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51. 发明申请

US20080318863A1 ISCHEMIA THERAPEUTIC AGENT 审中-公开
标题翻译： ISCHEMIA治疗剂
公开(公告)号：US20080318863A1
公开(公告)日：2008-12-25
申请号：US12136797
申请日：2008-06-11
申请人： Yasuhiko Tabata , Masashi Komeda
发明人： Yasuhiko Tabata , Masashi Komeda
IPC分类号： A61K38/39 , A61P9/10
CPC分类号： A61K38/014 , A61K9/0019 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K47/42 , A61K2300/00
摘要： The present invention provides a ischemia therapeutic agent that contains vascularization induction factor and gelatin hydrogel, and gradually releases vascularization induction factor, which is useful in treating ischemia accompanying peripheral circulatory disorders etc. encountering as complications of arteriosclerosis obliterans, Buerger's disease, diabetes and collagen disease.
摘要翻译：本发明提供含有血管形成诱导因子和明胶水凝胶的缺血治疗剂，并逐渐释放血管形成诱导因子，其可用于治疗伴随周围循环障碍等的缺血，其为闭塞性动脉硬化症，Buerger氏病，糖尿病和胶原性疾病的并发症。

52. 发明申请

US20070010436A1 Remedy for cardiomyopathy 审中-公开
标题翻译：心肌病的治疗方法
公开(公告)号：US20070010436A1
公开(公告)日：2007-01-11
申请号：US10551497
申请日：2003-04-01
申请人： Yasuhiko Tabata , Masashi Komeda
发明人： Yasuhiko Tabata , Masashi Komeda
IPC分类号： A61K38/17 , A61K38/39
CPC分类号： A61K9/0019 , A61K38/1833 , A61K47/42
摘要： The present invention provides a cardiomyopathy therapeutic agent that contains hepatocyte growth factor (HGF) and gelatin hydrogel, and gradually releases HGF, which is useful in treating cardiomyopathy.
摘要翻译：本发明提供含有肝细胞生长因子（HGF）和明胶水凝胶的心肌病治疗剂，逐渐释放可用于治疗心肌病的HGF。

53. 发明申请

US20060251719A1 Sustained-release hydrogel preparation 有权
标题翻译：缓释水凝胶制剂
公开(公告)号：US20060251719A1
公开(公告)日：2006-11-09
申请号：US10549695
申请日：2004-03-15
申请人： Yasuhiko Tabata
发明人： Yasuhiko Tabata
IPC分类号： A61K9/22
CPC分类号： A61K9/06
摘要： A sustained-release preparation is provided which comprises a drug and a bioabsorbable polymer hydrogel, wherein a concentration gradient of the drug is formed in the hydrogel. Also disclosed is a method of sustained release of a drug in vivo using the sustained-release preparation of the invention. The directionality of the drug release may be controlled by employing the sustained-release preparation of the invention. The sustained-release preparation of the invention is particularly useful as an anti-cancer agent.
摘要翻译：提供了一种持续释放制剂，其包含药物和生物可吸收聚合物水凝胶，其中在水凝胶中形成药物的浓度梯度。还公开了使用本发明的缓释制剂在体内持续释放药物的方法。可以通过使用本发明的缓释制剂来控制药物释放的方向性。本发明的缓释制剂作为抗癌剂是特别有用的。

54. 发明授权

US06969524B1 Interferon complex and medicinal use thereof 失效
标题翻译：干扰素复合物及其药用
公开(公告)号：US06969524B1
公开(公告)日：2005-11-29
申请号：US10110420
申请日：2000-10-12
申请人： Yasuhiko Tabata , Saburo Sone , Mayumi Seto , Miyuki Sato
发明人： Yasuhiko Tabata , Saburo Sone , Mayumi Seto , Miyuki Sato
IPC分类号： A61K38/21 , A61K47/48 , A61P27/02 , A61P35/00 , A61F2/02
CPC分类号： A61K38/215 , A61K38/21 , A61K47/61
摘要： An object of the present invention is to provide modified IFN so that duration of IFN in blood is prolonged and IFN acts specifically on tissues having neovasculature, particularly tumors or ophthalmic tissues having neovasculature. The present invention provides an interferon-dextran complex obtained by mixing interferon with dextran having chelate ligands in the presence of a metal ion.
摘要翻译：本发明的目的是提供修饰的IFN，使得IFN在血液中的持续时间延长，并且IFN特异性地对具有新血管系统的组织起作用，特别是具有新血管系统的肿瘤或眼科组织。本发明提供通过在金属离子的存在下将干扰素与具有螯合配体的葡聚糖混合而获得的干扰素 - 葡聚糖复合物。

55. 发明申请

US20050119745A1 Transplantation material for regenerating biological tissue and process for producing the same 审中-公开
标题翻译：用于再生生物组织的移植材料及其生产方法
公开(公告)号：US20050119745A1
公开(公告)日：2005-06-02
申请号：US10508091
申请日：2003-10-29
申请人： Yasuhiko Tabata , Yoshinobu Kubo , Akisige Hokugo
发明人： Yasuhiko Tabata , Yoshinobu Kubo , Akisige Hokugo
IPC分类号： A61L27/00 , A61L27/38 , A61L27/46 , A61L31/00 , A61L31/16 , A61L31/18 , A61F2/02
CPC分类号： A61L27/3821 , A61L27/3608 , A61L27/3625 , A61L27/365 , A61L27/3847 , A61L27/46 , A61L31/00 , A61L31/16 , A61L31/18 , A61L2300/414 , A61L2430/02
摘要： The object of the present invention is to promote adequate body tissue formation action in a body tissue filling material. The present invention provides a graft material for body tissue regeneration 1 provided with a tubular member 2 composed of a material that allows nutrients B to permeate to the outside from blood A that passes therein, a body tissue filling material 3 arranged around the periphery of the tubular member 2, and a film 4 composed of a biocompatible material that covers them.
摘要翻译：本发明的目的是促进身体组织填充材料中的适当的身体组织形成作用。本发明提供一种身体组织再生装置1，其具有管状部件2，所述管状部件2由允许营养物B从其中通过的血液A渗透到外部的材料构成;身体组织填充材料3，管状构件2和由覆盖它们的生物相容性材料构成的膜4。

56. 发明授权

US5298243A Colony stimulating factor-gelatin conjugate 失效
标题翻译：集落刺激因子 - 明胶缀合物
公开(公告)号：US5298243A
公开(公告)日：1994-03-29
申请号：US422701
申请日：1989-10-17
申请人： Yoshito Ikada , Yasuhiko Tabata , Hiroyasu Suzuki
发明人： Yoshito Ikada , Yasuhiko Tabata , Hiroyasu Suzuki
IPC分类号： A61K38/19 , A61K47/48 , C07K15/00 , C07K3/02
CPC分类号： A61K38/193 , A61K47/48292
摘要： Disclosed are a crosslinked gelatin microspheres containing CSF and a water soluble CSF-gelatin conjugate. Both the microspheres and the water soluble conjugate provide an improved CSF stability. They have a high potentiation on the antitumor activity of macrophages in respect of the CSF amount and the time required for macrophage activation and are effective in maintaining their activated state for a long period, compared with the native CSF. The mechanism of macrophage activation by the microspheres containing CSF is mediated via phagocytosis and different from that by native CSF, which is believed to activate macrophages via cell surface receptor. The species specificity of CSF may be abrogated when the CSF is internalized into macrophages through phagocytosis.
摘要翻译：公开了含有CSF和水溶性CSF-明胶缀合物的交联明胶微球。微球和水溶性缀合物都能提供改善的CSF稳定性。与天然CSF相比，它们对于巨噬细胞的CSF量和巨噬细胞活化所需的时间对抗巨噬细胞的抗肿瘤活性具有高增强作用，并且与天然CSF相比长效保持其活化状态是有效的。通过含有CSF的微球的巨噬细胞活化的机制是通过吞噬作用介导的，不同于被认为通过细胞表面受体激活巨噬细胞的天然CSF。当CSF通过吞噬作用内化于巨噬细胞时，CSF的物种特异性可能被消除。

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