专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US09181238B2 N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors 有权
标题翻译： N-（吡啶-2-基）磺酰胺及其组合物作为蛋白激酶抑制剂
公开(公告)号：US09181238B2
公开(公告)日：2015-11-10
申请号：US13577209
申请日：2011-02-04
申请人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
发明人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
IPC分类号： A61K31/444 , C07D213/75 , C07D471/04 , C07D401/14 , A61K31/506 , A61K31/519 , A61K45/06
CPC分类号： C07D471/04 , A61K31/444 , A61K31/506 , A61K31/519 , A61K45/06 , C07D401/14
摘要： The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的式（I）化合物（其中A，Y，R 2，R 3，R 4和R 5在本发明概述中定义），包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及B-Raf异常活化的疾病或病症。

52. 发明授权

US08346965B2 Systems and methods for multi-layer traffic grooming 有权
标题翻译：多层交通梳理的系统和方法
公开(公告)号：US08346965B2
公开(公告)日：2013-01-01
申请号：US12942586
申请日：2010-11-09
申请人： Qiong Zhang , Paparao Palacharla , Qingya She , Xi Wang , Motoyoshi Sekiya
发明人： Qiong Zhang , Paparao Palacharla , Qingya She , Xi Wang , Motoyoshi Sekiya
IPC分类号： G06F15/16
CPC分类号： H04J14/0257 , H04J14/0212
摘要： A method may include constructing an auxiliary graph for a network comprising a plurality of network elements, the network elements having an Internet Protocol layer, a lower layer, and a wavelength layer, the auxiliary graph including a plurality of directed edges, the plurality of directed edges indicative of connectivity of components of the plurality of network elements. The method may further include: (i) deleting directed edges from the auxiliary graph whose available bandwidth is lower than the required bandwidth of a selected demand; (ii) finding a path for the demand on the auxiliary graph via remaining directed edges; (iii) deleting at least one directed edge of the auxiliary graph on the wavelength layer along the path; (iv) adding lower layer lightpath edges to the auxiliary graph for a lower layer lightpath for the path; and (v) converting lower layer lightpaths to Internet Protocol lightpaths if a conversion condition is satisfied.
摘要翻译：方法可以包括为包括多个网络元件的网络构建辅助图形，所述网络元件具有互联网协议层，下层和波长层，所述辅助图形包括多个有向边缘，所述多个定向指示多个网络元件的组件的连接性的边缘。该方法还可以包括：（i）从可用带宽低于所选择的需求的所需带宽的辅助图中删除有向边; （ii）通过剩余的有向边找到对辅助图的需求的路径; （iii）沿所述路径删除所述波长层上的辅助图形的至少一个有向边缘; （iv）将下层光路边缘添加到辅助图形，用于路径的下层光路; 和（v）如果满足转换条件，则将下层光路转换为因特网协议光路。

53. 发明申请

US20110206374A1 System and Method for Demand Aggregation in Optical Networks Employing Shared Ring Protection 有权
标题翻译：使用共享环保护的光网络中的需求聚合的系统和方法
公开(公告)号：US20110206374A1
公开(公告)日：2011-08-25
申请号：US13022128
申请日：2011-02-07
申请人： Xi Wang , Qiong Zhang , Paparao Palacharla , Takao Naito
发明人： Xi Wang , Qiong Zhang , Paparao Palacharla , Takao Naito
IPC分类号： H04B10/20
CPC分类号： H04J14/0283 , H04J14/0257 , H04J14/0267 , H04J14/0295
摘要： In accordance with embodiments of the present disclosure, a method for demand aggregation is provided. The method may include routing demands in a ring network such that a length for each routed demand does not exceed a route length maximum, and a load imbalance at each node in the ring network is minimized. The method may also include maximizing optical line card sharing by assigning routed demands sharing common ends to the same wavelength.
摘要翻译：根据本公开的实施例，提供了一种用于需求聚合的方法。该方法可以包括在环形网络中的路由需求，使得每个路由需求的长度不超过路由长度最大值，并且环形网络中每个节点处的负载不平衡被最小化。该方法还可以包括通过将共享共同端点的路由需求分配到相同波长来最大化光线路卡共享。

54. 发明申请

US20100329120A1 Determining Disjoint Paths With An Optimized Number Of Regenerators 有权
标题翻译：确定具有优化数量的再生器的不相交路径
公开(公告)号：US20100329120A1
公开(公告)日：2010-12-30
申请号：US12494397
申请日：2009-06-30
申请人： Qiong Zhang , Xi Wang , Paparao Palacharla , Takao Naito
发明人： Qiong Zhang , Xi Wang , Paparao Palacharla , Takao Naito
IPC分类号： G08C15/00
CPC分类号： H04L45/00 , H04L45/123 , H04L45/124 , H04L45/128
摘要： According to particular embodiments, determining disjoint paths includes receiving a graph representing a network comprising nodes and links. The graph is transformed such that the number of intermediate nodes of a path indicates the number of regenerators for the path. A set of seed paths from a source node to a destination node of the transformed graph is generated. For each seed path, a shortest path from the source node to the destination node is determined to yield one or more pairs of disjoint paths from the source node to the destination node. An optimized pair of disjoint paths is selected, where the optimized pair of disjoint paths has an optimized number of regenerators.
摘要翻译：根据特定实施例，确定不相交路径包括接收表示包括节点和链路的网络的图。图形被变换，使得路径的中间节点的数量表示路径的再生器的数量。生成从变换图的源节点到目标节点的一组种子路径。对于每个种子路径，确定从源节点到目的地节点的最短路径以产生从源节点到目的地节点的一对或多对不相交路径。选择优化的一对不相交路径，其中优化的一对不相交路径具有优化的再生器数量。

55. 发明申请

US20100151448A1 Asymmetric PCR Amplification, its Special Primer and Application 有权
标题翻译：不对称PCR扩增，其特殊引物和应用
公开(公告)号：US20100151448A1
公开(公告)日：2010-06-17
申请号：US11661069
申请日：2004-11-22
申请人： Zhiwei Zhang , Can Wang , Lingxiang Zhu , Qiong Zhang , Jing Cheng
发明人： Zhiwei Zhang , Can Wang , Lingxiang Zhu , Qiong Zhang , Jing Cheng
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/686 , C12Q2531/107 , C12Q2525/155 , C12Q2525/15
摘要： The present invention discloses an asymmetric PCR amplification method, its special primer and application, aims to provide a simple, effective PCR amplification for preparation of single-stranded product. The asymmetric PCR primer of the invention comprises some PCR primer pairs, in which an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one primer. The asymmetric PCR amplification provided includes the steps: 1) preparative denaturing; 2) repetitiously denaturing, primers annealing, extending cycles as the first stage of PCR amplification; 3) repetitiously denaturing, primer extending cycles as the second stage of PCR amplification, wherein an unrelated nucleic acids sequence to target sequence to be detected is added onto 5′-terminal of one PCR primer of each pair in extension. With the asymmetric PCR amplification of the invention, high throughput of single-stranded products can be obtained, single PCR amplification or multiple PCR amplification can be carried out. And the method can be widely used in detection of nucleic acids.
摘要翻译：本发明公开了一种不对称PCR扩增方法及其特异性引物及其应用，旨在为单链产物的制备提供简单有效的PCR扩增。本发明的不对称PCR引物包含一些PCR引物对，其中将待检测的靶序列的不相关核酸序列添加到一个引物的5'末端。提供的不对称PCR扩增包括以下步骤：1）制备型变性; 2）重复变性，引物退火，延伸循环作为PCR扩增的第一阶段; 3）重复变性，引物延伸循环作为PCR扩增的第二阶段，其中将待检测的靶序列的不相关核酸序列添加到每对扩增中的一个PCR引物的5'末端。利用本发明的不对称PCR扩增，可以获得高通量的单链产物，可进行单PCR扩增或多重PCR扩增。该方法可广泛用于检测核酸。

56. 发明申请

US20090069327A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20090069327A1
公开(公告)日：2009-03-12
申请号：US12162313
申请日：2007-02-06
申请人： Qiang Ding , Pingda Ren , Qiong Zhang , Xia Wang , Taebo Sim , Pamela A. Albaugh , Nathanael S. Gray
发明人： Qiang Ding , Pingda Ren , Qiong Zhang , Xia Wang , Taebo Sim , Pamela A. Albaugh , Nathanael S. Gray
IPC分类号： A61K31/5377 , C07D403/14 , C07D413/14 , A61K31/444 , A61P43/00 , C07D239/42 , A61K31/497
CPC分类号： C07D239/42 , C07D401/04 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bmx, b-RAF, c-RAF, c-SRC, KDR, CSK, FGFR3, JAK2, Lck, Met, PKCα, SAPK2α, Tie2, TrkB and P70S6K kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，Bcr-Abl异常活化的疾病或病症，Bmx，b-RAF，c-RAF，c-SRC，KDR，CSK，FGFR3，JAK2，Lck，Met，PKCalpha，SAPK2alpha，Tie2，TrkB和P70S6K激酶。

57. 发明申请

US20070225286A1 Compounds and Compositions as Protein Kinase Inhibitors 有权
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US20070225286A1
公开(公告)日：2007-09-27
申请号：US11628881
申请日：2005-06-09
申请人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shull You , Qiong Zhang , Greg Chopiuk , Pamela Albaugh , Taebo Sim , Nathanael Gray
发明人： Pingda Ren , Xia Wang , Guobao Zhang , Qiang Ding , Shull You , Qiong Zhang , Greg Chopiuk , Pamela Albaugh , Taebo Sim , Nathanael Gray
IPC分类号： A61K31/496 , A61K31/497 , A61K31/5355 , C07D401/04 , C07D403/04
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, PDGF-R, trkB, c-SRC, BMX, FGFR3, b-RAF, ΣΓK, Ttε2, Λχκ, ΘNK2α2, MKK4, c-RAF, MKK6, SAPK2α and SAPK2β kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，PDGF-R，trkB，c-SRC，BMX，FGFR3，b-RAF，SigmaGammaK，Ttepsilon2，Lambdachikappa，ThetaNK2alpha2，MKK4，c-RAF，MKK6，SAPK2α和SAPK2β激酶。

58. 发明申请

US20180196159A1 IN-WELL MONITORING OF COMPONENTS OF DOWNHOLE TOOLS 审中-公开
公开(公告)号：US20180196159A1
公开(公告)日：2018-07-12
申请号：US15404237
申请日：2017-01-12
申请人： Qiong Zhang , Yi Liu , Thomas M. Scott
发明人： Qiong Zhang , Yi Liu , Thomas M. Scott
IPC分类号： G01V5/10
CPC分类号： G01V5/107
摘要： Systems and methods for downhole component monitoring including a monitored component doped with a pre-selected neutron absorbent, the monitored component being part of a downhole tool and a neutron monitoring system positioned relative to the monitored component. The neutron monitoring system includes a neutron source positioned at a first location relative to the monitored component and a neutron detector positioned at a second location relative to the monitored component, the neutron detector configured to detect neutrons from the neutron source and count said detected neutrons. A control unit is in communication with the neutron detector and configured to determine a status of the monitored component from the neutron count received from the neutron detector.

59. 发明授权

US08909049B2 Method and system for calculating spectrum granularity in flexible grid optical networks 有权
标题翻译：柔性网格光网络光谱粒度计算方法与系统
公开(公告)号：US08909049B2
公开(公告)日：2014-12-09
申请号：US13175154
申请日：2011-07-01
申请人： Xi Wang , Qiong Zhang , Inwoong Kim , Paparao Palacharla , Motoyoshi Sekiya
发明人： Xi Wang , Qiong Zhang , Inwoong Kim , Paparao Palacharla , Motoyoshi Sekiya
IPC分类号： H04B10/00 , H04J14/02
CPC分类号： H04J14/026 , H04J14/0224 , H04J14/0257
摘要： In accordance with embodiments of the present disclosure, a method may include determining individual spectrum requirements for each of a plurality of signals to be communicated in an optical network, wherein a first signal of the plurality of signals has a first spectrum requirement and a second signal of the plurality of signals has a second spectrum requirement. The method may also include calculating a minimum spectrum granularity based on the individual spectrum requirements. The method may further include assigning each particular signal a channel spectrum equal to an integer multiple of the minimum spectrum granularity.
摘要翻译：根据本公开的实施例，一种方法可以包括确定要在光网络中传送的多个信号中的每个信号的各个频谱要求，其中多个信号中的第一信号具有第一频谱要求和第二信号的多个信号具有第二频谱要求。该方法还可以包括基于各个频谱要求来计算最小频谱粒度。该方法还可以包括将每个特定信号分配为等于最小频谱粒度的整数倍的信道频谱。

60. 发明授权

US08831012B2 Determining paths in a network with asymmetric switches 有权
标题翻译：确定具有非对称开关的网络中的路径
公开(公告)号：US08831012B2
公开(公告)日：2014-09-09
申请号：US12574972
申请日：2009-10-07
申请人： Min He , Kevin Zhu , Srinivas Vobilisetti , Takao Naito , Paparao Palacharla , Xi Wang , Qiong Zhang
发明人： Min He , Kevin Zhu , Srinivas Vobilisetti , Takao Naito , Paparao Palacharla , Xi Wang , Qiong Zhang
IPC分类号： H04L12/28 , H04L12/46 , H04L12/701 , H04L12/721 , H04L12/735 , H04L12/707 , H04Q3/66
CPC分类号： H04L12/462 , H04L45/00 , H04L45/12 , H04L45/128 , H04L45/22 , H04Q3/66 , H04Q2213/13141 , H04Q2213/13148
摘要： According to particular embodiments, determining paths in a network with asymmetric switches includes receiving a graph representing the network. Each asymmetric switch has defined degree connectivity between one or more pairs of degrees of the asymmetric switch. The graph is transformed to yield a transformed graph that accounts for the asymmetric switches. A routing process is applied to the transformed graph to yield one or more paths through the network.
摘要翻译：根据特定实施例，使用非对称交换机确定网络中的路径包括接收表示网络的图形。每个非对称开关已经限定了非对称开关的一对或多对度之间的程度连接。转换图形以产生解释非对称开关的变换图。将路由过程应用于变换图，以产生通过网络的一个或多个路径。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式