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51. 发明授权

US06713049B1 Oral compositions providing optimal surface conditioning 有权
标题翻译：口服组合物提供最佳表面调理
公开(公告)号：US06713049B1
公开(公告)日：2004-03-30
申请号：US09710250
申请日：2000-11-10
申请人： Donald J. White, Jr. , William M. Glandorf , Henk J. Busscher , Jeannine R. Knight , Arif A. Baig
发明人： Donald J. White, Jr. , William M. Glandorf , Henk J. Busscher , Jeannine R. Knight , Arif A. Baig
IPC分类号： A61K716
CPC分类号： A23G4/06 , A23G4/126 , A61K6/0017 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/81 , A61K8/8147 , A61K2800/52 , A61Q11/00
摘要： The present invention relates to oral composition comprising a polymeric surface active agent wherein the oral composition provides surface conditioning effects on a subject's teeth and/or oral mucosa. The surface conditioning effects include (a) increased hydrophilic character of oral surfaces as measured by a decrease in water contact angles or an increase in anionic surface charge and surface charge density and (b) decreased pellicle film thickness. The present invention also relates to methods of providing surface conditioning effects to a subject's tooth and mucosal surfaces and methods of preventing and controlling tartar and tooth staining by administering to the subject an oral composition comprising a polymeric surface active agent.
摘要翻译：本发明涉及包含聚合物表面活性剂的口腔组合物，其中口腔组合物为受试者的牙齿和/或口腔粘膜提供表面调理作用。表面调理效果包括（a）通过水接触角降低或阴离子表面电荷和表面电荷密度的增加测量的口腔表面增加的亲水性，和（b）防护薄膜厚度降低。本发明还涉及通过向受试者施用包含聚合物表面活性剂的口腔组合物来向对象的牙齿和粘膜表面提供表面调理作用的方法以及预防和控制牙垢和牙齿染色的方法。

52. 发明授权

US06689343B1 Hemostatic and acid etch compositions containing sucralose 有权
标题翻译：含三氯蔗糖的止血和酸蚀组合物
公开(公告)号：US06689343B1
公开(公告)日：2004-02-10
申请号：US10289190
申请日：2002-11-05
申请人： Peter M. Allred , Steven D. Jensen
发明人： Peter M. Allred , Steven D. Jensen
IPC分类号： A61K716
CPC分类号： A61K6/0029 , A61K6/0088 , C08L71/02
摘要： Hemostatic compositions and dental etching compositions for oral use include sucralose in order to mask or disguise their otherwise sour or bitter taste. The sucralose, hemostatic and/or dental etching agent are dispersed within an aqueous carrier, which may be liquid or viscous as desired. In order to increase the stickiness and the viscosity of the carrier, a higher molecular weight polyol and/or a finely divided inorganic filler may be included. Sucralose is selected as a sweetener because it has been found to have enhanced stability in the presence of strongly acidic compositions compared to other non-nutritive sweeteners known in the art. In addition, sucralose does not leave behind a bitter after taste. For this reason, sucralose is uniquely suited for masking or disguising the profoundly sour or bitter taste of hemostatic agents and/or dental etching agents.
摘要翻译：用于口服使用的止血组合物和牙科蚀刻组合物包括三氯蔗糖以掩盖或伪装其它酸或苦味。三氯蔗糖，止血和/或牙科蚀刻剂分散在水性载体中，根据需要它可以是液体或粘稠的。为了增加载体的粘性和粘度，可以包括较高分子量的多元醇和/或细碎的无机填料。选择三氯蔗糖作为甜味剂，因为与本领域已知的其它非营养甜味剂相比，已经发现在强酸性组合物存在下具有增强的稳定性。此外，三氯蔗糖不会在味道后留下苦味。因此，三氯蔗糖特别适用于掩蔽或掩盖止血剂和/或牙科蚀刻剂的深度酸或苦味。

53. 发明授权

US06685918B1 Oral cleansing product 失效
标题翻译：口腔清洁用品
公开(公告)号：US06685918B1
公开(公告)日：2004-02-03
申请号：US10111178
申请日：2002-07-12
申请人： Kevin John Wills , Iain Stewart Duncan
发明人： Kevin John Wills , Iain Stewart Duncan
IPC分类号： A61K716
CPC分类号： A61K8/26 , A61Q11/00
摘要： There is disclosed an oral cleansing product comprising as an abrasive an alumnina in the form of particles having d10 below 3.5 &mgr;m, d50 below 1.0 &mgr;m, and a specific surface area below 6 m2/g.
摘要翻译：公开了一种口腔清洁产品，其包含具有d10低于3.5μm，d50低于1.0μm，比表面积低于6m 2 / g的颗粒形式的研磨剂。

54. 发明授权

US06682722B2 Oral compositions providing enhanced overall cleaning 有权
标题翻译：口服组合物提供增强的整体清洁
公开(公告)号：US06682722B2
公开(公告)日：2004-01-27
申请号：US10233880
申请日：2002-09-03
申请人： Satyanarayana Majeti , Niteen Vasant Bapat , Paula Denise Clymer , Elizabeth Ann Reno , William Michael Glandorf , Stephen Andras Kovacs
发明人： Satyanarayana Majeti , Niteen Vasant Bapat , Paula Denise Clymer , Elizabeth Ann Reno , William Michael Glandorf , Stephen Andras Kovacs
IPC分类号： A61K716
CPC分类号： A61Q11/02 , A61K8/24 , A61K8/8182 , A61Q11/00
摘要： Disclosed are oral care compositions and methods for overall cleaning, whitening and preventing, reducing or removing surface deposited stains on natural teeth and dental prosthesis, the compositions comprising in an orally acceptable carrier at least 0.1% by weight of a water-soluble or water-dispersible copolymer prepared by copolymerizing one or a mixture of vinyl pyrrolidone (VP) monomers with one or a mixture of C1-C19 alkyl carboxylic acid (AC) C2-C12 alkenyl ester monomers. Preferably, the compositions further comprise one or a mixture of other oral care agents selected from a water soluble alkali metal or ammonium tripolyphosphate in an amount at least about 0.5% by weight of the composition, an abrasive, preferably a precipitated silica abrasive, in an amount at least about 6% by weight of the composition and a bleaching agent in an amount at least about 0.1% by weight of the composition. This invention further relates to methods of cleaning, whitening and polishing natural teeth and dental prosthesis and of preventing, reducing or removing surface deposited stains from teeth by administering the present compositions.
摘要翻译：公开了用于整体清洁，增白和预防，减少或去除天然牙齿和假牙上的表面沉积污渍的口腔护理组合物和方法，所述组合物在口腔可接受的载体中包含至少0.1重量％的水溶性或水溶性的，通过将乙烯基吡咯烷酮（VP）单体的一种或混合物与C1-C19烷基羧酸（AC）C2-C12烯基酯单体的一种或混合物共聚制备的可分散共聚物。优选地，组合物还包含选自水溶性碱金属或三聚磷酸铵的其它口腔护理剂的一种或其混合物，其量为组合物重量的至少约0.5％，研磨剂，优选沉淀二氧化硅研磨剂，至少约6重量％的组合物和漂白剂，其量为组合物的至少约0.1重量％。本发明还涉及通过施用本发明的组合物来清洁，增白和抛光天然牙齿和牙科假体以及防止，减少或去除牙齿表面沉积的污渍的方法。

55. 发明授权

US06682720B2 Zinc citrate beads in oral compositions 有权
标题翻译：口服组合物中的柠檬酸锌珠
公开(公告)号：US06682720B2
公开(公告)日：2004-01-27
申请号：US10331666
申请日：2002-12-27
申请人： Christine Watson Ryles , David Robert Williams , Alexander George Ziemkiewicz , Jesus Antonio Urbaez
发明人： Christine Watson Ryles , David Robert Williams , Alexander George Ziemkiewicz , Jesus Antonio Urbaez
IPC分类号： A61K716
CPC分类号： A61K8/365 , A61K8/0241 , A61K8/025 , A61K8/27 , A61K8/731 , A61Q11/00
摘要： An oral product, particularly for anti-tartar use, is provided which includes from about 0.001 to about 20% of beads which include a zinc salt, the zinc salt having an average particle size ranging from about 0.01 to about 5 mm, and a dental base.
摘要翻译：提供了特别用于抗牙垢使用的口服产品，其包括约0.001至约20％的珠粒，其包括锌盐，平均粒度范围为约0.01至约5mm的锌盐和牙科基础。

56. 发明授权

US06676957B1 Non-absorbent substrates for the inhibition of exoprotein production from gram positive bacteria 失效
标题翻译：用于抑制革兰氏阳性细菌产生外源蛋白的非吸收性底物
公开(公告)号：US06676957B1
公开(公告)日：2004-01-13
申请号：US09724023
申请日：2000-11-28
申请人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
发明人： Kim L. Resheski-Wedepohl , Rae Ellen Syverson
IPC分类号： A61K716
CPC分类号： A61F13/8405 , A61K31/702 , A61L15/46 , A61L15/48 , A61L2300/232 , A61L2300/404 , Y10S514/841 , Y10S514/843 , Y10S514/967
摘要： Non-absorbent substrates for use in inhibiting the production of exoproteins from Gram positive bacteria, such as harmful proteins produced by Staphylococcus species, are provided. The substrates are particularly useful for inhibiting the production of TSST-1, alpha-toxin and/or enterotoxins A, B and C from S. aureus bacteria. The substrates include an alkyl polyglycoside incorporated in or on at least a portion of the substrate. The alkyl polyglycoside typically has an HLB of about 10 to 15 and/or an average number of carbon atoms in the alkyl chain of about 8 to about 12.
摘要翻译：提供了用于抑制革兰氏阳性细菌（例如由葡萄球菌物种产生的有害蛋白质）产生外来蛋白的非吸收性底物。底物对于抑制来自金黄色葡萄球菌的TSST-1，α-毒素和/或肠毒素A，B和C的产生特别有用。底物包括掺入到基质的至少一部分中或之上的烷基聚糖苷。烷基多糖苷通常具有约10至15的HLB和/或烷基链中的平均碳原子数约8至约12。

57. 发明授权

US06663850B2 Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation 失效
公开(公告)号：US06663850B2
公开(公告)日：2003-12-16
申请号：US10062701
申请日：2002-01-31
申请人： Stephen T. Sonis
发明人： Stephen T. Sonis
IPC分类号： A61K716
CPC分类号： A61K31/357 , A61K31/198 , A61K31/205 , A61K31/336 , A61K31/40 , A61K31/5375 , A61K38/063 , A61K38/465
摘要： Intervention for oral mucosal injury secondary to chemotherapy or radiation based on the inhibition in the synthesis of ceramide, blockage of its activity, or its digestion.

58. 发明授权

US06660250B1 Tooth cleaning composition and applicator 失效
标题翻译：牙齿清洁组合物和涂抹器
公开(公告)号：US06660250B1
公开(公告)日：2003-12-09
申请号：US10233446
申请日：2002-09-03
申请人： Pete B Higgins
发明人： Pete B Higgins
IPC分类号： A61K716
CPC分类号： A61K8/965 , A61C5/62 , A61C17/00 , A61C2202/00 , A61K8/19 , A61Q11/00
摘要： The present invention discloses a tooth cleaning composition and applicator that is particularly adapted for clearing and cleaning the area of the teeth in preparation of fillings or orthodontic appliances, such as braces or bridges. The cleaning agent of the present invention consists of various size ground pumice with a water soluble lubricant binder. The present invention limits the tendencies of spatter and overcomes prior art uses of ground pumice in dental applications.
摘要翻译：本发明公开了一种牙齿清洁组合物和施用器，其特别适用于清洁和清洁牙齿的区域，以准备填充物或矫正器具，例如大括号或桥梁。本发明的清洁剂由具有水溶性润滑剂粘合剂的各种尺寸的浮石组成。本发明限制了飞溅的倾向，并且克服了现有技术中的地面浮石在牙齿应用中的应用。

59. 发明授权

US06641801B1 Gargle method to reduce the duration of common cold symptoms 有权
标题翻译：漱口法减少常见感冒症状的持续时间
公开(公告)号：US06641801B1
公开(公告)日：2003-11-04
申请号：US09821653
申请日：2001-03-28
申请人： Amy Christine Brown
发明人： Amy Christine Brown
IPC分类号： A61K716
CPC分类号： A61Q11/00 , A61K8/34 , A61K8/97 , A61K31/045 , A61K36/35 , A61K36/53 , A61K36/534 , A61K36/537 , A61K36/81 , A61K36/8962 , A61K2300/00
摘要： The common cold is caused by a virus. Antiviral compounds that kill viruses would then be most likely to serve as a remedy for the common cold. This invention seeks to offer a unique use of an antiviral agent, ethanol (with or without additional homeopathic and/or herb ingredients) through the unique topical application of a mouthwash to a sore throat that is often the first symptom of a common cold. The sore throat is caused by the virus setting up to enter the body after which a cascade of immune response symptoms will occur. Current cold remedies do nothing but treat these immune response symptoms. This invention is unique in that it destroys the virus directly, blocking the cold virus at its point of entry, and the remaining cold symptoms never appear. It does not matter how many cold viruses exist, because the antiviral nature of ethanol kills viruses upon contact. This is the first time that treatment of a sore-throat with antiviral agents (ethanol with or without additional homeopathic and/or herb ingredients) is being used to effectively block the common cold. Research testing this common cold remedy have shown it to be effective in 18 out of 20 case studies, and a double-blind, placebo controlled clinical trial is being conducted.
摘要翻译：感冒是由病毒引起的。那么杀死病毒的抗病毒化合物最有可能成为感冒的补救方法。本发明寻求通过将唯一的局部应用漱口剂施用于通常是常见感冒的第一症状的喉咙痛来提供抗病毒剂，乙醇（具有或不具有额外的顺势疗法和/或草药成分）的独特用途。喉咙痛是由病毒进入身体引起的，之后会发生一系列免疫应答症状。目前的冷治疗方法除了治疗这些免疫反应症状外，什么都不做。本发明的独特之处在于它直接破坏病毒，在入口处阻止感冒病毒，并且其余的感冒症状不会出现。存在多少感冒病毒并不重要，因为乙醇的抗病毒性质在接触时会杀死病毒。这是第一次使用抗病毒药物（含或不含附加顺势疗法和/或草药成分的乙醇）治疗咽喉炎，有效阻止感冒。研究测试这种常见的感冒治疗措施已经显示在20例病例研究中的18项中有效，并进行了双盲安慰剂对照临床试验。

60. 发明授权

US06616916B1 Transparent dentifrices 有权
标题翻译：透明洁齿剂
公开(公告)号：US06616916B1
公开(公告)日：2003-09-09
申请号：US10016550
申请日：2001-12-10
申请人： Rajeev B. Karpe , Sunil S. Nadkarni , Ramanathan Ramakrishnan , John A. Kostinko
发明人： Rajeev B. Karpe , Sunil S. Nadkarni , Ramanathan Ramakrishnan , John A. Kostinko
IPC分类号： A61K716
CPC分类号： C01B33/193 , A61K8/25 , A61K2800/262 , A61Q11/00 , C01P2002/02 , C01P2004/61 , C01P2006/19 , C01P2006/60 , C01P2006/90
摘要： An abrasive, amorphous precipitated silica is provided that provides excellent abrasive performance, but also has a relatively high degree of transmittance, and an index of refraction that is sufficiently low to allow it to be a component of a transparent toothpaste composition having a relatively high concentration of water. The amorphous precipitated silica composition has a refractive index of less than about 1.4387, a light transmittance of greater than about 48%; and a Brass Einlehner abrasion value of greater than about 5 mg loss/100,000 rev. A dentifrice having a haze value of less than about 70 may be prepared using this abrasive, amorphous silica.
摘要翻译：提供了一种研磨性无定形沉淀二氧化硅，其提供优异的研磨性能，但也具有相对高的透射度，并且折射率足够低以使其成为具有较高浓度的透明牙膏组合物的组分的水。无定形沉淀二氧化硅组合物的折射率小于约1.4387，光透射率大于约48％; 和黄铜Einlehner磨损值大于约5毫克损失/ 100,000转。可以使用该研磨剂无定形二氧化硅制备雾度值小于约70的洁牙剂。

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