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51. 发明授权

US07312214B2 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors 有权
标题翻译： 1,1-二取代的环烷基衍生物作为因子Xa抑制剂
公开(公告)号：US07312214B2
公开(公告)日：2007-12-25
申请号：US10430024
申请日：2003-05-05
申请人： Jennifer X. Qiao , Donald J. Pinto , Michael J. Orwat , Sarah R. Friedrich , Wei Han
发明人： Jennifer X. Qiao , Donald J. Pinto , Michael J. Orwat , Sarah R. Friedrich , Wei Han
IPC分类号： A61K31/535 , A61K31/50 , A61K31/495 , A01N43/58 , A01N43/60
CPC分类号： C07D213/75 , C07D209/30 , C07D333/38 , C07D401/04 , C07D409/12 , C07D471/04
摘要： The present application describes 1,1-disubstituted cycloalkyl compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
摘要翻译：本申请描述了可用作因子Xa抑制剂的1,1-二取代的环烷基化合物及其衍生物或其药学上可接受的盐形式。

52. 发明申请

US20070203157A1 Heterocyclic dihydropyrimidine compounds 有权
标题翻译：杂环二氢嘧啶化合物
公开(公告)号：US20070203157A1
公开(公告)日：2007-08-30
申请号：US11511154
申请日：2006-08-28
申请人： Wei Han , Zilun Hu
发明人： Wei Han , Zilun Hu
IPC分类号： A61K31/519 , A61K31/727 , A61K38/28 , C07D487/04 , A61K31/4439 , A61K31/426 , A61K31/35 , A61K31/22
CPC分类号： C07D487/04
摘要： Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier, which have the structure stereoisomers including enantiomers thereof and diastereomers thereof, or a pharmaceutically acceptable salt thereof, wherein Q is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl or which is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R3 is wherein R1, R2, R4, R5, R6, R7, R8, R9 and R10 are defined herein. Methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds are also provided.
摘要翻译：可用作钾通道功能抑制剂的新型杂环二氢嘧啶化合物（特别是电压门控K +通道抑制剂，特别是K + 已经连接到具有包括其对映异构体和非对映异构体的结构立体异构体的超快速活化延迟整流剂的SUB> 1.5或其药学上可接受的盐，其中Q是烷基，取代的烷基，环烷基，取代的环烷基，环杂烷基，取代的环杂烷基或是芳基，取代的芳基，杂芳基或取代的杂芳基; R 3是其中R 1，R 2，R 2， R 4，R 5，R 6，R 7，R 8，R 8， 9和9本文定义的方法，使用这些化合物在预防和治疗心律失常和相关关系的病症中的方法，以及含有这些化合物的药物组合物 com 还提供磅。

53. 发明授权

US07115627B2 Glycinamides as factor Xa inhibitors 有权
公开(公告)号：US07115627B2
公开(公告)日：2006-10-03
申请号：US10304070
申请日：2002-11-25
申请人： Donald J. P. Pinto , Wei Han , Zilun Hu , Jennifer Qiao
发明人： Donald J. P. Pinto , Wei Han , Zilun Hu , Jennifer Qiao
IPC分类号： C07D405/10 , C07D471/04 , A61K31/423 , A61P7/02
CPC分类号： C07D213/75 , A61K31/423 , C07D209/30 , C07D209/42 , C07D213/81 , C07D295/15 , C07D333/38 , C07D401/04 , C07D413/04 , C07D413/14 , C07D471/04
摘要： The present application describes glycinamidic compounds and derivatives thereof, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.

54. 发明申请

US20060181960A1 Acoustic stimulation method with axial driver actuating moment arms on tines 有权
标题翻译：声刺激方法与轴向驱动器致动力矩臂在齿上
公开(公告)号：US20060181960A1
公开(公告)日：2006-08-17
申请号：US11059215
申请日：2005-02-16
申请人： James Birchak , Thomas Ritter , Ali Mese , Diederik Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel Kusmer , Mark Proett , Ferdinand Bas , Peter Sman , Jeroen Groenenboom , Pedro Zuiderwijk
发明人： James Birchak , Thomas Ritter , Ali Mese , Diederik Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel Kusmer , Mark Proett , Ferdinand Bas , Peter Sman , Jeroen Groenenboom , Pedro Zuiderwijk
IPC分类号： H04R17/00
CPC分类号： G10K9/121
摘要： A method for generating acoustic waves, the method having the steps of: extending a tine from a support structure so that a proximal end of the tine is attached to the support structure and a distal end of the tine is uninhibited; positioning an oscillator so as to be supported by the support structure and to mechanically communicate with the tine; and oscillating the tine with the oscillator.
摘要翻译：一种用于产生声波的方法，所述方法具有以下步骤：从支撑结构延伸齿，使得齿的近端附接到支撑结构，并且尖齿的远端不被抑制; 定位振荡器以便由支撑结构支撑并与齿机械连通; 并用振荡器振荡齿。

55. 发明申请

US20050273547A1 Method for balancing data access to non-volatile memory 审中-公开
标题翻译：用于平衡数据访问到非易失性存储器的方法
公开(公告)号：US20050273547A1
公开(公告)日：2005-12-08
申请号：US10859223
申请日：2004-06-03
申请人： Tony Tsai , David Ho , Wei Han
发明人： Tony Tsai , David Ho , Wei Han
IPC分类号： G06F12/00 , G11C16/10 , G11C16/34
CPC分类号： G11C16/102 , G11C16/349
摘要： The present invention discloses a method for balancing the data access to a non-volatile memory by sorting a block number of an unwritten memory block of a non-volatile memory with a queue structure. If the data in any memory block of the non-volatile memory is erased, the block number of the memory block in which the data is erased will be appended to the tail of the queue. If a data is written into the non-volatile memory, a block number of the memory block is obtained from the head of the queue and the desired data is written into the memory block with the corresponding block number, and in the meanwhile the block number is deleted from the queue.
摘要翻译：本发明公开了一种通过使用队列结构对非易失性存储器的未写入存储块的块数进行排序来平衡对非易失性存储器的数据访问的方法。如果非易失性存储器的任何存储器块中的数据被擦除，则擦除数据的存储器块的块号将附加到队列的尾部。如果将数据写入非易失性存储器，则从队列的头部获取存储块的块号，并将所需数据写入具有相应块号的存储块中，同时块号从队列中删除。

56. 发明申请

US20050176955A1 N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as hiv integrase inhibitors 失效
标题翻译：可用作hiv整合酶抑制剂的N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺
公开(公告)号：US20050176955A1
公开(公告)日：2005-08-11
申请号：US10508094
申请日：2003-03-12
申请人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
发明人： Melissa Egbertson , H. Marie Langford , Jeffrey Melamed , John Wai , Wei Han , Debbie Perlow , Linghang Zhuang , Mark Embrey , Steven Young
IPC分类号： A61K31/4375 , A61K31/541 , A61K31/549 , A61K45/00 , A61P31/18 , A61P43/00 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： N-(Substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides are inhibitors of HIV integrase and inhibitors of HIV replication. The naphthyridine carboxamides are of Formula (I): wherein R1′, R2′ and R3′ are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.
摘要翻译： N-（取代的苄基）-8-羟基-1,6-萘啶-7-甲酰胺是HIV整合酶和HIV复制抑制剂的抑制剂。萘啶甲酰胺具有式（I）：其中R 1，R 2和R 3'在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。

57. 发明授权

US06866482B2 High-performance propeller 有权
标题翻译：高性能螺旋桨
公开(公告)号：US06866482B2
公开(公告)日：2005-03-15
申请号：US10204984
申请日：2001-02-05
申请人： Wei Han , Yuanling Li , Lianyun Sun
发明人： Wei Han , Yuanling Li , Lianyun Sun
IPC分类号： B63H1/26 , B63H1/16 , B63H1/28 , B64C11/00 , B64C11/18 , F04D29/38 , F04D29/18
CPC分类号： B63H1/28 , B63H1/16 , B64C11/001 , B64C11/18 , F04D29/384
摘要： A high-performance propeller has one hub and a plurality of blades, characterized in that a double-side or a single-side arc brim is provided at the tip of each blade. The propeller of the invention can provide a small induced drag and convert the centrifugal force to the effective force so as is to increase the differential pressure near the tip of blades and thereby increase the acting force on blades. Under the condition of same power consumption, it has been tested for the large propeller in the type of lateral inclination that the amount of flow is increased about 12%˜17%, which is equivalent to save energy 40%˜70%. Since the fluid dynamic performance presents the aspect ratio approaching infinity, the width of the blades can be increased whereas the induced drag is not increased. Applying the method of increasing the area of the blades and decreasing the velocity of outflow fluid, the effect on saving of energy can be further improved greatly on the present basis.
摘要翻译：高性能螺旋桨具有一个轮毂和多个叶片，其特征在于，在每个叶片的尖端处设置双面或单侧弧形边缘。本发明的螺旋桨可以提供小的诱导阻力并将离心力转换成有效力，以便增加叶片尖端附近的差压，从而增加对叶片的作用力。在同等功耗的条件下，已经对横向倾斜型大型螺旋桨进行了测试，流量增加了约12％〜17％，相当于节能40％〜70％。由于流体动力学性能使纵横比接近无穷大，所以叶片的宽度可以增加，而感应阻力不增加。应用增加叶片面积和降低流出液速度的方法，在现有的基础上，可以大大提高对节能的效果。

58. 发明授权

US06755079B1 Method and apparatus for determining fluid viscosity 有权
标题翻译：用于确定流体粘度的方法和装置
公开(公告)号：US06755079B1
公开(公告)日：2004-06-29
申请号：US09536840
申请日：2000-03-27
申请人： Mark A. Proett , Michael T. Pelletier , Wei Han , Bruce H. Storm, Jr. , Roger L. Schultz , Thomas E. Ritter
发明人： Mark A. Proett , Michael T. Pelletier , Wei Han , Bruce H. Storm, Jr. , Roger L. Schultz , Thomas E. Ritter
IPC分类号： G01N1104
CPC分类号： E21B47/06 , E21B47/00 , E21B49/08 , E21B2049/085 , G01N11/08
摘要： A downhole tool and method for determining the viscosity of a reservoir fluid, the tool including a passage having entry, intermediate and exit regions, in which the reservoir fluid flowing through the passage will have a lower Reynolds number in the intermediate region as compared to the entry region, the tool also including differential pressure gauge for measuring the differential pressure across the intermediate region, and either a velocity controller or fluid velocity meter, for either setting or measuring the fluid velocity.
摘要翻译：一种用于确定储存器流体粘度的井下工具和方法，该工具包括具有入口，中间和出口区域的通道，在该通道中流过通道的储存流体在中间区域将具有较低的雷诺数，入口区域，该工具还包括用于测量跨越中间区域的压差的差压计，以及用于设定或测量流体速度的速度控制器或流体速度计。

59. 发明授权

US06627442B1 Methods for stable transduction of cells with hiv-derived viral vectors 失效
标题翻译：用hiv来源的病毒载体稳定转导细胞的方法
公开(公告)号：US06627442B1
公开(公告)日：2003-09-30
申请号：US09653088
申请日：2000-08-31
申请人： Laurent Humeau , Wei Han , Xiaobin Lu , Vladimir Slepushkin , Mechelle Lesher , Brian Davis , Yung-Nien Chang , Boro Dropulic
发明人： Laurent Humeau , Wei Han , Xiaobin Lu , Vladimir Slepushkin , Mechelle Lesher , Brian Davis , Yung-Nien Chang , Boro Dropulic
IPC分类号： C12N1585
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/16043
摘要： The present invention provides methods, as well as compositions related thereto, for the efficient transduction of cells using viral vectors. The efficiency of transduction is increased by contacting the cell to be transduced with one or more molecules that bind the cell surface. Contact with a cell surface binding molecule may occur before, after, or simultaneously with contact between the viral vector and the cell. The transduced vectors may be constructed to express a gene of interest, permitting the transduced cells to be used as therapeutic and prophylactic agents.
摘要翻译：本发明提供了使用病毒载体有效转导细胞的方法以及与之相关的组合物。通过使待转导的细胞与结合细胞表面的一种或多种分子接触来增加转导效率。与细胞表面结合分子的接触可以在病毒载体和细胞之间的接触之前，之后或同时发生。可以构建转导载体以表达感兴趣的基因，允许转导的细胞用作治疗和预防剂。

60. 外观设计

USD987169S1 Fire extinguisher 有权
公开(公告)号：USD987169S1
公开(公告)日：2023-05-23
申请号：US29854637
申请日：2022-09-27
申请人： Wei Han
设计人： Wei Han
摘要： FIG. 1 is a front, right and top perspective view of a fire extinguisher, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines shown in the drawings are included for the purpose of illustrating portions of the fire extinguisher that form no part of the claimed design.

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