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51. 发明专利

CY451A Benzenesulphonyl-ureas and process for preparing them 未知
公开(公告)号：CY451A
公开(公告)日：1968-08-23
申请号：CY45168
申请日：1968-08-23
申请人： HOECHST AG
IPC分类号： A61K31/64 , C07D209/46 , C07D335/02 , C07D27/50
摘要： Novel benzenesulphonyl ureas of the Formula I and their physiologically tolerable salts wherein R is H or CH3, Z and Z1 are H or halogen atoms or C1- 4 alkyl or alkoxy groups, Y is a straight or branched chain hydrocarbon group of 1-4 carbon atoms and R1 is (a) a 3 or 4 carbon atom alkyl group; (b) a cyclohexylmethyl group; (c) a C1- 3-alkyl-cyclohexyl or C1- 3 alkoxy-cyclohexyl group; (d) a C5- 8 cycloalkyl group; (e) a cyclohexenyl or cyclohexenylmethyl group; or (f) an endoalkylenecyclohexyl, - cyclohexenyl, - cyclohexylmethyl or -cyclohexenylmethyl group each containing 1 or 2 endoalkylene carbon atoms, are made by (a) reacting an appropriately substituted benzenesulphonyl isocyanate, carbamic ester, thiocarbamic ester, carbamic halide or urea with an amine R1NH2; (b) reacting an R1 substituted isocyanate, carbamic or thiocarbamic ester, carbamic halide or urea with the appropriately substituted benzenesulphonamide; (c) hydrolysing the corresponding isourea or isothiourea ether or parabanic acid compound; (d) replacing the sulphur atom in a corresponding benzenesulphonylthiourea by oxygen by known methods; (e) oxidizing a benzenesulphuryl or benzenesulphenyl urea; or (f) subjecting a compound of the Formula III or IV to ring closure Phthalimidinoalkyl - benzenesulphonamides 4-(b - Phthalimidinoethyl) - benzenesulphonamide is made by reacting phthalide with 4-(b -aminoethyl) - benzenesulphonamide and subjecting the resulting 4-(b -o-hydroxymethyl-benzamidoethyl) - benzenesulphonamide to ring closure. 4 - (b - Phthalimidino - a - methylethyl)- benzenesulphonamide is made by reacting 4-a -methyl - b - aminoethyl) benzenesulphonamide with phthalic anhydride and reducing the resulting 4 - (b - phthalimido - a - methylethyl)-benzenesulphonamide with tin and HCl. 4-(b - 5 - Chlorophthalimidoethyl) - benzenesulphonamide is made by reducing the corresponding phthalimide derivative. 4 - Phthalimidinomethyl - benzenesulphonamide and 4 - (b - 3 ethyl - phthalimidinoethyl)-benzenesulphonamide are made by chlorosulphonating the corresponding phthalimidinoalkyl benzenes and treating the resulting sulphonyl chlorides with ammonia. 4 - (b - o - Hydroxymethylbenzamidoethyl)-benzenesulphonamide is prepared by reaction of 4 - (b - aminoethyl) - benzenesulphonamide with phthalide. N - [4 - (b - Phthalimidino - ethyl) - benzenesulphonyl] - N1 - cyclohexyl - isourea methyl ether is formed by treating the corresponding thiourea compound with mercury oxide in methanol. N - [4 - (b - Phthalimidinoethyl) - benzenesulphonyl]-carbamic acid methyl ester is obtained by the action of methyl chloroformate on the corresponding sulphonamide. Pharmaceutical preparations having hypoglycaemic activity comprise the above novel compounds in admixture or conjunction with a carrier preferably in a form adapted to oral administration such as tablets.

52. 发明专利

CY787A NOVEL PHTALIMIDINE COMPOUNDS 未知
公开(公告)号：CY787A
公开(公告)日：1976-06-01
申请号：CY78770
申请日：1970-10-02
申请人： AMERICAN HOME PROD
IPC分类号： C07D209/48 , C07D233/22 , C07D233/64 , C07D27/50

53. 发明专利

MY7500060A NOVEL PHTHALIMIDINE COMPOUNDS 未知
公开(公告)号：MY7500060A
公开(公告)日：1975-12-31
申请号：MY7500060
申请日：1975-12-30
申请人： AMERICAN HOME PROD
IPC分类号： C07D209/48 , C07D233/22 , C07D233/64 , C07D27/50

54. 发明专利

PL82740B1 未知
公开(公告)号：PL82740B1
公开(公告)日：1975-10-31
申请号：PL15145071
申请日：1971-11-03
IPC分类号： C07D209/14 , A61K20060101 , A61K31/33 , C07C20060101 , C07D209/04 , C07D209/44 , C07D209/46 , C07D27/50

55. 发明专利

SU479292A3 未知
公开(公告)号：SU479292A3
公开(公告)日：1975-07-30
申请号：SU1917368
申请日：1973-05-07
IPC分类号： C08L27/00 , C07D209/44 , C07D209/50 , C08K5/34 , C08K5/3417 , C08L1/00 , C08L7/00 , C08L21/00 , C08L23/00 , C08L101/00 , C09B57/04 , C07D27/50
摘要： Disclosed are compounds of formula I, in which R1 and R2, which may be the same or different, each signifies a fluorine atom, a chlorine atom, a bromine atom, a methyl radical, a methoxy radical or an ethoxy radical, PROCESS FOR THE PRODUCTION THEREOF, AND USE THEREOF AS PIGMENTS FOR SYNTHETIC POLYMERIC MATERIAL, SPUN-DYED VISCOSE AND CELLULOSE ACETATE FILAMENTS, PAPER AND IN SURFACE COATINGS SUCH AS EMULSION PAINTS.

56. 发明专利

HU166919B 未知
公开(公告)号：HU166919B
公开(公告)日：1975-06-28
申请号：HURO000767
申请日：1974-02-06
IPC分类号： C07D209/48 , C07D209/44 , C07D401/04 , C07D27/50
摘要： Procedure for preparing new isoindoline derivatives, of general formula: ** formula ** in which Ar represents a phenyl radical or a pyridyl radical, optionally substituted by 1 or 2 atoms or radicals, identical or different, chosen from among the atoms of halogen and alkyl radicals containing 1 to 4 carbon atoms, alkyloxy, the alkyl part of which contains 1 to 4 carbon atoms, cyano and trifluoromethyl, T represents a straight or branched alkylene radical containing 2 to 6 atoms of carbon, and R1 and R2 identical or different, represent a hydrogen atom or a straight or branched alkyl radical containing from 1 to 4 carbon atoms, as well as their addition salts with acids, characterized in that an amine is reacted, of general formula ** formula ** in which R1 and R2 are defined as above, on an isoindoline derivative, of general formula ** formula ** in which Ar and T are defined as above and Z represents a residue of this reagent and then the product obtained is eventually transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)

58. 发明专利

AU5610573A CYCLOPROPANE CARBOXYLIC ACIDS AND ESTERS AND INSECTICIDAL 未知
公开(公告)号：AU5610573A
公开(公告)日：1974-11-28
申请号：AU5610573
申请日：1973-05-24
申请人： NAT RES DEV
发明人： PULMAN DAVID ALLEN , ELLIOTT MICHAEL , JANES NORMAN FRANK
IPC分类号： C07C61/04 , C07C69/74 , C07C45/16 , A01N9/00 , A01N9/22 , A01N9/24 , A01N9/30 , C07C121/66 , C07D5/16 , C07D27/50 , C07D27/52

59. 发明专利

DE2411683A1 未知
公开(公告)号：DE2411683A1
公开(公告)日：1974-10-24
申请号：DE2411683
申请日：1974-03-12
申请人： HUGHES AIRCRAFT CO
发明人： BILOW NORMAN , LANDIS ABRAHAM L , MILLER LEROY J
IPC分类号： C08G73/00 , C08G73/06 , C08G73/10 , C08J5/24 , C07D27/50 , C07C121/78 , C08G20/32

60. 发明专利

DE2402220A1 未知
公开(公告)号：DE2402220A1
公开(公告)日：1974-07-25
申请号：DE2402220
申请日：1974-01-17
申请人： FUJI PHOTO FILM CO LTD
发明人： OKUMURA AKIO , SUGIZAKI ATSUSHI , ARAI ATSUAKI
IPC分类号： C07D207/40 , C07D207/404 , C07D207/412 , C07D207/416 , C07D207/444 , C07D207/448 , C07D209/48 , C07D209/76 , C07D211/88 , C07D233/72 , C07D233/74 , C07D233/78 , C07D263/44 , C07D265/32 , C07D275/02 , C07D275/06 , C07D277/20 , C07D277/34 , C07D491/048 , G03C7/305 , C07D27/50 , C07D49/32

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