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61. 发明公开

EP2144615A2 METHODS OF USE OF GAMMA INHIBITOR COMPOUNDS FOR THE ATTENUATION OF PAIN 审中-公开
标题翻译：方法γ抑制剂化合物用于缓解疼痛的使用
公开(公告)号：EP2144615A2
公开(公告)日：2010-01-20
申请号：EP08745252.0
申请日：2008-04-07
申请人： Kai Pharmaceuticals, Inc.
发明人： HARRISON, Stephen, D.
IPC分类号： A61K31/70 , A61K31/7012 , A61K38/08 , A61K38/17 , A61K39/21
CPC分类号： A61K38/45 , A61K47/645 , C12N9/1205
摘要： The disclosure herein relates to modified γPKC inhibitory peptides, methods of generating such peptides, and method for using γPKC inhibitory peptides for the treatment of pain.

62. 发明公开

EP2109619A2 MODIFICATIONS OF PEPTIDE COMPOSITIONS TO INCREASE STABILITY AND DELIVERY EFFICIENCY 有权
标题翻译：变形金刚PEPTIDZUSAMMENSETZUNGENFÜRERHÖHTESTABILITÄTUND AUSGABEEFFIZIENZ
公开(公告)号：EP2109619A2
公开(公告)日：2009-10-21
申请号：EP08728081.4
申请日：2008-01-22
申请人： Kai Pharmaceuticals, Inc.
发明人： MACLEAN, Derek
IPC分类号： C07K14/00
CPC分类号： C12N9/96 , A61K38/10 , A61K47/64 , A61K47/645 , C07K7/00 , C12N9/12 , C12Y207/11013
摘要： The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed invention relates to methods to increase the stability and delivery efficiency of protein kinase C (PKC) modulatory peptide compositions. A "therapeutic peptide composition" comprises a "carrier peptide" and a "cargo peptide." A "carrier peptide" is a peptide or amino acid sequence within a peptide that facilitates the cellular uptake of the therapeutic peptide composition. The "cargo peptide" is a PKC modulatory peptide. Peptide modifications to either the carrier peptide, the cargo peptide, or both, which are described herein increase the stability and delivery efficiency of therapeutic peptide compositions by reducing disulfide bond exchange, physical stability, reducing proteolytic degradation, and increasing efficiency of cellular uptake.
摘要翻译：所公开的发明涉及改进肽组合物以提高稳定性和递送效率的方法。具体地，所公开的发明涉及增加蛋白激酶C（PKC）调节肽组合物的稳定性和递送效率的方法。 “治疗性肽组合物”包含“载体肽”和“货物肽”。“载体肽”是促进细胞摄取治疗性肽组合物的肽内的肽或氨基酸序列。 “货物肽”是PKC调节肽。通过减少二硫键交换，物理稳定性，减少蛋白水解降解和提高细胞摄取效率，本文所述的肽载体肽，载体肽或两者的肽修饰增加了治疗性肽组合物的稳定性和递送效率。

63. 发明授权

EP1144447B1 TUBERCULOSIS DIAGNOSTIC TEST 有权
标题翻译：结核病诊断测试
公开(公告)号：EP1144447B1
公开(公告)日：2009-10-14
申请号：EP99952697.3
申请日：1999-11-03
申请人： ISIS INNOVATION LIMITED
发明人： LALVANI, Ajit, Nuffield Dep. of Clinical Medicine , PATHAN, Ansar A., Nuffield Dep. of Clinical Med.
IPC分类号： C07K14/35 , C07K7/08 , C07K16/12 , C12Q1/68 , G01N33/68 , G01N33/569 , G01N33/53 , A61K38/10 , A61K31/70
CPC分类号： G01N33/6893 , A61K38/00 , A61K48/00 , C07K14/35 , G01N33/5695 , Y10S435/975
摘要： A method of diagnosing in a host infection by or exposure to a mycobacterium which expresses ESAT-6 comprising (i) contacting a population of T cells from the host with one or more peptides or analogues selected from the peptides represented by SEQ ID NO:1 to 11 and analogues thereof which can bind a T cell receptor which recognises any of the said peptides, and (ii) determining whether the T cells of said T cell population recognise the peptide(s) and/or analogue(s). The method may be performed in vivo. Peptides and a kit which enable the method to be carried out are provided.

64. 发明公开

EP2074427A1 DIAGNOSTIC BIOMOLECULE(S) 有权
标题翻译：诊断生物分子（E）
公开(公告)号：EP2074427A1
公开(公告)日：2009-07-01
申请号：EP07794274.6
申请日：2007-08-20
申请人： National University of Singapore
发明人： CHOOLANI, Mahesh Arjandas , JABARULLAH KHAN, Khalil Razvi, B., M. , ANNAMALAI, Loganath , BISWAS, Arijit , ZHAO, Changqing
IPC分类号： G01N33/574 , G01N33/53 , G01N33/50 , G01N33/68
CPC分类号： G01N33/574 , G01N33/57449 , G01N2800/52
摘要： The present invention relates to methods for the identification and/or quantification of biomolecule(s). There is also provided a novel method of identifying and/or quantitating biomolecule(s) in a proliferative cell disorder by providing at least one cyst fluid sample and determining the expression of haptoglobin protein, derivative, mutant and/or fragment thereof.

65. 发明公开

EP1982191A1 MAST CELL CARBOXYPEPTIDASE AS A MARKER FOR ANAPHYLAXIS AND MASTOCYTOSIS 有权
标题翻译：肥大细胞羧AS标志物过敏症和肥大细胞增多症
公开(公告)号：EP1982191A1
公开(公告)日：2008-10-22
申请号：EP07705345.2
申请日：2007-01-19
申请人： University of Southampton
发明人： WALLS, Andrew, Finlay , ZHOU, Xiaoying
IPC分类号： G01N33/573 , G01N33/68
CPC分类号： C12Q1/37 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to use of mast cell carboxypeptidase as a marker for anaphylaxis or mastocytosis in serum, plasma or saliva samples. Detection of elevated mast cell caroboxypeptidase in for example serum samples is proposed for reducing false negatives in relation to diagnosis of anaphylaxis and various categories of mastocytosis by picking up serum tryptase-negative cases.

66. 发明公开

EP1915446A2 IN VITRO RECOMBINATION METHOD 有权转让
标题翻译：在体外重建
公开(公告)号：EP1915446A2
公开(公告)日：2008-04-30
申请号：EP06813388.3
申请日：2006-08-11
申请人： The J. Craig Venter Institute
发明人： YOUNG, Lei , SMITH, Hamilton, O.
IPC分类号： C12N15/09
CPC分类号： C12N15/902 , C12N9/1252 , C12N9/22 , C12N9/93 , C12N15/10 , C12N15/64 , C12N15/66 , C12P19/34 , C12Q1/62 , C12Q1/686 , C12Q1/6862 , C12Q2521/501 , C12Q2522/101 , C12Y207/07007 , C12Y301/11003 , C12Y605/01001
摘要： The present invention relates, e.g., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) DNA molecules of interest, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule share a region of sequence identity, comprising contacting the two DNA molecules in a reaction mixture with (a) a non-processive 5′ exonculease; (b) a single stranded DNA binding protein (SSB) which accelerates nucleic acid annealing; (c) a non strand-displacing DNA polymerase; and (d) a ligase, under conditions effective to join the two DNA molecules to form an intact double stranded DNA molecule, in which a single copy of the region of sequence identity is retained. The method allows the joining of a number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes.
摘要翻译：本发明涉及例如使用分离的蛋白质试剂连接目标的两个双链（ds）DNA分子的体外方法，其中第一DNA分子的远端区域和第二DNA分子的近端区域共享一个包括使反应混合物中的两个DNA分子与（a）非进程性5'外切酶接触; （b）加速核酸退火的单链DNA结合蛋白（SSB）; （c）非链置换DNA聚合酶; 和（d）连接酶，在有效连接两个DNA分子以形成完整双链DNA分子的条件下，其中保留了序列同一性区域的单拷贝。该方法允许以预定顺序和取向连接多个DNA片段，而不使用限制酶。

67. 发明公开

EP1874940A1 TRANSFECTION OF COLLAGEN-PRODUCING CELLS 审中-公开
标题翻译：转染胶原生成细胞
公开(公告)号：EP1874940A1
公开(公告)日：2008-01-09
申请号：EP06721430.4
申请日：2006-04-27
申请人： Cellixe Pty Ltd
发明人： DIWAN, Ashish D. , CHUNG, Sylvia A.
IPC分类号： C12N15/87 , A61K35/32
CPC分类号： A61K48/0025 , A61K38/45 , A61K48/005 , C12N5/0602
摘要： The invention provides a method for introducing at least one polynucleotide of interest into an intervertebral disc cell, wherein the polynucleotide of interest is transfected with a lipid-based delivery agent. The invention also provides methods for introducing polynucleotides encoding one or more telomerase catalytic subunits into collagen-producing cells and methods for increasing extracellular matrix formation in collagen-producing cells.

68. 发明公开

EP1863848A2 ANTIBODIES AND RELATED MOLECULES THAT BIND TO 161P2F10B PROTEINS 审中-公开
标题翻译： AN 161P2F10B蛋白结合抗体及相关分子
公开(公告)号：EP1863848A2
公开(公告)日：2007-12-12
申请号：EP06749164.7
申请日：2006-03-31
申请人： Agensys, Inc.
发明人： JAKOBOVITS, Aya , KANNER, Steven, B. , CHALLITA-EID, Pia, M. , PEREZ-VILLAR, Juan, J. , SATPAEV, Daulet , RAITANO, Arthur, B. , MORRISON, Robert, Kendall , MORRISON, Karen, Jane, Meyrick , JIA, Xiao-chi , GUDAS, Jean
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/73
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.

69. 发明公开

EP1799261A2 METHODS AND COMPOSITIONS FOR COMBINATORAL-BASED PRODUCTION OF MULTIVALENT RECOMBINANT ANTIGENS 有权
标题翻译：方法和组合物用于制造组合的多价重组抗原
公开(公告)号：EP1799261A2
公开(公告)日：2007-06-27
申请号：EP05808466.6
申请日：2005-10-17
申请人： Neugenesis Corporation
发明人： STUART, Dorsey, W. , CAMBARERI, Edward, B.
IPC分类号： A61K39/395 , A61K39/00 , A61K39/116
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/523 , A61K2039/70 , C12N2760/16134 , C40B40/10
摘要： The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from pathogenic organisms have been introduced. The resulting vaccines are multivalent.

70. 发明公开

EP1756136A2 KITS AND PROCESSES FOR REMOVING CONTAMINANTS FROM NUCLEIC ACIDS IN ENVIRONMENTAL AND BIOLOGICAL SAMPLES 有权转让
标题翻译：试剂盒和方法从NUCLEIC生物样品和环境样品污染的去除
公开(公告)号：EP1756136A2
公开(公告)日：2007-02-28
申请号：EP05856744.7
申请日：2005-05-20
申请人： Mo Bio Laboratories, Inc.
发明人： BROLASKI, Mark, N. , VENUGOPAL, Raveendran, J. , STOLOW, David
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C12N15/1003 , C12Q1/6806 , C12Q1/6848 , C12Q2565/113 , C12Q2527/125
摘要： The invention provides methods and compositions, e.g., kits, for removing contaminants from nucleic acids in a sample, e.g., environmental or biological samples such as soil, food, plant, animal, microorganism or water samples. The invention provides methods and compositions for isolating nucleic acids from environmental and biological samples in a scaleable process free of contaminating substances that inhibit PCR and other downstream applications. Exemplary sample types include soil, water, plant and food. The methods and compositions of the invention can be used for isolating and/or detecting nucleic acids from prokaryotic and eukaryotic organisms and for detecting multiple types of organisms in a sample. Thus, the methods and compositions of the invention are useful for detecting organisms pertaining to agriculture, forensics biology and/or combating bioterrorism.

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