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51. 发明申请

US20110293565A1 NOVEL SYNTHETIC AGONISTS OF TLR9 审中-公开
公开(公告)号：US20110293565A1
公开(公告)日：2011-12-01
申请号：US12695883
申请日：2010-01-28
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K39/00 , A61P35/00 , A61P29/00 , A61K38/21 , A61P17/00 , A61P37/08 , A61P11/06 , C07H21/04 , A61P31/00
CPC分类号： C12N15/115 , A61K39/39 , A61K2039/53 , A61K2039/6025 , C12N15/117 , C12N2310/16 , C12N2310/17
摘要： The invention relates to synthetic chemical compositions that are useful for modulation of Toll-Like Receptor (TLR)-mediated immune responses. In particular, the invention relates to agonists of Toll-Like Receptor 9 (TLR9) that generate unique cytokine and chemokine profiles.

52. 发明申请

US20110123561A1 METHODS AND COMPOSITIONS FOR INDUCTION OR PROMOTION OF IMMUNE TOLERANCE 审中-公开
标题翻译：感染或促进免疫耐受的方法和组合物
公开(公告)号：US20110123561A1
公开(公告)日：2011-05-26
申请号：US12855671
申请日：2010-08-12
申请人： Franck BARRAT , Robert L. COFFMAN
发明人： Franck BARRAT , Robert L. COFFMAN
IPC分类号： A61K39/385 , C07H21/04 , A61K31/7088 , A61P37/02
CPC分类号： A61K39/0008 , A61K2039/6025 , C07K14/47
摘要： The invention provides non-immunostimulatory polynucleotide antigen conjugates and methods for treating unwanted immune reactions in individuals using the non-immunostimulatory polynucleotide antigen conjugates.
摘要翻译：本发明提供非免疫刺激性多核苷酸抗原缀合物和使用非免疫刺激性多核苷酸抗原缀合物治疗个体中不想要的免疫反应的方法。

53. 发明授权

US07850975B2 Chemically programmable immunity 有权
标题翻译：化学可编程免疫
公开(公告)号：US07850975B2
公开(公告)日：2010-12-14
申请号：US11606564
申请日：2006-11-30
申请人： Kary B. Mullis
发明人： Kary B. Mullis
IPC分类号： A61K39/00 , A61K31/7088 , C07H21/00
CPC分类号： A61K39/385 , A61K2039/6025 , Y02A50/386
摘要： The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.
摘要翻译：本发明涉及能够立即针对任何分子或化合物免疫人或动物的方法和组合物。本发明包括具有至少两个位点的免疫接头分子; （1）结合已针对第一结合位点预免疫的人或动物中的免疫系统分子的第一结合位点，和（2）特异性结合所需化合物或分子的一个或多个第二结合位点。第一结合位点和第二结合位点通过分子的接头部分连接。

54. 发明授权

US07527798B2 Composition and method for preventing or treating a virus infection 有权
标题翻译：用于预防或治疗病毒感染的组合物和方法
公开(公告)号：US07527798B2
公开(公告)日：2009-05-05
申请号：US10541771
申请日：2004-01-14
申请人： Walter Gerhard , Laslo Otvos
发明人： Walter Gerhard , Laslo Otvos
IPC分类号： A61K39/385 , A61K39/145 , C07K17/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/55544 , A61K2039/55561 , A61K2039/6025 , A61K2039/6087 , A61K2039/645 , A61K2039/70 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , Y02A50/472
摘要： The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
摘要翻译：本发明提供了多种抗原剂组合物及其用于预防或治疗病毒感染的用途。

55. 发明申请

US20070160623A1 Innate immune system-directed vaccines 审中-公开
公开(公告)号：US20070160623A1
公开(公告)日：2007-07-12
申请号：US11709993
申请日：2007-02-23
申请人： Ruslan Medzhitov , Elizabeth Kopp
发明人： Ruslan Medzhitov , Elizabeth Kopp
IPC分类号： A61K39/00 , C07H21/04 , C12P21/04 , C07K14/47
CPC分类号： C07K14/20 , A61K39/385 , A61K2039/55561 , A61K2039/6025 , A61K2039/6031 , A61K2039/6043 , A61K2039/6068 , C07K14/245 , C07K14/47 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62 , Y02A50/386 , Y02A50/412
摘要： The present invention provides novel vaccines, methods for the production of such vaccines and methods of using such vaccines. The novel vaccines of the present invention combine both of the signals necessary to activate native T-cells—a specific antigen and the co-stimulatory signal—leading to a robust and specific T-cell immune response.

56. 发明申请

US20040146515A1 Chemically programmable immunity 有权
标题翻译：化学可编程免疫
公开(公告)号：US20040146515A1
公开(公告)日：2004-07-29
申请号：US10696770
申请日：2003-10-29
发明人： Kary B. Mullis
IPC分类号： A61K039/395
CPC分类号： A61K39/385 , A61K2039/6025 , Y02A50/386
摘要： Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.
摘要翻译：立即将个体免疫任何分子或化合物的方法和组合物。本发明包括具有至少两个位点的免疫接头; （1）至少一个第一结合位点，其结合已经用通用免疫原预先免疫的个体中的免疫应答组分，和（2）至少一个特异性结合所需化合物或分子的第二结合位点，目标。

57. 发明申请

US20030143213A1 Methods for increasing a cytotoxic T lymphocyte response in vivo 审中-公开
公开(公告)号：US20030143213A1
公开(公告)日：2003-07-31
申请号：US10340275
申请日：2003-01-10
发明人： Eyal Raz , Hearn Jay Cho , Douglas Richman , Anthony A. Horner
IPC分类号： A61K048/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/53 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55 , A61K2039/55561 , A61K2039/57 , A61K2039/585 , A61K2039/6025 , C12N2740/16134 , C12Q1/703
摘要： The invention provides methods for T helper-independent activation of an antigen-specific cytotoxic T lymphocyte response in an individual. The methods generally involve administering to an individual an immunostimulatory nucleic acid molecule in an amount effective to increase an antigen-specific CTL response in the individual. The invention further provides methods for increasing chemokine secretion, which can block HIV infection.

58. 发明申请

US20020061312A1 Innate immune system-directed vaccines 审中-公开
标题翻译：先天免疫系统导向疫苗
公开(公告)号：US20020061312A1
公开(公告)日：2002-05-23
申请号：US09752832
申请日：2001-01-03
发明人： Ruslan Medzhitov
IPC分类号： A61K039/35 , C12N005/10
CPC分类号： A61K39/385 , A61K2039/55561 , A61K2039/6025 , A61K2039/6068 , C07K2319/02 , C07K2319/21 , C07K2319/40 , Y02A50/412
摘要： The present invention provides novel vaccines, methods for the production of such vaccines and methods of using such vaccines. The novel vaccines of the present invention combine both of the signals necessary to activate native T-cells-a specific antigen and the co-stimulatory signal-leading to a robust and specific T-cell immune response.
摘要翻译：本发明提供新型疫苗，生产这种疫苗的方法和使用这种疫苗的方法。本发明的新型疫苗结合了激活天然T细胞所必需的两种信号 - 特异性抗原和共刺激信号，导致鲁棒且特异性的T细胞免疫应答。

59. 发明公开

KR1020140076550A 분자 의태 점막 에이즈 백신 无效
标题翻译：分子MIMIC MUCOSAL AIDS VACCINE
公开(公告)号：KR1020140076550A
公开(公告)日：2014-06-20
申请号：KR1020147005436
申请日：2012-08-15
申请人： 고꾸리쯔다이가꾸호오진 구마모또 다이가꾸 , 엘에스아이피 환도 운에이고우도우가이샤
发明人： 미스미쇼고 , 쇼지쇼조 , 다카무네노부토키
IPC分类号： A61K39/395 , A61K39/39 , A61K39/00 , A61P31/18
CPC分类号： A61K47/4833 , A61K31/166 , A61K39/12 , A61K39/21 , A61K47/646 , A61K2039/545 , A61K2039/6025 , A61K2039/6093 , A61K2039/62 , C07K14/005 , C12N2740/15034 , C12N2740/16034 , C12N2740/16122 , A61K2300/00
摘要： 본 발명의 과제는, 점막 면역을 유도할 수 있고, HIV 감염에 의한 면역계의 파탄(破綻)을 방어할 수 있고, HIV의 이(易)변이원성에 의한 면역계로부터의 도피를 방지할 수 있고, HIV의 신속한 감염을 방지할 수 있는 에이즈 백신을 제공하는 것이다.
본 발명에 의하면, Hub 항원과 N
2 ,N
6 -비스[N
2 ,N
6 -비스(3,4,5-트리히드록시벤조일)-L-리실]-N-(2-아미노에틸)-L-리신아미드(TGDK)와 페투인과의 복합체로 이루어지는 에이즈 백신이 제공된다.

60. 发明公开

KR1020110111517A ＴＬＲ9의 합성 효능제 无效
标题翻译： TLR9合成激素
公开(公告)号：KR1020110111517A
公开(公告)日：2011-10-11
申请号：KR1020117020174
申请日：2010-01-28
申请人： 이데라 파마슈티칼즈, 인코포레이티드
发明人： 칸디말라,에캄발 , 푸타,말리칼주나 , 왕,다킹 , 유,동 , 바가트,라크슈미 , 아그라왈,수디르
IPC分类号： C12N15/117 , A61K31/7088 , A61K48/00 , A61P37/02
CPC分类号： C12N15/115 , A61K39/39 , A61K2039/53 , A61K2039/6025 , C12N15/117 , C12N2310/16 , C12N2310/17
摘要： 본 발명은 톨-유사 수용체(TLR)-매개 면역 반응의 조절에 유용한 합성 화학 조성물에 관한 것이다. 특히, 본 발명은 독특한 시토킨 및 케모킨 프로필을 생성하는 톨-유사 수용체 9(TLR9)의 효능제에 관한 것이다.

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