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51. 发明授权

US08187269B2 Medical instruments and techniques for treating pulmonary disorders 有权
标题翻译：用于治疗肺部疾病的医疗仪器和技术
公开(公告)号：US08187269B2
公开(公告)日：2012-05-29
申请号：US12947228
申请日：2010-11-16
申请人： John H. Shadduck , Michael Hoey
发明人： John H. Shadduck , Michael Hoey
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B17/32037 , A61B2017/00809 , A61B2018/00315 , A61B2018/048
摘要： A surgical instrument for delivering energy to lung tissue, for example to cause lung volume reduction. In one embodiment, an elongated catheter has a handle portion that includes an interior chamber that is supplied with a biocompatible liquid media under pressure. An energy source delivers energy to the media to cause a liquid-to-vapor phase change within the interior chamber and ejects a flow of vapor media from the working end of the catheter. The delivery of energy and the flow of vapor are controlled by a computer controller to cause a selected pressure and selected volume of vapor to propagate to the extremities of the airways. Contemporaneously, the vapor undergoes a vapor-to-liquid phase transition which delivers large amount of energy to the airway tissue. The thermal energy delivered is equivalent to the heat of vaporization of the fluid media, which shrinks and collapses the treated airways. The treated tissue is the maintained in a collapsed state by means of aspiration for a short interval to enhance tissue remodeling. Thereafter, the patient's wound healing response causes fibrosis and further remodeling to cause permanent lung volume reduction.
摘要翻译：用于向肺组织递送能量的手术器械，例如以减少肺容积。在一个实施例中，细长导管具有手柄部分，该手柄部分包括在压力下供应生物相容性液体介质的内部腔室。能量源将能量传递到介质以在内部室内引起液体 - 气相变化，并从导管的工作端喷出蒸气介质流。能量的传递和蒸气的流动由计算机控制器控制，以使所选压力和选定体积的蒸气传播到气道的末端。同时，蒸气经历气 - 液相转移，其向气道组织输送大量的能量。传递的热能相当于流体介质的蒸发热量，这会使经过处理的气道收缩和收缩。经处理的组织通过抽吸短时间保持在折叠状态以增强组织重塑。此后，患者的伤口愈合反应引起纤维化并进一步重塑以造成永久肺容积减少。

52. 发明申请

US20120078361A1 Accommodating Intraocular Lenses and Methods of Use 有权
标题翻译：适应眼内镜片和使用方法
公开(公告)号：US20120078361A1
公开(公告)日：2012-03-29
申请号：US13300245
申请日：2011-11-18
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1601 , A61F2/1624 , A61F2/1648 , A61F2/1694 , A61F2002/1682 , A61F2002/16901 , A61F2210/0014 , A61F2250/0003 , A61F2310/00023
摘要： Fluid-driven accommodating intraocular lenses comprising deformable optic portions.
摘要翻译：流体驱动的容纳人造眼镜包括可变形的光学部分。

53. 发明申请

US20120017919A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20120017919A1
公开(公告)日：2012-01-26
申请号：US13188385
申请日：2011-07-21
申请人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
发明人： Edward M. Gillis , John H. Shadduck , Csaba Truckai , Andrew Poutiatine , Paul J. Buscemi
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A method of treating an airway disorder includes placing an implant in a patient's tongue, wherein the implant has first and second end portions that attach to tissue, and a tensioned medial portion between the first and second ends. The medial portion is configured to apply a pressure of less than a predetermined amount. Device systems associated with such methods are also provided.
摘要翻译：治疗气道障碍的方法包括将植入物放置在患者舌头中，其中植入物具有连接到组织的第一和第二端部以及在第一和第二端之间的张紧的中间部分。内侧部分构造成施加小于预定量的压力。还提供了与这种方法相关联的设备系统。

54. 发明授权

US08075555B2 Surgical sealing surfaces and methods of use 有权
标题翻译：手术密封面及使用方法
公开(公告)号：US08075555B2
公开(公告)日：2011-12-13
申请号：US11681740
申请日：2007-03-02
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B18/18 , H01C7/10 , H05B3/42
CPC分类号： A61B18/14 , A61B18/1442 , A61B2018/0063
摘要： Various embodiments provide compositions that exhibit positive temperature coefficient of resistance (PTCR) properties for use in thermal interactions with tissue—including thermal sensing and I2R current-limiting interactions. Embodiments also provide tissue-engaging surfaces having PTCR materials that provide very fast switching times between low resistance and high, current-limiting resistance. One embodiment provides a matrix for an electrosurgical energy delivery surface comprising a PTCR material and a heat exchange material disposed within an interior of the matrix. The PTCR material has a substantially conductive state and a substantially non-conductive state. The heat exchange material has a structure configured to have an omni-directional thermal diffusivity for exchanging heat with the PTCR material to cause rapid switching of the PTCR material between the conductive state and non-conductive state. Preferably, the structure comprises a graphite foam having an open cell configuration. The matrix can be carried by tissue contacting surfaces of various electrosurgical devices.
摘要翻译：各种实施方案提供了组合物，其表现出与包含组织的热感测和I2R限流相互作用的热相互作用中的正电温度系数（PTCR）性质。实施例还提供具有PTCR材料的组织接合表面，其在低电阻和高电流限制电阻之间提供非常快的开关时间。一个实施例提供了一种用于电外科能量输送表面的基质，其包含PTCR材料和设置在基质内部的热交换材料。 PTCR材料具有基本上导电的状态和基本上不导电的状态。热交换材料具有被配置为具有用于与PTCR材料进行热交换的全向热扩散性以使PTCR材料在导电状态和非导电状态之间快速切换的结构。优选地，该结构包括具有开孔构造的石墨泡沫。基质可以由各种电外科装置的组织接触表面携带。

55. 发明授权

US08066716B2 Instruments and techniques for controlled removal of epidermal layers 有权
标题翻译：用于控制去除表皮层的仪器和技术
公开(公告)号：US08066716B2
公开(公告)日：2011-11-29
申请号：US11417709
申请日：2006-05-03
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61B17/50 , A61M35/00
CPC分类号： A61B17/545 , A61B17/50 , A61B17/54 , A61B2017/00761 , A61B2017/320004 , A61B2217/005 , A61B2217/007 , A61M1/0064 , A61M35/00
摘要： An instrument and technique for the removal of epidermal layers in a controlled manner utilizing a hand-held instrument with a working end that (i) a vacuum aspiration system, (ii) a source for delivery of a sterile fluids or pharmacological agents to the skin; and (iii) a skin interface surface in the working end that has specially shape structure for abrading surface layers of the patient's epidermis as the working end is moved over the patient's skin while at the same time causing rapid penetration of the fluids into the skin for therapeutic purposes. Movement of the working end across the skin causes abrasion of the surface layers in a path over the patient's skin. The method of the invention may be used in a periodic treatment for the removal of superficial skin layers that enhances the synthesis of dermal collagen aggregates by inducing the body's natural wound healing response. The method of the invention creates more normal dermal architectures in skin with limited depths of skin removal by the series of superficial treatments that may be comparable to the extent of neocollagenesis caused by a deep skin removal treatment (e.g., CO2 laser skin removal).
摘要翻译：一种利用具有工作端的手持式仪器以受控方式去除表皮层的仪器和技术，该工具包括（i）真空抽吸系统，（ii）用于将无菌流体或药物剂递送至皮肤的源 ; 和（iii）工作端中的皮肤界面表面，其具有特殊的形状结构，用于当工作端移动到患者皮肤上同时使流体快速渗透到皮肤中时，用于研磨患者表皮的表面层治疗目的。穿过皮肤的工作端的移动导致患者皮肤上的路径中的表面层的磨损。本发明的方法可用于周期性治疗以通过诱导人体的自然伤口愈合反应来去除表皮层，从而增强真皮胶原聚集体的合成。本发明的方法在皮肤中产生更正常的皮肤结构，通过一系列表皮处理有限的皮肤去除深度，其可以与由深层皮肤去除处理（例如，CO2激光皮肤去除）引起的新胶原形成的程度相当。

56. 发明申请

US20110226263A1 SYSTEMS AND METHODS FOR TREATMENT OF SLEEP APNEA 有权
标题翻译：用于治疗睡眠APNEA的系统和方法
公开(公告)号：US20110226263A1
公开(公告)日：2011-09-22
申请号：US13053059
申请日：2011-03-21
申请人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
发明人： Edward M. Gillis , Andrew Poutiatine , John H. Shadduck , Csaba Truckai
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2/00 , A61F5/56 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body includes an adjustment element configured to allow in-situ adjustment of the implant body between first and second tensioning forces applied to the site. Methods of using such systems are also provided.
摘要翻译：一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。在一些实施例中，植入物主体包括调整元件，其被配置为允许植入物本体在施加到部位的第一和第二张力之间进行原位调整。还提供了使用这种系统的方法。

57. 发明申请

US20100228344A1 Accommodating Intraocular Lens 审中-公开
标题翻译：容纳人工晶状体
公开(公告)号：US20100228344A1
公开(公告)日：2010-09-09
申请号：US12782644
申请日：2010-05-18
申请人： John H. Shadduck
发明人： John H. Shadduck
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1601 , A61F2/1624 , A61F2/1648 , A61F2/1694 , A61F2002/1682 , A61F2002/16901 , A61F2210/0014 , A61F2250/0003 , A61F2310/00023
摘要： A deformable intracapsular implant device for shaping an enucleated lens capsule sac for use in cataract procedures and refractive lensectomy procedures. In one embodiment, the intraocular implant devices rely on thin film shape memory alloys and combine with the post-phaco capsular sac to provide a biomimetic complex that can mimic the energy-absorbing and energy-releasing characteristics of a young accommodative lens capsule. In another embodiment, the capsular shaping body is combined with an adaptive optic. The peripheral capsular shaping body carries at least one fluid-filled interior chamber that communicates with a space in a adaptive optic portion that has a deformable lens surface. The flexing of the peripheral shaping body in response to zonular tensioning and de-tensioning provides an inventive adaptive optics mechanism wherein fluid media flows between the respective chambers “adapts” the optic to increase and decrease the power thereof. In one embodiment, the capsular shaping body carries a posterior negative power adaptive optic that can be altered in power during accommodation to cooperate with an independent drop-in exchangeable intraocular lens.
摘要翻译：一种可变形的囊内植入装置，用于成形用于白内障手术和折射镜片切除术程序的去核晶状体囊囊。在一个实施例中，眼内植入装置依赖于薄膜形状记忆合金并与后囊膜囊囊组合以提供可模仿年轻调节性晶状体囊的能量吸收和释放能量的仿生复合物。在另一个实施例中，囊状成形体与自适应光学元件组合。周边胶囊成形体携带至少一个流体填充的内部室，其与具有可变形透镜表面的自适应光学部分中的空间连通。外围成形体响应于zonular张力和张力的弯曲提供了本发明的自适应光学机构，其中流体介质在各个腔室之间流动“适配”光学元件以增加和减小其功率。在一个实施例中，囊状成形体携带后负电力自适应光学器件，其在调节期间可以改变功率，以与独立的可插入的可交换眼内透镜协作。

58. 发明申请

US20100174320A1 BONE ANCHOR APPARATUS AND METHOD 有权
标题翻译：骨锚固装置和方法
公开(公告)号：US20100174320A1
公开(公告)日：2010-07-08
申请号：US12683358
申请日：2010-01-06
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61B17/88 , A61B17/86
CPC分类号： A61B17/70 , A61B17/7001 , A61B17/8685
摘要： A bone anchor can include an elongated body and a plurality of separate elements. The bone anchor can be configured to be insertable into bone. The bone anchor can be coupleable to a spine treatment apparatus. The bone anchor can be revisable so that after a treatment interval attached to a spine treatment apparatus, the spine treatment apparatus can be detached and the bone anchor revised by removing the plurality of separate elements from the bone thus allowing a new anchor to be implanted in the bone.
摘要翻译：骨锚可以包括细长主体和多个单独的元件。骨锚可构造成可插入骨中。骨锚可以与脊椎治疗装置相连。可以修复骨锚，使得在经脊柱处理装置的治疗间隔之后，可以将脊柱处理装置拆下，并通过从骨中移除多个分离的元件来修复骨锚，从而允许将新的锚植入骨头。

59. 发明申请

US20100145325A1 Systems and Methods for Treatment of Prostatic Tissue 有权
标题翻译：前列腺组织治疗系统与方法
公开(公告)号：US20100145325A1
公开(公告)日：2010-06-10
申请号：US12614218
申请日：2009-11-06
申请人： Michael Hoey , John H. Shadduck
发明人： Michael Hoey , John H. Shadduck
IPC分类号： A61B18/08
CPC分类号： A61B18/04 , A61B18/082 , A61B18/14 , A61B2018/00017 , A61B2018/00029 , A61B2018/00547 , A61B2018/00559 , A61B2018/00577 , A61B2018/048 , A61B2018/1472 , A61B2034/2063 , A61B2218/002 , A61B2218/007
摘要： A prostate therapy system is provided that may include any of a number of features. One feature of the prostate therapy system is that it can access a prostate lobe transurethrally. Another feature of the prostate therapy system is that it can deliver condensable vapor into the prostate to ablate the prostate tissue. Methods associated with use of the prostate therapy system are also covered.
摘要翻译：提供了可以包括多个特征中的任何一个的前列腺治疗系统。前列腺治疗系统的一个特点是可以经尿道前列腺进入前列腺。前列腺治疗系统的另一个特征是它可以将可冷凝的蒸气输送到前列腺中以消融前列腺组织。还涉及与使用前列腺治疗系统相关的方法。

60. 发明申请

US20100137986A1 IMPLANTS AND METHODS FOR TREATING BONE 有权
标题翻译：用于治疗骨的植入物和方法
公开(公告)号：US20100137986A1
公开(公告)日：2010-06-03
申请号：US12624086
申请日：2009-11-23
申请人： Csaba Truckai , John H. Shadduck
发明人： Csaba Truckai , John H. Shadduck
IPC分类号： A61F2/44
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00004 , A61F2/44 , A61F2/4455 , A61F2/4611 , A61F2002/30062 , A61F2002/30289 , A61F2002/30579 , A61F2002/30677 , A61F2210/0004 , A61F2230/0091
摘要： An orthopedic implant comprising a deformable, expandable implant body configured for treating abnormalities in bones, such as compression fractures of vertebra, necrosis of femurs and the like. An exemplary implant body comprises a small cross-section threaded element that is introduced into a bone region and thereafter is expanded into a larger cross-section, monolithic assembly to provide a bone support. In one embodiment, the implant body is at least partly fabricated of a magnesium alloy that is biodegradable to allow for later tissue ingrowth.
摘要翻译：一种矫形植入物，包括可变形的，可扩张的植入体，其被配置用于治疗骨骼的异常，例如椎骨的压缩性骨折，股骨的坏死等。示例性植入物主体包括被引入到骨区域中的小横截面的螺纹元件，然后被扩展成更大的横截面的整体式组件以提供骨支撑。在一个实施例中，植入体至少部分地由可生物降解的镁合金制成，以允许稍后的组织向内生长。

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