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51. 发明授权

US10634604B2 Automated real-time particle characterization and three-dimensional velocimetry with holographic video microscopy 有权
公开(公告)号：US10634604B2
公开(公告)日：2020-04-28
申请号：US15665126
申请日：2017-07-31
申请人： NEW YORK UNIVERSITY
发明人： David G. Grier , Fook Chiong Cheong , Ke Xiao
IPC分类号： G01N15/14 , G02B21/00 , G03H1/00 , G01N15/00
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G02B21/008 , G02B21/0056 , G02B21/0068 , G03H1/0005 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.

52. 发明授权

US10619192B2 Methods and apparatus for performing digital assays using polydisperse droplets 有权
公开(公告)号：US10619192B2
公开(公告)日：2020-04-14
申请号：US15301798
申请日：2015-04-08
申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
发明人： Daniel T. Chiu , Jason E. Kreutz , Gloria S. Yen , Bryant S. Fujimoto
IPC分类号： C12Q1/68 , G01N15/14 , G01N21/64 , C12Q1/6816 , G06T7/62 , G01N21/47 , G06K9/00 , G06K9/46
CPC分类号： C12Q1/6816 , G01N15/1434 , G01N21/47 , G01N21/6428 , G06K9/0014 , G06K9/4647 , G06T7/62 , G01N2015/1445 , G01N2021/6439 , G06T2207/10056 , G06T2207/30072 , C12Q1/6816 , C12Q2531/113 , C12Q2537/157 , C12Q2563/107 , C12Q2563/159
摘要： Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.

53. 发明授权

US09869851B2 Centrifuge force microscope modules and systems for use in a bucket of a centrifuge 有权
公开(公告)号：US09869851B2
公开(公告)日：2018-01-16
申请号：US14530434
申请日：2014-10-31
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人： Kenneth A. Halvorsen , Tony P. Hoang
IPC分类号： G02B21/00 , G01N11/00 , G01N15/14
CPC分类号： G02B21/0004 , G01N11/00 , G01N15/1434 , G01N15/1436 , G01N2015/0053 , G01N2015/1445
摘要： A centrifuge force microscope module for use within a bucket of a centrifuge in measuring a characteristic of a sample under a centrifugal force and/or in monitoring a sample under a centrifugal force. The centrifuge force microscope module includes an electronics module and an optical module. The electronics module includes a housing removably disposable in the bucket of the centrifuge, and at least one of a power source and a connector operably connectable to a power source for powering the electronics module. The optical module is operable to receive and direct light from the sample. The optical module is releaseably connectable to the housing of the electronics module.

54. 发明申请

US20180011001A1 AUTOMATED REAL-TIME PARTICLE CHARACTERIZATION AND THREE-DIMENSIONAL VELOCIMETRY WITH HOLOGRAPHIC VIDEO MICROSCOPY 审中-公开
公开(公告)号：US20180011001A1
公开(公告)日：2018-01-11
申请号：US15665126
申请日：2017-07-31
申请人： NEW YORK UNIVERSITY
发明人： David G. GRIER , Fook Chiong CHEONG , Ke XIAO
IPC分类号： G01N15/14 , G02B21/00 , G03H1/00 , G01N15/00
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N2015/003 , G01N2015/0065 , G01N2015/1445 , G01N2015/1454 , G01N2015/1493 , G01N2015/1497 , G02B21/0056 , G02B21/0068 , G02B21/008 , G03H1/0005 , G03H2001/005
摘要： An in-line holographic microscope can be used to analyze on a frame-by-frame basis a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. Through a combination of applying a combination of Lorenz-Mie analysis with selected hardware and software methods, this analysis can be carried out in near real time. An efficient particle identification methodology automates initial position estimation with sufficient accuracy to enable unattended holographic tracking and characterization.

55. 发明授权

US09842408B2 Methods and apparati for nondestructive detection of undissolved particles in a fluid 有权
公开(公告)号：US09842408B2
公开(公告)日：2017-12-12
申请号：US15192920
申请日：2016-06-24
申请人： Amgen Inc.
发明人： Graham F. Milne , Erwin Freund , Ryan L. Smith
IPC分类号： G06T7/246 , G06T7/60 , G01N21/90 , G01N21/31 , G01N21/51 , G06T7/00 , G01N21/88 , G01N15/14 , G01N15/10
CPC分类号： G06T7/60 , G01N15/1427 , G01N15/1429 , G01N15/1475 , G01N21/31 , G01N21/51 , G01N21/8851 , G01N21/9027 , G01N2015/1075 , G01N2015/1087 , G01N2015/144 , G01N2015/1445 , G01N2015/1452 , G01N2015/1472 , G01N2015/1477 , G01N2015/1493 , G01N2015/1497 , G06T7/0012 , G06T7/246 , G06T2207/10004 , G06T2207/10016 , G06T2207/30004 , G06T2207/30241 , G06T2207/30242
摘要： The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

56. 发明申请

US20170059468A1 FAST FEATURE IDENTIFICATION FOR HOLOGRAPHIC TRACKING AND CHARACTERIZATION OF COLLOIDAL PARTICLES 审中-公开
标题翻译：用于全息跟踪和胶体颗粒表征的快速特征鉴定
公开(公告)号：US20170059468A1
公开(公告)日：2017-03-02
申请号：US15118785
申请日：2015-02-12
申请人： New York University
发明人： Aaron Yevick , Mark Hannel , David G. Grier , Bhaskar Jyoti Krishnatreya
IPC分类号： G01N15/14 , G06F17/11 , G06N99/00 , G01N21/41 , G03H1/00
CPC分类号： G01N15/1429 , G01N15/1434 , G01N21/4133 , G01N2015/1445 , G01N2015/1493 , G03H1/0005 , G03H1/0443 , G03H2001/0033 , G03H2001/0038 , G03H2001/005 , G03H2001/0447 , G06F17/11 , G06N20/00
摘要： A method and system for identification of holographic tracking and identification of features of an object. A holograph is created from scattering off the object, intensity gradients are established for a plurality of pixels in the holograms, the direction of the intensity gradient is determined and those directions analyzed to identify features of the object and enables tracking of the object. Machine learning devices can be trained to estimate particle properties from holographic information.
摘要翻译：用于识别物体的全息跟踪和识别特征的方法和系统。通过散射物体产生全息图，为全息图中的多个像素建立强度梯度，确定强度梯度的方向，并分析这些方向以识别物体的特征，并使物体能够跟踪。可以训练机器学习装置以从全息信息估计粒子特性。

57. 发明申请

US20160379377A1 METHODS AND APPARATI FOR NONDESTRUCTIVE DETECTION OF UNDISSOLVED PARTICLES IN A FLUID 有权
公开(公告)号：US20160379377A1
公开(公告)日：2016-12-29
申请号：US15193704
申请日：2016-06-27
申请人： Amgen Inc.
发明人： Graham F. Milne , Erwin Freund , Ryan L. Smith
IPC分类号： G06T7/60 , G01N21/88 , G01N21/90 , G06T7/00 , G01N15/14
CPC分类号： G06T7/60 , G01N15/1427 , G01N15/1429 , G01N15/1475 , G01N21/31 , G01N21/51 , G01N21/8851 , G01N21/9027 , G01N2015/1075 , G01N2015/1087 , G01N2015/144 , G01N2015/1445 , G01N2015/1452 , G01N2015/1472 , G01N2015/1477 , G01N2015/1493 , G01N2015/1497 , G06T7/0012 , G06T7/246 , G06T2207/10004 , G06T2207/10016 , G06T2207/30004 , G06T2207/30241 , G06T2207/30242
摘要： The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

58. 发明授权

US08947510B2 Functional imaging of cells with optical projection tomography 有权
标题翻译：光学投影断层扫描的细胞功能成像
公开(公告)号：US08947510B2
公开(公告)日：2015-02-03
申请号：US12999515
申请日：2009-06-08
申请人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A Lancaster , Thomas Neumann , Mark E. Fauver
发明人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A Lancaster , Thomas Neumann , Mark E. Fauver
IPC分类号： H04N13/02 , G06T11/00 , G01N15/14
CPC分类号： G06T11/006 , G01N15/1434 , G01N15/1475 , G01N21/49 , G01N21/6458 , G01N2015/1445
摘要： A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).
摘要翻译：一种用于在其中通过引入至少一种纳米颗粒 - 生物标志物标记生物体（1）的亚细胞结构的光学层析成像系统中的生物物体（1）的3D成像的方法。标记的生物体（1）相对于显微镜物镜（62）移动以呈现不同的视角，并且用波长在150nm和900nm之间的辐射照射标记的生物物体（1）。用彩色照相机或一组至少四个单色照相机检测在至少一个波长带内通过标记的生物物体（1）和显微镜物镜（62）发射的辐射。形成并重构来自感测辐射的生物体（1）的多个横截面图像，以便制成标记的生物体（1）的3D图像。

59. 发明授权

US08830476B2 Methods and apparatuses for contact-free holographic imaging of aerosol particles 有权
标题翻译：气溶胶颗粒无接触全息成像的方法和装置
公开(公告)号：US08830476B2
公开(公告)日：2014-09-09
申请号：US13423825
申请日：2012-03-19
申请人： Matthew J. Berg , Gorden Videen
发明人： Matthew J. Berg , Gorden Videen
IPC分类号： G01B9/021 , G01N15/02
CPC分类号： G01N15/0227 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N2015/0096 , G01N2015/1445
摘要： Methods and apparatuses provide holographic contact-free imaging of aerosol particles in an efficient manner. One apparatus for holographic imaging of an aerosol particle may include: a delivery device configured to deliver the particle into a region; a light source for outputting a first beam of light and a second beam of light, wherein the first beam travels into the region producing a first light wave which is un-scattered by the particle and a second light wave that is scattered by the particle, and the second beam does not travel into the region; a beam splitter for combining the second beam with the scattered light of the first beam into combined interference light; an image sensor for sensing an interference pattern created by the combined interference light; and an image processor configured to generate an image of the aerosol particle based on the sensed interference pattern.
摘要翻译：方法和装置以有效的方式提供气溶胶颗粒的全息无接触成像。用于气溶胶颗粒的全息成像的一种装置可以包括：配置成将颗粒输送到区域中的输送装置; 用于输出第一光束和第二光束的光源，其中所述第一光束进入所述区域，所述区域产生未被所述粒子散射的第一光波和由所述粒子散射的第二光波，并且第二光束不会进入该区域; 分束器，用于将第二光束与第一光束的散射光组合成组合的干涉光; 用于感测由所述组合干涉光产生的干涉图案的图像传感器; 以及图像处理器，被配置为基于所感测的干涉图案来生成气溶胶粒子的图像。

60. 发明授权

US08780181B2 Optical sectioning of a sample and detection of particles in a sample 有权
标题翻译：样品的光学切片和样品中颗粒的检测
公开(公告)号：US08780181B2
公开(公告)日：2014-07-15
申请号：US13132713
申请日：2009-12-04
申请人： Tom Olesen , Martin Christian Valvik , Niels Agersnap Larsen , Rasmus Helmsby Sandberg
发明人： Tom Olesen , Martin Christian Valvik , Niels Agersnap Larsen , Rasmus Helmsby Sandberg
IPC分类号： H04N13/02 , G01N15/14 , H04N13/00 , G01N17/00
CPC分类号： G02B21/367 , G01N15/1434 , G01N15/1475 , G01N17/00 , G01N2015/1445 , G01N2015/1452 , G02B21/002 , G06K9/00134 , G06T7/0012 , G06T2207/10016 , G06T2207/10061 , G06T2207/30024 , G06T2207/30101 , H04N13/189 , H04N13/239 , H04N13/296
摘要： The invention relates to an apparatus, a method and a system for obtaining a plurality of images of a sample arranged in relation to a sample device. The apparatus comprises at least a first optical detection assembly having an optical axis and at least one translation unit arranged to move the sample device and the first optical detection assembly relative to each other. The movement of the sample device and the first optical detection assembly relative to each other is along a scanning path, which defines an angle theta relative to the optical axis, wherein theta is larger than zero.
摘要翻译：本发明涉及一种用于获得相对于样本装置布置的样本的多个图像的装置，方法和系统。该装置至少包括具有光轴的第一光学检测组件和布置成使样本装置和第一光学检测组件相对于彼此移动的至少一个平移单元。样品装置和第一光学检测组件相对于彼此的运动沿着扫描路径，该扫描路径限定相对于光轴的角度θ，其中θ大于零。

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