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61. 发明授权

EP2927328B1 SSEA4 and ST3GAL2 as chemotherapeutic drug response biomarkers 有权转让
公开(公告)号：EP2927328B1
公开(公告)日：2018-10-10
申请号：EP14305477.3
申请日：2014-04-01
申请人： Miltenyi Biotec GmbH , XenTech
发明人： Hardt, Olaf , Bosio, Andeas , Aloia, Andrea , Judde, Jean-Gabriel , Petrova, Evgeniya , Cairo, Stefano , Deas, Olivier
IPC分类号： C12Q1/6886
CPC分类号： G01N33/57492 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2405/10
摘要： The present invention provides the use of the biomarkers SSEA4 and/or ST3GAL2 for assessing the outcome for chemotherapeutic treatment of a cancer in an individual and methods thereof.

62. 发明公开

EP3315511A1 ADAPTER CHIMERIC ANTIGEN RECEPTOR EXPRESSING CELLS FOR TARGETING OF MULTIPLE ANTIGENS 审中-公开
标题翻译：表达用于靶向多种抗原的细胞表达嵌合抗体的嵌合抗原受体
公开(公告)号：EP3315511A1
公开(公告)日：2018-05-02
申请号：EP16196487.9
申请日：2016-10-29
申请人： Miltenyi Biotec GmbH
发明人： KAISER, Andrew , MITTELSTAET, Joerg , HUPPERT, Volker , MILTENYI, Stefan , SCHLEGEL, Patrick , SEITZ, Christian , LANG, Peter , HANDGRETINGER, Rupert
IPC分类号： C07K14/725 , A61K31/4188 , C07K16/28
CPC分类号： C07K14/7051 , A61K31/4188 , C07K14/70503 , C07K14/70517 , C07K14/70578 , C07K16/18 , C07K16/2896 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The present invention provides an extracellular anti-linker/label epitope chimeric antigen receptor (anti-LLE CAR) comprising I) a linker/label epitope (LLE) binding domain, II) a transmembrane domain, and III) a signal transduction domain, wherein said extracellular LLE binding domain binds a target cell binding molecule (TCBM) comprising i) an antigen binding moiety (ABM), wherein said ABM binds specifically to an antigen expressed on a target cell, ii) a label moiety (LaM), wherein said LaM is a naturally occurring molecule in a subject or a derivative thereof, iii) a linker moiety (LiM) conjugating said ABM and said LaM, thereby forming a linker/label epitope (LLE), wherein said extracellular LLE binding domain binds said LLE with a higher preference than said naturally occurring molecule.
摘要翻译：本发明提供了包含I）接头/标记表位（LLE）结合结构域，II）跨膜结构域和III）信号转导结构域的细胞外抗接头/标记表位嵌合抗原受体（抗LLE CAR），其中所述细胞外LLE结合结构域结合包含i）抗原结合部分（ABM），其中所述ABM特异性结合靶细胞上表达的抗原的靶细胞结合分子（TCBM），ii）标记部分（LaM），其中所述 LaM是受试者或其衍生物中天然存在的分子，iii）缀合所述ABM和所述LaM的接头部分（LiM），由此形成接头/标记表位（LLE），其中所述胞外LLE结合结构域将所述LLE与比所述天然存在的分子更优选。

63. 发明公开

EP3276005A1 COMPOSITION AND METHOD FOR AFFECTING THE BINDING OF ANTIGEN-BINDING POLYPEPTIDES TO ANTIGENS 有权转让
标题翻译：影响抗原结合多肽与抗原结合的组合物和方法
公开(公告)号：EP3276005A1
公开(公告)日：2018-01-31
申请号：EP16181971.9
申请日：2016-07-29
申请人： Miltenyi Biotec GmbH , Dübel, Stefan
发明人： DÜBEL, Stefan , KELLMANN, Sarah-Jane , THIE, Holger
IPC分类号： C12N15/85
CPC分类号： C07K14/4728 , C07K16/40 , C07K2317/56 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N9/12 , C12Y207/11018
摘要： The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Ca 2+ binding site of calmodulin; wherein the binding of said calmodulinbinding molecule and of said ions to said Ca 2+ binding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.
摘要翻译：本发明提供了一种组合物，其包含：i）包含钙调蛋白和两个免疫球蛋白超家族结构域的多肽，其中所述两个免疫球蛋白超家族结构域通过所述钙调蛋白连接; ii）钙调蛋白结合分子; iii）与钙调蛋白的Ca 2+结合位点结合的离子; 其中所述钙调蛋白结合分子和所述离子与钙调蛋白的所述Ca 2+结合位点的结合影响所述多肽与待与所述多肽结合的抗原的结合。钙调蛋白可以是置换钙调蛋白。还公开了使用所述组合物影响多肽与抗原结合的方法。

64. 发明公开

EP3241905A1 METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL 审中-公开
标题翻译：将核酸引入细胞的方法
公开(公告)号：EP3241905A1
公开(公告)日：2017-11-08
申请号：EP16168589.6
申请日：2016-05-06
申请人： Miltenyi Biotec GmbH
发明人： JURK, Marion , WILD, Stefan , BOSIO, Andreas
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , C07K14/4703
摘要： The present invention provides the use of a nucleic acid encoding SOCS 1 for enhancing the efficacy of introducing at least one nucleic acid of interest into a cell; a method of repeated transfection of a cell with at least one nucleic acid of interest comprising the steps of adding
a) nucleic acid encoding SOCS1, and simultaneously or subsequently b) at least one nucleic acid of interest encoding at least one polypeptide of interest, wherein at least step b) is repeated at least once; and a method of electroporation of a cell with at least one nucleic acid of interest comprising the steps of adding to the cell a) a nucleic acid encoding SOCS1, and simultaneously or subsequently b) said at least one nucleic of interest. The at least one nucleic acid of interest and the nucleic acid encoding SOCS 1 may be mRNAs, wherein each of said mRNAs has a poly(A) tail at its 3'end comprising at least 200 adenines.
摘要翻译：本发明提供编码SOCS1的核酸用于增强将至少一种感兴趣的核酸导入细胞的功效的用途; 用至少一种目标核酸重复转染细胞的方法，包括以下步骤：添加a）编码SOCS1的核酸，并且同时或随后b）编码至少一种目的多肽的至少一种感兴趣的核酸，其中至少步骤b）重复至少一次; 以及用至少一种感兴趣的核酸对细胞进行电穿孔的方法，所述方法包括以下步骤：向细胞中加入a）编码SOCS1的核酸，并且同时或随后b）所述至少一种感兴趣的核酸。所述至少一种目的核酸和编码SOCS1的核酸可以是mRNA，其中每种所述mRNA在其3'末端具有包含至少200个腺嘌呤的聚（A）尾。

65. 发明授权

EP2900809B1 METHOD FOR POLYCLONAL STIMULATION OF T CELLS BY MOBILE NANOMATRICES 有权转让
标题翻译：用移动纳米粒子多克隆刺激T细胞的方法
公开(公告)号：EP2900809B1
公开(公告)日：2017-05-31
申请号：EP13766319.1
申请日：2013-09-24
申请人： Miltenyi Biotec GmbH
发明人： SCHEFFOLD, Alexander , ASSENMACHER, Mario
IPC分类号： C12N5/0783 , C12N5/00
CPC分类号： C12N5/0637 , A61K35/17 , C12N5/0075 , C12N5/0636 , C12N2501/51 , C12N2501/515 , C12N2501/998 , C12N2533/70 , C12N2539/00
摘要： The present invention provides a method polyclonal stimulation of T cells, the method comprising contacting a population of T cells with a nanomatrix, the nanomatrix comprising a) a flexible matrix, wherein said matrix is of polymeric material; and b) attached to said polymeric flexible matrix one or more polyclonal stimulatory agents which provide activation signals to the T cells; thereby activating and inducing the T cells to proliferate; wherein the nanomatrix is 1 to 500 nm in size. At least one first and one second stimulatory agents are attached to the same or to separate flexible matrices. If the stimulatory agents are attached to separate beads, fine-tuning of nanomatrices for the stimulation of the T cells is possible.
摘要翻译：本发明提供了T细胞多克隆刺激的方法，所述方法包括使T细胞群与纳米基质接触，所述纳米基质包含a）柔性基质，其中所述基质为聚合物材料; 和b）连接到所述聚合物柔性基质上的一种或多种向T细胞提供激活信号的多克隆刺激剂; 从而激活并诱导T细胞增殖; 其中纳米基体的尺寸为1至500nm。至少有一种第一种和第二种刺激剂附着在其上或分开柔性基质。如果刺激剂附着于单独的珠上，可以微调纳米基质以刺激T细胞。

66. 发明公开

EP3138905A1 METHOD FOR NATURAL KILLER CELL EXPANSION 审中-公开
标题翻译： VERFAHRENFÜRNATÜRLICHEKILLERZELLENEXPANSION
公开(公告)号：EP3138905A1
公开(公告)日：2017-03-08
申请号：EP15183968.5
申请日：2015-09-04
申请人： Miltenyi Biotec GmbH
发明人： GRANZIN, Markus , HUPPERT, Volker
IPC分类号： C12N5/0783
CPC分类号： C12N5/0646 , C12N2501/2302 , C12N2501/2315 , C12N2501/2321
摘要： The present invention provides a method for in-vitro culturing and expanding natural killer (NK) cells in a cell culture medium comprising a population of NK cells, the method comprising a) adding an effective concentration of interleukin-21 (IL-21) at the beginning of the culturing process to said medium, b) adding repeatedly an effective concentration of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) to said medium, and c) adding repeatedly feeder cells or membrane particles thereof to said medium, wherein said feeder cells are B cell derived which are EBV immortalized; and wherein said expansion of NK cells in said cell culture medium is maintained for at least 3 weeks.
摘要翻译：本发明提供了在包含NK细胞群的细胞培养基中体外培养和扩增天然杀伤（NK）细胞的方法，所述方法包括：a）将有效浓度的白细胞介素-21（IL-21）加入到培养过程开始于所述培养基，b）向所述培养基反复加入白细胞介素-2（IL-2）和/或白细胞介素-15（IL-15）的有效浓度，c）重复加入饲养细胞或膜其中所述饲养细胞是B细胞衍生的，其是EBV永生化的; 并且其中所述细胞培养基中NK细胞的所述扩增保持至少3周。

67. 发明公开

EP2900809A1 METHOD FOR POLYCLONAL STIMULATION OF T CELLS BY MOBILE NANOMATRICES 有权转让
标题翻译： VERFAHREN ZUR POLYKLONALEN刺激VON T-ZELLEN DURCH柔性NANOMATRICEN
公开(公告)号：EP2900809A1
公开(公告)日：2015-08-05
申请号：EP13766319.1
申请日：2013-09-24
申请人： Miltenyi Biotec GmbH
发明人： SCHEFFOLD, Alexander , ASSENMACHER, Mario
IPC分类号： C12N5/0783 , C12N5/00
CPC分类号： C12N5/0637 , A61K35/17 , C12N5/0075 , C12N5/0636 , C12N2501/51 , C12N2501/515 , C12N2501/998 , C12N2533/70 , C12N2539/00
摘要： The present invention provides a method polyclonal stimulation of T cells, the method comprising contacting a population of T cells with a nanomatrix, the nanomatrix comprising a) a flexible matrix, wherein said matrix is of polymeric material; and b) attached to said polymeric flexible matrix one or more polyclonal stimulatory agents which provide activation signals to the T cells; thereby activating and inducing the T cells to proliferate; wherein the nanomatrix is 1 to 500 nm in size. At least one first and one second stimulatory agents are attached to the same or to separate flexible matrices. If the stimulatory agents are attached to separate beads, fine-tuning of nanomatrices for the stimulation of the T cells is possible.
摘要翻译：本发明提供了T细胞的多克隆刺激的方法，该方法包括使一组T细胞与纳米基质接触，所述纳米基质包含a）柔性基质，其中所述基质是聚合物材料; 和b）连接到所述聚合物柔性基质上的一种或多种向T细胞提供活化信号的多克隆刺激剂; 从而激活和诱导T细胞增殖; 其中纳米线的尺寸为1〜500nm。至少一个第一和第二个刺激剂连接到相同的或分开的柔性基质。如果刺激剂附着到分离的珠子上，则可以对用于刺激T细胞的纳米片进行微调。

68. 发明公开

EP4416270A1 METHOD FOR THE GENERATION OF GENETICALLY MODIFIED NK CELLS 审中-实审
公开(公告)号：EP4416270A1
公开(公告)日：2024-08-21
申请号：EP22803182.9
申请日：2022-10-13
申请人： Miltenyi Biotec B.V. & Co. KG
发明人： ZHANG, Congcong , QUADFLIEG, Melissa , MÖKER, Nina
IPC分类号： C12N5/0783 , C12N15/85
CPC分类号： C12N5/0636 , C12N2510/0020130101 , C12N2730/0004320130101 , C12N15/907 , C12N2740/1604320130101 , A61K48/005 , A61K39/464429 , A61K39/4613 , A61K39/4631 , A61K39/464402

69. 发明公开

EP4240404A1 METHODS AND COMPOSITIONS FOR ELIMINATING ENGINEERED IMMUNE CELLS 审中-实审
公开(公告)号：EP4240404A1
公开(公告)日：2023-09-13
申请号：EP21806709.8
申请日：2021-11-05
申请人： Miltenyi Biotec B.V. & Co. KG
发明人： LOCK, Dominik , BRANDES, Caroline , SCHASER, Thomas
IPC分类号： A61K39/00 , C07K14/725 , C07K14/005

70. 发明授权

EP3927812B1 CELL CULTURE MEDIUM AND METHOD FOR GENERATION OF EPITHELIAL ORGANOIDS FROM EPITHELIAL STEM CELLS 有权
公开(公告)号：EP3927812B1
公开(公告)日：2023-09-06
申请号：EP20704323.3
申请日：2020-02-18
发明人： AGORKU, David, Joel , HARDT, Olaf, Thorsten , BOSIO, Andreas , BECKER, Kristin , ECKARDT, Dominik
IPC分类号： C12N5/071

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