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51. 发明申请

WO2007049041A8 4- (3-AMINOPYRAZOLE) PYRIMIDINE DERIVATIVES FOR USE AS TYROSINE KINASE INHIBITORS IN THE TREATMENT OF CANCER 审中-公开
标题翻译：在治疗癌症中用作酪氨酸激酶抑制剂的4-（3-氨基吡唑）吡嗪衍生物
公开(公告)号：WO2007049041A8
公开(公告)日：2012-11-01
申请号：PCT/GB2006003978
申请日：2006-10-26
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , FENG XIAOMEI , GUAN HUIPING , KAN YING , IOANNIDIS STEPHANOS , PENG BO , SU MEI , WANG BIN , WANG TAO , ZHANG HAI-JUN
发明人： FENG XIAOMEI , GUAN HUIPING , KAN YING , IOANNIDIS STEPHANOS , PENG BO , SU MEI , WANG BIN , WANG TAO , ZHANG HAI-JUN
IPC分类号： C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D403/14
摘要： This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

52. 发明申请

WO2011038028A9 ENHANCED BLOCK REQUEST STREAMING USING BLOCK PARTITIONING OR REQUEST CONTROLS FOR IMPROVED CLIENT-SIDE HANDLING 审中-公开
公开(公告)号：WO2011038028A9
公开(公告)日：2011-05-19
申请号：PCT/US2010049862
申请日：2010-09-22
申请人： QUALCOMM INC , LUBY MICHAEL G , WATSON MARK , VICISANO LORENZO , PAKZAD PAYAM , WANG BIN
发明人： LUBY MICHAEL G , WATSON MARK , VICISANO LORENZO , PAKZAD PAYAM , WANG BIN
IPC分类号： H04L29/06
CPC分类号： H04L65/604 , H04L65/4084 , H04L65/602 , H04L65/607 , H04L65/80 , H04N21/23106 , H04N21/23406 , H04N21/234327 , H04N21/235 , H04N21/2401 , H04N21/25808 , H04N21/2662 , H04N21/435 , H04N21/44004 , H04N21/440227 , H04N21/44209 , H04N21/84 , H04N21/8456
摘要： A block request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server. A client device can be adapted to take advantage of the ingestion process. The client device might be configured to optimize use of resources, given the information available to it from the ingestion system. This may include configurations to determine the sequence, timing and construction of block requests based on monitoring buffer size and rate of change of buffer size, use of variable sized requests, mapping of block requests to underlying transport connections, flexible pipelining of requests, and/or use of whole file requests based on statistical considerations.

53. 发明申请

WO2008145984A8 GRAFT FIXATION DEVICE 审中-公开
标题翻译： GRAFT固定装置
公开(公告)号：WO2008145984A8
公开(公告)日：2009-08-20
申请号：PCT/GB2008001800
申请日：2008-05-27
申请人： UNIV HOSPITAL OF SOUTH MANCHES , WANG BIN , CHIZARI MAHMOUD , SNOW DAVID MARTYN
发明人： WANG BIN , CHIZARI MAHMOUD , SNOW DAVID MARTYN
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2002/0835 , A61F2002/0858
摘要： A graft fixation device (1) comprising a sheath (2) having a body (9) that defines an inner longitudinal bore (8) and a member (3) for receipt within said bore (8), wherein said sheath (2) comprises at least one projection (15) moveably connected to said sheath body (9) and said at least one projection (15) is arranged so as to be displaceable radially outwardly of said sheath body (9) upon receipt of said member (3) within said bore (8).
摘要翻译：一种移植物固定装置（1），包括具有限定内纵向孔（8）的本体（9）和用于容纳在所述孔（8）内的构件）的护套（2），其中所述护套（2）包括可移动地连接到所述护套主体（9）和所述至少一个突出部（15）的至少一个突出部（15）布置成在所述护套主体（9）内部收到所述部件所述孔（8）。

54. 发明申请

WO2006123113A3 PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：可用作酪氨酸激酶抑制剂的吡唑啉氨基吡啶衍生物
公开(公告)号：WO2006123113A3
公开(公告)日：2007-01-04
申请号：PCT/GB2006001760
申请日：2006-05-12
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , WANG BIN , WANG TAO
发明人： WANG BIN , WANG TAO
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14
摘要： This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

55. 发明申请

WO2005103010A3 PYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的吡咯衍生物
公开(公告)号：WO2005103010A3
公开(公告)日：2006-03-02
申请号：PCT/GB2005001512
申请日：2005-04-20
申请人： ASTRAZENECA AB , ASTRAZENECA UK LTD , LYNE PAUL , WANG BIN , WANG TAO
发明人： LYNE PAUL , WANG BIN , WANG TAO
IPC分类号： C07D231/06 , C07D231/38 , A61K31/517
CPC分类号： C07D231/06 , C07D231/38
摘要： This invention relates to novel compounds having the formul and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有方法及其药物组合物及其使用方法的新化合物。这些新型化合物为癌症提供治疗。

56. 发明申请

WO2011038032A3 ENHANCED BLOCK-REQUEST STREAMING USING URL TEMPLATES AND CONSTRUCTION RULES 审中-公开
标题翻译：使用URL模板和构造规则增强了块请求流式传输
公开(公告)号：WO2011038032A3
公开(公告)日：2011-11-24
申请号：PCT/US2010049869
申请日：2010-09-22
申请人： QUALCOMM INC , LUBY MICHAEL G , WATSON MARK , VICISANO LORENZO , PAKZAD PAYAM , WANG BIN , STOCKHAMMER THOMAS
发明人： LUBY MICHAEL G , WATSON MARK , VICISANO LORENZO , PAKZAD PAYAM , WANG BIN , STOCKHAMMER THOMAS
IPC分类号： H04L29/06 , H04N7/24
CPC分类号： H04L65/604 , H04L65/4084 , H04L65/602 , H04L65/607 , H04L65/80 , H04N21/23106 , H04N21/23406 , H04N21/234327 , H04N21/235 , H04N21/2401 , H04N21/25808 , H04N21/2662 , H04N21/435 , H04N21/44004 , H04N21/440227 , H04N21/44209 , H04N21/84 , H04N21/8456
摘要： A block-request streaming system provides for improvements in the user experience and bandwidth efficiency of such systems, typically using an ingestion system that generates data in a form to be served by a conventional file server (HTTP, FTP, or the like), wherein the ingestion system intakes content and prepares it as files or data elements to be served by the file server, which might include a cache. A client device can be adapted to take advantage of the ingestion process as well as improvements that make for a better presentation independent of the ingestion process. The client devices and ingestion system can be coordinated to have a predefined mapping and template for making block requests to HTTP file names that a conventional file server can accept through the use of URL construction rules. Segment size might be specified in an approximate manner for more efficient organization.
摘要翻译：块请求流式传输系统通常使用产生由传统文件服务器（HTTP，FTP等）提供的形式的数据的摄取系统来提供这种系统的用户体验和带宽效率的改进，其中摄入系统摄入内容并将其准备为文件服务器要提供的文件或数据元素，这可能包括缓存。客户端设备可以适应于利用摄取过程以及独立于摄取过程而进行更好呈现的改进。可以协调客户端设备和摄取系统以具有预定义的映射和模板，用于向传统文件服务器可以通过使用URL构建规则接受的HTTP文件名发出块请求。分段大小可以近似指定，以提高组织效率。

57. 发明申请

WO2011109106A2 IMMUNOGENIC COMPOSITIONS AGAINST HUMAN PROGASTRIN PEPTIDES 审中-公开
标题翻译：免疫组织化学反应人类孕激素
公开(公告)号：WO2011109106A2
公开(公告)日：2011-09-09
申请号：PCT/US2011000413
申请日：2011-03-03
申请人： ONKOLOGIX LTD , ASCIONE RICHARD , QI SHENGMEI , WANG BIN
发明人： ASCIONE RICHARD , QI SHENGMEI , WANG BIN
CPC分类号： A61K39/0005 , A61K47/646 , A61K47/65 , C07K14/595
摘要： Immunogens against human extended-progastrin species comprise (A) a mimetic peptide comprised of (i) the amino acid sequence of a progastrin or a N- and/or C-terminal processed species of a progastrin joined to (ii) a 7 amino-acid spacer coupled to (B) an immunogenic carrier. Illustrative of the mimetic peptide/spacer combination are a 21 amino-acid peptide (SEQ ID NO.: 1) and other, related polypeptides (SEQ ID NOs.: 2-5). Pharmaceutical compositions containing such an immunogen display improved immunological properties, including the induction of effective antibody levels shortly after the administration of an initial course of immunogen. Levels of antibody thus elicited stay elevated for several months and readily elevate to higher levels upon subsequent boosting by a single injection of immunogen.
摘要翻译：针对人类延伸的前胃泌素物种的免疫原包含（A）模仿肽，其包含（i）泌乳素或N-和/或C-末端加工物种的泌乳素的氨基酸序列，连接到（ii）与（B）免疫原性载体偶联的酸性间隔基。示例性的模拟肽/间隔物组合是21个氨基酸的肽（SEQ ID NO：1）和其它相关多肽（SEQ ID NO：2-5）。含有这种免疫原的药物组合物显示出改善的免疫学性质，包括在施用免疫原的初始过程之后不久诱导有效的抗体水平。因此引发的抗体水平保持升高几个月，并且通过单次注射免疫原随后升高时容易升高至较高水平。

58. 发明申请

WO2008137779A3 NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开
标题翻译： HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：WO2008137779A3
公开(公告)日：2009-01-08
申请号：PCT/US2008062552
申请日：2008-05-02
申请人： INTERMUNE INC , ARRAY BIOPHARMA INC , BLATT LAWRENCE M , PAN LIN , SEIWERT SCOTT , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BEIGELMAN LEONID , LIU JYANWEI , CONDROSKI KEVIN , JIANG YUTONG , KAUS ROBERT , KENNEDY APRIL , KERCHER TIMOTHY , LYON MICHAEL , WANG BIN
发明人： BLATT LAWRENCE M , PAN LIN , SEIWERT SCOTT , ANDREWS STEVEN W , MARTIN PIERRE , SCHUMACHER ANDREAS , BEIGELMAN LEONID , LIU JYANWEI , CONDROSKI KEVIN , JIANG YUTONG , KAUS ROBERT , KENNEDY APRIL , KERCHER TIMOTHY , LYON MICHAEL , WANG BIN
IPC分类号： C07D487/04 , A61K31/407 , A61P31/12 , C08H1/00
CPC分类号： C07D487/04
摘要： The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
摘要翻译：实施方案提供了通式I的大环化合物，以及包含主题化合物的组合物，包括药物组合物。实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。

59. 发明申请

WO2007084775A3 COMPOSITIONS AND METHODS FOR MODULATION OF SUPPRESSOR T CELL ACTIVATION 审中-公开
标题翻译：用于调节抑制剂T细胞活化的组合物和方法
公开(公告)号：WO2007084775A3
公开(公告)日：2008-07-03
申请号：PCT/US2007001677
申请日：2007-01-22
申请人： UNIV PENNSYLVANIA , PHILADELPHIA CHILDREN HOSPITAL , WANG BIN , GREENE MARK I , SAQUAF SANDRA , LI BIN , ZHANG HONGTAO , HANCOCK WAYNE W
发明人： WANG BIN , GREENE MARK I , SAQUAF SANDRA , LI BIN , ZHANG HONGTAO , HANCOCK WAYNE W
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12N5/0636 , A61K31/19 , A61K35/17 , A61K38/1793 , A61K39/00 , A61K39/0011 , A61K39/39 , A61K49/0008 , C12N15/1137 , C12N2310/14 , A61K2300/00
摘要： Methods of treating autoimmune disorders, coronary artery disease, allergy symptoms, allograft rejection sepsis/toxic shock are disclosed. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3 in combination with a T suppressor stimulus and/or an antigen. Some methods comprise administering one or more regulatory compositions to activate the T suppressor cells by increasing the acetylation level and/or protein level of FOXP3. Some methods comprise administering soluble GITR or antibodies that bind to GITR ligand. Methods of treating cancer, infectious diseases, and immune deficiency are also disclosed as are vaccination methods. The methods comprise administering one or more regulatory compositions to inactivate the T suppressor cells by reducing the acetylation level and/or protein level of FOXP3. Improved vaccines and vaccination methods are disclosed. Methods of identifying compounds that are useful to modulate acetylation level and/or protein level of FOXP3 and treat diseases are disclosed.
摘要翻译：公开了治疗自身免疫性疾病，冠状动脉疾病，过敏症状，同种异体移植排斥败血症/中毒性休克的方法。一些方法包括施用一种或多种调节组合物以通过与T抑制刺激和/或抗原组合增加FOXP3的乙酰化水平和/或蛋白水平来激活T抑制细胞。一些方法包括施用一种或多种调节组合物以通过增加FOXP3的乙酰化水平和/或蛋白质水平来激活T抑制细胞。一些方法包括施用可结合GITR配体的可溶性GITR或抗体。疫苗接种方法也公开了治疗癌症，感染性疾病和免疫缺陷的方法。所述方法包括施用一种或多种调节组合物以通过降低FOXP3的乙酰化水平和/或蛋白质水平来灭活T抑制细胞。公开了改进的疫苗和疫苗接种方法。公开了鉴定可用于调节FOXP3的乙酰化水平和/或蛋白质水平并治疗疾病的化合物的方法。

60. 发明申请

WO2008002541A2 CUBE WIRE-GRID POLARIZING BEAM SPLITTER AND PROJECTION DISPLAY WITH SAME 审中-公开
标题翻译： CUBE WIRE-GRID偏振光束分离器和投影显示器
公开(公告)号：WO2008002541A2
公开(公告)日：2008-01-03
申请号：PCT/US2007014751
申请日：2007-06-25
申请人： MOXTEK INC , WANG BIN , GARDNER ERIC , PERKINS RAYMOND
发明人： WANG BIN , GARDNER ERIC , PERKINS RAYMOND
IPC分类号： G03B21/14
CPC分类号： G03B21/14 , G03B21/2073 , H04N9/3167
摘要： A cube wire-grid polarizing beam splitter (10, 10b) includes a pair of prisms (18, 22) secured together to form a cube. An array (30) of parallel conductive wires (34) is disposed between the pair of prisms. A pair of continuous film layers (42) is disposed on one side of the wires between the wires and one of the pair of prisms with an intermediate film layer (46, 46b) adjacent the prism having a refractive index greater than both i) a refractive index of a rear film layer (50, 50b) adjacent the plate wire grid polarizer, and ii) a refractive index of an adjacent prism. A layer of ribs (62) is disposed on another side of the wires between the wires and another of the pair of prisms, the ribs being aligned with and supporting the array of parallel conductive wires. A display apparatus (100) includes a cube wire-grid polarizing beam splitter.
摘要翻译：立方体线栅偏振分束器（10,10b）包括固定在一起以形成立方体的一对棱镜（18,22）。平行导线（34）的阵列（30）设置在一对棱镜之间。一对连续的薄膜层（42）设置在金属丝之间的金属丝的一侧，并且一对棱镜之一具有与棱镜相邻的中间薄膜层（46,46b），其折射率大于i）a 与板线栅偏振器相邻的后膜层（50,50b）的折射率，以及ii）相邻棱镜的折射率。一层肋（62）设置在导线与一对棱镜中的另一个棱之间的导线的另一侧上，这些棱对准并支撑平行导线阵列。显示设备（100）包括立方体线栅偏振分束器。

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