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51. 发明授权

US08057813B2 Multiple drug delivery from a balloon and a prosthesis 有权
标题翻译：来自气球和假体的多次药物递送
公开(公告)号：US08057813B2
公开(公告)日：2011-11-15
申请号：US11084172
申请日：2005-03-18
申请人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
发明人： John L. Toner , Sandra E. Burke , Keith R. Cromack , Randolf von Oepen
IPC分类号： A61F13/00
CPC分类号： A61F2/91 , A61F2/86 , A61F2/915 , A61F2/958 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2002/91591 , A61F2250/0067 , A61F2310/0097 , A61K47/6957 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00
摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.
摘要翻译：公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

52. 发明授权

US07771459B2 Fastener having torque optimized head 失效
标题翻译：紧固件具有扭矩优化头
公开(公告)号：US07771459B2
公开(公告)日：2010-08-10
申请号：US11145692
申请日：2005-06-06
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61B17/86 , A61B17/58
CPC分类号： A61B17/888 , A61B17/8615 , A61B17/864 , A61B2017/00004
摘要： Disclosed is a medical fastener that can be mounted to a bone of a patient. The medical fastener can include a head portion comprising a recess having a first portion, a second tapered portion extending from the first portion, and a third cylindrical portion extending from the second tapered portion. A threaded body portion can extend from the head portion. The first portion and the second portion can have a Torx geometry or star-shaped configuration. Also disclosed is a driver usable to mount the medical fastener to the bone. The driver can include a tip that is complementary to the recess and an end that enables the driver to mount to a drill or other device that can rotate the driver.
摘要翻译：公开了可以安装到患者的骨骼上的医疗紧固件。医疗紧固件可以包括头部，头部包括具有第一部分的凹部，从第一部分延伸的第二锥形部分和从第二锥形部分延伸的第三圆柱形部分。螺纹体部分可以从头部延伸。第一部分和第二部分可以具有Torx几何形状或星形配置。还公开了可用于将医疗紧固件安装到骨头的驱动器。驱动器可以包括与凹部互补的尖端和使得驱动器能够安装到能够旋转驱动器的钻孔或其他装置的端部。

53. 发明申请

US20100076377A1 Expandable Member Formed Of A Fibrous Matrix Having Hydrogel Polymer For Intraluminal Drug Delivery 有权
标题翻译：具有用于腔内药物递送的水凝胶聚合物的纤维基质的可膨胀构件
公开(公告)号：US20100076377A1
公开(公告)日：2010-03-25
申请号：US12238026
申请日：2008-09-25
申请人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
发明人： Kevin J. Ehrenreich , Richard R. Newhauser , Randolf von Oepen , John Stankus
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M25/1029 , A61L29/085 , A61L29/16 , A61L2300/606 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
摘要： An intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent incorporated therein. The hydrogel polymer can be coated on the fiber elements in a co-axial configuration. The fiber elements may also have a second coating including a protective substance surrounding the hydrogel polymer having a therapeutic agent therein. The matrix of fiber elements can be formed by electrospinning. A process of delivering a therapeutic agent to a target site includes providing an intraluminal catheter device having an expandable member formed of a matrix of fiber elements, the expandable member including a hydrogel polymer having a therapeutic agent dispersed therein, and advancing the catheter device at a desired treatment site. Once at the desired treatment site, fluid is introduced into the inflation lumen to expand the expandable member from a first profile to a second profile, and the therapeutic agent is released from the hydrogel polymer and delivered to the desired treatment site.
摘要翻译：一种管腔内导管装置，其具有由纤维元件基质形成的可膨胀构件，所述可扩张构件包括其中结合有治疗剂的水凝胶聚合物。水凝胶聚合物可以以同轴构型涂覆在纤维元件上。纤维元件还可以具有包含围绕水凝胶聚合物的保护性物质的第二涂层，其中具有治疗剂。纤维元素的基质可以通过静电纺丝形成。将治疗剂递送到靶位置的过程包括提供具有由纤维元件基质形成的可扩张构件的管腔内导管装置，所述可扩张构件包括其中分散有治疗剂的水凝胶聚合物，并将导管装置推进到所需治疗部位。一旦在期望的治疗部位，将流体引入充气腔，以将可膨胀构件从第一轮廓扩张到第二轮廓，并且将治疗剂从水凝胶聚合物释放并递送到所需的治疗部位。

54. 发明申请

US20080172083A1 METHOD AND APPARATUS FOR DISTAL PROTECTION DURING A MEDICAL PROCEDURE 审中-公开
标题翻译：医疗过程中远程保护的方法和装置
公开(公告)号：US20080172083A1
公开(公告)日：2008-07-17
申请号：US11953816
申请日：2007-12-10
申请人： Ib Erling Joergensen , Gerd Seibold , Bodo Stefan Josef Quint , Kenneth J. Michlitsch , Martina Stueven , Randolf von Oepen
发明人： Ib Erling Joergensen , Gerd Seibold , Bodo Stefan Josef Quint , Kenneth J. Michlitsch , Martina Stueven , Randolf von Oepen
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0069
摘要： Apparatus and methods for providing distal protection during a medical procedure that include a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.
摘要翻译：在医疗过程中提供远端保护的装置和方法，其包括血管过滤器，所述血管过滤器具有自膨胀多孔泡沫体，所述自扩张多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。过滤器联接到诸如导丝的细长构件的远侧区域。还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。

55. 发明申请

US20070213800A1 Method and apparatus for stenting comprising enhanced embolic protection coupled with improved protections against restenosis and thrombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和血栓形成的保护
公开(公告)号：US20070213800A1
公开(公告)日：2007-09-13
申请号：US11731882
申请日：2007-03-30
申请人： Joost Fierens , Silvio Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost Fierens , Silvio Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

56. 发明申请

US20070179601A1 Methods and apparatus for stenting comprising enhanced embolic protections coupled with improved protections against restenosis and trombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护以及改进的针对再狭窄和慢性淋巴细胞形成的保护
公开(公告)号：US20070179601A1
公开(公告)日：2007-08-02
申请号：US11732244
申请日：2007-04-02
申请人： Joost Fierens , Silvio Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost Fierens , Silvio Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

57. 发明授权

US06755856B2 Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation 有权
标题翻译：用于支架置入的方法和装置包括增强的栓塞保护，以及改进的针对再狭窄和血栓形成的保护
公开(公告)号：US06755856B2
公开(公告)日：2004-06-29
申请号：US09967789
申请日：2001-09-28
申请人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
发明人： Joost J. Fierens , Silvio R. Schaffner , Marc Gianotti , Gerd Seibold , Randolf von Oepen
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/82 , A61F2/856 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/0086 , A61F2002/91508 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2220/0016 , A61F2220/005
摘要： Apparatus and methods for stenting are provided comprising a stent attached to a porous biocompatible material that is permeable to endothelial cell ingrowth, but impermeable to release of emboli of predetermined size. Preferred stent designs are provided, as well as preferred manufacturing techniques. Apparatus and methods are also provided for use at a vessel branching. Moreover, embodiments of the present invention may comprise a coating configured for localized delivery of therapeutic agents. Embodiments of the present invention are expected to provide enhanced embolic protection, improved force distribution, and improved recrossability, while reducing a risk of restenosis and thrombus formation.
摘要翻译：提供了用于支架置入的装置和方法，其包括附着于多孔生物相容性材料的支架，所述多孔生物相容性材料可渗透内皮细胞向内生长，但不能透过预定尺寸的栓塞。提供优选的支架设计，以及优选的制造技术。还提供了用于血管分支的装置和方法。此外，本发明的实施方案可以包括被配置用于局部递送治疗剂的涂层。预期本发明的实施方案可提供增强的栓塞保护，改善的力分布和改善的再交联性，同时降低再狭窄和血栓形成的风险。

58. 发明授权

US06533809B2 Stent 有权
标题翻译：支架
公开(公告)号：US06533809B2
公开(公告)日：2003-03-18
申请号：US09774595
申请日：2001-02-01
申请人： Randolf von Oepen
发明人： Randolf von Oepen
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054
摘要： A stent has a tubular flexible body with a wall having a web structure. The web structure has several adjoining cells. The cells are surrounded by webs of the web structure. Each cell has at least one spring element.
摘要翻译：支架具有管状柔性体，其壁具有腹板结构。网状结构具有几个邻接的单元。细胞被网状结构的腹板包围。每个单元具有至少一个弹簧元件。

59. 发明授权

US10874512B2 System and methods for delivering and deploying an artificial heart valve within the mitral annulus 有权
公开(公告)号：US10874512B2
公开(公告)日：2020-12-29
申请号：US15724499
申请日：2017-10-04
申请人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
发明人： Randolf von Oepen , Sean A. McNiven , Francisco Valencia
IPC分类号： A61F2/24 , A61F2/95
CPC分类号： A61F2/2436 , A61F2/2439 , A61F2/2409 , A61F2/9517 , A61F2/9522 , A61F2210/0014
摘要： The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures/tethers which maintain proximal tension on the valve prior to deployment.

60. 发明申请

US20180028787A1 COMBINATION STEERABLE CATHETER AND SYSTEMS 审中-公开
公开(公告)号：US20180028787A1
公开(公告)日：2018-02-01
申请号：US15662013
申请日：2017-07-27
申请人： Sean A. McNiven , Francisco Valencia , Randolf von Oepen
发明人： Sean A. McNiven , Francisco Valencia , Randolf von Oepen
IPC分类号： A61M25/01 , A61M25/00 , A61B5/00 , A61F2/24 , A61B5/0215 , A61B5/01
摘要： A steerable catheter has a body with an outer surface and an inner surface defining a central lumen. The outer surface and inner surface define a wall of the body, which has a plurality of steering lumen and control lumen extending longitudinally therethrough. The body includes a body material. The steering lumen and control lumen have a control lumen lining and steering lumen lining, respectively, with a higher durometer than the body material. A steering wire is positioned within the steering lumen and a control wire is positioned within the control lumen.

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