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51. 发明授权

US07555336B2 Automatic LV/RV capture verification and diagnostics 有权
标题翻译：自动LV / RV捕获验证和诊断
公开(公告)号：US07555336B2
公开(公告)日：2009-06-30
申请号：US11312163
申请日：2005-12-20
申请人： Nirav V. Sheth , Karen J. Kleckner , John E. Burnes
发明人： Nirav V. Sheth , Karen J. Kleckner , John E. Burnes
IPC分类号： A61B5/0402
CPC分类号： A61N1/371 , A61N1/3712
摘要： The present invention provides a technique for verifying pacing capture of a ventricular chamber, particularly to ensure desired delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”). The invention also provides for ventricular capture management by delivering a single ventricular pacing stimulus and checking inter-ventricular conduction during a temporal window to determine if the ventricular pacing stimulus captured the chamber. If a loss-of-capture (LOC) signal results from the capture management testing, then the characteristics of the applied pacing pulses are modified and the conduction test repeated. In the event that the LOC signal persists, a pacing mode-switch to an atrial-based pacing therapy and/or non-bi-ventricular pacing regimen can be implemented.
摘要翻译：本发明提供了一种用于验证心室的起搏捕获的技术，特别是确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的期望递送。本发明还通过递送单个心室起搏刺激和在时间窗口期间检查心室间传导来确定心室起搏刺激是否捕获腔室来提供心室捕获管理。如果捕获管理测试产生捕获损失（LOC）信号，则应用起搏脉冲的特性被修改，并重复传导测试。在LOC信号持续存在的情况下，可以实现起搏模式切换到基于心房的起搏治疗和/或非双心室起搏方案。

52. 发明授权

US09572982B2 Techniques for placing medical leads for electrical stimulation of nerve tissue 有权
标题翻译：放置用于电刺激神经组织的医疗线的技术
公开(公告)号：US09572982B2
公开(公告)日：2017-02-21
申请号：US12433766
申请日：2009-04-30
申请人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
发明人： John E. Burnes , Kenneth C. Gardeski , Ruth N. Klepfer , Patrick E. Macaulay , Mary M. Morris , Avram Scheiner
IPC分类号： A61B19/00 , A61N1/36 , A61N1/05 , A61M25/09
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译：本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。

53. 发明授权

US08532793B2 Techniques for placing medical leads for electrical stimulation of nerve tissue 有权
标题翻译：放置用于电刺激神经组织的医疗线的技术
公开(公告)号：US08532793B2
公开(公告)日：2013-09-10
申请号：US12433809
申请日：2009-04-30
申请人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
发明人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.
摘要翻译：本公开涉及用于在患者体内靠近神经组织布置医疗引线和电刺激和/或感测电极的额外的，内部的和经血管内的医疗引线放置技术。

54. 发明授权

US08478406B2 Apparatus and methods of delivering an enhanced refractory period stimulation therapy 有权
$Apparatus and methods of delivering an enhanced refractory period stimulation therapy$
标题翻译：递送增强型不应期刺激疗法的装置和方法
公开(公告)号：US08478406B2
公开(公告)日：2013-07-02
申请号：US11379886
申请日：2006-04-24
申请人： John E. Burnes , David E. Euler
发明人： John E. Burnes , David E. Euler
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514
摘要： Refractory period stimulation (RPS) disclosed herein includes apparatus and methods to enhance cardiac performance by delivering monophasic stimulation pulses during the refractory period. The disclosure describes several system level improvements to RPS that include one or more of the following: (i) Delivery of RPS therapy pulses at multiple sites in an automatically alternating way to avoid increasing demand at any one location for prolonged periods of time. (ii) Delivery of RPS therapy pulses at multiple sites to determine one or more optimal electrode configurations for chronic RPS therapy delivery. (iii) Use of separate electrode(s) for sensing ventricular activity to properly time and adjust the application of RPS thereby avoiding limitations associated with electrode polarization that occurs due to the amount of energy delivered during the RPS. (iv) Use of a relatively long active recharge pulse at the RPS stimulation electrodes to remove the undesirable effects of polarization.
摘要翻译：本文公开的难治性周期刺激（RPS）包括通过在不应期期间递送单相刺激脉冲来增强心脏性能的装置和方法。本公开描述了对RPS的几个系统级改进，其包括以下一个或多个：（i）以自动交替方式在多个位置递送RPS治疗脉冲，以避免在任何一个位置长时间增加需求。（ii）在多个位点递送RPS治疗脉冲以确定用于慢性RPS治疗递送的一种或多种最佳电极配置。（iii）使用单独的电极来感测心室活动以适当地时间和调整RPS的应用，从而避免由于在RPS期间递送的能量的量而发生的与电极极化相关的限制。（iv）在RPS刺激电极处使用相对长的主动再充电脉冲以消除不期望的极化影响。

55. 发明申请

US20130013017A1 APPARATUS AND METHODS FOR AUTOMATIC ADJUSTMENT OF AV INTERVAL TO ENSURE DELIVERY OF CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
标题翻译：用于自动调整AV间隔以确保进行心脏再生治疗的装置和方法
公开(公告)号：US20130013017A1
公开(公告)日：2013-01-10
申请号：US13610163
申请日：2012-09-11
申请人： Thomas J. Mullen , John E. Burnes , Aleksandre T. Sambelashvili
发明人： Thomas J. Mullen , John E. Burnes , Aleksandre T. Sambelashvili
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles) and delivering fusion pacing using a decremented value of the intrinsic PR interval.
摘要翻译：左心室起搏的方法和装置，包括自动调整心房（AV）起搏延迟间隔和固有AV节点传导测试。因此，在AV传导测试揭示生理上可接受的固有PR间隔的情况下，然后将生理上可接受的PR间期存储在存储器结构中（例如，来自一个或多个心动周期的中值PR）并且使用递减值内在PR间期。

56. 发明授权

US08135463B2 Algorithm for the automatic determination of optimal AV and VV intervals 有权
标题翻译：自动确定最佳AV和VV间隔的算法
公开(公告)号：US08135463B2
公开(公告)日：2012-03-13
申请号：US11751250
申请日：2007-05-21
申请人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
发明人： John E. Burnes , Yong K. Cho , David Igel , Luc R. Mongeon , John C. Rueter , Harry Stone , Jodi Zilinski
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
摘要翻译：用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。

57. 发明申请

US20100113943A1 SYSTEM AND METHOD FOR SIMULTANEOUS CENTRAL AND BRACHIAL ARTERIAL PRESSURE MONITORING 审中-公开
标题翻译：同时中央和手持式压力监测的系统和方法
公开(公告)号：US20100113943A1
公开(公告)日：2010-05-06
申请号：US12262349
申请日：2008-10-31
申请人： John E. Burnes , Mustafa Karamanoglu
发明人： John E. Burnes , Mustafa Karamanoglu
IPC分类号： A61B5/0215
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/02125 , A61B5/02156 , A61B5/6846 , A61N1/36564
摘要： An implantable medical device system and corresponding method to monitor blood pressure by transforming a measured pressure signal to estimate a blood pressure metric or waveform corresponding to a target site. An implantable sensor generates a signal corresponding to blood pressure at a first arterial branch location and a processor receiving the signal applies a transfer function to the signal to derive a blood pressure metric or waveform at a target site.
摘要翻译：一种可植入医疗装置系统和相应的方法，用于通过变换测量的压力信号来估计对应于目标部位的血压量度或波形来监测血压。可植入传感器产生对应于第一动脉分支位置处的血压的信号，并且接收信号的处理器对信号施加传递函数以导出目标部位的血压度量或波形。

58. 发明申请

US20090276023A1 TECHNIQUES FOR PLACING MEDICAL LEADS FOR ELECTRICAL STIMULATION OF NERVE TISSUE 有权
公开(公告)号：US20090276023A1
公开(公告)日：2009-11-05
申请号：US12433809
申请日：2009-04-30
申请人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
发明人： Mary M. Morris , Avram Scheiner , Ruth N. Klepfer , John E. Burnes
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61M25/09 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/057 , A61N1/36085 , A61N1/36114 , A61N1/36125 , A61N1/36128
摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

59. 发明申请

US20080269823A1 Apparatus and Methods for Automatic Determination of a Fusion Pacing Pre-Excitation Interval 有权
标题翻译：自动确定融合起搏预激间隔的装置和方法
公开(公告)号：US20080269823A1
公开(公告)日：2008-10-30
申请号：US11742230
申请日：2007-04-30
申请人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
发明人： John E. Burnes , Thomas J. Mullen , Aleksandra T. Sambelashvili
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.
摘要翻译：用于提供血液动力学有效的融合起搏治疗的预激发间隔（PEI）的自动调整。

60. 发明授权

US07181284B2 Apparatus and methods of energy efficient, atrial-based Bi-ventricular fusion-pacing 有权
标题翻译：节能，基于心房的双心室融合起搏的装置和方法
公开(公告)号：US07181284B2
公开(公告)日：2007-02-20
申请号：US10803570
申请日：2004-03-17
申请人： John E. Burnes , Thomas J. Mullen
发明人： John E. Burnes , Thomas J. Mullen
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The bi-ventricular implantable pulse generator described and depicted herein enables hemodynamic efficiencies for patients suffering from intraventricular conduction delays or conduction blockage. The pulse generator effectively overcomes such conduction delay or block (e.g., left bundle branch block, “LBBB,” or right bundle branch block, “RBBB”) by delivering a novel form of cardiac resynchronization therapy (CRT). Specifically, a single ventricular pre-excitation pacing stimulus is triggered from an atrial event (e.g., intrinsic or evoked depolarization). The triggering event may emanate from the right atrium (RA) or the left atrium (LA). A single ventricular pre-excitation pacing stimulus is delivered prior to the intrinsic depolarization of the other ventricle and thus promotes intraventricular electromechanical synchrony during CRT delivery.
摘要翻译：本文描述和描述的双心室可植入脉冲发生器能够对患有心室内传导延迟或传导阻塞的患者进行血液动力学效率。通过递送心脏再同步治疗（CRT）的新形式，脉冲发生器有效地克服了这种传导延迟或阻滞（例如左束支传导阻滞“LBBB”或右束支传导阻滞“RBBB”）。具体来说，从心房事件（例如内在或诱发的去极化）触发单个心室预激发起搏刺激。触发事件可能从右心房（RA）或左心房（LA）发出。在另一个心室的内在去极化之前输送单个心室预激励起搏刺激，从而在CRT输送期间促进脑室内机电同步。

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