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51. 发明授权

US08440981B2 Compact pyroelectric sealed electron beam 有权
标题翻译：紧凑型热电密封电子束
公开(公告)号：US08440981B2
公开(公告)日：2013-05-14
申请号：US13159304
申请日：2011-06-13
申请人： Leslie Bromberg , Ching Wu
发明人： Leslie Bromberg , Ching Wu
IPC分类号： H01J37/06 , H01J29/08
CPC分类号： H01J49/147
摘要： A non-radioactive source for Atmospheric Pressure Ionization is described. The electron-beam sealed tube uses a pyroelectric crystal(s). One end of the crystal is grounded while the other end has a metallic cap with sharp feature to generate an electron beam of a given energy. The rate of heating and/or cooling of the crystal is used to control the current generated from a tube. A heating and/or cooling element such as a Peltier element is useful for controlling the rate of cooling of the crystal. A thin window that is transparent to electrons but impervious to gases is needed in order to prolong the life of the tube and allow the extraction of the electrons. If needed, multiple crystals with independent heaters can be used to provide continuous operation of the device. Dielectric shielding of the pyroelectric crystal is used to minimize discharge of the crystal.
摘要翻译：描述了用于大气压电离的非放射源。电子束密封管使用热电晶体。晶体的一端接地，而另一端具有尖锐特征的金属盖，以产生给定能量的电子束。使用晶体的加热和/或冷却速度来控制从管产生的电流。诸如珀尔帖元件的加热和/或冷却元件可用于控制晶体的冷却速率。需要对电子透明但不透气体的薄窗，以延长管的寿命并允许电子的提取。如果需要，可以使用具有独立加热器的多个晶体来提供设备的连续操作。热电晶体的介电屏蔽用于使晶体的放电最小化。

52. 发明授权

US08217338B2 Method and apparatus for chemical and biological sample separation 有权
标题翻译：化学和生物样品分离的方法和装置
公开(公告)号：US08217338B2
公开(公告)日：2012-07-10
申请号：US12577062
申请日：2009-10-09
申请人： Clinton Alawn Krueger , Ching Wu , Christopher K Hilton
发明人： Clinton Alawn Krueger , Ching Wu , Christopher K Hilton
IPC分类号： B01D59/44 , H01J49/34
CPC分类号： G01N27/622
摘要： The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.
摘要翻译：本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。

53. 发明申请

US20120126139A1 MULTI-DIMENSIONAL ION MOBILITY SPECTROMETRY METHODS AND APPARATUS 有权
公开(公告)号：US20120126139A1
公开(公告)日：2012-05-24
申请号：US13360758
申请日：2012-01-29
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： H01J27/02 , G01N1/02
CPC分类号： G01N27/622
摘要： Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.

54. 发明申请

US20120049057A1 ION MOBILITY BASED SEPARATION METHODS AND APPARATUS 有权
标题翻译：离子移动基于分离方法和装置
公开(公告)号：US20120049057A1
公开(公告)日：2012-03-01
申请号：US13293317
申请日：2011-11-10
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
IPC分类号： H01J49/26
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译：本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。通过改变IMS的漂移介质来实现基于匹配特性的分离。除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。

55. 发明授权

US08063361B2 Ion mobility based separation methods and apparatus 有权
标题翻译：基于离子迁移的分离方法和装置
公开(公告)号：US08063361B2
公开(公告)日：2011-11-22
申请号：US12610306
申请日：2009-10-31
申请人： Ching Wu , Clinton Alawn Krueger
发明人： Ching Wu , Clinton Alawn Krueger
IPC分类号： H01J49/00 , H01J49/26 , B01D59/44
CPC分类号： G01N27/622
摘要： The present invention describes separating components in a sample in an ion mobility based spectrometer using at least one matching property of the components other than the molecular properties in conventional ion mobility measurements in noble drift gases to enhance separation and resolution of the sample. Separation based on the matching property is realized by altering the drift media of the IMS. Besides altering drift media, energy level of ions and/or drift media are also controlled during the separation process. This invention describes an ion mobility apparatus wherein an energy source is added to the IMS that provides additional energy to the ions and/or drift media and tuning methods that involve selecting drift media and optimizing the energy level in order to achieve optimal performance.
摘要翻译：本发明描述了使用离子迁移率光谱仪中的样品中的组分，其使用除贵族漂移气体中的常规离子迁移率测量中的分子特性以外的组分的至少一个匹配性质以增强样品的分离和分离。通过改变IMS的漂移介质来实现基于匹配特性的分离。除了改变漂移介质之外，还可以在分离过程中控制离子和/或漂移介质的能级。本发明描述了一种离子迁移率装置，其中向IMS提供能量源，其为离子和/或漂移介质提供额外的能量以及涉及选择漂移介质并优化能级以便实现最佳性能的调谐方法。

56. 发明申请

US20080173809A1 METHODS AND APPARATUS FOR THE ION MOBILITY BASED SEPARATION AND COLLECTION OF MOLECULES 审中-公开
标题翻译：基于离子移动的分离和收集分子的方法和装置
公开(公告)号：US20080173809A1
公开(公告)日：2008-07-24
申请号：US11776392
申请日：2007-07-11
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： H01J49/26
CPC分类号： H01J49/165 , C07B63/00 , G01N27/622
摘要： This invention describes an apparatus for the separation and collection of components in a sample of interest comprising: an ionization source; an ion mobility separator and an ion collector positioned to receive ions leaving the ion mobility separator. The ion mobility separator having an inlet to supply at least one separating substance which comprises particles which selectively interact with at least one analyte component of interest to certain degree different from the others. The analyte component of interest may be enantiomers, diastereomers, stereoisomers, isomers, etc. The ion collector can be used to conduct analytical, preparative, and semi-preparative separation. In addition, a combined primary electrospray and secondary electrospray ionization source is disclosed to enhance ionization efficiency of interest.
摘要翻译：本发明描述了一种用于分离和收集感兴趣样品中的组分的装置，包括：电离源; 离子迁移率分离器和离子收集器，定位成接收离开离子迁移分离器的离子。离子迁移率分离器具有供应至少一种分离物质的入口，所述分离物质包含与至少一种目标分析物组分选择性相互作用的颗粒，其与其它分离物质不同。感兴趣的分析物成分可以是对映异构体，非对映体，立体异构体，异构体等。离子收集器可用于进行分析，制备和半制备分离。此外，公开了组合的初级电喷雾和次级电喷雾离子源以增强感兴趣的电离效率。

57. 发明申请

US20080073503A1 Multidimensional Ion Mobility Spectrometry Apparatus and Methods 有权
标题翻译：多维离子迁移光谱仪器及方法
公开(公告)号：US20080073503A1
公开(公告)日：2008-03-27
申请号：US11618430
申请日：2006-12-29
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： G01N27/64
CPC分类号： G01N27/622
摘要： Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.
摘要翻译：公开了具有多于一个漂移室的多维离子迁移率分析仪的各种实施方案，并且可以获得物质的多维离子迁移谱。该装置的漂移室可以例如在独立操作条件下操作，以根据其可区分的化学/物理性质分离带电粒子。该装置的第一尺寸漂移室可以根据分析仪的操作模式用作存储装置，反应室和/或漂移室。还提出了操作离子迁移谱仪的各种方法，包括但不限于连续的第一维电离方法，其能够使得样品中的所有化学组分电离，而不管其电荷亲和力如何。

58. 发明申请

US20070278396A1 ION MOBILITY SPECTROMETER APPARATUS AND METHODS 有权
标题翻译：离子移动光谱仪装置和方法
公开(公告)号：US20070278396A1
公开(公告)日：2007-12-06
申请号：US11674646
申请日：2007-02-13
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： G01N27/64 , H01J49/40
CPC分类号： G01N27/622 , H01J49/062
摘要： An ion mobility spectrometer includes a protective housing. A drift tube having at least one inlet and at least one outlet confines a drift gas. An ion gate is positioned in the drift tube. The ion gate defines a reaction region and a drift region in the drift tube. An ion detector is positioned in the drift tube downstream of the ion gate at an end of the drift region. A helical resistive wire coil is positioned around the drift tube. A power supply generates an electric field in the helical resistive wire coil that rapidly controls the temperature of the drift gas.
摘要翻译：离子迁移谱仪包括保护壳体。漂移管具有至少一个入口和至少一个出口限制漂移气体。离子门位于漂移管中。离子门限定了漂移管中的反应区和漂移区。离子检测器位于漂移管的漂移区末端的离子门下游。螺旋电阻线圈位于漂移管周围。电源在螺旋电阻线圈中产生电场，其迅速地控制漂移气体的温度。

59. 发明申请

US20190285583A1 APPARATUS AND METHOD FOR ION MOBILITY SPECTROMETRY AND SAMPLE INTRODUCTION 审中-公开
公开(公告)号：US20190285583A1
公开(公告)日：2019-09-19
申请号：US16430309
申请日：2019-06-03
申请人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
发明人： Ching Wu , Mark A. Osgood , Eugenie Hainsworth , Clinton Alawn Krueger , Taeman Kim
IPC分类号： G01N27/62 , H01J49/16 , H01J49/06
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.

60. 发明申请

US20190259595A1 CHEMICALLY MODIFIED ION MOBILITY SEPARATION APPARATUS AND METHOD 审中-公开
公开(公告)号：US20190259595A1
公开(公告)日：2019-08-22
申请号：US16396715
申请日：2019-04-28
申请人： Ching Wu , Mark A. Osgood
发明人： Ching Wu , Mark A. Osgood
IPC分类号： H01J49/06 , G01N27/62 , C07B63/00 , H01J49/00
摘要： An ion mobility spectrometry apparatus and method used to separate ions and select some of the ions using an AC gate; the selected ions are further separated along a drift axis of a drift tube, where the AC gate is controlled using a series of AC voltages and/or frequencies to select different ions for the drift tube.

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