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51. 发明授权

US08309745B2 Epigallocatechin dimers or trimers having lipase inhibitory activity and/or antioxidant activity 有权
标题翻译：具有脂肪酶抑制活性和/或抗氧化活性的表没食子儿茶素二聚体或三聚体
公开(公告)号：US08309745B2
公开(公告)日：2012-11-13
申请号：US12872872
申请日：2010-08-31
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami
IPC分类号： C07D311/62
CPC分类号： C07D311/62 , A23L33/105
摘要： An object of the present invention is to provide a lipase activity inhibitor that shows high inhibitory activity against pancreatic lipase to suppress the absorption of meal-derived fat and/or which contributes to suppressing and preventing obesity, as well as a food or beverage that has such lipase activity inhibitor incorporated therein. Another object of the invention is to provide a lipase inhibitor of tea origin that suits most consumers' taste and which will not impair the flavor of the food or beverage when incorporated therein. Still another object of the invention is to provide a process for producing said lipase inhibitors. Further object of the invention is to provide antioxidants. To attain these objects, epigallocatechin dimers (oolong homobisflavans) or trimers are incorporated in foods or beverages. As a result, the absorption of meal-derived fat can be suppressed and, in addition, antioxidation effect is obtained. The compounds of the invention can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：本发明的目的是提供一种脂肪酶活性抑制剂，其对胰脂肪酶具有高抑制活性以抑制膳食衍生的脂肪的吸收和/或有助于抑制和预防肥胖症，以及具有掺入其中的这种脂肪酶活性抑制剂。本发明的另一个目的是提供一种适合大多数消费者口味的茶源脂肪酶抑制剂，并且当其中掺入时不会损害食品或饮料的风味。本发明的另一个目的是提供一种生产所述脂肪酶抑制剂的方法。本发明的另一个目的是提供抗氧化剂。为了达到这些目的，将表没食子儿茶素二聚体（乌龙双黄）或三聚体掺入食品或饮料中。结果，可以抑制膳食来源的脂肪的吸收，并且还可以获得抗氧化作用。本发明的化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

52. 发明申请

US20120065410A1 ANTI-OBESITY AGENT COMPRISING COMPOUND CONTAINING BENZOTROPOLONE RING 有权
标题翻译：抗生素剂包含化合物包含苯并吡喃酮环
公开(公告)号：US20120065410A1
公开(公告)日：2012-03-15
申请号：US13321299
申请日：2010-05-21
申请人： Yuko Fukui , Sumio Asami , Mitsuru Maeda
发明人： Yuko Fukui , Sumio Asami , Mitsuru Maeda
IPC分类号： C07D311/04
CPC分类号： C07D311/64 , A23F3/16 , A23L2/52 , A23L33/105 , A23V2002/00 , A61K31/122 , A61K31/353 , C07C62/38 , C07D311/04 , C07D311/62 , A23V2200/332
摘要： The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages.According to the present invention, a safe and palatable anti-obesity agent can be provided by incorporating a benzotropolone ring-containing compound which has tea-derived, high inhibitory activities against lipase and alfa-glucosidase. The anti-obesity agent of the present invention does not compromise the flavor of foods and beverage, has palatability, and can be used in various use applications including foods and beverages intended for health enhancement such as reduction in triglycerides.
摘要翻译：本发明的目的是提供一种含有茶衍生成分的抗肥胖剂，其是安全的并且不损害食品和饮料的风味。根据本发明，可以通过掺入具有茶衍生，对脂肪酶和α-葡糖苷酶的高抑制活性的含有苯佐龙酮酮环的化合物来提供安全可口的抗肥胖剂。本发明的抗肥胖剂不损害食品和饮料的味道，具有适口性，并且可以用于各种用途，包括用于健康增强的食品和饮料，例如甘油三酯的还原。

53. 发明申请

US20090215186A1 Method for Procyanidin Analysis 审中-公开
标题翻译：原花青素分析方法
公开(公告)号：US20090215186A1
公开(公告)日：2009-08-27
申请号：US11922982
申请日：2006-06-28
申请人： Yuko Fukui
发明人： Yuko Fukui
IPC分类号： G01N33/00
CPC分类号： G01N33/14 , G01N2030/8813 , Y10T436/142222
摘要： The present invention relates to a novel method for quantifying procyanidin and flavan-3-ols contained in natural products, foods and drinks, pharmaceuticals and/or cosmetics. The present invention provides a method for quantifying procyanidin (a generic name for a mixture of catechin n-mer; n≧1) contained in test samples such as natural products, foods and drinks, pharmaceuticals and/or cosmetics, which comprises a) pretreating a test sample using a column to remove contaminants which affect the analysis of procyanidin and flavan-3-ol; and b) effecting high performance liquid chromatography (HPLC) to separate and quantify procyanidin and flavan-3-ols in the solution treated to remove contaminants during the above pretreatment step a).
摘要翻译：本发明涉及量化天然产物，食品和饮料，药物和/或化妆品中所含的原花青素和黄烷-3-醇的新方法。本发明提供了用于定量试验样品如天然产物，食品和饮料，药物和/或化妆品中的原花青素（儿茶素n-n = 1的混合物的通用名称）的方法，其包括：a）使用色谱柱预处理测试样品以去除影响原花青素和黄烷-3-醇分析的污染物; 和b）在上述预处理步骤a）期间，进行高效液相色谱（HPLC）分离和定量处理以除去污染物的溶液中的原花青素和黄烷-3-醇。

54. 发明申请

US20080275258A1 Epigallocatechin Dimers or Trimers Having Lipase Inhibitory Activity and/or Antioxidant Activity 有权
标题翻译：具有脂肪酶抑制活性和/或抗氧化活性的表没食子儿茶素二聚体或三聚体
公开(公告)号：US20080275258A1
公开(公告)日：2008-11-06
申请号：US11597291
申请日：2005-05-26
申请人： Masaaki Nakai , Yuko Fukui , Sumio Asami
发明人： Masaaki Nakai , Yuko Fukui , Sumio Asami
IPC分类号： C07D311/04
CPC分类号： C07D311/62 , A23L33/105
摘要： It is intended to provide a lipase activity inhibitor which shows a high inhibitory activity on pancreatic lipase, regulates the absorption of fat from meals and/or contributes to the regulation or prevention of obesity, a food and a drink containing the same, and a tea-origin lipase inhibitor being highly preferable and not worsening taste. It is also intended to provide a method of producing the lipase inhibitor. It is further intended to provide antioxidative agent. To overcome these problems, an epigallocatechin dimer (oolong homo bis flavans) or trimer is added to foods or drinks. Thus, the absorption of fat from meals can be regulated and an antioxidative effect can be obtained. The above compounds can be produced by reacting epigallocatechin gallate with formaldehyde in the presence of an acid.
摘要翻译：旨在提供对胰脂肪酶具有高抑制活性的脂肪酶活性抑制剂，调节从膳食中吸收脂肪和/或有助于调节或预防肥胖症的食物和饮料，以及茶 - 原料脂肪酶抑制剂是非常优选的，而不是恶化味道。还旨在提供一种生产脂肪酶抑制剂的方法。还旨在提供抗氧化剂。为了克服这些问题，向食物或饮料中加入表没食子儿茶素二聚体（乌龙同双双黄烷）或三聚体。因此，可以调节从膳食中吸收脂肪，并且可以获得抗氧化作用。上述化合物可以通过在酸的存在下使表没食子儿茶素没食子酸酯与甲醛反应来制备。

55. 发明授权

US4878921A Natural blue dye composition and colorant using the same: prepared by reacting taurine and genipin 失效
标题翻译：天然蓝色染料组合物和使用其的着色剂：通过使牛磺酸和京尼平反应制备
公开(公告)号：US4878921A
公开(公告)日：1989-11-07
申请号：US65033
申请日：1987-06-19
申请人： Kunimasa Koga , Shigeaki Fujikawa , Yuko Fukui
发明人： Kunimasa Koga , Shigeaki Fujikawa , Yuko Fukui
IPC分类号： A23L1/275 , C09B61/00
CPC分类号： C12Y302/01021 , A23L5/43 , C09B61/00
摘要： A natural blue dye composition that has improved stability and which can be used as a colorant in a broad range of applications including foodstuffs and drugs, and a process for preparing the same are disclosed.Genipin which is derived from gardenia fruit by hydrolysis of iridoid glycoside geniposide under action of .beta.-glucosidase, is reacted with taurine to produce a stable blue dye compositions.
摘要翻译：公开了一种天然蓝色染料组合物，它具有改进的稳定性，并可广泛应用于食品和药物中的着色剂，以及其制备方法。通过β-葡萄糖苷酶作用下的环烯醚萜苷苷栀子苷的水解衍生自栀子果实的栀子素与牛磺酸反应以产生稳定的蓝色染料组合物。

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