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51. 发明公开

EP3126529A1 DETECTING COLORECTAL NEOPLASM 有权转让
标题翻译：结直肠肿瘤的检测
公开(公告)号：EP3126529A1
公开(公告)日：2017-02-08
申请号：EP15774156.2
申请日：2015-03-26
申请人： Mayo Foundation for Medical Education and Research , Exact Sciences Corporation
发明人： AHLQUIST, David Alan , TAYLOR, William Russell , MAHONEY, Douglas W. , LIDGARD, Graham P. , ALLAWI, Hatim T.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

52. 发明公开

EP2640858A4 METHYLATION ASSAY 有权转让
标题翻译：甲基化分析
公开(公告)号：EP2640858A4
公开(公告)日：2014-04-16
申请号：EP11842202
申请日：2011-11-02
申请人： EXACT SCIENCES CORP
发明人： ZOU HONGZHI , LIDGARD GRAHAM P , DOMANICO MICHAEL J , ALLAWI HATIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q2600/154 , C12Q2521/301 , C12Q2523/125 , C12Q2561/109

53. 发明公开

EP2650377A1 Epigenetic change in selected genes and cancer 有权转让
标题翻译： Epigenetische Veraenderungen bei selektierten Genen und Krebs
公开(公告)号：EP2650377A1
公开(公告)日：2013-10-16
申请号：EP13156618.4
申请日：2008-01-09
申请人： MDxHealth SA
发明人： Van Engeland, Manon , De Bruine, Manon Adriaan , Griffioen, Arjan , Louwagie, Joost , Bierau, Katja , Britchard, Gontran , Otto, Gaëtan , Penning, Maarten
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16
摘要： A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, SOX17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer. Also described are pharmacogenetic methods for determining suitable treatment regimens for cancer and methods for treating cancer patients, based around selection of the patients according to the methods of the invention. The present invention is also concerned with improved methods of collecting, processing and analyzing samples, in particular body fluid samples. These methods may be useful in diagnosing, staging or otherwise characterizing various diseases. The invention also relates to methods for identifying, diagnosing, staging or otherwise characterizing cancers, in particular gastrointestinal cancers such as colorectal cancers, gastric cancers and oesophageal cancers. The methods of the invention relate, inter alia, to isolating and analyzing the human DNA component from faecal samples and blood-based samples.
摘要翻译：检测样品中的癌症的倾向或发病率的方法包括检测至少一种选自NDRG4 / NDRG2亚家族基因，GATA4，OSMR，GATA5，SFRP1，ADAM23，JPH3，SFRP2， APC，MGMT，TFPI2，BNIP3，FOXE1，SYNE1，SOX17，PHACTR3和JAM3，其中表观遗传改变的检测表明癌症的倾向或发生率。还描述了基于根据本发明的方法选择患者的用于确定癌症的合适治疗方案的药物遗传学方法和用于治疗癌症患者的方法。本发明还涉及采集，加工和分析样品，特别是体液样品的改进方法。这些方法可用于诊断，分期或以其他方式表征各种疾病。本发明还涉及用于鉴定，诊断，分期或以其他方式表征癌症，特别是胃肠癌如结肠直肠癌，胃癌和食管癌的方法。本发明的方法尤其涉及从粪便样品和基于血液的样品中分离和分析人类DNA组分。

54. 发明授权

EP1238103B1 METHODS FOR DISEASE DETECTION 有权
标题翻译：法发现疾病
公开(公告)号：EP1238103B1
公开(公告)日：2009-01-07
申请号：EP00960085.9
申请日：2000-09-08
申请人： Exact Sciences Corporation
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.

55. 发明公开

EP1291657A2 Methods for detecting colon cancer from stool samples 失效
标题翻译： Verfahren zum Nachweis von Kolonkrebs aus Stuhlproben
公开(公告)号：EP1291657A2
公开(公告)日：2003-03-12
申请号：EP02024382.0
申请日：1996-12-20
申请人： Exact Sciences Corporation
发明人： Lapidus, Stanley N. , Ulmer, Kevin M. , Shuber, Anthony P.
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57419 , C12Q1/6806 , C12Q1/6886 , C12Q2600/106
摘要： The present invention provides methods for screening for the presence of a subpopulation of cancerous or precancerous cells in a heterogeneous cellular sample, such as a stool sample. The methods take advantage of the recognition that cellular debris from cancerous and precancerous cells is deposited onto only a longitudinal stripe of stool as the stool is forming in the colon. Accordingly, methods of the invention comprise obtaining a representative sample, such as a cross-sectional sample of stool in order to ensure that any cellular debris that is shed by colonic cells is obtained in the sample.
摘要翻译：本发明提供了筛选异种细胞样品例如粪便样品中存在癌细胞或癌前细胞亚群的方法。该方法利用了识别，当粪便在结肠中形成时，来自癌细胞和癌前细胞的细胞碎片沉积到仅在纵向条状条上。因此，本发明的方法包括获得代表性样品，例如粪便的横截面样品，以确保在样品中获得由结肠细胞脱落的任何细胞碎片。

56. 发明公开

EP1238103A2 METHODS FOR DISEASE DETECTION 有权
标题翻译：法发现疾病
公开(公告)号：EP1238103A2
公开(公告)日：2002-09-11
申请号：EP00960085.9
申请日：2000-09-08
申请人： Exact Sciences Corporation
发明人： SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.

57. 发明公开

EP1131468A2 PRIMER EXTENSION METHODS UTILIZING DONOR AND ACCEPTOR MOLECULES FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译： “引物延伸”的方法，使用的供体和受体分子对于核酸的检测
公开(公告)号：EP1131468A2
公开(公告)日：2001-09-12
申请号：EP99968045.7
申请日：1999-11-23
申请人： Exact Sciences Corporation
发明人： LAPIDUS, Stanley, N. , SHUBER, Anthony, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6818 , C12Q1/6827 , C12Q1/6886 , C12Q2600/16 , C12Q2535/125 , C12Q2525/186 , C12Q2565/101 , C12Q2533/101
摘要： Methods are provided for selective nucleic acid sequence detection in primer extension reactions of high specificity. These methods are useful for detecting small amounts of mutant nucleic acid in a heterogeneous biological sample. These methods are particularly useful for identifying individuals with gene mutations indicative of early colorectal cancer.

58. 发明授权

EP3434791B1 EPIGENETIC CHANGE IN SELECTED GENES AND CANCER 有权转让
公开(公告)号：EP3434791B1
公开(公告)日：2020-05-27
申请号：EP18176135.4
申请日：2008-01-09
申请人： Exact Sciences Development Company, LLC
发明人： VAN ENGELAND, Manon , DE BRUINE, Manon, Adriaan , GRIFFIOEN, Arjan , LOUWAGIE, Joost , BIERAU, Katja , BRICHARD, Gontran , OTTO, Gaëtan , PENNING, Maarten
IPC分类号： C12Q1/6886

59. 发明公开

EP3488004A1 METHYLATED CONTROL DNA 有权转让
公开(公告)号：EP3488004A1
公开(公告)日：2019-05-29
申请号：EP17831807.7
申请日：2017-07-19
申请人： Exact Sciences Development Company, LLC
发明人： ALLAWI, Hatim T. , LIDGARD, Graham P.
IPC分类号： C12N15/10 , C12Q1/68

60. 发明公开

EP3230744A4 COMPOSITIONS AND METHODS FOR PERFORMING METHYLATION DETECTION ASSAYS 有权转让
公开(公告)号：EP3230744A4
公开(公告)日：2018-07-11
申请号：EP15868202
申请日：2015-12-11
申请人： EXACT SCIENCES DEV COMPANY LLC
发明人： ALLAWI HATIM T , LIDGARD GRAHAM P
IPC分类号： G01N33/574 , C12Q1/6881 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q1/6881 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/166
摘要： Provided herein is technology relating compositions and methods for detecting tissue cell-specific DNA, such as epithelial cell-specific DNA, in blood or blood products from a subject. The technology also relates to use of tissue cell-specific DNAs as internal controls for methylation assays.

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