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51. 发明授权

US07683057B2 Kinase inhibitor compounds 有权
公开(公告)号：US07683057B2
公开(公告)日：2010-03-23
申请号：US12005872
申请日：2007-12-28
申请人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号： A61K31/5377 , A61K31/404 , C07D413/14 , C07D209/34
CPC分类号： C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

52. 发明申请

US20090277944A9 Apparatus and method for attaching a surgical buttress to a stapling apparatus 审中-公开
标题翻译：用于将手术支撑件附接到缝合装置的装置和方法
公开(公告)号：US20090277944A9
公开(公告)日：2009-11-12
申请号：US11633291
申请日：2006-12-04
申请人： David A. Dalessandro , Zhigang Li , Angelo G. Scopelianos
发明人： David A. Dalessandro , Zhigang Li , Angelo G. Scopelianos
IPC分类号： A61B17/068
CPC分类号： A61B17/07292 , A61B17/00491 , A61B17/07207 , A61B2017/00004 , A61B2017/00889
摘要： The present invention is an apparatus for equipping a surgical stapling device with a surgical buttress in order to provide reinforced surgical fastener suture lines and includes means for aligning the apparatus with the surgical staple device, an elastomeric foam surgical buttress contained within the alignment means and means for retaining the foam buttress within the alignment means, which alignment means is formed as a unitary body containing a frame, guide channel walls and means for receiving the elastomeric foam surgical buttress.
摘要翻译：本发明是一种用于为外科缝合装置配备手术支撑件的装置，以便提供加强的手术紧固件缝合线，并且包括用于使装置与外科缝合装置对准的装置，包含在对准装置内的弹性泡沫手术支架用于将泡沫支撑件保持在对准装置内，该对准装置形成为包含框架的整体，引导通道壁和用于接收弹性体泡沫外科支撑的装置。

53. 发明申请

US20090076005A1 Kinase inhibitor compounds 有权
标题翻译：激酶抑制剂化合物
公开(公告)号：US20090076005A1
公开(公告)日：2009-03-19
申请号：US12005872
申请日：2007-12-28
申请人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
发明人： Congxin Liang , Ming Qi , Shu Gao , Zhigang Li
IPC分类号： A61K31/5377 , C07D209/04 , A61K31/404 , C07D295/00 , C07D261/02 , C07D213/02 , A61P35/00 , C12N9/99 , C12Q1/48 , A61K31/4427 , A61K31/42 , A61K31/454 , C07D239/24 , A61K31/505
CPC分类号： C07D493/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C12Q1/485
摘要： The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.
摘要翻译：本发明涉及化合物，包含该化合物的组合物，以及使用该化合物和化合物组合物的方法。本文所述的化合物，组合物和方法可用于激酶介导的过程的治疗调节，以及疾病和疾病症状的治疗，特别是由某些激酶的介导的那些症状。

54. 发明授权

US09173773B2 Punctal plugs for the delivery of active agents 有权
标题翻译：用于递送活性剂的针刺塞
公开(公告)号：US09173773B2
公开(公告)日：2015-11-03
申请号：US11759327
申请日：2007-06-07
申请人： Maureen J. Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael J. Trezza, II
发明人： Maureen J. Borgia , Hassan Chaouk , Han Cui , Walter Laredo , Zhigang Li , Aruna Nathan , Michael J. Trezza, II
IPC分类号： A61F2/00 , A61F13/00 , A61F9/007 , A61F9/00 , A61M31/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61M31/002
摘要： The invention provides punctal plugs for the delivery of active agent to one or both of the tear fluid of the eye and to the nasolacrimal duct. The plugs of the invention have a body, a reservoir contained within the body, and optionally a collarette. The reservoir has at least one opening and contains a polymeric material and at least one active agent.
摘要翻译：本发明提供了用于将活性剂递送到眼睛的泪液和鼻泪管中的一种或两种的泪点塞。本发明的塞子具有主体，容纳在主体内的储存器，以及可选地是围兜。储存器具有至少一个开口并且包含聚合材料和至少一种活性剂。

55. 发明申请

US20140332524A1 Door Opening Structure for Microwave Oven 有权
标题翻译：微波炉开门结构
公开(公告)号：US20140332524A1
公开(公告)日：2014-11-13
申请号：US14117243
申请日：2012-01-30
申请人： Zhigang Li , Zhihua Chen , Jie Li , Cheng Jiang
发明人： Zhigang Li , Zhihua Chen , Jie Li , Cheng Jiang
IPC分类号： H05B6/64
CPC分类号： H05B6/6414 , A47J36/12 , E05F1/1215 , E05F5/00 , E05Y2201/20 , E05Y2201/21 , E05Y2201/256 , E05Y2201/264 , E05Y2900/308 , F24C15/023
摘要： A door opening structure for microwave oven includes an upper hinge fastened on a door body assembly, and a lower hinge fastened on a oven body of a microwave oven, wherein the door body assembly is hinged with the oven body by the upper hinge and the lower hinge. An elastic element is provided between the upper hinge and the lower hinge, and the upper hinge is connected with a damper. Both ends of the upper hinge are provided with first connectors that are hinged with the lower hinge, and the middle portion of the upper hinge is provided with second connectors that are hinged with one end of the damper by spring pins.
摘要翻译：用于微波炉的门开口结构包括紧固在门体组件上的上铰链和紧固在微波炉的炉体上的下铰链，其中门体组件通过上铰链和下铰链铰接在烤箱本体上合页。弹性元件设置在上铰链和下铰链之间，上铰链与阻尼器连接。上铰链的两端设置有与下铰链铰接的第一连接器，并且上铰链的中间部分设置有第二连接器，其通过弹簧销与阻尼器的一端铰接。

56. 发明申请

US20130190536A1 METHOD FOR SALTING-OUT EXTRACTION OF ACETONE AND BUTANOL FROM A FERMENTATION BROTH 有权
标题翻译：从发酵豆中提取丙酮和丁醇的方法
公开(公告)号：US20130190536A1
公开(公告)日：2013-07-25
申请号：US13812133
申请日：2010-12-27
申请人： Yaqin Sun , Zhigang Li , Zhilong Xiu
发明人： Yaqin Sun , Zhigang Li , Zhilong Xiu
IPC分类号： C07C45/86
CPC分类号： C07C45/86 , C07C29/86 , C07C45/80 , C07C49/08 , C07C31/12
摘要： The present invention provided a method for salting-out extraction of acetone and butanol from a fermentation broth, characterized in that one type, or two or more types of salts and one type, or two or more types of extractants are added to an acetone-butanol-ethanol (ABE) fermentation broth, in which the salt saturation achieves 10%˜100%; and the volume ratio of the fermentation broth containing salts to the extractants is 1:0.1˜1:5. The mixture is allowed to stand until phase separation is formed. The top phase is a solvent phase or extraction phase enriched with acetone and butanol whereas the bottom phase is a salt-enriched phase or raffinate phase. This method involves many advantages, such as the simplified operation procedure, accelerated separation process and low separation cost, and therefore becomes a promising method of separating acetone and butanol in industrial application.
摘要翻译：本发明提供了一种从发酵液中提取丙酮和丁醇的方法，其特征在于将一种或两种或更多种类型的盐和一种或两种或更多种提取剂加入到丙酮 - 丁醇 - 乙醇（ABE）发酵液，盐饱和度达到10％〜100％; 含有盐的发酵液与萃取剂的体积比为1:0.1〜1:5。使混合物静置直至形成相分离。顶相是富含丙酮和丁醇的溶剂相或萃取相，而底相是富含富油相或萃余相。该方法具有操作简便，加速分离，分离成本低等优点，成为工业应用中分离丙酮和丁醇的有前景的方法。

57. 发明授权

US08377042B2 Ophthalmic devices for the controlled release of active agents 有权
标题翻译：用于控释活性剂的眼科装置
公开(公告)号：US08377042B2
公开(公告)日：2013-02-19
申请号：US12779238
申请日：2010-05-13
申请人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
发明人： Zhigang Li , Michael J. Trezza, II , Maureen J. Borgia , Aruna Nathan , Bret A. Coldren
IPC分类号： A61K9/22
CPC分类号： A61F9/0017 , A61F9/00772 , A61F2250/0068 , A61K9/0043 , A61K9/0051
摘要： The invention provides devices useful for the delivery of active agents to the eye in a controlled manner. In the devices of the invention, the active agent is present within the device in a continuous or discontinuous concentration gradient.
摘要翻译：本发明提供了用于以受控方式将活性剂递送至眼睛的装置。在本发明的装置中，活性剂以连续或不连续的浓度梯度存在于装置内。

58. 发明授权

US08261086B2 Computer and method for sending security information for authentication 有权
标题翻译：用于发送用于认证的安全信息的计算机和方法
公开(公告)号：US08261086B2
公开(公告)日：2012-09-04
申请号：US12315979
申请日：2008-12-09
申请人： Zhigang Li , Min Hu , Rongfeng Feng , Yi Zhang
发明人： Zhigang Li , Min Hu , Rongfeng Feng , Yi Zhang
IPC分类号： G06F21/00
CPC分类号： H04L63/083 , G06F21/33 , G06F21/46 , H04L63/1441
摘要： The present invention provides a computer and a method of sending security information for authentication, which relate to transmission of data information in computers. The present invention solves the vulnerability of information when a user conducts network transaction activities by a terminal. The computer of the present invention comprises: a virtual system platform; a first guest operating system installed on the virtual system platform, which is for installing a service application module, wherein the service application module generates a security information input interface when it is being executed; a second guest operating system installed on the virtual system platform; the second guest operating system comprises: a dynamic password generation module for generating security information, the security information is input into the security information input interface and is sent to a network server for authentication. The security of network activities conducted by users can be enhanced.
摘要翻译：本发明提供了一种用于发送用于认证的安全信息的计算机和方法，其涉及计算机中的数据信息的传输。本发明解决了当用户通过终端进行网络交易活动时的信息的脆弱性。本发明的计算机包括：虚拟系统平台; 安装在所述虚拟系统平台上的用于安装服务应用模块的第一客户机操作系统，其中所述服务应用模块在执行时生成安全信息输入接口; 安装在虚拟系统平台上的第二个客户操作系统; 第二客户操作系统包括：用于生成安全信息的动态密码生成模块，将安全信息输入到安全信息输入接口中，并发送到网络服务器进行认证。用户进行网络活动的安全性可以得到提高。

59. 发明申请

US20120018436A1 TANK CONTAINER, TANK BODY AND PROCESSING METHOD OF TANK BODY 有权
标题翻译：坦克容器，罐体和罐体加工方法
公开(公告)号：US20120018436A1
公开(公告)日：2012-01-26
申请号：US13260892
申请日：2010-05-19
申请人： Guang Li , Yuebin Yu , Zhongbo Li , Zhen Zhu , Qipeng Yang , Enqiang Lei , Jungsong Wang , Zhigang Li , Lianhua Lou , Jian Zhao , Yongfeng Yi
发明人： Guang Li , Yuebin Yu , Zhongbo Li , Zhen Zhu , Qipeng Yang , Enqiang Lei , Jungsong Wang , Zhigang Li , Lianhua Lou , Jian Zhao , Yongfeng Yi
IPC分类号： B65D1/42 , B23K31/02
CPC分类号： B65D88/128 , B23K31/027 , B23K2101/12 , B23K2103/04 , B23K2103/06
摘要： A container tank body and a processing method thereof are provided. The tank body is arranged in a frame with a square-shaped cross section and comprises a cylindrical main body part, end enclosures arranged at two ends of the cylindrical main body part and fixedly connected with the cylindrical main body part, and a tank body strengthening device. The cylindrical main body part comprises a plurality of parts with an arc-shaped cross section, the parts are formed by bending and welding a same panel, and the cross section of the cylindrical main body part of the tank body is generally arranged between the square-shaped cross section of the frame and an inscribed circle of the square-shaped cross section. A tank container comprising the tank body is also disclosed. As the cylindrical main body part is made by continuously bending a whole panel, the molding process is simplified so that the cylindrical main body part is only provided with one welding line, thereby remarkably lowering the leakage risk of the container tank body in use and improving the reliability of the container tank body in work; and the structure has quite strong self-anti-load capacity, thereby decreasing the number of the used tank strengthening devices and reducing the deadweight.
摘要翻译：提供容器罐体及其加工方法。罐体布置成具有正方形截面的框架，并且包括圆柱形主体部分，末端壳体布置在圆柱形主体部分的两端并与圆柱形主体部分固定连接，并且罐体加强设备。圆柱形主体部分包括具有弧形横截面的多个部分，这些部分通过弯曲和焊接同一个面板而形成，并且罐体的圆筒形主体部分的横截面通常布置在正方形形状的横截面和方形截面的内切圆。还公开了一种包括罐体的罐容器。由于圆筒形主体部分通过连续弯曲整个面板而制成，所以成型工艺简化，使得圆筒形主体部分仅设置有一根焊接线，从而显着降低了在使用中的容器箱体的泄漏风险和改进容器箱体工作的可靠性; 并且结构具有相当强的自承载能力，从而减少了使用的罐加固装置的数量并减少了自重。

60. 发明申请

US20110281857A1 PI3K/MTOR KINASE INHIBITORS 失效
标题翻译： PI3K / MTOR激酶抑制剂
公开(公告)号：US20110281857A1
公开(公告)日：2011-11-17
申请号：US13128687
申请日：2009-11-11
申请人： Congxin Liang , Zhigang Li
发明人： Congxin Liang , Zhigang Li
IPC分类号： A61K31/5386 , C07D498/08 , A61K31/5377 , A61P35/00 , A61P5/00 , A61P9/00 , A61P31/12 , A61P29/00 , A61P3/00 , A61P25/00 , C07D487/04 , A61P37/00
CPC分类号： C07D487/04
摘要： 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mTOR activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
摘要翻译： 6-吗啉-4-基 - 吡唑并[3,4-d]嘧啶和2-吗啉-4-基-7H-吡咯并[2,3-d]嘧啶衍生物具有作为PI3和/或mTOR抑制剂的意想不到的药物特性激酶，并且可用于治疗与异常PI3K / mTOR活性相关的疾病，例如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。

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