乙二胺的反应产物，表氯醇与双六亚甲基三胺的反应产物或表氯醇与六亚甲基二胺的反应产物的基本上不含甲醛的固化剂。

63. 发明申请

WO2004063313A2 PROCESSES AND APPARATUSES FOR TREATING HALOGEN-CONTAINING GASES 审中-公开
标题翻译：处理含卤素气体的工艺和设备
公开(公告)号：WO2004063313A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000688
申请日：2004-01-12
申请人： BATTELLE MEMORIAL INSTITUTE , JOSEPHSON, Gary, B. , LESSOR, Delbert, L. , RAPPE, Kenneth, G. , ORTH, Rick, J. , AARDAHL, Christopher, L.
发明人： JOSEPHSON, Gary, B. , LESSOR, Delbert, L. , RAPPE, Kenneth, G. , ORTH, Rick, J. , AARDAHL, Christopher, L.
IPC分类号： C10L
CPC分类号： B01D53/68 , B01D53/32 , B01D53/70 , B01D53/79 , B01D2259/818
摘要： There are disclosed various processes, apparatuses and systems for treating a halogen-containing gas such as F 2 that involve generating a plasma in order to reduce chemically the halogen-containing gas into products that are more environmentally manageable. According to a particular embodiment, a reducing agent is mixed with the halogen-containing gas to produce a feed gas mixture and a non-thermal plasma is generated in the feed gas mixture in the presence of liquid water. According to another embodiment, a vaporized portion of a liquid reducing agent is mixed with the halogen-containing gas to produce a reaction mixture and a non-thermal plasma is generated in the reaction gas mixture to reduce the halogen-containing gas.
摘要翻译：公开了用于处理诸如F 2的含卤素气体的各种工艺，装置和系统，其涉及产生等离子体以便化学还原含卤素气体纳入更环保可管理的产品中。根据具体的实施方式，将还原剂与含卤素的气体混合以产生进料气体混合物，并且在液态水存在下在进料气体混合物中产生非热等离子体。根据另一个实施方案，液体还原剂的蒸发部分与含卤素气体混合以产生反应混合物，并且在反应气体混合物中产生非热等离子体以还原含卤素气体。

64. 发明申请

WO2004048644A2 ELECTROSYNTHESIS OF NANOFIBERS AND NANO-COMPOSITE FILMS 审中-公开
标题翻译：纳米纤维和纳米复合薄膜的电合成
公开(公告)号：WO2004048644A2
公开(公告)日：2004-06-10
申请号：PCT/US2003/016273
申请日：2003-05-21
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： LIN, Yuehe , LIANG, Liang , LIU, Jun
IPC分类号： C25D
CPC分类号： B82Y30/00 , C09D5/4476 , C25D9/00
摘要： A method of producing an array of oriented nanofibers that involves forming a solution that includes at least one electroactive species. An electrode substrate is brought into contact with the solution. A current density is applied to the electrode substrate that includes at least a first step of applying a first substantially constant current density for a first time period and a second step of applying a second substantially constant current density for a second time period. The first and second time periods are of sufficient duration to electrically deposit on the electrode substrate an array of oriented nanofibers produced from the electroactive species. Also disclosed are films that include arrays or networks of oriented nanofibers and a method for amperometrically detecting or measuring at least one analyte in a sample.
摘要翻译：生产取向纳米纤维阵列的方法，其涉及形成包含至少一种电活性物质的溶液。使电极基板与溶液接触。向电极基板施加电流密度，该电流密度至少包括在第一时间段施加第一基本上恒定的电流密度的第一步骤和在第二时间段施加第二基本上恒定的电流密度的第二步骤。第一和第二时间段具有足够的持续时间以在电极基板上电沉积由电活性物质产生的取向纳米纤维的阵列。还公开了包含取向纳米纤维的阵列或网络的膜以及用于安培检测或测量样品中的至少一种分析物的方法。

65. 发明申请

WO2004004659A2 ALKALOID DERIVATIVES AND METHODS OF THEIR USE 审中-公开
标题翻译： ALKALOID衍生物及其使用方法
公开(公告)号：WO2004004659A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/021456
申请日：2003-07-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BEWLEY, Carole , NICHOLAS, Gillian , NICOLAOU, K., C. , BARLUENGA, Sofia , PFEFFERKORN, Jeffrey , HUGHES, Robert
发明人： BEWLEY, Carole , NICHOLAS, Gillian , NICOLAOU, K., C. , BARLUENGA, Sofia , PFEFFERKORN, Jeffrey , HUGHES, Robert
IPC分类号： A61K
CPC分类号： C07C323/41
摘要： Synthetic alkaloid derivatives useful as inhibitors of acyl gluc osaminyl inositol amidase activity, including mycothiol-S-conjugate amidase, are disclosed. In addition, methods of using the inhibitors of acyl glucosaminyl inositol amidase in the treatment of bacterial infections, including those caused by Mycobacterium tuberculosis , are also disclosed.
摘要翻译：公开了可用作酰基葡糖胺基甲酰肌醇酰胺酶活性抑制剂的合成生物碱衍生物，包括咪唑硫醇-S-共轭酰胺酶。此外，还公开了使用酰基葡糖胺基肌醇酰胺酶抑制剂治疗细菌感染的方法，包括由结核分枝杆菌引起的那些。

66. 发明申请

WO2022103692A1 AQUEOUS SILICONE ELASTOMERS AS ROOF COATINGS 审中-公开
公开(公告)号：WO2022103692A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/058426
申请日：2021-11-08
申请人： INDUSTRIAL CONTROL DEVELOPMENT, INC. , KRYTENBERG, Timothy
发明人： KRYTENBERG, Timothy
IPC分类号： C09D183/04 , E04D5/06 , E04D7/00 , E04D11/02
摘要： A method including coating a liquid aqueous silicone elastomer-containing composition onto a surface of a building roof substrate, wherein the building roof substrate is an element of a standing building roofing system, and then drying the liquid aqueous silicone elastomer-containing composition resulting in forming a topcoat on the building roof substrate.

67. 发明申请

WO2021242917A1 TARGETING THE CHOLECYSTOKININ-B RECEPTOR FOR IMAGING AND EARLY DETECTION OF PANCREATIC CANCER AND PRE-CANCEROUS LESIONS 审中-公开
公开(公告)号：WO2021242917A1
公开(公告)日：2021-12-02
申请号：PCT/US2021/034339
申请日：2021-05-26
申请人： GEORGETOWN UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： SMITH, Jill P. , STERN, Stephan
IPC分类号： A61K47/60 , A61K47/62 , A61K47/64 , A61K47/69 , A61K49/00 , A61P35/00 , C12N15/00
摘要： A method that includes detecting the presence of a pancreatic intraepithelial neoplasia lesion in a subject in vivo comprising administering to the subject a construct, or a pharmaceutically acceptable salt thereof, wherein the construct comprises: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a detectable moiety complexed with, or conjugated to, the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.

68. 发明申请

WO2021188448A1 STABILIZATION OF COMPOUNDS AS CYCLODEXTRIN COMPLEXES 审中-公开
公开(公告)号：WO2021188448A1
公开(公告)日：2021-09-23
申请号：PCT/US2021/022395
申请日：2021-03-15
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： FREEMAN, Bruce A. , SCHOPFER, Francisco J. , SALVATORE, Sonia R.
IPC分类号： A61K47/40 , A61K31/724 , A61K49/18 , A61K31/04 , C07C203/04 , A61P37/00 , A61P3/00 , A61P3/10 , A61P9/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P13/12 , A61P35/00 , A61P43/00
摘要： A composition comprising a complex of a cyclodextrin with a nitroalkene.

69. 发明申请

WO2018085835A1 NANOSCALE BIOCHEMICAL SAMPLE PREPARATION AND ANALYSIS 审中-公开
标题翻译：纳米生物化学样品的制备与分析
公开(公告)号：WO2018085835A1
公开(公告)日：2018-05-11
申请号：PCT/US2017/060399
申请日：2017-11-07
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： KELLY, Ryan, T. , ZHU, Ying , SMITH, Richard, D.
IPC分类号： C12Q1/6881 , G01N33/483
摘要： Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.
摘要翻译：本文提供用于生物化学分析的方法和系统，包括用于处理和分析小细胞群体和生物样品（例如，机器人控制的基于芯片的纳米小滴平台）的组合物和方法。在具体的方面，本文描述的方法可以在单个反应器容器（例如单个液滴反应器内）内将常规体积的总处理体积减小至纳升体积，同时使损失最小化，例如由于样品蒸发。

70. 发明申请

WO2018067705A1 REVERSIBLY PROTECTED THIOLATED ELECTROPHILIC FATTY ACIDS AS PRODRUGS 审中-公开
标题翻译：可逆地保护唾液酸化的电子脂肪酸作为前药
公开(公告)号：WO2018067705A1
公开(公告)日：2018-04-12
申请号：PCT/US2017/055149
申请日：2017-10-04
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , FREEMAN, Bruce, A. , KHOO, Nicholas , SCHOPFER, Francisco, Jose , WOODCOCK, Steven
发明人： FREEMAN, Bruce, A. , KHOO, Nicholas , SCHOPFER, Francisco, Jose , WOODCOCK, Steven
IPC分类号： A61K31/20 , A61P29/00 , A61P3/04 , A61P3/00 , A61P13/12
摘要： Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
摘要翻译：本发明的各种实施方案涉及用于治疗疾病的药物组合物和方法。这样的实施方案的组合物包括硫醇化的硝基脂肪酸。各种实施方案的方法包括向需要治疗的患者施用有效量的任何这些药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式