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61. 发明申请

WO2010042866A1 NICOTINE IMMUNONANOTHERAPEUTICS 审中-公开
公开(公告)号：WO2010042866A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060236
申请日：2009-10-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , IANNACONE, Matteo , VON ANDRIAN, Ulrich , FAROKHZAD, Omid, C. , ALEXIS, Frank , BASTO, Pamela , SHI, Jinjun , MOSEMAN, Ashley , LANGER, Robert , TONTI, Elena
发明人： IANNACONE, Matteo , VON ANDRIAN, Ulrich , FAROKHZAD, Omid, C. , ALEXIS, Frank , BASTO, Pamela , SHI, Jinjun , MOSEMAN, Ashley , LANGER, Robert , TONTI, Elena
IPC分类号： A61K39/00
CPC分类号： A61K39/00
摘要： The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
摘要翻译：本发明提供用于将纳米载体递送至免疫系统细胞的组合物和系统。本发明提供能够刺激T细胞和/或B细胞中的免疫应答的纳米载体。本发明提供包含具有多个尼古丁部分的免疫表面的纳米载体。本发明提供包含纳米载体的药物组合物。本发明提供了纳米载体及其药物组合物的设计，制造和使用方法。例如，本发明描述能够引发免疫应答和产生抗尼古丁抗体的纳米载体。

62. 发明申请

WO2010036329A2 PROCESS FOR MAKING QUINOLONE COMPOUNDS 审中-公开
标题翻译：制备喹啉酮化合物的方法
公开(公告)号：WO2010036329A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/005276
申请日：2009-09-23
申请人： RIB-X PHARMACEUTICALS, INC. , HANSELMANN, Roger , REEVE, Maxwell, M. , JOHNSON, Graham
发明人： HANSELMANN, Roger , REEVE, Maxwell, M. , JOHNSON, Graham
IPC分类号： C07D401/14 , C07D401/04 , C07D401/02 , C07D215/56 , A61K31/47 , A61K31/495 , A61P33/02
CPC分类号： C07D401/14
摘要： The present invention relates to the field of synthesizing anti-infective compounds. More particularly, the invention relates to synthesizing a family of quinolone compounds useful as anti-infective agents. The invention includes a process for preparing a quinolone compound wherein less than about 0.40% of dimeric impurity of the quinolone is produced.
摘要翻译：本发明涉及抗感染化合物的合成领域。更具体地，本发明涉及合成可用作抗感染剂的喹诺酮化合物家族。本发明包括一种喹诺酮化合物的制备方法，其中产生小于约0.40％的喹诺酮二聚体杂质。

63. 发明申请

WO2010014913A1 TOLL-LIKE RECEPTOR AGONIST FORMULATIONS AND THEIR USE 审中-公开
标题翻译：类似于受体的受体激动剂制剂及其用途
公开(公告)号：WO2010014913A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052422
申请日：2009-07-31
申请人： VENTIRX PHARMACEUTICALS, INC. , HOWBERT, J., Jeffry , DUVVURI, Muralikrishna , HERSHBERG, Rob , DIETSCH, Greg
发明人： HOWBERT, J., Jeffry , DUVVURI, Muralikrishna , HERSHBERG, Rob , DIETSCH, Greg
IPC分类号： A61K39/395
CPC分类号： A61K31/55 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/724 , A61K47/40 , A61K47/48969 , A61K47/6951 , B82Y5/00 , C07D223/16 , C08B37/0012 , Y02A50/393
摘要： The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonist which comprise a cyclodextrin.
摘要翻译：本发明总体上涉及用于治疗癌症，优选实体瘤和淋巴瘤的TLR激动剂（优选TLR7或TLR8激动剂）的稳定制剂。具体而言，本发明涉及包含环糊精的至多50mg / ml的TLR激动剂的稳定制剂。

64. 发明申请

WO2009158513A1 GENE EXPRESSION PROFILING FOR IDENTIFICATION, MONITORING, AND TREATMENT OF OSTEOARTHRITIS 审中-公开
标题翻译：基因表达谱鉴定，监测和治疗OSTEOARTHRITIS
公开(公告)号：WO2009158513A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048684
申请日：2009-06-25
申请人： SOURCE PRECISION MEDICINE, INC. , BANKAITIS-DAVIS, Danute , SCICONOLFI, Lisa , STORM, Kathleen , WASSMANN, Karl
发明人： BANKAITIS-DAVIS, Danute , SCICONOLFI, Lisa , STORM, Kathleen , WASSMANN, Karl
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： A method is provided in various embodiments for determining a profile data set for a subject with osteoarthritis or conditions related to osteoarthritis based on a sample from the subject, wherein the sample provides a source of RNAs. The method includes using amplification for measuring the amount of RNA corresponding to at least one constituent from Tables 1-2, 4-6, and 8. The profile data set comprises the measure of each constituent, and amplification is performed under measurement conditions that are substantially repeatable.
摘要翻译：在各种实施方案中提供了一种用于基于来自受试者的样品确定骨关节炎或与骨关节炎有关的病症的受试者的轮廓数据集的方法，其中所述样品提供RNA源。该方法包括使用扩增来测量与表1-2,4-6和8中的至少一种成分相对应的RNA的量。分布数据集包括每个成分的量度，并且在测量条件下进行扩增基本可重复。

65. 发明申请

WO2009140383A2 APTAMERS THAT BIND TO P-SELECTIN AND THEIR USE AS COAGULATION, THROMBOTIC, INFLAMMATORY, AND METASTATIC DISEASE THERAPEUTICS 审中-公开
标题翻译：与P选择性相关的APTAMERS及其作为凝血，血栓，炎症和分化疾病治疗的用途
公开(公告)号：WO2009140383A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043787
申请日：2009-05-13
申请人： ARCHEMIX CORP. , SCHAUB, Robert , KURZ, Jeffrey
发明人： SCHAUB, Robert , KURZ, Jeffrey
IPC分类号： A61K51/00
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/351
摘要： The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to P-selectin, which are useful as therapeutics in and diagnostics of coagulation/thrombotic, inflammatory, metastatic and/or other pathologies, diseases or disorders in which P-selectin has been implicated. In addition, the aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to P-selectin.
摘要翻译：本发明一般涉及核酸领域，更具体地涉及结合P-选择蛋白的适体，其可用作凝血/血栓形成，炎症，转移和/或其他病理学，疾病或病症中的治疗剂和诊断，其中P - 选择素已被牵连。此外，适配体可以在医疗过程之前，期间和/或之后使用以减少其并发症或副作用。本发明还涉及用于施用结合P-选择蛋白的适体的材料和方法。

66. 发明申请

WO2009128913A1 SUBSTITUTED TETRACYCLINE COMPOUNDS 审中-公开
标题翻译：取代的四唑化合物
公开(公告)号：WO2009128913A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/002344
申请日：2009-04-14
申请人： PARATEK PHARMACEUTICALS, INC. , BERNIAC, Joel , BOWSER, Todd
发明人： BERNIAC, Joel , BOWSER, Todd
IPC分类号： A01N37/18
CPC分类号： A61K31/65 , Y02A50/473
摘要： The present invention pertains, at least in part, to methods of treating a microorganism-associated infection in a subject comprising administering to said subject an effective amount of a tetracycline compound.
摘要翻译：本发明至少部分地涉及治疗受试者中微生物相关感染的方法，其包括向所述受试者施用有效量的四环素化合物。

67. 发明申请

WO2009114862A1 DNA REPAIR PROTEINS ASSOCIATED WITH TRIPLE NEGATIVE BREAST CANCERS AND METHODS OF USE THEREOF 审中-公开
标题翻译：与三阴性乳腺癌相关的DNA修复蛋白及其使用方法
公开(公告)号：WO2009114862A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/037303
申请日：2009-03-16
申请人： DNAR, INC. , WEAVER, David, T. , WANG, XioaZhe , SPROTT, Kam, Marie
发明人： WEAVER, David, T. , WANG, XioaZhe , SPROTT, Kam, Marie
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/54 , G01N2800/56
摘要： The present invention provides methods of detecting triple negative breast cancer recurrence using biomarkers.
摘要翻译：本发明提供使用生物标志物检测三阴性乳腺癌复发的方法。

68. 发明申请

WO2009079259A2 ANTIBODIES AGAINST INFLUENZA VIRUS AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗流感病毒的抗体及其使用方法
公开(公告)号：WO2009079259A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/085876
申请日：2008-12-08
申请人： DANA-FARBER CANCER INSTITUTE, INC. , BURNHAM INSTITUTE FOR MEDICAL RESEARCH , MARASCO, Wayne, A. , SUI, Jianhua , LIDDINGTON, Robert, C.
发明人： MARASCO, Wayne, A. , SUI, Jianhua , LIDDINGTON, Robert, C.
IPC分类号： C07K16/00
CPC分类号： C07K16/1018 , A61K2039/505 , C07K14/005 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/40 , C12N2760/16122
摘要： The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing a influenza related disease or disorder such bird flu The invention also provides methods of vaccinating a patient against influenza. Also provided are methods of diagnosing influenza- related diseases or disorders and methods of detecting the presence of a influenza in a sample.
摘要翻译：本发明提供了中和流感病毒的人scFv抗体和单克隆抗体。还提供了治疗和/或预防流感相关疾病或病症如禽流感的方法。本发明还提供了针对流感病人接种患者的方法。还提供了诊断流感相关疾病或病症的方法和检测样品中流感存在的方法。

69. 发明申请

WO2009062181A1 BROAD-BASED NEUROTOXIN-RELATED GENE MUTATION ASSOCIATION FROM A GENE TRANSCRIPT TEST 审中-公开
标题翻译：基于基因突变检测的基于广泛的神经毒素相关基因突变协会
公开(公告)号：WO2009062181A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/083037
申请日：2008-11-10
申请人： IVERSON GENETIC DIAGNOSTICS, INC. , SPROLES, Dean, I.
发明人： SPROLES, Dean, I.
IPC分类号： G06F19/00
CPC分类号： G06F19/28 , G06F19/20
摘要： Broad-based genetic mutation association gene transcript test and data structure. Genetic mutation considerations for this unique test include a custom set of genetic sequences associated in peer-reviewed literature with various known genetic mutation related to exposure to toxic substances. Such genetic mutations include specific gene sequence alterations based on exposure to diesel fuel, aviation fuel, jet fuel, and many other toxic substances often needed in the aviation and refining industries. The base dataset may be developed through clinical samples obtained by third-parties. Online access of real-time phenotype/genotype associative testing for physicians and patients may be promoted through an analysis of a customized microarray testing service.
摘要翻译：基于广泛的遗传突变关联基因转录检测和数据结构。该独特测试的遗传突变考虑包括与同行评议的文献相关的一系列遗传序列，其具有与暴露于有毒物质相关的各种已知遗传突变。这种基因突变包括基于暴露于柴油燃料，航空燃料，喷气燃料以及航空和精炼行业通常需要的许多其它有毒物质的特定基因序列变化。基础数据集可以通过第三方获得的临床样本来开发。可以通过分析定制的微阵列测试服务来促进医生和患者的实时表型/基因型联合检测的在线访问。

70. 发明申请

WO2009042213A1 METHODS OF TREATING OR PREVENTING CARDIAC DISEASE ASSOCIATED WITH A HIGH FAT DIET 审中-公开
标题翻译：治疗或预防与高脂肪饮食相关的心脏病的方法
公开(公告)号：WO2009042213A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/011203
申请日：2008-09-26
申请人： SYNVISTA THERAPEUTICS, INC. , THOMAS, Merlin , FORBES, Josephine , TIKELLIS, Chris
发明人： THOMAS, Merlin , FORBES, Josephine , TIKELLIS, Chris
IPC分类号： A61K31/46 , A61P3/04 , A61P9/00
CPC分类号： A61K31/426
摘要： The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.
摘要翻译：本发明涉及治疗或预防与高脂肪饮食相关的心脏病，心肌炎症或心肌氧化应激或使用本发明的噻唑鎓化合物和组合物进行高脂肪饮食的患者的方法。本发明还涉及一种改善体重增加，相关的心肌AGE积聚，线粒体超氧化物产生，RAGE表达或用高脂肪饮食的PPARα表达或使用噻唑鎓化合物和发明。

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