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61. 发明公开

EP1706142A1 STREPTOCOCCUS PHOCAE VACCINE 有权
标题翻译：链球菌，phocae疫苗
公开(公告)号：EP1706142A1
公开(公告)日：2006-10-04
申请号：EP04804631.2
申请日：2004-12-01
申请人： Intervet International BV
发明人： GRISEZ, Luc , SEGERS, Ruud Philip Antoon Maria , NG, Chow Yong
IPC分类号： A61K39/09
CPC分类号： A61K39/092
摘要： The present invention relates to the use of bacteria of the species Streptococcus phocae for the manufacture of a vaccine, to methods for the production of such vaccines, to bacteria of the species Streptococcus phocae for use in a vaccine and to methods for the combating of Streptococcus phocae infection in fish.

62. 发明授权

EP1219711B1 Lawsonia intracellularis vaccine 有权
标题翻译：细胞内罗森氏菌疫苗
公开(公告)号：EP1219711B1
公开(公告)日：2006-06-14
申请号：EP01204919.3
申请日：2001-12-14
申请人： Intervet International BV
发明人： Jacobs, Antonius A. C. , Vermeij, Paul
IPC分类号： C12N15/31 , C12N1/21 , C12Q1/68 , C07K14/195 , A61K39/02 , A61K39/295 , A61K39/40 , A61K48/00 , G01N33/569 , C07K14/205
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/195

63. 发明公开

EP1664097A2 PIROPLASMID VACCINE 有权
标题翻译： PIROPLASMID疫苗
公开(公告)号：EP1664097A2
公开(公告)日：2006-06-07
申请号：EP04787138.9
申请日：2004-09-14
申请人： Universiteit Utrecht Holding B.V.
发明人： DE VRIES, Erik , GAFFAR, Fasilla, Razzia , YATSUDA, Ana, Patricia , SCHAAP, Theodorus, Cornelis
IPC分类号： C07K14/00
CPC分类号： C07K14/44
摘要： The invention relates to a Piroplasmid protein or an immunogenic fragment of said protein, and to a nucleic acid encoding said Piroplasmid protein or said immunogenic fragment. Furthermore, the invention relates to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising said nucleic acid. Also the invention relates to host cells comprising said cDNA fragments, recombinant DNA molecules and live recombinant carriers. Finally, the invention relates to vaccines comprising a Piroplasmid protein or an immunogenic fragment of said protein, to methods for the preparation of such vaccines, to the use of such proteins or fragments for vaccine purposes, and to diagnostic tests.
摘要翻译：本发明涉及所述蛋白质的Pimoplasmid蛋白质或免疫原性片段，以及编码所述Pimoplasmid蛋白质或所述免疫原性片段的核酸。此外，本发明涉及包含所述核酸的cDNA片段，重组DNA分子和活重组载体。本发明还涉及包含所述cDNA片段的宿主细胞，重组DNA分子和活重组载体。最后，本发明涉及包含所述蛋白质或所述蛋白质的免疫原性片段的疫苗，用于制备此类疫苗的方法，涉及这些蛋白质或片段用于疫苗目的的用途以及诊断测试。

64. 发明授权

EP1180041B1 VACCINE AGAINST ISA VIRUS 有权
标题翻译： IMPFSTOFF GEGEN ISA病毒
公开(公告)号：EP1180041B1
公开(公告)日：2006-03-08
申请号：EP00931748.8
申请日：2000-05-29
申请人： Akzo Nobel N.V.
发明人： RIMSTAD, Espen
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： C07K14/005 , A61K2039/53 , C12N2760/16022 , C12N2760/16034
摘要： The invention relates to vaccine against infectious salmon anaemia (ISA) virus, DNA sequences endocing immunogenic proteins from ISA virus, diagnostic kit for detection of ISA specific nucleic acid sequences and proteins and exploitation of the ISA virus genome or parts of it as a general model organism.
摘要翻译：本发明涉及针对感染性鲑鱼贫血（ISA）病毒的疫苗，从ISA病毒引起的免疫原性蛋白质的DNA序列，用于检测ISA特异性核酸序列和蛋白质的诊断试剂盒以及ISA病毒基因组的开发或其部分作为一般模型生物。

65. 发明公开

EP1586646A2 Lawsonia intracellularis vaccine 有权
标题翻译：细胞内罗森氏菌疫苗
公开(公告)号：EP1586646A2
公开(公告)日：2005-10-19
申请号：EP05104073.1
申请日：2001-12-14
申请人： Akzo Nobel N.V.
发明人： Jacobs, Antonius Arnoldus Christiaan , Vermeij, Paul
IPC分类号： C12N15/31 , C12N1/21 , C12Q1/68 , C07K14/195 , C07K14/205 , A61K39/02 , A61K39/40 , G01N33/569
CPC分类号： C07K14/205 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/195
摘要： The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acid sequences, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.

66. 发明公开

EP1543028A2 LIVE ANTENUATED PARASITE VACCINE 审中-公开
标题翻译：用疫苗减毒活寄生虫
公开(公告)号：EP1543028A2
公开(公告)日：2005-06-22
申请号：EP03750636.7
申请日：2003-09-19
申请人： Akzo Nobel N.V.
发明人： VAN POPPEL, Nicole, Francisca, Johanna , VERMEULEN, Arnoldus, Nicolaas , SCHAAP, Theodorus, Cornelis
IPC分类号： C07K14/45 , C12N15/63
CPC分类号： C07K14/245 , A61K2039/52 , C07K14/43595 , C07K2319/00 , C12N15/635 , Y02A50/41 , Y02A50/412
摘要： The present invention relates inter alia to attenuated live parasites of the phylum Apicomplexa and the family of Trypanosomatdae and to the use of such attenuated live parasites in a vaccine and in the manufacturing of such a vaccine. Furthermore, the present invention relates to vaccines comprising such attenuated live parasites and to methods for the production of such vaccines. Finally, the invention relates to specific tet-repressor fusion proteins and to attenuated live parasites according to the invention comprising such tet-repressor fusion proteins.

67. 发明公开

EP1525312A2 BRACHYSPIRA HYODYSENTERIAE VACCINE 审中-公开
公开(公告)号：EP1525312A2
公开(公告)日：2005-04-27
申请号：EP03763845.9
申请日：2003-07-11
申请人： Akzo Nobel N.V.
发明人： ADLER, Ben , CULLEN, Paul, Antony , COUTTS, Scott, Adam, James , BULACH, Dieter, Mark , SEGERS, Ruud, Philip, Antoon, Maria
IPC分类号： C12N15/31 , C12N15/63 , C12N1/21 , C07K14/20 , A61K48/00 , A61K39/02 , A61K39/40 , C12Q1/68 , G01N33/569
CPC分类号： C07K14/20 , A61K39/00 , A61K2039/505 , A61K2039/523 , A61K2039/53
摘要： The present invention relates to nucleic acid sequences encoding a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.
摘要翻译：本发明涉及编码61kD和20kD猪痢疾短螺旋体脂蛋白的核酸序列以及编码此类脂蛋白的免疫原性片段的这些核酸序列的部分，以及DNA片段，重组DNA分子，活重组载体和宿主包含此类核酸序列或其部分的细胞。本发明还涉及由这样的序列编码的61kD和20kD Brachyspira hyodysenteriae脂蛋白及其免疫原性部分。此外，本发明涉及包含此类核酸序列及其部分的DNA疫苗，DNA片段，重组DNA分子，活重组载体和包含此类核酸序列或其部分的宿主细胞，脂蛋白或其免疫原性部分以及抗此类脂蛋白的抗体或其免疫原性部分。而且，本发明涉及所述脂蛋白在疫苗中的用途以及用于制备疫苗的用途。而且，本发明涉及所述核酸序列，脂蛋白或抗体用于诊断或接种目的的用途。最后，本发明涉及包含这种核酸，脂蛋白或抗此类脂蛋白的抗体的诊断试剂盒。

68. 发明公开

EP1518558A2 Vaccine against infection with Actinobacillus pleuropneumoniae comprising purified ApxIV toxin 失效
标题翻译： Impfstoffe gegen胸膜肺炎放线杆菌感染，死亡霍乱毒素窒息
公开(公告)号：EP1518558A2
公开(公告)日：2005-03-30
申请号：EP04077590.0
申请日：1998-04-08
申请人： Akzo Nobel N.V.
发明人： Frey, Joachim , Segers, Ruud P.A.M.
IPC分类号： A61K39/102 , A61K39/295 , G01N33/569 , G01N33/68 , C12N1/20 , C12N1/21
CPC分类号： C12R1/01 , A61K39/00 , A61K39/102 , C07K14/195 , C07K14/285 , C12N15/74 , G01N33/6854 , G01N2333/285 , G01N2469/20
摘要： The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The invention also relates to methods for the production of such bacteria. Also vaccines comprising such bacteria and methods for the production of such vaccines are part of the invention. The invention further relates to subunit vaccines comprising an ApxIV toxin, to methods for the production of such vaccines and to methods for the protection of animals against infection with bacteria of the genus Actinobacillus pleuropneumoniae . In addition, the invention relates to the promoter of the apxlV gene. Finally, the invention relates to diagnostic tests for the selective diagnosis of Actinobacillus pleuropneumoniae infections and to diagnostic tests discriminating between Actinobacillus pleuropneumoniae field strains and vaccine strains.
摘要翻译：本发明涉及在apxIV基因中具有突变的胸膜肺炎放线杆菌属的减毒细菌，使得不产生功能性的ApxIV毒素。本发明还涉及生产这种细菌的方法。还包括这种细菌的疫苗和用于生产这种疫苗的方法是本发明的一部分。本发明还涉及包含ApxIV毒素的亚单位疫苗，用于生产这种疫苗的方法以及用于保护动物免受胸膜肺炎放线杆菌属细菌感染的方法。此外，本发明涉及apx1V基因的启动子。最后，本发明涉及胸膜肺炎放线芽孢杆菌感染的选择性诊断的诊断试验和区分放线杆菌胸膜肺炎放线芽孢杆菌场和疫苗株的诊断试验。

69. 发明公开

EP1515763A1 NEEDLE-LESS INJECTOR 有权转让
标题翻译：无针注射
公开(公告)号：EP1515763A1
公开(公告)日：2005-03-23
申请号：EP03738001.1
申请日：2003-06-05
申请人： Akzo Nobel N.V.
发明人： MEIJERING, Antonie, Hendrikus , JACOBS, Andreas, Johannes, Maria
IPC分类号： A61M5/30 , A61M5/20
CPC分类号： A61M5/30 , A61M5/204
摘要： The invention relates to a needle-less injector having a housing comprising: a chamber defined within said injector for containing liquid to be injected; a liquid outlet for said chamber positioned at the front end of the injector; a dispensing member in contact with the liquid in said chamber and movable in a first direction to reduce the volume of said chamber to cause the liquid contained therein to be expelled through said liquid outlet; drive means for actuating said injector, wherein the dispensing member is a spring-loaded piston movable in said chamber by the spring in the first direction to a preferred position at which the volume of said chamber is at a minimum and the spring is nearly unloaded, and which piston is movable in a second direction opposite to the first direction by actuation of the drive means whilst counteracting a force from the spring and moving the piston to a non-preferred position at which the spring is loaded.

70. 发明授权

EP1176192B1 Helicobacter felis vaccine 有权
标题翻译：幽门螺杆菌疫苗的猫
公开(公告)号：EP1176192B1
公开(公告)日：2003-10-01
申请号：EP01202666.2
申请日：2001-07-11
申请人： Akzo Nobel N.V.
发明人： Kusters, Johannes Gerardus , Cattoli, Giovanni
IPC分类号： C12N9/80 , C07K14/205 , C07K16/12 , C12Q1/68 , A61K39/106 , A61K48/00 , G01N33/53 , G01N33/68
CPC分类号： C12N9/80 , A61K39/00 , C07K14/205

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