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61. 发明授权

EP1708770B1 ONE USE SYRINGE WITH RATCHET ON PLUNGER AND PAWL ON BODY 有权
标题翻译：带LOCK ON活塞和SPERRKLINKE BODY一次性注射器
公开(公告)号：EP1708770B1
公开(公告)日：2016-10-05
申请号：EP05700137.2
申请日：2005-01-28
申请人： Unitract Syringe Pty Ltd
发明人： KAAL, Joseph Hermes , THORLEY, Craig Stephen , JUDD, Damien
IPC分类号： A61M5/315
CPC分类号： A61M5/5013 , A61M5/502

62. 发明公开

EP2925611A1 DOSATOR FOR FILLING A CAPSULE WITH POWDER 有权转让
标题翻译： DOSATOR ZUMFÜLLENEINER KAPSEL MIT PULVER
公开(公告)号：EP2925611A1
公开(公告)日：2015-10-07
申请号：EP13853467.2
申请日：2013-11-08
申请人： Civitas Therapeutics, Inc.
发明人： PENACHIO, Ernest, D. , LAVIGNE, Kyle
IPC分类号： B65B1/04 , B65B31/00 , B65B43/42
CPC分类号： A61K9/4833 , A61J3/074 , A61K9/0073 , A61K9/0075 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/4808 , A61K9/4816 , A61K9/485 , A61K9/4858 , A61K31/198 , B65B1/16 , B65B1/26 , B65B1/36 , B65B63/028
摘要： The invention relates to a dosator which comprises a tapered elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen disposed between the stationary plunger and the bottom of the dosator; a dosator chamber defined between the mesh screen and the bottom of the dosator for receiving powder from a powder source and holding the powder until it is expelled into the capsule; at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density; and at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator and methods of filling capsules.
摘要翻译：本发明涉及一种定量器，其包括锥形细长腔; 设置在所述空腔内的固定柱塞; 设置在固定柱塞和定量器的底部之间的可移除的网状筛; 限定在筛网和定剂器底部之间的剂量器室，用于从粉末源接收粉末并保持粉末直到其被排出到胶囊中; 至少一个真空泵，其可操作地连接到所述定量器并且能够将粉末从粉末源吸入所述定量器室中，将所述粉末压实成具有预定堆积密度的粉末块; 以及至少一个正压源，可操作地连接到定量给药器并且能够提供正压力以从剂量器排出粉末塞子和填充胶囊的方法。

63. 发明公开

EP2916826A1 ULTRA LOW DENSITY PULMONARY POWDERS 有权转让
标题翻译：与超低密度肺粉
公开(公告)号：EP2916826A1
公开(公告)日：2015-09-16
申请号：EP13852608.2
申请日：2013-11-08
申请人： Civitas Therapeutics, Inc.
发明人： LIPP, Michael, M. , BATYCKY, Richard, P.
IPC分类号： A61K9/16 , A61K39/00 , A61P11/06
CPC分类号： A61K9/4833 , A61J3/074 , A61K9/0073 , A61K9/0075 , A61K9/145 , A61K9/1611 , A61K9/1617 , A61K9/4808 , A61K9/4816 , A61K9/485 , A61K9/4858 , A61K31/198 , B65B1/16 , B65B1/26 , B65B1/36 , B65B63/028
摘要： The invention relates to a dosator which comprises a tapered elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen disposed between the stationary plunger and the bottom of the dosator; a dosator chamber defined between the mesh screen and the bottom of the dosator for receiving powder from a powder source and holding the powder until it is expelled into the capsule; at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density; and at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator and methods of filling capsules.

64. 发明公开

EP2846622A1 PROPAGATION OF STRELITZIA (BIRD OF PARADISE) 有权
标题翻译： ZÜCHTUNGVON STRELITZIEN（PARADIESVOGELBLUME）
公开(公告)号：EP2846622A1
公开(公告)日：2015-03-18
申请号：EP13724880.3
申请日：2013-04-05
申请人： University of Limpopo
发明人： NIKOLOVA, Roumiana, Vassileva , RAMALEPE, Phillemon , DU PLESSIS, Helena, Jacoba
IPC分类号： A01H4/00
CPC分类号： A01H4/005
摘要： An
in vitro method for the propagation of a
Strelitzia species from a
Strelitzia seed includes chemically scarifying the
Strelitzia seed, and effecting surface sterilisation of the scarified seed. The scarified and sterilised seed is inoculated on germination media and allowed to germinate in darkness to establish a germinated seed culture. In a seedling development step, the germinated seed culture is subjected to light conditions for a suitable photoperiod for seedling development, whereafter a shoot explant is obtained by removing the root of the seedling. Apical dominance is uplifted in the shoot explant, and multiple shoot development is initiated on the shoot explant using plant growth regulators. The resulting multiple shoots are separated and axillary shoots subcultured to shoot induction media for further multiplication. Axillary shoots are transferred to root development media for inducing root growth, and hence plantlet regeneration. The resultant
in vitro produced plantlets are acclimitised.
摘要翻译：一种用于从鹤望兰种子繁殖鹤望兰的体外方法包括化学scar the ia ia种子，并进行表面灭菌的划痕种子。将经过清除和灭菌的种子接种在发芽培养基上，并在黑暗中发芽以形成发芽种子培养物。在幼苗发育步骤中，将发芽的种子培养物进行光照条件以获得用于幼苗发育的合适的光周期，然后通过除去幼苗的根部获得芽外植体。顶端优势在枝条外植体中提升，并且使用植物生长调节剂在枝条外植体上开始多次芽发育。分离得到的多个芽，并将腋芽传代培养以诱导诱导培养基进一步繁殖。将腋芽转移到根发育培养基以诱导根生长，并因此转移到小植株再生。所得到的体外产生的小植物被驯化。

65. 发明授权

EP2311972B1 Recombinant N-glycosylated proteins from procaryotic cells 有权
标题翻译：从原核细胞的重组N-糖基化蛋白
公开(公告)号：EP2311972B1
公开(公告)日：2015-01-21
申请号：EP10179208.3
申请日：2006-05-10
申请人： ETH Zurich
发明人： Aebi, Markus , Kowarik, Michael , Ahuja, Umesh
IPC分类号： C07K14/25 , C07K14/205 , C12P21/00
CPC分类号： C12P21/005 , C07K14/205 , C07K14/25 , C07K2319/034 , C12N9/1051 , C12N15/70 , C12Y204/01

66. 发明公开

EP2802652A2 CLOSTRIDIUM HISTOLYTICUM ENZYMES AND METHODS FOR THE USE THEREOF 有权转让
标题翻译： VERFAHREN ZU DAVON VERWENDUNG的胶原蛋白
公开(公告)号：EP2802652A2
公开(公告)日：2014-11-19
申请号：EP13736040.0
申请日：2013-01-10
申请人： Auxilium International Holdings, Inc.
发明人： HERBER, Wayne, K.
IPC分类号： C12N9/52
CPC分类号： A61K38/4886 , C12N9/50 , C12N9/52 , C12Q1/37 , G01N33/5044 , G01N33/56911 , G01N2333/96419 , Y02A50/473 , Y02A50/481
摘要： The invention relates to recombinant nucleic acid and polypeptides encoding collagenase I and collagenase II, methods for the preparation thereof and methods for the use thereof. The invention also encompasses methods related to releasing a composition comprising collagenase prior to therapeutic administration.
摘要翻译：本发明涉及编码胶原酶I和胶原酶II的重组核酸和多肽，其制备方法及其使用方法。本发明还包括在治疗性给药之前释放包含胶原酶的组合物的方法。

67. 发明公开

EP2790702A1 COMPOSITIONS OF BUPRENORPHINE AND MU-OPIOID RECEPTOR ANTAGONISTS 有权
标题翻译： ZUSAMMENSETZUNGEN AUS BUPRENORPHIN UND MU-OPIOID-REZEPTORANTAGONISTEN
公开(公告)号：EP2790702A1
公开(公告)日：2014-10-22
申请号：EP12830900.2
申请日：2012-12-14
申请人： Alkermes Pharma Ireland Limited
发明人： DEAVER, Daniel , EHRICH, Elliot
IPC分类号： A61K31/485 , A61P25/04 , A61K45/06 , A61P25/22 , A61P25/24
摘要： The invention relates to a composition comprising buprenorphine and a µ opioid receptor antagonist, wherein the composition is characterized by an Agonist Antagonist Activity Index (AAnAI) of between about 0.7 and about 2.2; wherein; AAnAI = / EC 50 c max BUP c max ANTAGONIST / IC 50 .
摘要翻译：本发明涉及包含丁丙诺非和μ阿片受体拮抗剂的组合物，其中该组合物的特征在于约0.7至约2.2的激动剂拮抗剂活性指数（AAnAI）; 其中; AAnAI = [C max⁡（BUB）BC 30] [C max（ANTAGONIST）IC 30]。

68. 发明公开

EP2786441A1 METHOD FOR ALKALIATING ANODES 有权
标题翻译： VERFAHREN ZUR LITHIIERUNG VON ANODEN
公开(公告)号：EP2786441A1
公开(公告)日：2014-10-08
申请号：EP12854244.6
申请日：2012-11-29
申请人： Nanoscale Components, Inc.
发明人： GRANT, Robert, W. , SWEETLAND, Matthew , ACHARIGE, Asela, Maha
IPC分类号： H01M8/08
CPC分类号： C25D11/00 , C25D3/54 , C25D3/665 , H01M4/0402 , H01M4/0459 , H01M4/139 , Y02E60/122
摘要： The present invention relates to a method for lithiation of an intercalation-based anode or a non-reactive plating-capable foil or a reactive alloy capable anode, whereby utilization of said lithiated intercalation-based anode or a plating-capable foil or reactive alloy capable anode in a rechargeable battery or electrochemical cell results in an increased amount of lithium available for cycling, and an improved reversible capacity during charge and discharge.
摘要翻译：本发明涉及一种基于插层的阳极或不具有反电镀能力的箔或具有反应性合金的阳极的锂化方法，由此利用所述锂化嵌层基阳极或具有电镀能力的箔或活性合金可再充电电池或电化学电池中的阳极导致可用于循环的锂的量增加，以及在充电和放电期间改善的可逆容量。

69. 发明公开

EP2768523A1 METHOD OF TREATING OR REDUCING EFP 有权转让
标题翻译：方法用于治疗或缓解便秘，肠瘘
公开(公告)号：EP2768523A1
公开(公告)日：2014-08-27
申请号：EP12842537.8
申请日：2012-10-19
申请人： Auxilium International Holdings, Inc.
发明人： HART, Susan G., Emeigh
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61K9/0021 , C12Y304/24003
摘要： The present invention is directed to a method of treating or reducing EFP in a patient comprising administering one or multiple low dose injections of collagenase to an area affected by EFP. The invention encompasses methods wherein the dose of collagenase per injection is between about 50 to about 200 ABC units and/or wherein the concentration of collagenase is between about 50 to about 2000 ABC units/milliliter (ml).

70. 发明公开

EP2766380A1 3,3 DISUBSTITUTED 19-NOR PREGNANE COMPOUNDS, COMPOSITIONS, AND USES THEREOF 有权
标题翻译： 3,3-二取代19-NOR孕化合物的组合物，使用体和
公开(公告)号：EP2766380A1
公开(公告)日：2014-08-20
申请号：EP12781534.8
申请日：2012-10-12
申请人： Sage Therapeutics, Inc.
发明人： UPASANI, Ravindra, B. , ASKEW, Benny, C. , HARRISON, Boyd, L. , DISTEFANO, Peter, Scott , SALITURO, Francesco, G. , ROBICHAUD, Albert, J.
IPC分类号： C07J5/00 , C07J7/00 , C07J31/00 , C07J43/00 , A61K31/57 , A61K31/573 , A61K31/58 , A61P25/00
CPC分类号： C07J43/003 , C07J5/0015 , C07J7/002 , C07J7/008 , C07J7/0085 , C07J9/005 , C07J31/006
摘要： Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.

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