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61. 发明申请

WO2006077102A2 DETECTION METHOD AND MATERIALS THEREFOR 审中-公开
标题翻译：检测方法及其材料
公开(公告)号：WO2006077102A2
公开(公告)日：2006-07-27
申请号：PCT/EP2006/000421
申请日：2006-01-17
申请人： DELFT DIAGNOSTIC LABORATORY BV , GLAXOSMITHKLINE BIOLOGICALS S.A. , COLAU, Brigitte Desiree Alberte , KLETER, Gijsbertus Everardus , QUINT, Wilhelmus Gregorius , VAN ALEWIJK, Dirk Cornelius Jerrefaas Gelde , VAN DEN MUNCKHOF, Henricus Arno Marie , VAN DOORN, Leendert
发明人： COLAU, Brigitte Desiree Alberte , KLETER, Gijsbertus Everardus , QUINT, Wilhelmus Gregorius , VAN ALEWIJK, Dirk Cornelius Jerrefaas Gelde , VAN DEN MUNCKHOF, Henricus Arno Marie , VAN DOORN, Leendert
IPC分类号： C12Q1/70
CPC分类号： C12Q1/708
摘要： The invention relates to materials and methods method for detection and/or typing of any HPV nucleic acid possibly present in a biological sample, the method comprising the steps of:(i) amplification of a polynucleic acid fragment comprising or consisting of the B region of any HPV nucleic acid in the sample, said B region being indicated in Figure 1, and (ii) contacting any amplified fragments from step (i) with at least one probe capable of specific hybridization with the B region of HPV, said B region being indicated in Figure 1.
摘要翻译：本发明涉及用于检测和/或分类可能存在于生物样品中的任何HPV核酸的材料和方法方法，所述方法包括以下步骤：（i）扩增包含或由其组成的多核苷酸片段的B区样品中的任何HPV核酸，所述B区域如图1所示，和（ii）将来自步骤（i）的任何扩增的片段与至少一种能够与HPV的B区进行特异性杂交的探针接触，所述B区为如图1所示。

62. 发明申请

WO2005108885A1 APPARATUS FOR SHELL FREEZING A LIQUID CONTENT IN A CONTAINER 审中-公开
标题翻译：用于在冷凝器内冷冻液体内容物的装置
公开(公告)号：WO2005108885A1
公开(公告)日：2005-11-17
申请号：PCT/EP2005/005124
申请日：2005-05-09
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , THILLY, Jacques , VANROY, Pierre-Jacques
发明人： THILLY, Jacques , VANROY, Pierre-Jacques
IPC分类号： F25D3/11
CPC分类号： F25D3/11 , F26B5/06
摘要： An apparatus for shell freezing a liquid content in a container, comprising an endless loop conveyor (100) having a conveying length (101) adapted to convey plural containers such as pharmaceutical vials (1010), incorporating plural rollers (106) to spin the containers as they are conveyed by the conveyor (100), and a return length (102), along at least part of the return length (102) the rollers (106) are immersed in a cooling liquid at a temperature below the freezing point of the liquid content of the containers, and along the conveying length (101) the rollers (106) are entirely above the surface of the cooling liquid. A preferred cooling liquid is liquid nitrogen (201), the evaporating vapour (203) of which can be used to shield vials (1010) on the conveying length (101).
摘要翻译：一种用于壳体冷冻容器中的液体含量的装置，包括具有适于输送多个容器（例如药物瓶）（1010）的输送长度（101）的环形输送机（100），其结合有多个辊（106）以旋转容器因为它们被输送机100输送，而返回长度102沿着返回长度102的至少一部分被浸入冷却液体中，该冷却液体的温度低于回收长度容器的液体含量，并且沿着输送长度（101），辊（106）完全在冷却液表面上方。优选的冷却液体是液氮（201），其蒸发蒸气（203）可用于屏蔽输送长度（101）上的小瓶（1010）。

63. 发明申请

WO2005105978A2 DRYING PROCESS 审中-公开
标题翻译：干燥过程
公开(公告)号：WO2005105978A2
公开(公告)日：2005-11-10
申请号：PCT/EP2005/004638
申请日：2005-04-28
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , MAYERESSE, Yves
发明人： MAYERESSE, Yves
IPC分类号： C12N1/04
CPC分类号： C12N1/04 , A61K47/26
摘要： The present invention relates to a method of drying biological and other labile samples so that they can be preserved as a highly viscous liquid. The method involves the steps of preparing a preservation sample by dissolving/suspending an active agent in a solution of a stabilising agent, subjecting the preservation sample to such temperature and pressure conditions that the preservation sample looses solvent by evaporation without freezing or bubbling to form a foam and removing solvent until the preservation sample dries to form a highly viscous liquid. The stabilising solution comprises a glass forming polyol and a second component which decreases the flow rate of the highly viscous liquid formed by the method.
摘要翻译：本发明涉及一种干燥生物和其他不稳定样品的方法，以便将其保存为高粘度液体。该方法包括通过将活性剂溶解/悬浮在稳定剂溶液中来制备保存样品的步骤，使保存样品经受保温样品通过蒸发而不冷冻或起泡而失去溶剂的温度和压力条件，形成泡沫和除去溶剂，直到保存样品干燥以形成高粘度液体。稳定溶液包括玻璃形成多元醇和第二组分，其降低通过该方法形成的高粘度液体的流速。

64. 发明申请

WO2005058349A2 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2005058349A2
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014379
申请日：2004-12-14
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , LUDWIG INSTITUTE FOR CANCER RESEARCH , METTENS, Pascal , UYTTENHOVE, Catherine , VAN SNICK, Jacques
发明人： METTENS, Pascal , UYTTENHOVE, Catherine , VAN SNICK, Jacques
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K2039/55555 , A61K2039/55566 , A61K2039/55577
摘要： The present invention relates to improved vaccines and immunogenic compositions, and processes for the preparation of such vaccines and immunogenic compositions. In particular, the present invention relates to vaccines and immunogenic compositions capable of generating an immune response against IL-12 or IL-23, or a subunit or component thereof, for the treatment of a disease, in particular an autoimmune-implicated disease.
摘要翻译：本发明涉及改进的疫苗和免疫原性组合物，以及制备这种疫苗和免疫原性组合物的方法。特别地，本发明涉及能够产生针对IL-12或IL-23或其亚基或其组分的免疫应答的疫苗和免疫原性组合物，用于治疗疾病，特别是自身免疫性牵连疾病。

65. 发明申请

WO2005005128A1 PROCESS AND APPARATUS FOR PRODUCING A VIAL IN A STERILE ENVIRONMENT 审中-公开
标题翻译：用于在无菌环境中生产阴茎的方法和装置
公开(公告)号：WO2005005128A1
公开(公告)日：2005-01-20
申请号：PCT/EP2004/007503
申请日：2004-07-07
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , THILLY, Jacques , VANDECASSERIE, Christian
发明人： THILLY, Jacques , VANDECASSERIE, Christian
IPC分类号： B29C45/17
CPC分类号： B29C45/006 , B29C45/1701 , B29C45/1769 , B29C45/42 , B29C65/565 , B29C65/568 , B29C66/001 , B29C66/131 , B29C66/1312 , B29C66/542 , B29C66/71 , B29C66/712 , B29C66/8322 , B29C66/843 , B29C66/863 , B29L2031/712 , B29L2031/753 , Y10T29/4998 , Y10T29/49998 , Y10T29/53322 , Y10T29/53443 , B29C65/00 , B29K2023/38 , B29K2021/003
摘要： A process for making a medicinal vial (10) in which a vial (10) and a closure (20) are moulded in parallel in respective vial and closure moulds (30, 40), then the closure (20) and vial (10) are automatically assembled together, all in a sterile environment. An apparatus for performing this process is also provided. By the process and apparatus of the invention sealed vials with a sterile interior may be made.
摘要翻译：一种用于制造药瓶（10）的方法，其中小瓶（10）和封闭件（20）在相应的小瓶和封闭模具（30,40）中并联模制，然后封闭件（20）和小瓶（10）自动组装在一起，全部在无菌环境中。还提供了一种用于执行该处理的装置。通过本发明的方法和装置，可以制备具有无菌内部的密封小瓶。

66. 发明申请

WO2004076481A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2004076481A2
公开(公告)日：2004-09-10
申请号：PCT/EP2004/001850
申请日：2004-02-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , JACQUET, Alain
发明人： JACQUET, Alain
IPC分类号： C07K14/435
CPC分类号： C07K14/43531 , A61K9/19 , A61K2039/57
摘要： The present invention provides a novel treatment for allergy comprising the provision of a recombinant Der p 1/ProDer p 1/PreProDer p 1 allergen derivative, ProDer p 3 or a recombinant ProDer p 3/Der p 3/ PreProDer p 3 allergen derivative with hypoallergenic activity. Pharmaceutical compositions comprising said mutant allergens which stimulate a Th1-type immune response in allergic or naïve individuals thereby reducing the potential for an allergic response upon contact with the wild-type allergen, are also provided.
摘要翻译：本发明提供了一种新的过敏治疗方法，包括提供重组Der p 1 / ProDer p 1 / PreProDer p 1变应原衍生物，ProDer p 3或具有低过敏原的重组ProDer p 3 / Der p 3 / PreProDer p 3变应原衍生物活动。还提供了包含所述突变过敏原的药物组合物，其在过敏或天真个体中刺激Th1型免疫应答，从而降低与野生型变应原接触时对过敏反应的可能性。

67. 发明申请

WO2004039399A1 IMMUNOGENIC COMPOSITION 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2004039399A1
公开(公告)日：2004-05-13
申请号：PCT/EP2003/012160
申请日：2003-10-30
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , MAYERESSE, Yves , STEPHENNE, Jean
发明人： MAYERESSE, Yves , STEPHENNE, Jean
IPC分类号： A61K39/13
CPC分类号： A61K39/13 , A61K39/12 , C12N2770/32634 , Y02A50/466
摘要： The present invention relates to immunogenic compositions comprising a dried solid or highly viscous liquid formulation of inactivated polio virus (IPV) and a stabilising agent wherein the IPV retains its antigenicity and/or immunogenicity. Methods of producing a dried formulation of IPV which retains its antigenicity/immunogenicity are described.
摘要翻译：本发明涉及免疫原性组合物，其包含灭活脊髓灰质炎病毒（IPV）的干燥固体或高粘度液体制剂和其中IPV保持其抗原性和/或免疫原性的稳定剂。描述了产生保留其抗原性/免疫原性的IPV干燥制剂的方法。

68. 发明申请

WO2003103706A2 IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：免疫组化
公开(公告)号：WO2003103706A2
公开(公告)日：2003-12-18
申请号：PCT/EP2003/006095
申请日：2003-06-06
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , GLAXO GROUP LIMITED , CASSART, Jean-Pol , GERARD, Catherine, Marie, Ghislaine , HAMBLIN, Paul, A , PALMANTIER, Remi, M
发明人： CASSART, Jean-Pol , GERARD, Catherine, Marie, Ghislaine , HAMBLIN, Paul, A , PALMANTIER, Remi, M
IPC分类号： A61K39/00
CPC分类号： A61K39/0011
摘要： The present invention relates to pharmaceutical/immunogenic compositions and methods for inducing an immune response against tumour-related antigens. More specifically, the invention relates to non-human prostate-specific antigens, more precisely to the non-human prostate-specific P501S, which can be used as xenogeneic antigen in prostate cancer vaccine therapy and as diagnostic agents for prostate tumours in humans, to immunogenic compositions containing them, to methods of manufacture of such compositions and to their use in medicine. Methods for formulating vaccines for immunotherapeutically treating P501S-expressing prostate tumors, prostatic hyperplasia, and prostate intraepithelilial neoplasia (PIN) are also provided.
摘要翻译：本发明涉及用于诱导针对肿瘤相关抗原的免疫应答的药物/免疫原性组合物和方法。更具体地，本发明涉及非人前列腺特异性抗原，更准确地涉及非人前列腺特异性P501S，其可以用作前列腺癌疫苗治疗中的异种抗原，并用作人类前列腺肿瘤的诊断剂，含有它们的免疫原性组合物，这些组合物的制造方法及其在医学中的应用。还提供了用于免疫治疗性治疗P501S表达前列腺肿瘤，前列腺增生和前列腺上皮内瘤变（PIN）的疫苗配制方法。

69. 发明申请

WO2003066094A3 HEPATITIS B VACCINES 审中-公开
公开(公告)号：WO2003066094A3
公开(公告)日：2003-08-14
申请号：PCT/EP2003/001214
申请日：2003-02-05
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , DE-HEYDER, Koen , SCHU, Peter , SERANTONI, Michelle , VAN-OPSTAL, Omer , STEPHENNE, Jean
发明人： DE-HEYDER, Koen , SCHU, Peter , SERANTONI, Michelle , VAN-OPSTAL, Omer , STEPHENNE, Jean
IPC分类号： A61K39/29
摘要： The invention relates to the use of a hepatitis B antigen free or substantially free of thiomersal, in the manufacture of a prophylactic or therapeutic hepatitis B vaccine for intradermal delivery.

70. 发明申请

WO2003051392A3 STREPTOCOCCUS PNEUMONIAE VACCINE 审中-公开
公开(公告)号：WO2003051392A3
公开(公告)日：2003-06-26
申请号：PCT/EP2002/014476
申请日：2002-12-18
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , LAFERRIERE, Craig, Anthony, Joseph , POOLMAN, Jan
发明人： LAFERRIERE, Craig, Anthony, Joseph , POOLMAN, Jan
IPC分类号： A61K39/09
摘要： The present invention provides an optimal formulation of multiple-serotype Streptococcus pneumoniae conjugate vaccines.

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