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61. 发明授权

US6054454A Method of controlling fish parasites 失效
标题翻译：控制鱼类寄生虫的方法
公开(公告)号：US6054454A
公开(公告)日：2000-04-25
申请号：US68827
申请日：1998-05-18
申请人： Hariolf Schmid , Ernst Hess
发明人： Hariolf Schmid , Ernst Hess
IPC分类号： A01N43/88 , A01N43/90 , A01N47/40 , A01N47/44 , A01N51/00
CPC分类号： A01N47/40 , A01N51/00
摘要： The present invention relates to the use of compounds of formula ##STR1## wherein A is an unsubstituted or mono- to tetrasubstituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical, where one to two of the substituents of A can be selected from the group consisting of halo-C.sub.1 -C.sub.3 alkyl, cyclopropyl, halocyclopropyl, C.sub.2 -C.sub.3 alkenyl, C.sub.2 -C.sub.3 alkynyl, halo-C.sub.2 -C.sub.3 alkenyl, halo-C.sub.2 -C.sub.3 alkynyl, halo-C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, halo-C.sub.1 -C.sub.3 alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro, and one to four of the substituents of A can be selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl; and X is N--NO.sub.2 or N--CN, in the free form or in salt form or, if appropriate, tautomers thereof, in the free form or in salt form, for controlling fish parasites, in particular sea lice.
摘要翻译： PCT No.PCT / EP96 / 05302 Sec。 371日期1999年5月18日 102（e）1999年5月18日PCT PCT 1996年11月29日PCT公布。公开号WO97 / 21350 PCT 日期：1996年6月19日本发明涉及下式化合物的用途，其中A是未取代的或单取代的，四取代的，芳族的或非芳香的单环或双环杂环基，其中A的一至两个取代基可以是选自卤代C 1 -C 3烷基，环丙基，卤代环丙基，C 2 -C 3烯基，C 2 -C 3炔基，卤代-C 2 -C 3烯基，卤代C 2 -C 3炔基，卤代-C 1 -C 3烷氧基，C 1 -C 3烷硫基， C3烷硫基，烯丙氧基，炔丙氧基，烯丙硫基，炔丙硫基，卤代烯丙氧基，卤代烯硫基，氰基和硝基，A至1-4个取代基可以选自C 1 -C 3烷基，C 1 -C 3烷氧基和卤素; R是氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6烯基或C 2 -C 6炔基; 和X为游离形式或盐形式的N-NO 2或N-CN，或其合适的互变异构体，以游离形式或盐形式用于控制鱼类寄生虫，特别是海虱。

62. 发明授权

US06002013A 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US06002013A
公开(公告)日：1999-12-14
申请号：US148276
申请日：1998-09-04
申请人： Walter Kunz , Beat Jau
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82 , C07D285/14 , C07D277/62 , C07C255/07 , C07C321/08
CPC分类号： C07D285/14 , C07C319/02 , C07C319/12 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen,n is 0, 1, 2 or 3;Z is CN, CO--A or CS--A,A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ;R.sub.1 to R.sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or NProcesses for the preparation of compounds of the formula I are described.
摘要翻译：式I化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要中间产物。在式I和III化合物中：X为卤素，n为0 ，1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。描述了公式I。

63. 发明授权

US5958708A Reshaped monoclonal antibodies against an immunoglobulin isotype 失效
公开(公告)号：US5958708A
公开(公告)日：1999-09-28
申请号：US476176
申请日：1995-06-07
申请人： Norman Hardman , Frank Kolbinger , Jose Saldanha
发明人： Norman Hardman , Frank Kolbinger , Jose Saldanha
IPC分类号： A61K38/00 , A61K47/48 , A61P37/08 , C07K16/42 , C07K16/46 , C12P21/08 , G01N33/567
CPC分类号： A61K47/48653 , C07K16/4291 , C07K16/465 , A61K2039/505 , A61K38/00 , C07K2317/565 , C07K2319/00
摘要： The invention relates to reshaped human monoclonal antibodies directed against isotypic determinants of immunoglobulin E (IgE), direct equivalents and derivatives of said antibodies. The molecules of the invention are useful for diagnostics, prophylaxis and treatment of allergy.

64. 发明授权

US5942221A Recombinant primate granulocyte macrophage-colony stimulating factor 失效
标题翻译：重组灵长类动物粒细胞巨噬细胞集落刺激因子
公开(公告)号：US5942221A
公开(公告)日：1999-08-24
申请号：US468694
申请日：1995-06-06
申请人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
发明人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong
IPC分类号： C12P21/02 , A61K38/00 , A61K38/17 , C07K14/535 , C12N15/27 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/19
CPC分类号： C07K14/535 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/00 , C12N2830/42 , C12N2840/105 , Y10S514/885
摘要： A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises: preparing RNA from a cell that produces CSF; preparing polyadenylated messenger RNA from said RNA; preparing single stranded cDNA from said messenger RNA; converting the single stranded cDNA to double stranded cDNA; inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies; picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool; transfecting the plasmid DNA into suitable host cells for expressing CSF protein; culturing the transfected cells and assaying the supernatant for CSF activity; and selecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e. CSF/cDNA), a microorganism or cell line transformed with a recombinant vector containing such CSF/cDNA, and a method for producing CSF protein by expressing said CSF/cDNA by culturing a microorganism or cell line.
摘要翻译：描述了制备和分离含有CSF / cDNA的转化载体的方法。该方法包括：从产生CSF的细胞制备RNA; 从所述RNA制备聚腺苷酸化的信使RNA; 从所述信使RNA制备单链cDNA; 将单链cDNA转化为双链cDNA; 将双链cDNA插入转化载体并用所述载体转化细菌以形成菌落; 分别取200至500个菌落的池，每个池中分离出质粒DNA; 将质粒DNA转染到合适的宿主细胞中以表达CSF蛋白; 培养转染的细胞并测定上清液的CSF活性; 并选择CSF阳性池并筛选用于制备池的菌落以鉴定具有CSF活性的菌落。还描述了编码具有CSF活性的蛋白质（即CSF / cDNA）的cDNA，用含有这种CSF / cDNA的重组载体转化的微生物或细胞系，以及通过培养表达所述CSF / cDNA来产生CSF蛋白的方法微生物或细胞系。

65. 发明授权

US5922612A Optical sensor system for determining pH values and ionic strengths 失效
标题翻译：用于测定pH值和离子强度的光学传感器系统
公开(公告)号：US5922612A
公开(公告)日：1999-07-13
申请号：US737034
申请日：1997-01-02
申请人： Alex Alder , Steven Barnard , Joseph Berger , Nils Blom , Marizel Rouilly
发明人： Alex Alder , Steven Barnard , Joseph Berger , Nils Blom , Marizel Rouilly
IPC分类号： G01N31/00 , C07D311/78 , C07D311/90 , C08F220/54 , C08F291/00 , C09D4/06 , G01N21/78 , G01N31/22 , G01N31/16
CPC分类号： G01N31/221 , C07D311/78 , C07D311/90 , C08F220/54 , C08F291/00 , C09D4/06
摘要： A method for the independent, reversible, optical determination of the pH value and the ionic strength of an aqueous sample with the aid of two different sensors in accordance with the fluorescence method, in which method two optical sensors, which are each composed of polymers of different structure but each contain the same fluorescent dye and which each consist of a coated material composed ofa) a carrier material, to which there is appliedb) at least one water-insoluble layer of a polymer comprising at least one hydrophilic monomer (A) from the group of substituted olefins, andc) a proton-sensitive fluorescent dye which is bonded directly or via a bridge group to the spine of polymer b) or which is incorporated in polymer b),are brought into contact with an aqueous test sample, irradiated with exciting light, the fluorescence is measured and the pH values and the ionic strengths are calculated from the measured fluorescence intensities with reference to calibration curves.
摘要翻译： PCT No.PCT / IB95 / 00302 Sec。 371日期1997年1月2日 102（e）日期1997年1月2日PCT提交1995年4月27日PCT公布。公开号WO95 / 30148 日期：1995年11月9日根据荧光法，借助于两种不同传感器，独立，可逆，光学测定水样品的pH值和离子强度的方法，其中两种光学传感器是每个由不同结构的聚合物组成，但每个都含有相同的荧光染料，并且每个由包含a）载体材料的涂层材料组成，其中施加有b）至少一种至少包含一种聚合物的水不溶性层一个亲水性单体（A），以及c）质子敏感的荧光染料，其直接或通过桥接基团与聚合物b）的骨架结合或掺入聚合物b）中，被引入与水性测试样品接触，用激发光照射，测量荧光，并根据测量的荧光强度参照校准计算pH值和离子强度曲线。

66. 发明授权

US5912375A Hydrogenation catalyst, process for the preparation thereof and hydrogenation process 失效
标题翻译：氢化催化剂，其制备方法和氢化方法
公开(公告)号：US5912375A
公开(公告)日：1999-06-15
申请号：US871478
申请日：1997-06-09
申请人： Felix Spindler , Ulrich Pittelkow
发明人： Felix Spindler , Ulrich Pittelkow
IPC分类号： B01J31/22 , B01J31/24 , C07B61/00 , C07C209/52 , C07C211/07 , C07C211/08 , C07C211/17 , C07C211/35 , C07C211/45 , C07C211/54 , C07C211/57 , C07C211/60 , C07C213/02 , C07C215/08 , C07C215/42 , C07C215/50 , C07C217/08 , C07C217/52 , C07C217/58 , C07C227/06 , C07C229/12 , C07C229/38 , C07C229/46 , C07F15/00 , C07F17/02 , C07F7/24
CPC分类号： B01J31/1845 , B01J31/04 , B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2419 , B01J31/2452 , C07C209/52 , C07F15/004 , C07F17/02 , B01J2231/643 , B01J2531/0205 , B01J2531/0266 , B01J2531/827 , B01J2531/842 , B01J31/26 , B01J31/30
摘要： Reaction products of an iridium (III) salt or a hydrate thereof, a diphosphine having secondary phosphine groups and a metal or ammonium chloride, bromide or iodide are excellent hydrogenation catalysts for ketimine. Using chiral diphosphines and prochiral ketimines, diastereoisomeric secondary amines are obtained in high optical yields.
摘要翻译：铱（III）盐或其水合物，具有仲膦基的二膦和金属或氯化铵，溴化物或碘化物的反应产物是用于酮亚胺的优异的氢化催化剂。使用手性二膦和前手性酮亚胺，以高光学收率获得非对映异构仲胺。

67. 发明授权

US5908632A Process for the preparation of spherical microparticles containing biologically active compounds 失效
标题翻译：制备含有生物活性化合物的球形微粒的方法
公开(公告)号：US5908632A
公开(公告)日：1999-06-01
申请号：US776401
申请日：1997-01-21
申请人： Rudolf Nastke , Ernst Neuenschwander
发明人： Rudolf Nastke , Ernst Neuenschwander
IPC分类号： B01J13/14 , A01N25/28 , A01N43/54 , A01N47/30 , A01N57/16 , B01J13/18
CPC分类号： A01N25/28
摘要： The invention relates to a process for encapsulating biologically active compounds in the form of substantially spherical microparticles, comprising the steps ofa) preparing an aqueous solution of surfactants, catalysts and monomers or prepolymers which are suitable for forming a crosslinked polycondensate,b) forming an emulsion of the substantially water-insoluble biologically active compound or mixture thereof in the solution a) by adding said solution under high shear force, andc) forming a solid capsule wall around the biologically active compound or mixture thereof by heating the reaction mixture to a temperature at which the crosslinking reaction tales place,which process comprises fusing the biologically active compound or mixture thereof and adding the melt to the aqueous reaction mixture at a temperature which is higher than the temperature of the reaction mixture.
摘要翻译： PCT No.PCT / EP95 / 02727 Sec。 371日期1997年1月21日 102（e）日期1997年1月21日PCT提交1995年7月12日PCT公布。公开号WO96 / 03040 日期1996年2月8日本发明涉及一种以基本上球形的微粒形式包封生物活性化合物的方法，包括以下步骤：a）制备适于形成交联缩聚物的表面活性剂，催化剂和单体或预聚物的水溶液 b）在溶液中形成基本上不溶于水的生物活性化合物或其混合物的乳液a）通过在高剪切力下加入所述溶液，和c）通过加热在生物活性化合物或其混合物周围形成固体胶囊壁将反应混合物加热至交联反应产生的温度，该方法包括将生物活性化合物或其混合物熔融并在高于反应混合物温度的温度下将熔体加入到水性反应混合物中。

68. 发明授权

US5866153A Process for the preparation of microcapsules 失效
标题翻译：微胶囊制备方法
公开(公告)号：US5866153A
公开(公告)日：1999-02-02
申请号：US512427
申请日：1995-08-08
申请人： Hans Walter Hasslin , Michael James Hopkinson
发明人： Hans Walter Hasslin , Michael James Hopkinson
IPC分类号： B01J13/16 , A01N25/34
CPC分类号： B01J13/16
摘要： The invention relates to a process for the preparation of an aqueous suspension of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide, by dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide in water and subsequently reacting the dispersion with a polyamine, which process comprises effecting the dispersion of the solution of the polyisocyanate in the sparingly water-soluble pesticide in water and the subsequent reaction of the dispersion with the polyamine in the presence of at least one water-soluble or water-dispersible nonionic surfactant of a block copolymer having at least one hydrophobic block and at least one hydrophilic block.
摘要翻译：本发明涉及一种制备具有聚脲胶囊壁并包封水不混溶农药的微胶囊的水性悬浮液的方法，通过将多异氰酸酯的溶液分散在微水溶性农药中并随后使分散体与多胺反应，该方法包括使多异氰酸酯在少量水溶性农药中的溶液分散在水中，随后在至少一种水溶性或水分散性非离子表面活性剂存在下分散体与多胺的反应具有至少一个疏水嵌段和至少一个亲水嵌段的嵌段共聚物的表面活性剂。

69. 发明授权

US5859300A Process for the hydrogenation of imines 失效
标题翻译：亚胺氢化方法
公开(公告)号：US5859300A
公开(公告)日：1999-01-12
申请号：US108
申请日：1998-01-26
申请人： Hans-Peter Jalett , Bernd Siebenhaar
发明人： Hans-Peter Jalett , Bernd Siebenhaar
IPC分类号： B01J31/24 , C07B61/00 , C07C209/52 , C07C211/03 , C07C213/02 , C07C217/08 , C07C231/02 , C07C233/18 , C07C241/02 , C07C319/20 , C07C323/25 , C07D333/36
CPC分类号： C07D333/36
摘要： A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide, or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers. Improved optical yields and high chemical conversion rates are achieved while the catalyst is easily separable.
摘要翻译： PCT No.PCT / EP96 / 03143 Sec。 371日期1998年1月26日 102（e）1998年1月26日PCT PCT 1996年7月17日PCT公布。出版物WO97 / 05095 日期1997年2月13日在含有二膦配体的铱催化剂的存在下，在高压下用氢气氢化亚胺的方法，在有或者没有惰性溶剂的情况下，反应混合物含有可溶性氯化铵，溴化物或碘化物或可溶性金属氯化物，溴化物或碘化物，其中除了离子交换剂之外，反应混合物还含有至少一种固体酸。在催化剂容易分离的同时，获得了提高的光学收率和高化学转化率。

70. 发明授权

US5852012A Oxadiazine derivatives 失效
标题翻译：恶二嗪衍生物
公开(公告)号：US5852012A
公开(公告)日：1998-12-22
申请号：US464931
申请日：1995-06-05
申请人： Peter Maienfisch , Laurenz Gsell
发明人： Peter Maienfisch , Laurenz Gsell
IPC分类号： A01N43/88 , A01N43/72 , A01N43/84 , A01N47/40 , A01N47/44 , A01N51/00 , A01P7/04 , C07D20060101 , C07D273/04 , C07D413/06 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号： C07D413/06 , A01N47/40 , A01N51/00 , C07D273/00 , C07D273/04 , C07D417/06
摘要： Compounds of the formula ##STR1## in which A is an unsubstituted or mono- to tetrasubstituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical, where one to two of the substituents of A can be selected from the group consisting of halo-C.sub.1 -C.sub.3 alkyl, cyclopropyl, halocyclopropyl, C.sub.2 -C.sub.3 alkenyl, C.sub.2 -C.sub.3 alkynyl, halo-C.sub.2 -C.sub.3 alkenyl, halo-C.sub.2 -C.sub.3 alkynyl, halo-C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkylthio, halo-C.sub.1 -C.sub.3 alkylthio, allyloxy, propargyloxy, allylthio, propargylthio, haloallyloxy, haloallylthio, cyano and nitro, and one to four of the substituents of A can be selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy and halogen; R is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl-C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl; and X is N--NO.sub.2 or N--CN, and, if appropriate, tautomers thereof, in each case in free form or in salt form, can be used as insecticidal active ingredients and can be prepared in a manner known per se.
摘要翻译：式（I）的化合物，其中A是未取代或单取代或单取代的，芳香族或非芳族的单环或双环杂环基，其中A的一至两个取代基可以选自卤代C 1 -C 3烷基，环丙基，卤代环丙基，C 2 -C 3烯基，C 2 -C 3炔基，卤代-C 2 -C 3烯基，卤代-C 2 -C 3炔基，卤代-C 1 -C 3烷氧基，C 1 -C 3烷硫基，卤代C 1 -C 3烷硫基，烯丙氧基，炔丙氧基，烯丙硫基，炔丙硫基，卤代烯丙氧基，卤代烯硫基，氰基和硝基，A至1-4个取代基可以选自C 1 -C 3烷基，C 1 -C 3烷氧基和卤素; R是氢，C 1 -C 6烷基，苯基-C 1 -C 4烷基，C 3 -C 6环烷基，C 2 -C 6烯基或C 2 -C 6炔基; 且X为N-NO 2或N-CN，并且如果合适，其互变异构体在各种情况下以游离形式或盐形式可用作杀虫活性成分，并且可以以本身已知的方式制备。

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