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51. 发明申请

WO2010000670A1 HIGH PERFORMANCE SOLUTION PROCESSABLE SEMINCONDUCTOR BASED ON DITHIENO [2,3-D:2',3'-D']BENZO[1,2-B:4,5-B'] DITHIOPHENE 审中-公开
标题翻译：基于DITHIENO [2,3-D：2'，3'-D'] BENZO [1,2-B：4,5-B']二氢苯的高性能溶液可处理的SEMINCONUCTOR
公开(公告)号：WO2010000670A1
公开(公告)日：2010-01-07
申请号：PCT/EP2009/057985
申请日：2009-06-25
申请人： BASF SE , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , KASTLER, Marcel , KOEHLER, Silke , MUELLEN, Klaus , GAO, Peng , BECKMANN, Dirk , FENG, Xinliang
发明人： KASTLER, Marcel , KOEHLER, Silke , MUELLEN, Klaus , GAO, Peng , BECKMANN, Dirk , FENG, Xinliang
IPC分类号： C07D495/12
CPC分类号： H01L51/0074 , C07D495/22 , C09K11/06 , C09K2211/1011 , C09K2211/1092 , G02B2006/12069 , H01L51/0545 , H01L51/5048 , H05B33/10 , H05B33/14 , Y02E10/549
摘要： Dithienobenzodithiophenes of general formula (I) in which R 1 to R 6 are each independently selected from a) H, b) halogen, c) -CN, d) -NO 2 , e) - OH, f) a C 1-20 alkyl group, g) a C 2-20 alkenyl group, h) a C 2-20 alkynyl group, i) a C 1-20 alkoxy group, j) a C 1-20 alkylthio group, k) a C 1-20 haloalkyl group, I) a -Y- C 3-10 cycloalkyl group, m) a -Y-C 6-14 aryl group, n) a -Y-3-12 membered cyclo- heteroalkyl group, or o) a -Y-5-14 membered heteroaryl group, wherein each of the C 1-20 alkyl group, the C 2-20 alkenyl group, the C 2-20 alkynyl group, the C 3-10 cycloalkyl group, the C 6-14 aryl group, the 3-12 membered cyc- loheteroalkyl group, and the 5-14 membered heteroaryl group is optionally substituted with 1 -4 R 7 groups, wherein R 1 and R 3 and R 2 and R 4 may also together form an aliphatic cyclic moiety, Y is independently selected from divalent a C 1-6 alkyl group, a divalent C 1 - 6 haloalkyl group, or a covalent bond; and m is independently selected from 0, 1, or 2. The invention also relates to the use of the dithienobenzodithiophenes according to any of claims 1 to 4 as semiconductors or charge transport materials, as thin-film transistors (TFTs), or in semiconductor components for organic light-emitting diodes (OLEDs), for photovoltaic components or in sensors, as an electrode material in batteries, as optical waveguides or for electrophotography applications.
摘要翻译：通式（I）的二噻吩并苯并二噻吩，其中R 1至R 6各自独立地选自a）H，b）卤素，c）-CN，d）-NO 2，e）-OH，f）C 1-20烷基，）C2-20烯基，h）C2-20炔基，i）C1-20烷氧基，j）C1-20烷硫基，k）C1-20卤代烷基，I）a -Y- C3-10环烷基，m）a-Y-C6-14芳基，n）a -Y-3-12元环杂烷基，或o）-Y-5-14元杂芳基，其中各 C 1-20烷基，C 2-20烯基，C 2-20炔基，C 3-10环烷基，C 6-14芳基，3-12元环杂烷基，和5-14 任选被1-4个R 7基团取代，其中R 1和R 3以及R 2和R 4也可以一起形成脂族环状部分，Y独立地选自二价C 1-6烷基，二价C 1-6卤代烷基，或共价键; 并且m独立地选自0,1或2.本发明还涉及根据权利要求1至4中任一项所述的二噻吩并苯并噻吩作为半导体或电荷传输材料，作为薄膜晶体管（TFT）或半导体用于有机发光二极管（OLED）的组件，用于光伏组件或传感器，作为电池中的电极材料，作为光波导或电子照相应用。

52. 发明申请

WO99003859A1 NOVEL SPIROAZABICYCLIC HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：新型螺旋化合物杂环化合物
公开(公告)号：WO99003859A1
公开(公告)日：1999-01-28
申请号：PCT/SE1998/001364
申请日：1998-07-10
IPC分类号： C07D491/22 , A61K20060101 , A61K31/395 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/438 , A61K31/439 , A61K31/44 , A61K31/444 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/695 , A61P20060101 , A61P1/00 , A61P1/04 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P43/00 , C07D20060101 , C07D491/12 , C07D491/20 , C07D495/12 , C07D499/21 , C07F5/02 , C07F7/18
CPC分类号： C07D491/22
摘要： A compound of formula (I) wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H2 or F2; A is N or C(R ); G is N or C(R ); D is N or C(R ); with the proviso that no more than one of A, G, and D is nitrogen, but at least one of Y, A, G, and D is nitrogen or NO; R is hydrogen or C1 to C4 alkyl; R , R , and R are independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R , -CN, -NO2, -NR R , -CF3, -OSO2CF3 or R and R , or R and R , respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively, containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents: independently hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, aryl, heteroaryl, OH, OC1-C4 alkyl, CO2R , -CN, -NO2, -NR R , -CF3, -OSO2CF3; R and R are independently hydrogen, C1-C4 alkyl, C(O)R , C(O)NHR , C(O)OR , SO2R or may together be (CH2)jQ(CH2)k where Q is O, S, NR , or a bond; j is 2 to 7, k is 0 to 2; R , R , R , R , and R are independently C1-C4 alkyl, aryl, or heteroaryl, or an enantiomer thereof, and the pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.
摘要翻译：式（I）的化合物，其中n为0或1; m为0或1; p为0或1; X是氧或硫; Y为CH，N或NO; W是氧，H2或F2; A是N或C（R 2）; G是N或C（R 3）; D是N或C（R 4）; 条件是A，G和D中不超过一个为氮，但Y，A，G和D中的至少一个为氮或NO; R 1是氢或C 1至C 4烷基; R 2，R 3和R 4独立地是氢，卤素，C 1 -C 4烷基，C 2 -C 4烯基，C 2 -C 4炔基，芳基，杂芳基，OH，OC 1 -C 4烷基，CO 2 R 1 ，-CN，-NO 2，-NR 5 R 6，-CF 3，-OSO 2 CF 3或R 2和R 3，或R 3和R 4分别可一起形成分别分别含有0和2个氮原子的A和G或G和D的六元芳族或杂芳族环，并被一至两个以下取代基取代：独立地是氢，卤素，C 1 -C 4烷基， C 4链烯基，C 2 -C 4炔基，芳基，杂芳基，OH，OC 1 -C 4烷基，CO 2 R 1，-CN，-NO 2，-NR 5 R 6，-CF 3，-OSO 2 CF 3; R 5和R 6独立地是氢，C 1 -C 4烷基，C（O）R 7，C（O）NHR 8，C（O）OR 9，SO 2 R 10或可以一起为（CH 2）j Q（CH 2）k，其中Q为O，S，NR 11或键; j为2〜7，k为0〜2; R 7，R 8，R 9，R 10和R 11独立地为C 1 -C 4烷基，芳基或杂芳基，或其对映异构体及其药学上可接受的盐，方法用于制备它们，含有它们的组合物及其在治疗中的用途，特别是治疗或预防精神病和智力障碍障碍。

53. 发明申请

US20230135894A1 MK2 DEGRADERS AND USES THEREOF 有权
公开(公告)号：US20230135894A1
公开(公告)日：2023-05-04
申请号：US17855336
申请日：2022-06-30
申请人： Kymera Therapeutics, Inc.
发明人： Bin YANG , Matthew M. WEISS , Xiao ZHU , Huijun DONG , Isaac MARX
IPC分类号： C07D471/22 , C07D405/14 , C07D495/12 , C07D401/04 , C07D519/00 , C07D491/048 , C07D471/14 , C07D471/04
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

54. 发明申请

US20210387998A1 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS 有权
公开(公告)号：US20210387998A1
公开(公告)日：2021-12-16
申请号：US17400861
申请日：2021-08-12
申请人： Incyte Corporation , Incyte Holdings Corporation
发明人： Yun-Long Li , Wenyu Zhu , Song Mei , Joseph Glenn
IPC分类号： C07D495/14 , C07D495/12 , A61K31/437
摘要： The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

55. 发明授权

US10370387B2 Tricyclic fused thiophene derivatives as JAK inhibitors 有权
公开(公告)号：US10370387B2
公开(公告)日：2019-08-06
申请号：US15874140
申请日：2018-01-18
申请人： Incyte Corporation , Incyte Holdings Corporation
发明人： Yun-Long Li , Wenyu Zhu , Song Mei
IPC分类号： A61K31/437 , C07D495/12 , C07D495/14
摘要： The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

56. 发明授权

US09320741B2 Compositions and methods for treating neoplasia, inflammatory disease and other disorders 有权
公开(公告)号：US09320741B2
公开(公告)日：2016-04-26
申请号：US14502840
申请日：2014-09-30
申请人： Dana-Farber Cancer Institute, Inc.
发明人： James Elliott Bradner , Jun Qi
IPC分类号： A61K31/5517 , A61K31/551 , C07D487/04 , C07D495/12 , C07D519/00 , C07D495/14
CPC分类号： C07D495/14 , A61K31/551 , A61K31/5517 , C07D487/04 , C07D495/12 , C07D519/00 , Y02A50/411
摘要： The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).

57. 发明申请

US20070160871A1 MATERIAL FOR ORGANIC ELECTROLUMINESCENT DEVICE AND ORGANIC ELECTROLUMINESCENT DEVICE 审中-公开
标题翻译：有机电致发光器件和有机电致发光器件的材料
公开(公告)号：US20070160871A1
公开(公告)日：2007-07-12
申请号：US11616545
申请日：2006-12-27
申请人： Hironobu Morishita , Chishio Hosokawa , Hisayuki Kawamura
发明人： Hironobu Morishita , Chishio Hosokawa , Hisayuki Kawamura
IPC分类号： H01L51/54 , C07D487/12 , C07D495/12
CPC分类号： H01L51/0072 , C07D335/12 , C07D487/04 , C09K11/06 , C09K2211/1011 , C09K2211/1044 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/5088 , H05B33/14
摘要： A material for an organic electroluminescent device represented by the following formula (I): wherein X1 and X2 are independently one of specific divalent groups; Y1 to Y4 are independently a carbon atom or a nitrogen atom; R1 to R4 are independently a hydrogen atom, an alkyl group, an aryl group, a heterocyclic group, a halogen atom, a fluoroalkyl group, or a cyano group; and R1 and R2, and R3 and R4 may be bonded together to form a ring, respectively.
摘要翻译：由下式（I）表示的有机电致发光器件的材料：其中X 1和X 2独立地是特定二价基团之一; Y 1至Y 4独立地为碳原子或氮原子; R 1至R 4独立地为氢原子，烷基，芳基，杂环基，卤素原子，氟代烷基或氰基; R 1和R 2，R 3和R 4和R 4可以结合在一起形成环，分别。

58. 发明申请

US20050004099A1 Spiroazabicyclic heterocyclic compounds 失效
标题翻译：螺环双环杂环化合物
公开(公告)号：US20050004099A1
公开(公告)日：2005-01-06
申请号：US10801085
申请日：2004-03-15
申请人： Eifion Phillips , Robert Mack , John Macor , Simon Semus
发明人： Eifion Phillips , Robert Mack , John Macor , Simon Semus
IPC分类号： C07D491/22 , A61K20060101 , A61K31/395 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/438 , A61K31/439 , A61K31/44 , A61K31/444 , A61K31/4738 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/695 , A61P20060101 , A61P1/00 , A61P1/04 , A61P25/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P43/00 , C07D20060101 , C07D491/12 , C07D491/20 , C07D495/12 , C07D499/21 , C07F5/02 , C07F7/18 , A61K31/55 , C07D487/14
CPC分类号： C07D491/22
摘要： A pharmaceutical composition comprising a compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, or pharmaceutically acceptable salts thereof, its use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.
摘要翻译：一种药物组合物，其包含下式化合物其中n，m，p，X，Y，W，A，G和D如说明书中所定义，其对映体或其药学上可接受的盐，其用于治疗，治疗或预防精神病和智力障碍。

59. 发明授权

US4816461A 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b] indole, a process for their preparation and medicaments containing them 失效
标题翻译： 7,8,9,10-四氢噻吩并[3,2-e]吡啶并[4,3-b]吲哚，其制备方法和含有它们的药物
公开(公告)号：US4816461A
公开(公告)日：1989-03-28
申请号：US61255
申请日：1987-06-10
申请人： Peter-Rudolf Seidel , Gunter Schollnhammer
发明人： Peter-Rudolf Seidel , Gunter Schollnhammer
IPC分类号： C07D333/62 , A61K31/435 , A61K31/44 , A61P25/18 , A61P25/24 , A61P25/26 , C07C205/56 , C07D333/54 , C07D333/66 , C07D495/12 , C07D495/14
CPC分类号： C07D333/54 , C07C205/45 , C07C205/56 , C07C323/00 , C07D495/14
摘要： The invention concerns the provision of 7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b] indoles, useful, inter alia, as antidepressants, and intermediates for the preparation thereof. Also included in the invention are compositions containing said indoles and methods for the use of said indoles and indole compositions as antidepressants.
摘要翻译：本发明涉及提供7,8,9,10-四氢噻吩并[3,2-e]吡啶并[4,3-b]吲哚，尤其可用作抗抑郁剂，以及其制备的中间体。本发明还包括含有所述吲哚的组合物和使用所述吲哚和吲哚组合物作为抗抑郁药的方法。

60. 发明授权

US4496725A Substituted 1,2,3-triazino[4',5':4,5]-thieno[2,3-B]quinolin-4(3H)-ones 失效
标题翻译：取代的1,2,3-三嗪并[4'，5'：4,5]噻吩并[2,3-b]喹啉-4（3H） - 酮
公开(公告)号：US4496725A
公开(公告)日：1985-01-29
申请号：US496800
申请日：1983-05-23
申请人： James R. McCarthy , Paul J. Widner
发明人： James R. McCarthy , Paul J. Widner
IPC分类号： A61K31/53 , A61P37/08 , C07D215/20 , C07D215/54 , C07D495/04 , C07D495/14 , C07D495/22 , C07D495/12
CPC分类号： C07D495/04 , C07D215/20 , C07D215/54 , C07D495/14
摘要： Substituted 1,2,3-triazino[4',5':4,5]thieno[2,3-b]quinolin-4(3H)-ones useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate substituted 3-aminothieno[2,3-b]quinoline-2-carboxamide with sodium nitrite in an acid such as acetic acid.
摘要翻译：本文描述了可用作抗过敏剂的取代的1,2,3-三嗪[4'，5'：4,5]噻吩并[2,3-b]喹啉-4（3H） - 酮。通过在酸如乙酸中将适当的取代的3-氨基噻吩并[2,3-b]喹啉-2-甲酰胺与亚硝酸钠反应来制备化合物。

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